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Molecules, Volume 23, Issue 8

August 2018 - 252 articles

Cover Story: A viral protein R-derived 7-mer peptide with photo-reactive benzoylphenylalanyl and biotin residues that exhibits low micromolar HIV-1 integrase (IN) inhibitory potency, was shown to bind directly to IN during photo-crosslinking experiments. The peptide does not interfere with IN–DNA interactions or induce higher-order aberrant IN multimerization, suggesting a mode of action distinct from clinically used integrase strand transfer inhibitors (INSTIs) and experimental allosteric IN inhibitors. This pharmacological tool may aid identifying a site for therapeutic development. View this paper.
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Articles (252)

  • Article
  • Open Access
27 Citations
5,286 Views
14 Pages

A Comparative Metabolomics Analysis Reveals the Tissue-Specific Phenolic Profiling in Two Acanthopanax Species

  • Ke-Xin Wu,
  • Jia Liu,
  • Yang Liu,
  • Xiao-Rui Guo,
  • Li-Qiang Mu,
  • Xiao-Hang Hu and
  • Zhong-Hua Tang

20 August 2018

Acanthopanax senticosus (Rupr. Maxim.) Harms (ASH) and Acanthopanax sessiliflorus (Rupr. Maxim.) Seem (ASS), are members of the Araliaceae family, and both are used in Asian countries. These herbals have drawn much attention in recent years due to th...

  • Article
  • Open Access
7 Citations
4,428 Views
11 Pages

Structure-Immunogenicity Relationship of α- and β-Tetrasaccharide Glycoforms from Bacillus anthracis Exosporium and Fragments Thereof

  • Riccardo De Ricco,
  • Christy L. Ventura,
  • Filippo Carboni,
  • Rina Saksena,
  • Pavol Kováč and
  • Roberto Adamo

20 August 2018

The tetrasaccharide (2-O-methyl-4-(3-hydroxy-3-methylbutamido)-4,6-dideoxy-α-d-glucopyranosyl-(1→3)-α-l-rhamnopyranosyl-(1→3)-α-l-rhamnopyranosyl-(1→2)-l-rhamnopyranose) from the major exosporium protein (BclA) of Bac...

  • Article
  • Open Access
19 Citations
5,489 Views
16 Pages

Comparative Transcriptome Profiling Reveals Defense-Related Genes against Meloidogyne incognita Invasion in Tobacco

  • Xiaohui Li,
  • Xuexia Xing,
  • Pei Tian,
  • Mingzhen Zhang,
  • Zhaoguang Huo,
  • Ke Zhao,
  • Chao Liu,
  • Duwei Duan,
  • Wenjun He and
  • Tiezhao Yang

20 August 2018

Root-knot nematodes Meloidogyne incognita are one of the most destructive pathogens, causing severe losses to tobacco productivity and quality. However, the underlying resistance mechanism of tobacco to M. incognita is not clear. In this study, two t...

  • Article
  • Open Access
36 Citations
5,793 Views
9 Pages

Morphological, Release and Antibacterial Performances of Amoxicillin-Loaded Cellulose Aerogels

  • Shan Ye,
  • Shu He,
  • Chen Su,
  • Lei Jiang,
  • Yanyi Wen,
  • Zhongjie Zhu and
  • Wei Shao

20 August 2018

Cellulose has been widely used in the biomedical field. In this study, novel cellulose aerogels were firstly prepared in a NaOH-based solvent system by a facile casting method. Then amoxicillin was successfully loaded into cellulose aerogels with dif...

  • Article
  • Open Access
5 Citations
4,590 Views
20 Pages

Suppression of Hepatitis C Virus Genome Replication and Particle Production by a Novel Diacylglycerol Acyltransferases Inhibitor

  • Dahee Kim,
  • Ja-Il Goo,
  • Mi Il Kim,
  • Sung-Jin Lee,
  • Moonju Choi,
  • Thoa Thi Than,
  • Phuong Hong Nguyen,
  • Marc P. Windisch,
  • Kyeong Lee and
  • Yongseok Choi
  • + 1 author

20 August 2018

Diacylglycerol acyltransferases (DGATs) play a critical role in the biosynthesis of endogenous triglycerides (TGs) and formation of lipid droplets (LDs) in the liver. In particular, one member of DGATs, DGAT-1 was reported to be an essential host fac...

  • Article
  • Open Access
28 Citations
6,292 Views
16 Pages

Synthesis and Evolution of Berberine Derivatives as a New Class of Antiviral Agents against Enterovirus 71 through the MEK/ERK Pathway and Autophagy

  • Yan-Xiang Wang,
  • Lu Yang,
  • Hui-Qiang Wang,
  • Xiao-Qiang Zhao,
  • Ting Liu,
  • Ying-Hong Li,
  • Qing-Xuan Zeng,
  • Yu-Huan Li and
  • Dan-Qing Song

20 August 2018

Taking berberine (BBR) as the lead, 23 new BBR derivatives were synthesized and examined for their antiviral activities against four different genotype enterovirus 71 (EV71) strains with a cytopathic effect (CPE) assay. Structure-activity relationshi...

  • Article
  • Open Access
20 Citations
5,602 Views
13 Pages

Phenanthrenes from Juncus Compressus Jacq. with Promising Antiproliferative and Anti-HSV-2 Activities

  • Csaba Bús,
  • Norbert Kúsz,
  • Gusztáv Jakab,
  • Seyyed Ashkan Senobar Tahaei,
  • István Zupkó,
  • Valéria Endrész,
  • Anita Bogdanov,
  • Katalin Burián,
  • Boglárka Csupor-Löffler and
  • Judit Hohmann
  • + 1 author

20 August 2018

Juncaceae species are rich sources of phenanthrenes. The present study has focused on the isolation and structure determination of biologically active components from Juncus compressus. Eleven compounds (nine phenanthrenes and two flavonoids) have be...

  • Article
  • Open Access
27 Citations
6,886 Views
19 Pages

20 August 2018

In this study, quaternary-ammonium-functionalized metal–organic frameworks (MOFs) Et-N-Cu(BDC-NH2)(DMF), were prepared, characterized, and applied for the highly effective removal of metal cyanide complexes, including Pd(CN)42−, Co(CN)63&...

  • Feature Paper
  • Review
  • Open Access
123 Citations
14,217 Views
19 Pages

20 August 2018

Peptides are important biomolecules which facilitate the understanding of complex biological processes, which in turn could be serendipitous biological targets for future drugs. They are classified as a unique therapeutic niche and will play an impor...

  • Review
  • Open Access
411 Citations
68,034 Views
29 Pages

Current Concepts and Treatments of Schizophrenia

  • Piotr Stępnicki,
  • Magda Kondej and
  • Agnieszka A. Kaczor

20 August 2018

Schizophrenia is a debilitating mental illness which involves three groups of symptoms, i.e., positive, negative and cognitive, and has major public health implications. According to various sources, it affects up to 1% of the population. The pathome...

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Molecules - ISSN 1420-3049