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  • Review
  • Open Access
71 Citations
11,661 Views
14 Pages

20 October 2023

Multi-omics is a cutting-edge approach that combines data from different biomolecular levels, such as DNA, RNA, proteins, metabolites, and epigenetic marks, to obtain a holistic view of how living systems work and interact. Multi-omics has been used...

  • Review
  • Open Access
63 Citations
10,583 Views
30 Pages

6 September 2024

High-throughput omics technologies have dramatically changed biological research, providing unprecedented insights into the complexity of living systems. This review presents a comprehensive examination of the current landscape of high-throughput omi...

  • Review
  • Open Access
18 Citations
9,607 Views
19 Pages

Biomarkers in Ovarian Cancer: Towards Personalized Medicine

  • Carlos López-Portugués,
  • María Montes-Bayón and
  • Paula Díez

Ovarian cancer is one of the deadliest cancers in women. The lack of specific symptoms, especially at the initial stages of disease development, together with the malignancy heterogeneity, lower the life expectancy of patients. Aiming to improve surv...

  • Review
  • Open Access
10 Citations
8,559 Views
66 Pages

Proteomics continues to forge significant strides in the discovery of essential biological processes, uncovering valuable information on the identity, global protein abundance, protein modifications, proteoform levels, and signal transduction pathway...

  • Review
  • Open Access
8 Citations
7,805 Views
17 Pages

Spatial Proteomics for the Molecular Characterization of Breast Cancer

  • Klára Brožová,
  • Brigitte Hantusch,
  • Lukas Kenner and
  • Klaus Kratochwill

Breast cancer (BC) is a major global health issue, affecting a significant proportion of the female population and contributing to high rates of mortality. One of the primary challenges in the treatment of BC is the disease’s heterogeneity, whi...

  • Review
  • Open Access
3 Citations
7,364 Views
31 Pages

The Current Molecular and Cellular Landscape of Chronic Obstructive Pulmonary Disease (COPD): A Review of Therapies and Efforts towards Personalized Treatment

  • Luke A. Farrell,
  • Matthew B. O’Rourke,
  • Matthew P. Padula,
  • Fernando Souza-Fonseca-Guimaraes,
  • Gaetano Caramori,
  • Peter A. B. Wark,
  • Shymali C. Dharmage and
  • Phillip M. Hansbro

Chronic obstructive pulmonary disease (COPD) ranks as the third leading cause of global illness and mortality. It is commonly triggered by exposure to respiratory irritants like cigarette smoke or biofuel pollutants. This multifaceted condition manif...

  • Review
  • Open Access
7 Citations
6,636 Views
17 Pages

Proteomics of Extracellular Vesicles: Recent Updates, Challenges and Limitations

  • Mohini Singh,
  • Prashant Kumar Tiwari,
  • Vivek Kashyap and
  • Sanjay Kumar

Extracellular vesicles (EVs) are lipid-bound vesicles secreted by cells, including exosomes, microvesicles, and apoptotic bodies. Proteomic analyses of EVs, particularly in relation to cancer, reveal specific biomarkers crucial for diagnosis and ther...

  • Review
  • Open Access
29 Citations
6,420 Views
29 Pages

Post-Translational Modifications in Histones and Their Role in Abiotic Stress Tolerance in Plants

  • Madhvi Sharma,
  • Amanpreet K. Sidhu,
  • Mahesh Kumar Samota,
  • Mamta Gupta,
  • Pushpendra Koli and
  • Mukesh Choudhary

22 November 2023

Abiotic stresses profoundly alter plant growth and development, resulting in yield losses. Plants have evolved adaptive mechanisms to combat these challenges, triggering intricate molecular responses to maintain tissue hydration and temperature stabi...

  • Review
  • Open Access
16 Citations
6,387 Views
25 Pages

Proteomics-Based Identification of Dysregulated Proteins and Biomarker Discovery in Invasive Ductal Carcinoma, the Most Common Breast Cancer Subtype

  • Anca-Narcisa Neagu,
  • Danielle Whitham,
  • Logan Seymour,
  • Norman Haaker,
  • Isabella Pelkey and
  • Costel C. Darie

Invasive ductal carcinoma (IDC) is the most common histological subtype of malignant breast cancer (BC), and accounts for 70–80% of all invasive BCs. IDC demonstrates great heterogeneity in clinical and histopathological characteristics, progno...

  • Review
  • Open Access
10 Citations
6,382 Views
19 Pages

Proteomics-Driven Biomarkers in Pancreatic Cancer

  • Luís Ramalhete,
  • Emanuel Vigia,
  • Rúben Araújo and
  • Hugo Pinto Marques

Pancreatic cancer is a devastating disease that has a grim prognosis, highlighting the need for improved screening, diagnosis, and treatment strategies. Currently, the sole biomarker for pancreatic ductal adenocarcinoma (PDAC) authorized by the U.S....

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Proteomes - ISSN 2227-7382