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Molecules 2018, 23(8), 2077; https://doi.org/10.3390/molecules23082077

Origanum vulgare ssp. vulgare: Chemical Composition and Biological Studies

1
Department of Pharmacognosy, Iuliu Hatieganu University of Medicine and Pharmacy, 12 I. Creanga Street, Cluj-Napoca 400010, Romania
2
Department of Chemistry and Chemical Engineering, Babes-Bolyai University, 11 A. Janos Street, Cluj-Napoca 400028, Romania
3
Faculty of Medicine, Pharmacy and Dental Medicine, Vasile Goldiş Western University of Arad, 86 L. Rebreanu Street, Arad 310414, Romania
4
Department of Paraclinics, University of Agricultural Sciences and Veterinary Medicine, 3-5 Mănăştur Street, Cluj-Napoca 400372, Romania
5
Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, 6 L. Pasteur Street, Cluj-Napoca, 400349, Romania
6
Department of Drug Industry and Biotechnology, Iuliu Hatieganu University of Medicine and Pharmacy, 12 I. Creanga Street, Cluj-Napoca 400010, Romania
These authors contributed equally to this paper.
*
Authors to whom correspondence should be addressed.
Received: 19 July 2018 / Revised: 14 August 2018 / Accepted: 15 August 2018 / Published: 19 August 2018
(This article belongs to the Section Natural Products Chemistry)
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Abstract

The biological properties and main phenolic compounds of the O. vulgare L. ssp. vulgare extract are described in the present paper. The polyphenolic compounds were analyzed by chromatographic and spectrophotometric techniques. The antioxidant potential was evaluated using several methods: CUPRAC (cupric ion reducing antioxidant capacity), FRAP (ferric reducing ability of plasma), inhibition of lipid peroxidation catalyzed by cytochrome c, and superoxide (SO) scavenging assays. The antimicrobial activity of the oregano extract was evaluated by means of agar-well diffusion assay. The hepatoprotective effect of the O. vulgare extract on CCl4-induced hepatotoxicity was evaluated in rats. Liver injury was estimated by determination of alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), gamma-glutamyl transferase GGT, total protein and albumin concentrations, glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD) and malondialdehyde (MDA). These values were improved by the administration of oregano extract. A specific phenolic profile was evidenced by these data, with large amounts of rosmarinic and chlorogenic acids. The oregano extract showed very strong antioxidant activity in good agreement with the phenolic content. Antimicrobial activity was good, especially against Salmonella enteritidis and Aspergillus niger strains. The high hepatoprotective, antioxidant and antimicrobial activity, along with polyphenol-rich content, can support the use of O. vulgare in therapy. We also expect our results to open new research directions for designing important new drug products, using indigenous plant material. View Full-Text
Keywords: Origanum vulgare; polyphenols; cythocrome c; antioxidant; antimicrobial; hepatoprotective Origanum vulgare; polyphenols; cythocrome c; antioxidant; antimicrobial; hepatoprotective
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Oniga, I.; Pușcaș, C.; Silaghi-Dumitrescu, R.; Olah, N.-K.; Sevastre, B.; Marica, R.; Marcus, I.; Sevastre-Berghian, A.C.; Benedec, D.; Pop, C.E.; Hanganu, D. Origanum vulgare ssp. vulgare: Chemical Composition and Biological Studies. Molecules 2018, 23, 2077.

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