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Molecules 2018, 23(8), 2063;

Effect of Volatile Organic Chemicals in Chrysanthemum indicum Linné on Blood Pressure and Electroencephalogram

Department of Food Science, Gyeongnam National University of Science and Technology, Jinju, Gyeongnam 52725, Korea
Gyeongnam Oriental Medicinal Herb Institute, Sancheong 52215, Korea
Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea
Department of Food and Biotechnology, Korea University, Sejong 30019, Korea
School of Human Environmental Sciences, University of Arkansas, Fayetteville, AR 72701, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Francesco Epifano
Received: 8 August 2018 / Revised: 16 August 2018 / Accepted: 16 August 2018 / Published: 17 August 2018
(This article belongs to the Special Issue Natural Product Isolation, Identification and Biological Activity)
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This study identified the volatile organic compounds in the essential oils that are extracted from Chrysanthemum indicum Linné (C. indicum Linné) and investigated the effects of the inhalation of these compounds. We detected a total of 41 volatile organic compounds, including 32 hydrocarbons, four acids, three alcohols, two ketones, and one aldehyde. In a sniffing test, seven types of volatile organic compounds were identified. Furthermore, the volatile organic compounds in C. indicum Linné that were identified were found to be derived from 1,8-cineole and camphor. After inhalation of the essential oils, the subjects’ systolic blood pressure and heart rate decreased. This indicates that inhalation of the essential oils extracted from C. indicum Linné provides mental and physical relaxation. We examined the changes in electroencephalogram findings that are observed after C. indicum Linné essential oil inhalation. An increase in theta and alpha waves, which usually appear during relaxation, as well as a decrease in beta and gamma waves, which appear during brain activity such as excessive attention, were noted. These results indicate that C. indicum Linné essential oil inhalation helps to reduce blood pressure and may provide mental and physical relaxation. View Full-Text
Keywords: Chrysanthemum indicum Linné; essential oil; volatiles; electroencephalogram; blood pressure Chrysanthemum indicum Linné; essential oil; volatiles; electroencephalogram; blood pressure

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kim, D.-S.; Goo, Y.-M.; Cho, J.; Lee, J.; Lee, D.Y.; Sin, S.M.; Kil, Y.S.; Jeong, W.M.; Ko, K.H.; Yang, K.J.; Kim, Y.G.; Kim, S.G.; Kim, K.; Kim, Y.J.; Kim, J.K.; Shin, E.-C. Effect of Volatile Organic Chemicals in Chrysanthemum indicum Linné on Blood Pressure and Electroencephalogram. Molecules 2018, 23, 2063.

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