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23 Results Found

  • Article
  • Open Access
1,069 Views
46 Pages

This paper investigates the acceptability of focused Objects with [+corrective, +exhaustive] features in Italian and French, considering the role of syntactic rigidity, Exhaustivity Markers (EMs), and argument structure. We conducted two parallel acc...

  • Article
  • Open Access
248 Views
20 Pages

31 December 2025

This study, based on naturalistic discourse in Mano and on both morphosyntactic and prosodic characteristics, analyses the Mano constructions formed with the marker lɛ́, including the identifying construction, referent introduction, focus,...

  • Article
  • Open Access
5 Citations
3,867 Views
13 Pages

The Distinctive Forehead Cleft of the Risso’s Dolphin (Grampus griseus) Hardly Affects Biosonar Beam Formation

  • Chong Wei,
  • Lachlan G. Gill,
  • Christine Erbe,
  • Adam B. Smith and
  • Wei-Cheng Yang

8 December 2022

The Risso’s dolphin (Grampus griseus) has a distinctive vertical crease (or cleft) along the anterior surface of the forehead. Previous studies have speculated that the cleft may contribute to biosonar beam formation. To explore this, we constr...

  • Article
  • Open Access
2 Citations
2,689 Views
11 Pages

The frequency of cleft lip and palate births in Japan is approximately 0.146%. The study aimed to compare the effects of NAM on restoring nasal morphology and improving extraoral nasal morphology in children with cleft lip and palate in the first sta...

  • Article
  • Open Access
3,899 Views
51 Pages

Negative Indefinite Constructions in Bantu: ‘Nobody’

  • Maud Devos,
  • Johan van der Auwera and
  • Rasmus Bernander

This paper presents a first typology of negative indefinites in Bantu languages. The lack of interest in expressions of ‘nobody’ in Bantu languages is connected with the idea that they merely involve a generic noun for ‘person&rsquo...

  • Article
  • Open Access
3,246 Views
12 Pages

A Special (Question) View on Wh-Doubling in Lombard Varieties

  • Jacopo Garzonio,
  • Enrico Castro and
  • Jessica Rita Messina

20 September 2023

In this article, we examine a specific type of Wh-Doubling (WhD) that can be observed in some Northern Lombard varieties. Differently from all the previous types of WhD described for Lombard and other Northern Italo-Romance varieties, in the phenomen...

  • Technical Note
  • Open Access
1 Citations
1,689 Views
18 Pages

Innovative Approach to Computer-Aided Measurement of Unilateral Cleft Lip and Palate Models Using OnyxCeph3

  • Sarah Bühling,
  • Cedric Thedens,
  • Katrin Eßing,
  • Sara Eslami,
  • Babak Sayahpour,
  • Nicolas Plein,
  • Robert Sader and
  • Stefan Kopp

17 March 2025

As advancements in digital technologies reshape the modern healthcare, integrating digital impression techniques, such as intraoral 3D scanning and 3D analysis and treatment planning, is becoming increasingly essential in the standard care of infants...

  • Article
  • Open Access
7 Citations
3,245 Views
33 Pages

17 January 2023

Focus is cross-linguistically associated with a number of different strategies, such as fronting, clefting, markers, and prosody. In some cases, the choice between one strategy or another is determined by language-specific rules, while in others, two...

  • Article
  • Open Access
5 Citations
2,617 Views
8 Pages

Instrument Development and Validation to Assess Care Barriers for Patients in Saudi Arabia with Oral Clefts

  • Layla Khogeer,
  • Narmin Helal,
  • Osama Basri,
  • Sara Madani,
  • Abeer Basri and
  • Azza A. El-Houseiny

The study objective was to construct and validate a tool to assess, measure, and evaluate the barriers and obstacles that patients with orofacial clefts (OFCs), and their families, face during treatment. The Effective Accessibility and Accommodation...

  • Article
  • Open Access
28 Citations
4,761 Views
16 Pages

Toward Biofabrication of Resorbable Implants Consisting of a Calcium Phosphate Cement and Fibrin—A Characterization In Vitro and In Vivo

  • Tilman Ahlfeld,
  • Anja Lode,
  • Richard Frank Richter,
  • Winnie Pradel,
  • Adrian Franke,
  • Martina Rauner,
  • Bernd Stadlinger,
  • Günter Lauer,
  • Michael Gelinsky and
  • Paula Korn

26 January 2021

Cleft alveolar bone defects can be treated potentially with tissue engineered bone grafts. Herein, we developed novel biphasic bone constructs consisting of two clinically certified materials, a calcium phosphate cement (CPC) and a fibrin gel that we...

  • Article
  • Open Access
7 Citations
3,222 Views
15 Pages

Fibrin with Laminin-Nidogen Reduces Fibrosis and Improves Soft Palate Regeneration Following Palatal Injury

  • Doris H. Rosero Salazar,
  • René E. M. van Rheden,
  • Manon van Hulzen,
  • Paola L. Carvajal Monroy,
  • Frank A. D. T. G. Wagener and
  • Johannes W. Von den Hoff

19 October 2021

This study aimed to analyze the effects of fibrin constructs enhanced with laminin-nidogen, implanted in the wounded rat soft palate. Fibrin constructs with and without laminin-nidogen were implanted in 1 mm excisional wounds in the soft palate of 9-...

  • Article
  • Open Access
146 Views
19 Pages

12 January 2026

Background/Objectives: Multidisciplinary outcome studies are carried out to evaluate long-term treatment in patients with cleft lip and palate. Speech function as one of the key outcomes of the treatment is examined by means of an auditory-perceptual...

