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Molecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Exclusive Feature Papers in Synthetic Medicinal Chemistry submission deadline 31 Dec 2025 | 4 articles | Viewed by 9185 | Submission Open
Keywords: antitumor activity; antibacterial activity; natural and synthetic compounds
(This special issue belongs to the Section Organic Chemistry)
Biological Activities of Traditional Medicinal Plants, 2nd Edition submission deadline 31 Dec 2025 | 6 articles | Viewed by 9130 | Submission Open
Keywords: traditional medicinal plants; ethnobotany; bioactive compounds; extraction strategies; phytochemical profiling; biological activities; health applications; nutraceuticals
(This special issue belongs to the Section Natural Products Chemistry)
New Insight into Edible Oil: From Food Chemistry to Health Benefits submission deadline 31 Dec 2025 | 4 articles | Viewed by 8801 | Submission Open
Keywords: edible oils; fats; structured lipids; bioactive compounds; quality; stability; degradation; contamination
(This special issue belongs to the Section Food Chemistry)
Phytochemicals as Valuable Tools for Fighting Metabolic Disorders
edited by Anna Ramunno and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 8738 | Submission Open
Keywords: phytochemicals; metabolic disorders; obesity; diabetes; antioxidants; therapeutic applications
(This special issue belongs to the Section Natural Products Chemistry)
Phytochemical Profiling, Bioactivity, Biotechnology Studies and Practical Applications of Medicinal and Cosmetic Plants submission deadline 31 Dec 2025 | 6 articles | Viewed by 8366 | Submission Open
Keywords: plant metabolites; plant biotechnology; bioactive natural compounds; natural products metabolomics; pharmacological activity of natural compounds; cosmetic applications of natural compounds; isolation of natural compounds; essential oils; biological activity of natural compounds; in vitro approach; in vivo approach; clinical investigations; ethnopharmacological indications; ethnobotanical indications; technology of cosmetic formulations; skin permeability; irritating potential; agricultural practices
(This special issue belongs to the Section Natural Products Chemistry)
Analysis and Biological Evaluation of Bioactive Compounds from Natural Sources, 2nd Edition
edited by Luana Pulvirenti and Rosanna Avola
submission deadline 31 Dec 2025 | 7 articles | Viewed by 8113 | Submission Open
Keywords: natural products; natural product chemistry; polyphenols; vegetable extract profiling; herbal medicine; phytochemicals; biological applications of natural products; mechanism of action
(This special issue belongs to the Section Natural Products Chemistry)
Developments in Conducting Polymers: Applications for Electrochemistry submission deadline 31 Dec 2025 | 3 articles | Viewed by 7710 | Submission Open
Keywords: conducting polymers; sensors; electrochemical applications; batteries
(This special issue belongs to the Section Macromolecular Chemistry)
Renewable Energy, Fuels and Chemicals from Biomass, 2nd Edition
edited by and
submission deadline 31 Dec 2025 | 5 articles | Viewed by 7286 | Submission Open
Keywords: biomass conversion technologies; renewable energy; biofuel synthesis; catalytic biomass transformation; bioethanol; biodiesel; green/sustainable chemistry; biotechnological applications
(This special issue belongs to the Section Applied Chemistry)
Analytical Chemistry in Asia, 2nd Edition
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 7245 | Submission Open
Keywords: analytical chemistry; Asia; HPLC; sample preparation; bioanalysis; mass spectrometry
(This special issue belongs to the Section Analytical Chemistry)
Functional Nanomaterials for Energy and Environmental Sustainability
edited by Dezhi Chen, Junfei Liang and
submission deadline 31 Dec 2025 | 5 articles | Viewed by 7161 | Submission Open
Keywords: functional nanomaterials; resource recovery; secondary batteries; supercapacitors; water purification; carbon capture; VOC elimination
(This special issue belongs to the Section Applied Chemistry)
