Sirtuins as Novel Biological Targets for Pharmacological Intervention in Physiology and Pathology—2nd Edition
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 633
Special Issue Editors
Interests: sirtuins; metabolism; extracellular vesicles; autophagy; mitophagy; apoptosis
Special Issues, Collections and Topics in MDPI journals
Interests: sirtuins; hypoxia inflammation; metabolism; autophagy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The sirtuin family of proteins is a class of enzymes that is highly conserved from yeast to humans, possessing a high homology in their sequences and cellular functions, underlying the fact that these proteins play important physiological roles. Seven mammalian sirtuins have been identified, which are characterized by different cellular functions, structures and localizations that can vary based on different stimuli. Sirtuins were first characterized as histone deacetylases, but the presence of non-histone targets underline their involvement in many cellular processes such as the cell cycle, differentiation, senescence, stress response, inflammation, aging, and metabolism. On the other hand, sirtuins are involved in several pathological conditions, such as neurodegenerative disorders, cardiovascular diseases, metabolism-related disorders, carcinogenesis, and tumor development, in which they can act as disease promoters or protective factors based on their targets and functions. Nuclear sirtuins, due to their epigenetic role, and mitochondrial sirtuins, due to their involvement in several metabolic processes, such as the tricarboxylic acid cycle, respiratory chain, fatty acid β-oxidation, ketogenesis, glutamine metabolism, etc., represent an important object of investigation hallmarks of carcinogenesis, represented by metabolic reprogramming and uncontrolled cell proliferation. In a broader analysis that also considers the influence of sirtuins in physiological and pathological conditions, this class of proteins represents a promising potential target of molecular and pharmacological strategies that could counteract the effects of several pathological conditions acting at various levels in molecular and cellular mechanisms. This Special Issue aims to collect and summarize the latest findings on the potential of sirtuin-based pharmacological interventions to modulate activity and counteract damage and the onset of pathological states, favoring the physiological homeostasis of tissues.
Dr. Michele Aventaggiato
Dr. Marco Tafani
Guest Editors
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Keywords
- sirtuins
- metabolism
- cancer
- hypoxia
- damage recovery
- cell death
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