Research Advances in Targeted Therapy for Facial Skin Diseases

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 25 May 2026 | Viewed by 8131

Special Issue Editors


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Guest Editor
Department of Dermatology, Universidade Federal de Sao Paulo, São Paulo 04023-062, Brazil
Interests: skin; anti-aging medicine; acne; retinoids; photoaging; melasma; rosacea; dermocosmetics

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Guest Editor
Department of Dermatology, Universidade Federal de Sao Paulo, São Paulo 04023-062, Brazil
Interests: acne; rosacea; photoaging; skin diseases; inflammatory skin diseases

E-Mail
Guest Editor
Department of Dermatology, Universidade Federal de Sao Paulo, São Paulo 04023-062, Brazil
Interests: adult female acne; rosacea; photoaging; cosmetic dermatology

Special Issue Information

Dear Colleagues,

Facial skin diseases pose unique challenges due to the high visibility, complex anatomy, and psychosocial impact associated with the facial region. While conventional therapies offer symptomatic relief, they often lack specificity and may lead to undesirable effects. This Special Issue highlights the growing shift toward mechanism-driven, targeted interventions that improve efficacy while minimizing off-target actions.

We invite contributions on the discovery and development of novel targeted therapeutics, including small molecules, biologics, peptides, nucleic acid-based agents, and topical nanocarriers designed for enhanced facial skin penetration. Submissions should emphasize target identification and validation—for instance, cytokines, signaling pathways, microbiome components, or neuroimmune interactions—and incorporate robust pharmacological characterization through binding, cellular, and tissue-level assays.

Both original research and comprehensive review articles are invited for submission.

Dr. Edileia Bagatin
Dr. Marco Alexandre Rocha
Dr. Diogo Pazzini Bomfim
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • facial dermatoses
  • targeted therapy
  • biologics
  • precision dermatology
  • acne vulgaris
  • topical drug delivery

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Published Papers (2 papers)

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Review

13 pages, 1132 KB  
Review
A Global Delphi Consensus on Acne and the Microbiome: Integrating International Expertise for Innovative Prevention and Therapeutic Strategies
by Marco Rocha, Leonel Fierro-Arias, Alison Layton, Vincenzo Bettoli, Ncoza Dlova, Eirini Merika, Thomas Dirschka, Pawinee Rerknimitr and Rakesh Newaj
Pharmaceuticals 2026, 19(5), 697; https://doi.org/10.3390/ph19050697 - 29 Apr 2026
Viewed by 501
Abstract
Acne is a prevalent dermatological condition occurring globally and influenced by a variety of endogenous and exogenous factors. The microbiome and its contribution to skin disease have been increasingly explored, along with the influence of the exposome and host immune responses on this [...] Read more.
Acne is a prevalent dermatological condition occurring globally and influenced by a variety of endogenous and exogenous factors. The microbiome and its contribution to skin disease have been increasingly explored, along with the influence of the exposome and host immune responses on this complex microbial system. Nine experts from different countries in Africa, America, Asia, and Europe gathered to harmonise definitions, identify key pathogenic and protective microbial strains, and prioritise the factors that most significantly impact the skin’s microbiome in the context of acne. Opportunity areas on the role of the microbiome in the prevention, treatment, recurrence, and sequelae avoidance in acne were identified. The relationships between current treatments and the diversity of the microbiome were described. Current microbiome-targeted strategies were assessed, including practical considerations of innovative future perspectives. The panel discussions emphasise the urgent need for universally adaptable guidelines encompassing alternatives to oral antibiotic therapies, in light of increasing antimicrobial resistance and the significant burden of treatment-related adverse events. Full article
(This article belongs to the Special Issue Research Advances in Targeted Therapy for Facial Skin Diseases)
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41 pages, 484 KB  
Review
Biological Treatment of Psoriasis—Data So Far
by Mateusz Matwiejuk, Agnieszka Mikłosz, Hanna Myśliwiec, Adrian Chabowski and Iwona Flisiak
Pharmaceuticals 2026, 19(2), 340; https://doi.org/10.3390/ph19020340 - 21 Feb 2026
Viewed by 7250
Abstract
Psoriasis is a chronic, inflammatory skin disease occurring worldwide that significantly affects patients’ quality of life. This common skin condition is characterized by abnormal hyperplasia of keratinocytes, which leads to the formation of raised, scaly plaques, typically located on the head, elbows, knees, [...] Read more.
Psoriasis is a chronic, inflammatory skin disease occurring worldwide that significantly affects patients’ quality of life. This common skin condition is characterized by abnormal hyperplasia of keratinocytes, which leads to the formation of raised, scaly plaques, typically located on the head, elbows, knees, and lumbar region. Psoriasis usually requires long-term drug therapy, which aims not only to combat skin symptoms but also to improve quality of life. Although topical treatments, systemic treatments (methotrexate, cyclosporine, acitretin), and phototherapy play a role, biologic agents have improved the efficacy of treatment of moderate-to-severe psoriasis. The purpose of this article is to comprehensively review the clinical trial data and evaluate and compare the key features of the currently approved biologic drugs for the treatment of psoriasis. Full article
(This article belongs to the Special Issue Research Advances in Targeted Therapy for Facial Skin Diseases)
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