Characterization and Instrumental Analysis of Aroma-Active Compounds in Fermented Food and Beverage, the Second Edition
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 7063 | Submission Open
Keywords: fermentation; fermented food production; fermented food flavor; aroma characterization; gas chromatography– mass spectrometry/olfactory (GC-MS/O); Sensorial properties; HS-SPME; stir bar and thin-film sorptive extraction
(This special issue belongs to the Section Flavours and Fragrances)
The 30th Anniversary of Molecules—Recent Advances in Natural Products Chemistry submission deadline 31 Dec 2025 | 4 articles | Viewed by 6869 | Submission Open
Keywords: natural compounds; bioactive molecules; drug discovery; pharmacological activity; formulations; drug delivery systems; food applications and additives; cosmetic applications; synthesis
(This special issue belongs to the Section Natural Products Chemistry)
Nanostructured Materials: Synthesis, Functionalization and Applications in Biomedicine—2nd Edition
edited by , and Hanping Yu
submission deadline 31 Dec 2025 | 5 articles | Viewed by 6829 | Submission Open
Keywords: nanostructured materials; biomaterials; dental materials; biomedicine; biomedical applications; drug delivery; bone defect repair; orthopedic surgery; skin wound healing; anti-tumor; biosensing; bioimaging; diagnosis; therapy
(This special issue belongs to the Section Nanochemistry)
Heterocyclic Chemistry with Applications (Second Edition)
edited by Hachemi Kadri and
submission deadline 31 Dec 2025 | 4 articles | Viewed by 6818 | Submission Open
Keywords: heterocycles; medicinal chemistry; natural products; organic synthesis; synthetic methods; drug discovery; nucleosides; biologically active heterocycles
(This special issue belongs to the Section Organic Chemistry)
Essential Oils—Third Edition
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 6760 | Submission Open
Keywords: essential oils; volatile organic compounds (VOCs); chemical fingerprinting; isoprenoids; gas chromatography-mass spectrometry (GC-MS); nuclear magnetic resonance (NMR) spectroscopy; physiological functions of essential oils in plants; molecular mechanisms of essential oils; in vitro and in vivo bioactivities; antimicrobial agents; anti-infective properties; antioxidant potential; allelopathic interactions; biosynthetic pathways; extraction techniques
(This special issue belongs to the Section Natural Products Chemistry)
Anticancer Natural Products
edited by Zongtao Tom Lin
submission deadline 31 Dec 2025 | 3 articles | Viewed by 6505 | Submission Open
Keywords: anticancer; drug discovery; chemical biology; natural products; analytical methods; bioactive compounds; cancer therapy
(This special issue belongs to the Section Natural Products Chemistry)
Synthesis, Modification and Application of Heterocyclic Compounds
edited by and Yongjia Shang
submission deadline 31 Dec 2025 | 4 articles | Viewed by 6500 | Submission Open
Keywords: heterocyclic compounds; synthesis; modification; asymmetric catalysis; cyclization; natural products
(This special issue belongs to the Section Organic Chemistry)
Food Bioactive Components in Functional Foods and Nutraceuticals submission deadline 31 Dec 2025 | 4 articles | Viewed by 6294 | Submission Open
Keywords: functional foods; nutraceuticals; bioactive compounds; health benefits; disease prevention; bioavailability
(This special issue belongs to the Section Food Chemistry)
Virgin Olive Oil: Processing, Byproducts, Quality Control, and Nutraceutical Profile—3rd Edition submission deadline 31 Dec 2025 | 3 articles | Viewed by 6173 | Submission Open
Keywords: virgin olive oil quality authentication; byproduct management; volatile compounds; phenolic compounds; sensory analysis; health-promoting properties; biological activity; authentication of origin; innovative extraction processes
(This special issue belongs to the Section Natural Products Chemistry)
Synthesis and Applications of Natural Polymers and Their Derivatives submission deadline 31 Dec 2025 | 3 articles | Viewed by 6010 | Submission Open