  • Article
  • Open Access
27 Citations
13,947 Views
18 Pages

Construction of a Humanized Artificial VHH Library Reproducing Structural Features of Camelid VHHs for Therapeutics

  • Taihei Murakami,
  • Shigefumi Kumachi,
  • Yasuhiro Matsunaga,
  • Miwa Sato,
  • Kanako Wakabayashi-Nakao,
  • Hidekazu Masaki,
  • Ryo Yonehara,
  • Maiko Motohashi,
  • Naoto Nemoto and
  • Masayuki Tsuchiya

30 January 2022

A variable domain of heavy chain antibody (VHH) has different binding properties than conventional antibodies. Conventional antibodies prefer binding to the convex portion of the antigen, whereas VHHs prefer epitopes, such as crevices and clefts on t...

  • Article
  • Open Access
1,254 Views
35 Pages

20 August 2025

Verbal nouns in Insular Celtic languages have long been a subject of interest because they are capable of exhibiting both nominal and verbal properties, posing a persistent challenge when it comes to determining their precise categorization. This stu...

  • Review
  • Open Access
3 Citations
4,157 Views
17 Pages

Compositions and Structural Geometries of Scaffolds Used in the Regeneration of Cleft Palates: A Review of the Literature

  • Víctor A. Reyna-Urrutia,
  • Arely M. González-González and
  • Raúl Rosales-Ibáñez

28 January 2022

Cleft palate (CP) is one of the most common birth defects, presenting a multitude of negative impacts on the health of the patient. It also leads to increased mortality at all stages of life, economic costs and psychosocial effects. The embryological...

  • Article
  • Open Access
7 Citations
3,666 Views
14 Pages

Lyophyllin, a Mushroom Protein from the Peptidase M35 Superfamily Is an RNA N-Glycosidase

  • Jia-Qi Lu,
  • Wei-Wei Shi,
  • Meng-Jie Xiao,
  • Yun-Sang Tang,
  • Yong-Tang Zheng and
  • Pang-Chui Shaw

27 October 2021

Ribosome-inactivating proteins (RIPs) hydrolyze the N-glycosidic bond and depurinate a specific adenine residue (A-4324 in rat 28S ribosomal RNA, rRNA) in the conserved α-sarcin/ricin loop (α-SRL) of rRNA. In this study, we have purified and characte...

  • Article
  • Open Access
5 Citations
2,702 Views
20 Pages

1 February 2023

Lexical expletives can be divided into two main classes: (i) CP expletives required by the V2 constraint and, hence, by the necessity to lexicalize the position on the left of the inflected verb and (ii) TP expletives connected with the negative valu...

  • Article
  • Open Access
3 Citations
4,536 Views
28 Pages

In this article, an interdisciplinary lens is applied to French migrants’ reflections on their everyday language practices, investigating how embodied and embedded language, such as accent and London-French translanguaging, serve as both in-group and...

  • Article
  • Open Access
3 Citations
2,097 Views
12 Pages

Preoperative Prediction of New Vertebral Fractures after Vertebral Augmentation with a Radiomics Nomogram

  • Yang Jiang,
  • Wei Zhang,
  • Shihao Huang,
  • Qing Huang,
  • Haoyi Ye,
  • Yurong Zeng,
  • Xin Hua,
  • Jinhui Cai,
  • Zhifeng Liu and
  • Qingyu Liu

16 November 2023

The occurrence of new vertebral fractures (NVFs) after vertebral augmentation (VA) procedures is common in patients with osteoporotic vertebral compression fractures (OVCFs), leading to painful experiences and financial burdens. We aim to develop a r...

  • Article
  • Open Access
25 Citations
8,175 Views
17 Pages

25 April 2012

Studies related to the engineering of calcium binding sites of CGTase are limited. The calcium binding regions that are known for thermostability function were subjected to site-directed mutagenesis in this study. The starting gene-protein is a varia...

  • Article
  • Open Access
2,535 Views
14 Pages

Identification and Functional Analysis of a Pseudo-Cysteine Protease from the Midgut Transcriptome of Sphenophorus levis

  • Priscila Yumi Tanaka Shibao,
  • Milene Ferro,
  • Fernando Fonseca Pereira de Paula,
  • Bruno Salata Lima and
  • Flávio Henrique-Silva

25 October 2021

The Sphenophorus levis (Coleoptera, Curculionidae) is one of the main pests of sugarcane in Brazil. Although its major digestive proteases are known, its complex digestive process still needs to be further understood. We constructed a transcriptome f...

  • Article
  • Open Access
5 Citations
3,035 Views
18 Pages

Potency Evaluations of Recombinant Botulinum Neurotoxin A1 Mutants Designed to Reduce Toxicity

  • Polrit Viravathana,
  • William H. Tepp,
  • Marite Bradshaw,
  • Amanda Przedpelski,
  • Joseph T. Barbieri and
  • Sabine Pellett

17 August 2024

Recombinant mutant holotoxin BoNTs (rBoNTs) are being evaluated as possible vaccines against botulism. Previously, several rBoNTs containing 2–3 amino acid mutations in the light chain (LC) showed significant decreases in toxicity (2.5-million-...

  • Review
  • Open Access
84 Citations
10,955 Views
25 Pages

24 February 2020

The synaptic cleft has been vastly investigated in the last decades, leading to a novel and fascinating model of the functional and structural modifications linked to synaptic transmission and brain processing. The classic neurocentric model encompas...