Novel Antimicrobial Agents: Discovery, Design and New Therapeutic Strategies

Dear Colleagues,

The increase in antibiotic resistance raises concerns that, at least in some regions (especially developing countries), we are returning to a pre-antibiotic era, in particular for Gram-negative infections. The CV-19 outbreak exemplifies that resistance originating from some parts of the world has global effects, hence we need to act now to eradicate antimicrobial resistance worldwide. There are few novel anti-Gram-negative/positive drugs entering clinical trials, therefore, novel drugs, but also development of novel techniques and methods that lead to new drugs, are needed. Overcoming resistance to restore the activity of existing drugs and repurposing with an excellent safety record are also important topics. This Topic is seeking original research articles and synopses (reviews) that make substantial advances within this field and we are inviting researchers from different fields (chemistry, biology, biochemistry, medicinal chemistry, PK PD modellers) to contribute to this editorial project. We aim to cover not only traditional but also non-traditional products, with both broad range and single target antibiotics both for human and animal use.

Dr. Daniele Castagnolo
Dr. Jürgen Brem
Prof. Dr. Mark G. Moloney
Dr. Sónia Silva
Topic Editors