Keywords: biological synthesis; semisynthetic derivatives; polysaccharides and polyhydroxyalkanoates; fungal proteins; processing techniques; composites; nanoparticles; biomedical; pharmaceutical; drug delivery systems; food protection applications
(This special issue belongs to the Section Macromolecular Chemistry)
Synthesized and Functionalized Nanoparticles in Natural Compounds
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5778 | Submission Open
Keywords: nanoparticles; green synthesis; two step-based mechanism growth for nanostructures; template synthetic approach; essential oil (EO); functionalized nanoparticles; shape factor (SF); antibacterial features; cytotoxicity properties; cultural heritage reparation; drug delivery and discovery; nano-carrier in biotechnologies
(This special issue belongs to the Section Materials Chemistry)
(Mass Spectrometric) Non Target Screening–Techniques and Strategies: Volume II
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 5772 | Submission Open
Keywords: mass spectrometric non-target screening; NTS workflows; NTS strategies; NTS techniques (separation; ionization; detection); HPLC; SFC; GC; CE; HRMS; MS/MS; NTS software solutions; NTS open access software; NTS data evaluation; NTS and quality management
(This special issue belongs to the Section Analytical Chemistry)
Innovative Technologies for Functional Foods Development submission deadline 31 Dec 2025 | 3 articles | Viewed by 5702 | Submission Open
Keywords: nutraceuticals; functional foods; plant ingredients; phytochemicals; health claims; in vitro and in vivo studies
(This special issue belongs to the Section Food Chemistry)
Advanced Oxidation/Reduction Processes in Water Treatment
edited by Fuxiang Tian and Yuqiong Gao
submission deadline 31 Dec 2025 | 4 articles | Viewed by 5588 | Submission Open
Keywords: advanced oxidation processes; advanced reduction processes; disinfection byproducts; hybrid treatment processes; micropollutant removal; emerging contaminant removal
(This special issue belongs to the Section Green Chemistry)
Exclusive Feature Papers in Inorganic Chemistry, 3rd Edition submission deadline 31 Dec 2025 | 5 articles | Viewed by 5529 | Submission Open
Keywords: coordination chemistry; metal complexes; metal-based assemblies; inorganic anions; inorganic materials; coordination polymers; functional materials; chemosensors
(This special issue belongs to the Section Inorganic Chemistry)
Chemical Profiling of Plant Extracts with Antioxidant Activity: Identification of Bioactive Compounds submission deadline 31 Dec 2025 | 2 articles | Viewed by 5479 | Submission Open
Keywords: flavonoids; phenolic acids; terpenoids; anthocyanins; antioxidant activity; chemical profiling
(This special issue belongs to the Section Natural Products Chemistry)
New Sights in Nanomaterials for Photoelectrochemistry
edited by Yibo Yan
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5454 | Submission Open
Keywords: photoelectrochemical catalysis; photoelectrochemical cells; photoelectrochemical sensors; photoelectrochemical characterizations; photoelectrochemical conversion; photoelectrochemical transformations; optoelectronic devices; photoelectrochemical CO2 reduction
(This special issue belongs to the Section Nanochemistry)
Feature Papers in Photochemistry and Photocatalysis—2nd Edition
edited by
submission deadline 31 Dec 2025 | 6 articles | Viewed by 5391 | Submission Open
Keywords: photocatalytic processes; quantum yield; solar light; upconversion; heterojunctions
(This special issue belongs to the Section Photochemistry)
Biomass Materials in Materials Chemistry: Preparation and Characterization, 2nd Edition
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 5388 | Submission Open
Keywords: biomass material (including chitosan; chitin; starch; and biomass waste); catalyst; food packing; coating and film; adsorption
(This special issue belongs to the Section Materials Chemistry)
Chemistry and Health: Nitrogen Heterocycle Chemistry and Medicinal Chemistry, 2nd Edition
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 5205 | Submission Open
Keywords: heterocycles; azines; azoles; anticancer; anti-tuberculosis; antimicrobial; growth factors
