Development of Specific Dosage Form: Wound Dressing, 2nd Edition

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: 25 May 2026 | Viewed by 1075

Special Issue Editors


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Physical and Colloidal Chemistry Department, Innovative Therapeutic Structures Research and Development Center (InnoTher), Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania
Interests: biomaterials (collagen drug delivery systems); rheology; cosmeceuticals; drug systems formulation and technological processes optimization; response surface methodology; Taguchi design
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Collagen Department, Division of Leather and Footwear Research Institute, National Research and Development Institute for Textile and Leather, Bucharest, Romania
Interests: wound dressings; scaffolds; collagen; antimicrobial activity; cartilage repair; biomaterials
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Physical and Colloidal Chemistry Department, Innovative Therapeutic Structures Research and Development Center (InnoTher), Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania
Interests: quality by design (QbD); analytical quality by design (AQbD); drug systems formulation (Chitosan); Surfaces characteristics (wettability/hydrophilicity/hydrophobicity—pharmaceutical powders)
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Physical and Colloidal Chemistry Department, Innovative Therapeutic Structures Research and Development Center (InnoTher), Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania
Interests: targeted drug delivery; nanoparticulate systems; solubility enhancement techniques; biotechnology; topical/transdermal drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

From ancient times up until today, despite the comprehensive research and development of various wound care strategies, the wound healing process still represents a massive challenge for the medical and pharmaceutical fields. Wound management is a complex procedure that involves various factors playing crucial roles in the healing mechanism. Even if cutaneous lesions are caused by diseases, trauma, surgery, chemical, thermal, or electrical factors, they can happen at any time throughout a person’s life, affecting their quality of life to a lesser or greater extent. Globally, the incidence of skin lesions is continuously increasing from year to year, and, currently, it is estimated that there are more than 8 million people who are affected by different skin injuries, with or without infections. Wound care total cost estimation varies from 28 billion USD to 97 billion USD, diabetic ulcers and surgical lesions being the most expensive to cure.

Wound healing is a highly particular dynamic, various multi-phase process involving multiple cellular and molecular mechanisms for tissue repair. Some wounds’ complexity and healing complications appeal to new approaches for their management. Therefore, no single treatment is sufficient to finalize wound healing. To surmount these limitations, a highly explored therapeutic strategy is to develop different innovative wound dressings, designed on various biomaterials, from natural and synthetic biopolymers to their combinations, applied in different forms, ranging from hydrogels, hydrocolloids, films, sponges, foams, to scaffolds and textiles improved with natural compounds, plant extracts, drugs, or nanoparticles. The synergy of biocompatibility and cellular proliferative actions of these wound dressing compounds is expressed in the acceleration of the healing process, enhancing structural, functional, and cosmetic properties of the novel grown tissue.

This Special Issue has the main objective of presenting the most recent research regarding the new original tailored wound dressings, enriched with a myriad of natural and synthetic compounds as potential therapeutic and delivery systems for the treatment and management of various cutaneous lesions.

Prof. Dr. Mihaela Violeta Ghica
Dr. Madalina Georgiana Albu Kaya
Prof. Dr. Lacramioara Popa
Prof. Dr. Cristina Elena Dinu-Pirvu
Guest Editors

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Keywords

  • skin lesion
  • wound healing
  • wound dressing
  • regenerative medicine
  • biomaterials
  • smart biopolymers
  • therapeutic system
  • controlled delivery system
  • scaffolds
  • biocompatibility

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Published Papers (1 paper)

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Research

19 pages, 1004 KB  
Article
Chinese Expert Consensus for the Application of rh-aFGF for Chronic Refractory Wounds
by Junli Zhou, Xuanru Zhu, Dongcheng Ye, Xiaobing Fu, Yuesheng Huang and Professional Committee of Wound Repair of Chinese Medical Doctor Association
Pharmaceuticals 2026, 19(2), 328; https://doi.org/10.3390/ph19020328 - 17 Feb 2026
Viewed by 793
Abstract
Background and Objective: Chronic refractory wounds not only persist and delay healing, causing physical and mental suffering to patients and reducing their quality of life but also impose a heavy burden on their families and society. Recombinant human acidic fibroblast growth factor (rh-aFGF), [...] Read more.
Background and Objective: Chronic refractory wounds not only persist and delay healing, causing physical and mental suffering to patients and reducing their quality of life but also impose a heavy burden on their families and society. Recombinant human acidic fibroblast growth factor (rh-aFGF), approved in China for decades, is a growth factor with multiple biological effects which can promote the healing of various wounds. It is crucial to develop an rh-aFGF expert consensus for standardizing the clinical application of aFGF and enhancing its clinical value. Methods: The literature related to rh-aFGF, including clinical trials, experimental research, and reviews, was collected and selected from PubMed, Web of Science, Medline, CNKI, and the Wangfang database. The expert recommendations were formed by a combination of clinical research quality, use of the Delphi questionnaire, and consensus reached during meetings involving experts. Results: A total of 12 consensus recommendations for clinical application of rh-aFGF on chronic refractory wounds (CRWs) were successfully formulated, of which seven strong, four moderate, and one weak recommendations were suitable for various clinical sets. The recommendations include specifications for duration of rh-aFGF treatment, dosage, types of wounds, and its combination with other products and dressings. Conclusions: rh-aFGF has vital clinical value for healing chronic wounds. This consensus provides clinicians with a reference to guide the application not only of rh-aFGF but also of other growth factor drugs with similar mechanisms for CRWs. Full article
(This article belongs to the Special Issue Development of Specific Dosage Form: Wound Dressing, 2nd Edition)
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