Polymers, Nanoparticles and Hydrogels for Drug Delivery: Strategies and Applications

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 1227

Special Issue Editors


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Instituto Politécnico Nacional, Escuela Superior de Ingenieria Quimica e Industrias Extractivas Laboratorio de Investigación en Polímero y Nanomateriales, Av. Luis Enrique Erro S/N, Unidad Profesional Adolfo López Mateos, Zacatenco, Alcaldía Gustavo A. Madero, Mexico City 07738, Mexico
Interests: polymers; nanocomposite materials; tissue engineering materials and drug delivery systems

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Instituto Politécnico Nacional, Centro de Investigación en Biotecnología Aplicada, Ex-Hacienda San Juan Molino, Tlaxcala 43126, Mexico
Interests: synthesis of nanostructured materials; biosensors for the detection of pathogens; micro and nanoencapsulation of drugs and plant extracts with biological activity
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Instituto Politecnico Nacional, Escuela Superior de Ingenieria Quimica e Industrias Extractivas, Departamento de Ingenieria en Metalurgia y Materiales, Av. Luis Enrique Erro S/N, Unidad Profesional Adolfo López Mateos, Zacatenco, Alcaldía Gustavo A. Madero, Mexico City 07738, Mexico
Interests: organic-inorganic hybrids; polymers; vitreous and ceramics materials for tissue engineering

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Guest Editor
Departamento de Química Orgánica, Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Prolongación de Carpio y Plan de Ayala s/n, Alcaldía Miguel Hidalgo, Mexico City, Mexico
Interests: organic chemistry; tissue engineering materials; scaffolds

Special Issue Information

Dear Colleagues,

Polymers, nanoparticles, and hydrogels have been widely used for the design and development of drug delivery systems. This also implies looking for individual molecules, studying the interaction between their functional groups and cells at micro and nano levels, controlling the properties of artificial and biological systems. These technologies involve the synthesis and use of materials, devices, and systems. The drug delivery includes design of micro and nano carriers, synthesis of nanomedicines and nanosystems production able to drug therapeutic delivery to specific organs or tissues in the body during scheduled times. For the design and formulation of dosing system, the important parameters are device size, trapping method, drug stability, matrix degradation parameters, and dosage kinetics. The absorption or conjugation of a drug into material could protect the drug from its inactivation and help store it for long periods of time, decrease its toxicity and in this way, achieve flexibility in the administration. In this Special Issue, original research articles and reviews are welcome. Research areas could include (but are not limited to) multi-stimuli-responsive “smart” hydrogels for tumor microenvironment-targeted release, self-assembling peptide-based nanocarriers for neurological disorders with BBB penetration, bioresponsive polymer-drug conjugates with enzyme-triggered release for precision oncology, AI-driven design of polymer/nanoparticle systems for optimized drug compatibility and release kinetics, 4D-printed hydrogel implants for minimally invasive, shape-memory drug delivery, nanoparticle–hydrogel hybrid composites for sustained release of biologics, eco-friendly polymers from renewable sources for sustainable drug delivery, intra-articular hydrogels for osteoarthritis treatment and cartilage regenerationscalable manufacturing approaches (microfluidics, 3D bioprinting) for complex systems, among others.

Dr. Mónica de la Luz Corea Téllez
Dr. Marlon Rojas López
Dr. Lucia Tellez-Jurado
Dr. Rogelio Jiménez-Juárez
Guest Editors

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Keywords

  • drug delivery
  • medical applications
  • hydrogels
  • polymers
  • nanoparticles
  • drug delivery system
  • multi-stimuli-responsive materials
  • nanocomposites
  • biofilms
  • biomarkers

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Published Papers (2 papers)

