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Molecules 2018, 23(8), 2080; https://doi.org/10.3390/molecules23082080

Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review

1
Phytomedicine Programme, Department of Paraclinical Sciences, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa
2
Department of Food Science and Technology, Faculty of Agriculture, University of Khartoum, Khartoum North 13314, Sudan
*
Author to whom correspondence should be addressed.
Received: 30 July 2018 / Revised: 14 August 2018 / Accepted: 19 August 2018 / Published: 20 August 2018
(This article belongs to the Special Issue Cyclic Peptides)
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Abstract

Peptides are important biomolecules which facilitate the understanding of complex biological processes, which in turn could be serendipitous biological targets for future drugs. They are classified as a unique therapeutic niche and will play an important role as fascinating agents in the pharmaceutical landscape. Until now, more than 40 cyclic peptide drugs are currently in the market, and approximately one new cyclopeptide drug enters the market annually on average. Interestingly, the majority of clinically approved cyclic peptides are derived from natural sources, such as peptide antibiotics and human peptide hormones. In this report, the importance of cyclic peptides is discussed, and their role in drug discovery as interesting therapeutic biomolecules will be highlighted. Recently isolated naturally occurring cyclic peptides from microorganisms, sponges, and other sources with a wide range of pharmacological properties are reviewed herein. View Full-Text
Keywords: cyclic peptides; microorganisms; sponges; therapeutic agents; clinical trials; anticancer activity; antimicrobial activity; antiviral activity cyclic peptides; microorganisms; sponges; therapeutic agents; clinical trials; anticancer activity; antimicrobial activity; antiviral activity
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Abdalla, M.A.; McGaw, L.J. Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review. Molecules 2018, 23, 2080.

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