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Open AccessArticle

Study on the Material Basis of Neuroprotection of Myrica rubra Bark

Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100193, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2019, 24(16), 2993; https://doi.org/10.3390/molecules24162993
Received: 20 July 2019 / Revised: 11 August 2019 / Accepted: 14 August 2019 / Published: 18 August 2019
(This article belongs to the Section Analytical Chemistry)
Background: Increasing attention has been given to the search for neuroprotective ingredients from natural plants. Myrica rubra bark (MRB) has been used in traditional oriental medicine for over thousand years and has potential neuroprotection. Methods and Results: Ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was used to identify the compounds in MRB extract, and the MTT assay was performed to evaluate the neuroprotection of six major compounds from MRB against glutamate-induced damage in PC12 cells. The result displayed nineteen compounds were identified, and myricitrin and myricanol 11-sulfate were shown to have neuroprotection, which prevented cell apoptosis through alleviating oxidative stress by reducing the levels of reactive oxygen species and methane dicarboxylic aldehyde, as well as by enhancing the activities of superoxide dismutase. Conclusions: Several active compounds from MRB may offer neuroprotection and have the potential for the development of new drugs against central nervous system diseases. View Full-Text
Keywords: Myrica rubra; UPLC-Q-TOF-MS; glutamate; neuroprotection; myricitrin; myricanol 11-sulfate Myrica rubra; UPLC-Q-TOF-MS; glutamate; neuroprotection; myricitrin; myricanol 11-sulfate
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MDPI and ACS Style

Shen, S.; Zhao, M.; Li, C.; Chang, Q.; Liu, X.; Liao, Y.; Pan, R. Study on the Material Basis of Neuroprotection of Myrica rubra Bark. Molecules 2019, 24, 2993.

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