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34 pages, 10503 KB  
Article
Polymeric Nanoparticles with Surface-Anchored Functional Groups as Chelating Agents for Calcium (Ca2+) and Magnesium (Mg2+) Ions to Inhibit Cellular Interactions
by Lazaro Ruiz-Virgen, Juan Luis Salazar-García, Ismael Arturo Garduño-Wilches, Marlon Rojas-López, Gabriela Martínez-Mejía, Rubén Caro-Briones, Nadia A. Vázquez-Torres, Andrés Castell-Rodríguez, Hugo Martínez-Gutiérrez, José Manuel del Río and Mónica Corea
Pharmaceuticals 2025, 18(12), 1774; https://doi.org/10.3390/ph18121774 - 21 Nov 2025
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Abstract
Background: Cancer therapeutics development has been a challenge in medical and scientific areas due to their toxicity, limited biocompatibility, and unfortunate side effects. However, despite advances in early detection and the study of novel treatments, the mortality rate for breast cancer remains high, [...] Read more.
Background: Cancer therapeutics development has been a challenge in medical and scientific areas due to their toxicity, limited biocompatibility, and unfortunate side effects. However, despite advances in early detection and the study of novel treatments, the mortality rate for breast cancer remains high, making it a significant global health concern. Objectives: In this study, poly(methyl methacrylate) (PMMA) nanoparticles functionalized with acrylic acid (AA), fumaramide (FA), and curcumin (CUR) as chelating and inhibitor agents were synthesized by emulsion polymerization techniques. Methods and Results: Comprehensive physiochemical characterization studies based on gravimetry, dynamic light scattering (DLS), electrophoresis, Fourier transform infrared (FT-IR), ultraviolet–visible (UV–Vis) and photoluminescence (PL) spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM) revealed a pH dependence of nanoparticles that exhibit structural changes upon interaction with calcium (Ca2+) and magnesium (Mg2+) ions. Calorimetric thermodynamic properties measured by isothermal titration calorimetry (ITC) confirmed chelating coordination and positive cooperativity between the nanoparticles and metal ions. In vitro studies showed the low cytotoxicity of nanoparticles by fibroblast proliferation, and their chelation process was observed by fluorescence microscopy, with the loss of interaction between cells. Conclusions: These results suggest that the functionalized nanoparticles have potential in drug delivery systems (DDS) for targeted breast cancer therapies, providing a promising polymer material for more efficient and less toxic treatments. Full article
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20 pages, 1053 KB  
Systematic Review
Advancing Photodynamic Cancer Therapy with Smart Light-Responsive Lipid and Polymeric Nanocarriers: Evidence from a Meta-Analysis of Efficacy and Pharmacokinetics
by Ahmed M. Agiba, Rabab A. El-Gazar, Mohamed A. Mekkawy, Nihal Elsayyad, Hala N. ElShagea, Patricia Segura-Medina and Raghda Rabe Hamed
Pharmaceuticals 2025, 18(12), 1796; https://doi.org/10.3390/ph18121796 - 25 Nov 2025
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Abstract
Background/Objectives: Conventional anticancer drugs often exhibit limited solubility and bioavailability due to unfavorable physicochemical properties and inherent physiological barriers. To overcome these persistent challenges, nanocarriers have been developed to enhance drug bioavailability and therapeutic efficacy. Among these, lipid and polymeric nanocarriers (LP-NCs) [...] Read more.
Background/Objectives: Conventional anticancer drugs often exhibit limited solubility and bioavailability due to unfavorable physicochemical properties and inherent physiological barriers. To overcome these persistent challenges, nanocarriers have been developed to enhance drug bioavailability and therapeutic efficacy. Among these, lipid and polymeric nanocarriers (LP-NCs) have emerged as particularly promising candidates for anticancer drug delivery. These systems can be engineered for targeted delivery and tailored to respond to specific stimuli, thereby enhancing their therapeutic potential. A notable advancement in this field is the development of smart light-responsive LP-NCs, which demonstrate superior performance over conventional nanocarriers by enabling controlled drug release in response to external light stimuli. Methods: This study presents a meta-analysis based on a curated selection of publications from multiple scientific databases and literature sources. The objective was to evaluate whether light-responsive LP-NCs offer superior anticancer drug bioavailability and therapeutic efficacy compared with their conventional counterparts. The primary outcome measure was the pharmacokinetic parameter area under the curve (AUC), derived from in vivo animal studies. Results: The analysis revealed a significant increase in AUC for light-responsive LP-NCs, indicating improved drug bioavailability and prolonged systemic exposure. Conclusions: These findings highlight the potential of LP-NCs as a promising strategy for enhancing targeted anticancer drug delivery. This approach could pave the way for more effective therapeutic interventions and warrants further investigation in future research and clinical trials. Full article
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