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Proteomes, Volume 13, Issue 4

December 2025 - 10 articles

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Articles (10)

  • Article
  • Open Access

3 November 2025

Background: Molecular mimicry contributes to the development of unwanted responses to self-antigens. Autoimmune phenomena have been observed in diseases caused by Aedes aegypti-transmitted arboviruses, but the occurrence of mimicry between salivary a...

  • Article
  • Open Access

3 November 2025

Background: Chronic ischemic heart disease (CIHD) is characterized by persistent myocardial ischemic due to long-term reduced coronary blood flow. In the past, we mainly relied on surgical intervention or drug therapy to alleviate symptoms, but effec...

  • Review
  • Open Access
236 Views
21 Pages

27 October 2025

Protein–protein interactions (PPIs) are significant in understanding the complex molecular processes of plant growth, disease resistance, and stress responses. Machine learning (ML) has recently emerged as a powerful tool that can predict and a...

  • Review
  • Open Access
822 Views
22 Pages

Marine Bioactive Peptides in the Regulation of Inflammatory Responses: Current Trends and Future Directions

  • D. M. N. M. Gunasekara,
  • H. D. T. U. Wijerathne,
  • Lei Wang,
  • Hyun-Soo Kim and
  • K. K. A. Sanjeewa

13 October 2025

Marine-derived bioactive peptides (MBPs) are emerging as promising natural agents for regulating inflammatory responses. MBPs, typically obtained through enzymatic hydrolysis of proteins from various marine organisms such as fish, mollusks, and algae...

  • Article
  • Open Access
286 Views
18 Pages

Temporal and Spatial Profiling of Escherichia coli O157:H7 Surface Proteome: Insights into Intestinal Colonisation Dynamics In Vivo

  • Ricardo Monteiro,
  • Ingrid Chafsey,
  • Charlotte Cordonnier,
  • Valentin Ageorges,
  • Didier Viala,
  • Michel Hébraud,
  • Valérie Livrelli,
  • Alfredo Pezzicoli,
  • Mariagrazia Pizza and
  • Mickaël Desvaux

10 October 2025

Background: EHEC O157:H7 causes severe gastrointestinal illness by first colonizing the large intestine. It intimately attaches to the epithelial lining, orchestrating distinctive “attaching and effacing” lesions that disrupt the host&rsq...

  • Article
  • Open Access
585 Views
11 Pages

Protein-Predicted Obesity Phenotypes and Cardiovascular Events: A Secondary Analysis of UK Biobank Proteomics Data

  • Chang Liu,
  • Bojung Seo,
  • Qin Hui,
  • Peter W. F. Wilson,
  • Arshed A. Quyyumi and
  • Yan V. Sun

Background: Proteomic profiling may improve the understanding of obesity and cardiovascular risk prediction. This study explores the use of protein-predicted scores for body mass index (PPSBMI), body fat percentage (PPSBFP), and waist–hip ratio...

  • Article
  • Open Access
545 Views
17 Pages

Protein Structural Modeling Explains Rapid Oxidation in Poultry and Fish Myoglobins Compared to Livestock Myoglobins

  • Greeshma Sreejesh,
  • Surendranath P. Suman,
  • Gretchen G. Mafi,
  • Morgan M. Pfeiffer and
  • Ranjith Ramanathan

Background: This study aimed to investigate rapid oxidation in poultry and fish myoglobin compared to livestock myoglobin using protein structural differences and bioinformatics tools. Methods: Myoglobins from beef (Bos taurus), bison (Bos bison), sh...

  • Review
  • Open Access
536 Views
30 Pages

Extracellular Vesicle (EV) Proteomics in Corneal Regenerative Medicine

  • Zohreh Arabpour,
  • Hanieh Niktinat,
  • Firouze Hatami,
  • Amal Yaghmour,
  • Zarife Jale Yucel,
  • Seyyedehfatemeh Ghalibafan,
  • Hamed Massoumi,
  • Zahra Bibak Bejandi,
  • Majid Salehi and
  • Elmira Jalilian
  • + 4 authors

Corneal regeneration has gained growing interest in recent years, largely due to the limitations of conventional treatments and the persistent shortage of donor tissue. Among the emerging strategies, extracellular vehicles (EVs), especially those der...

  • Article
  • Open Access
413 Views
22 Pages

Proteomic Characterization of Primary Human Pancreatic Cancer Cell Lines Following Long-Term Exposure to Gemcitabine

  • Manoj Amrutkar,
  • Yuchuan Li,
  • Anette Vefferstad Finstadsveen,
  • Caroline S. Verbeke and
  • Ivar P. Gladhaug

Background: Gemcitabine (GEM) remains a cornerstone in the treatment of pancreatic cancer. Upon exposure to GEM, pancreatic cancer cells (PCCs) tend to adapt quickly to outcompete drug-induced cytotoxicity, thereby contributing to treatment failure....

  • Review
  • Open Access
1 Citations
1,596 Views
47 Pages

In Search of Ideal Solutions for Cancer Diagnosis: From Conventional Methods to Protein Biomarkers in Liquid Biopsy

  • Anca-Narcisa Neagu,
  • Pathea S. Bruno,
  • Claudiu-Laurentiu Josan,
  • Natalie Waterman,
  • Hailey Morrissiey,
  • Victor T. Njoku and
  • Costel C. Darie

23 September 2025

Cancer detection has made significant progress, moving from conventional methods to innovative, non-invasive or minimally invasive approaches aimed at improving early diagnosis, precision, and treatment outcomes. This review examines current and emer...

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Proteomes - ISSN 2227-7382Creative Common CC BY license