(This special issue belongs to the Section Medicinal Chemistry)
Phytochemical Investigation of Bioactive Constituents from Medicinal Plants submission deadline 31 Dec 2025 | 3 articles | Viewed by 5196 | Submission Open
Keywords: primary metabolites; secondary metabolites; biological activity; phytochemistry; natural products; HPLC-analysis; spectral analysis; medicinal plants
(This special issue belongs to the Section Natural Products Chemistry)
Advances in Photocatalytic Degradation of Organic Pollutants
edited by Qianqian Liu, Quan Zhang and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 5133 | Submission Open
Keywords: photocatalysis; photocatalytic degradation of organic pollutants; functional materials; semiconductor photocatalysts; DFT
(This special issue belongs to the Section Green Chemistry)
Corrosion Electrochemistry: A Themed Issue in Honor of the Many Contributions of Prof. Dr. Changjian Lin
edited by Jiming Hu and Guozhe Meng
submission deadline 31 Dec 2025 | 4 articles | Viewed by 5005 | Submission Open
Keywords: corrosion electrochemistry; corrosion and protection; anti-corrosion coatings; electrochemical test
(This special issue belongs to the Section Electrochemistry)
Inorganic Chemistry in Europe 2025 submission deadline 31 Dec 2025 | 4 articles | Viewed by 4774 | Submission Open
Keywords: inorganic chemistry (main group and transition metal chemistry); coordination and organometallic chemistry; bioinorganic chemistry; sustainable catalysis and green chemistry; nanotechnology and smart materials; energy storage and conversion; metallodrugs and imaging agents; computational chemistry and AI in material science
(This special issue belongs to the Section Inorganic Chemistry)
Women’s Special Issue Series: Molecules submission deadline 31 Dec 2025 | 3 articles | Viewed by 4671 | Submission Open
Keywords: organic chemistry; medicinal chemistry; natural products chemistry; inorganic chemistry; physical chemistry; material chemistry; chemical biology; analytical chemistry; supramolecular chemistry; theoretical chemistry; green chemistry; photochemistry
Synthesis and Applications of Nanoparticles and Multifunctional Nanocomposites
edited by , and Iulia Ioana Lungu
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4604 | Submission Open
Keywords: nanoparticles; nanocomposites; synthesis; multifunctional platforms
(This special issue belongs to the Section Nanochemistry)
Bioactive Molecules in Foods: From Sources to Functional Applications submission deadline 31 Dec 2025 | 3 articles | Viewed by 4547 | Submission Open
Keywords: food compounds; biological activity; nutrition; health; food products; diet supplementary
(This special issue belongs to the Section Food Chemistry)
Innovative Chemical Pathways for CO2 Conversion
edited by and Juqin Zeng
submission deadline 31 Dec 2025 | 4 articles | Viewed by 4474 | Submission Open
Keywords: CO2 conversion; chemical reactions; CO2 utilization; CO2 reduction; green chemistry; sustainable chemistry; CO2 recycling; carbon neutrality; renewable energy; carbon footprint reduction; environmental impact; carbon-based fuels; sustainable processes; climate change mitigation; CO2 emissions; energy transition
(This special issue belongs to the Section Green Chemistry)
Exclusive Contributions by the Editorial Board Members (EBMs) of the Inorganic Chemistry Section of Molecules 2025 submission deadline 31 Dec 2025 | 5 articles | Viewed by 4451 | Submission Open
Keywords: inorganic chemistry; coordination chemistry; main-group chemistry; bioinorganic chemistry; solid-state chemistry; organometallic compounds; inorganic cluster chemistry; metal-based assemblies; inorganic anions; inorganic materials; theoretical inorganic chemistry
(This special issue belongs to the Section Inorganic Chemistry)
Small-Molecule Drug Design and Discovery
edited by Qiuqin He
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4446 | Submission Open
Keywords: small-molecule drug design; structure-based drug design; fragment-based drug discovery; PROTAC technology; artificial intelligence technology; biological evaluation
