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Compositions and Structural Geometries of Scaffolds Used in the Regeneration of Cleft Palates: A Review of the Literature

Laboratorio de Ingeniería Tisular y Medicina Traslacional, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tenayuca-Chalmita S/N, Cuautepec Barrio Bajo, Alcaldía Gustavo A. Madero, Ciudad de México CP 07239, Mexico
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Academic Editor: Shih-Feng Chou
Polymers 2022, 14(3), 547; https://doi.org/10.3390/polym14030547
Received: 22 November 2021 / Revised: 21 January 2022 / Accepted: 25 January 2022 / Published: 28 January 2022
Cleft palate (CP) is one of the most common birth defects, presenting a multitude of negative impacts on the health of the patient. It also leads to increased mortality at all stages of life, economic costs and psychosocial effects. The embryological development of CP has been outlined thanks to the advances made in recent years due to biomolecular successions. The etiology is broad and combines certain environmental and genetic factors. Currently, all surgical interventions work off the principle of restoring the area of the fissure and aesthetics of the patient, making use of bone substitutes. These can involve biological products, such as a demineralized bone matrix, as well as natural–synthetic polymers, and can be supplemented with nutrients or growth factors. For this reason, the following review analyzes different biomaterials in which nutrients or biomolecules have been added to improve the bioactive properties of the tissue construct to regenerate new bone, taking into account the greatest limitations of this approach, which are its use for bone substitutes for large areas exclusively and the lack of vascularity. Bone tissue engineering is a promising field, since it favors the development of porous synthetic substitutes with the ability to promote rapid and extensive vascularization within their structures for the regeneration of the CP area. View Full-Text
Keywords: cleft palate; three-dimensional scaffolding; tissue engineering; manufacturing technique cleft palate; three-dimensional scaffolding; tissue engineering; manufacturing technique
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MDPI and ACS Style

Reyna-Urrutia, V.A.; González-González, A.M.; Rosales-Ibáñez, R. Compositions and Structural Geometries of Scaffolds Used in the Regeneration of Cleft Palates: A Review of the Literature. Polymers 2022, 14, 547. https://doi.org/10.3390/polym14030547

AMA Style

Reyna-Urrutia VA, González-González AM, Rosales-Ibáñez R. Compositions and Structural Geometries of Scaffolds Used in the Regeneration of Cleft Palates: A Review of the Literature. Polymers. 2022; 14(3):547. https://doi.org/10.3390/polym14030547

Chicago/Turabian Style

Reyna-Urrutia, Víctor A., Arely M. González-González, and Raúl Rosales-Ibáñez. 2022. "Compositions and Structural Geometries of Scaffolds Used in the Regeneration of Cleft Palates: A Review of the Literature" Polymers 14, no. 3: 547. https://doi.org/10.3390/polym14030547

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