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Open AccessReview

Technetium Complexes and Radiopharmaceuticals with Scorpionate Ligands

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy
Department of Chemical and Pharmaceutical Sciences, University of Ferrara, 44121 Ferrara, Italy
Author to whom correspondence should be addressed.
Academic Editors: Carlo Santini and Maura Pellei
Molecules 2018, 23(8), 2039;
Received: 2 August 2018 / Revised: 9 August 2018 / Accepted: 14 August 2018 / Published: 15 August 2018
(This article belongs to the Special Issue Scorpionate Ligands: Ever-Young Chemistry Tools)
Scorpionate ligands have played a crucial role in the development of technetium chemistry and, recently, they have also fueled important advancements in the discovery of novel diagnostic imaging agents based on the γ-emitting radionuclide technetium-99m. The purpose of this short review is to provide an illustration of the most general and relevant results in this field, however without being concerned with the details of the analytical features of the various compounds. Thus, emphasis will be given to the description of the general features of technetium complexes with scorpionate ligands including coordination modes, structural properties and an elementary bonding description. Similarly, the most relevant examples of technetium-99m radiopharmaceuticals derived from scorpionate ligands and their potential interest for nuclear imaging will be summarized. View Full-Text
Keywords: scorpionate ligands; technetium; Tc cores; Tc-99m radiopharmaceuticals scorpionate ligands; technetium; Tc cores; Tc-99m radiopharmaceuticals
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MDPI and ACS Style

Martini, P.; Pasquali, M.; Boschi, A.; Uccelli, L.; Giganti, M.; Duatti, A. Technetium Complexes and Radiopharmaceuticals with Scorpionate Ligands. Molecules 2018, 23, 2039.

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