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Molecules 2018, 23(8), 2040; https://doi.org/10.3390/molecules23082040

A Dynamic Overview of Antimicrobial Peptides and Their Complexes

1
Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, USA
2
Centro de Biologia Estrutural e Bioimagem, Instituto de Bioquímica Médica, Centro Nacional de Ressonância Magnética Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Brian F. Volkman
Received: 20 July 2018 / Revised: 5 August 2018 / Accepted: 9 August 2018 / Published: 15 August 2018
Full-Text   |   PDF [3186 KB, uploaded 18 August 2018]   |  

Abstract

In this narrative review, we comprehensively review the available information about the recognition, structure, and dynamics of antimicrobial peptides (AMPs). Their complex behaviors occur across a wide range of time scales and have been challenging to portray. Recent advances in nuclear magnetic resonance and molecular dynamics simulations have revealed the importance of the molecular plasticity of AMPs and their abilities to recognize targets. We also highlight experimental data obtained using nuclear magnetic resonance methodologies, showing that conformational selection is a major mechanism of target interaction in AMP families. View Full-Text
Keywords: antimicrobial peptides; defensins; NMR; structure and dynamics; conformational selection antimicrobial peptides; defensins; NMR; structure and dynamics; conformational selection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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de Paula, V.S.; Valente, A.P. A Dynamic Overview of Antimicrobial Peptides and Their Complexes. Molecules 2018, 23, 2040.

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