(This special issue belongs to the Section Medicinal Chemistry)
The Design, Synthesis, and Biological Activity of New Drug Candidates, 2nd Edition
edited by Carolina S. Marques, and
submission deadline 31 Dec 2025 | 4 articles | Viewed by 4400 | Submission Open
Keywords: bioactive; in silico; in vitro; in vivo; ADMET; synthesis; privilege scaffold; active pharmaceutical ingredients
(This special issue belongs to the Section Medicinal Chemistry)
Bioactive Compounds and Antioxidant Activity of Extracts from Natural Plants, 2nd Edition submission deadline 31 Dec 2025 | 4 articles | Viewed by 4344 | Submission Open
Keywords: bioactive compounds; natural plant products; antioxidant activity; extraction methods; polyphenols; flavonoids
(This special issue belongs to the Section Natural Products Chemistry)
Determination, Adsorption and Degradation Mechanisms of Environmental Pollutants
edited by Alina Catrinel Ion
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4162 | Submission Open
Keywords: environmental pollutants; adsorption mechanisms; degradation pathways; analytical techniques; nanomaterials; heavy metals; organic contaminants
(This special issue belongs to the Section Green Chemistry)
Between Solid-State NMR and Nanoscience—a Long Journey with Great Perspectives: A Themed Issue in Honor of Professor Jacek Klinowski
edited by Leszek Stobinski and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4150 | Submission Open
Keywords: solid-state NMR; NMR; zeolites; ordered carbon nanostructures; MOFs; mathematics in crystallography
(This special issue belongs to the Section Physical Chemistry)
Design, Synthesis, and Catalytic Applications of Metal Complexes
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4137 | Submission Open
Keywords: metal complex; metal-based material; catalysis: electrocatalysis; photocatalysis; thermocatalysis
(This special issue belongs to the Section Applied Chemistry)
Discovery of Microbial Natural Products
edited by and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4061 | Submission Open
Keywords: microbial natural products; determination of structure; microorganism; drug candidate; bioactive secondary metabolites; microbial biotechnology
(This special issue belongs to the Section Natural Products Chemistry)
Vibrational Spectroscopy and Imaging for Chemical Application submission deadline 31 Dec 2025 | 4 articles | Viewed by 4054 | Submission Open
Keywords: Raman spectroscopy; infrared spectroscopy; Raman image analysis; infrared image analysis; chemometrics; multiway analysis; multivariate curve resolution; alternating least squares; multivariate image analysis; classification; machine learning
(This special issue belongs to the Section Analytical Chemistry)
Active Ingredients in Functional Foods and Their Impact on Health, 2nd Edition submission deadline 31 Dec 2025 | 3 articles | Viewed by 3971 | Submission Open
Keywords: functional foods; active ingredients; bioactive compounds; health impact; nutraceuticals; dietary patterns; personalized nutrition
(This special issue belongs to the Section Food Chemistry)
Cross-Coupling and Related Reactions: Past and New Reactions for the Future
edited by and Satenik Mkrtchyan
submission deadline 31 Dec 2025 | 1 articles | Viewed by 3912 | Submission Open
Keywords: C-C- cross coupling reactions; C-C bond formation by transition metal catalysis; C-C bond formation by organocatalysis; C-C bond formation by photoredox catalysis; C-C bond formation by enzymatic catalysis; sustainability; green chemistry; new trends in C-C bond formation
(This special issue belongs to the Section Organic Chemistry)
Plant Volatile Organic Compounds: Extraction, Characterization and Biological Activities submission deadline 31 Dec 2025 | 3 articles | Viewed by 3833 | Submission Open
Keywords: plant volatile organic compounds; biosynthesis and emission; essential oils; biological activities; green extraction; omics technologies; circular bioeconomy
(This special issue belongs to the Section Natural Products Chemistry)
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