Molecules, Volume 23, Issue 8 (August 2018) – 252 articles
Cover Story (view full-size image): A viral protein R-derived 7-mer peptide with photo-reactive benzoylphenylalanyl and biotin residues that exhibits low micromolar HIV-1 integrase (IN) inhibitory potency, was shown to bind directly to IN during photo-crosslinking experiments. The peptide does not interfere with IN–DNA interactions or induce higher-order aberrant IN multimerization, suggesting a mode of action distinct from clinically used integrase strand transfer inhibitors (INSTIs) and experimental allosteric IN inhibitors. This pharmacological tool may aid identifying a site for therapeutic development. View this paper.
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