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Discovery of Microbial Natural Products
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Discovery of Microbial Natural Products

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1450

Special Issue Editors

Prof. Dr. Yun Kwon

E-Mail Website
Guest Editor
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu 41566, Republic of Korea
Interests: streptomyces; actinomycetes; amycolatopsis; natural products; secondary metabolites; bioactive compounds
Dr. Sang-Jip Nam

E-Mail Website
Guest Editor
Department of Chemistry and Nano Science, College of Natural Sciences, Ewha Womans University, Seoul 120-750, Republic of Korea
Interests: marine natural products; structure elucidation of natural products; antibacterial and anti-cancer natural products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

There is a rich variety of microorganism species, and the number of cultured microorganisms is estimated to only account for about 10% of all microorganisms on Earth. These small organisms produce novel chemical structures that are not found in plants and organisms capable of movement. Microbial natural products have displayed a diversity of compounds, leading to the discovery of drug candidates with beneficial biological activities. 

In recent years, advances in biotechnology, such as the activation of various biosynthetic gene clusters (BGCs) which had remained silent for decades, have enabled the production of novel compounds from microorganisms. Our objective is to focus on the discovery of structurally and biologically novel microbial compounds and their potential in drug development. As the Guest Editors of this Special Issue, we welcome high-quality reviews or research articles on topics including, but not limited to, the following: microbial natural products; structural determination; microorganisms; drug candidates; bioactive secondary metabolites; and microbial biotechnology.

Prof. Dr. Yun Kwon
Dr. Sang-Jip Nam
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbial natural products
  • determination of structure
  • microorganism
  • drug candidate
  • bioactive secondary metabolites
  • microbial biotechnology

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Published Papers (2 papers)

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Research

15 pages, 3649 KiB  
Article
Unveiling the Role of Metabolites from a Bacterial Endophyte in Mitigating Soil Salinity and Reducing Oxidative Stress
by Pramod Kumar Sahu, Krishna Nanda Dhal, Nakul Kale, Vivek Kumar, Niharika Rai, Amrita Gupta, Durgesh Kumar Jaiswal and Alok Kumar Srivastava
Molecules 2025, 30(8), 1787; https://doi.org/10.3390/molecules30081787 - 16 Apr 2025
Viewed by 391
Abstract
Several plant-associated microbes have the capability of ameliorating the adverse effects of salinity stress in plants. Such microbes produce metabolites, including proline, glycine betaine, and secondary compounds, like melatonin, traumatic acid, and β-estradiol, which have been found to have a role in [...] Read more.
Several plant-associated microbes have the capability of ameliorating the adverse effects of salinity stress in plants. Such microbes produce metabolites, including proline, glycine betaine, and secondary compounds, like melatonin, traumatic acid, and β-estradiol, which have been found to have a role in reducing salinity-induced damage in plant cells. While the effects of these metabolites have been studied, their application-related aspects remain underexplored. In this study, we investigated the salinity-stress-alleviating potential of metabolites derived from the endophytic bacterium Bacillus safensis BTL5. The microbial metabolites were extracted using the hexane–chloroform fraction method and identified through LC-HRMS analysis. Four metabolites (traumatic acid, β-estradiol, arbutin, and α-mangostin), along with a fifth compound, melatonin, were initially screened for their salinity alleviation potential. Subsequently, two metabolites, i.e., arbutin and β-estradiol, were evaluated for their impact on growth parameters and enzymatic antioxidant activities under 200 mM salt stress. The results revealed that arbutin and β-estradiol significantly improved plant growth, chlorophyll content, and enzymatic activities while reducing oxidative damage. The dose-dependent effects highlighted optimal concentrations for maximum efficacy from these compounds under elevated salinity. This study signifies the potential of microbial metabolites in enhancing crop resilience to salinity, highlighting their role in sustainable agriculture. The outcomes of this study provide a baseline for the applied use of such microbial metabolites under field conditions. Full article
(This article belongs to the Special Issue Discovery of Microbial Natural Products)
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10 pages, 1665 KiB  
Article
Three New Depsipeptides, Homiamides A–C, Isolated from Streptomyces sp., ROA-065
by Jeong-Hyeon Kim, Ji Young Lee, Juri Lee, Prima F. Hillman, Jihye Lee, Byeongchan Choi, Man-Jeong Paik, Songyi Lee and Sang-Jip Nam
Molecules 2024, 29(23), 5539; https://doi.org/10.3390/molecules29235539 - 23 Nov 2024
Viewed by 887
Abstract
Three new depsipeptides, homiamides A–C (1–3), were isolated from a marine sediment-derived strain of Streptomyces sp., ROA-065. The planar structures of homiamides A–C (1–3) were elucidated using mass spectrometry (MS) and nuclear magnetic resonance (NMR) [...] Read more.
Three new depsipeptides, homiamides A–C (1–3), were isolated from a marine sediment-derived strain of Streptomyces sp., ROA-065. The planar structures of homiamides A–C (1–3) were elucidated using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopic data. The absolute configurations of 1–3 were deduced from the application of the Marfey’s method and GC-MS analysis after formation of the O-trifluoroacetylated (S)-(+)-methyl-2-butyl ester derivatives of amino acids. Compounds 1–3 exhibited weak anti-bacterial activities against both Gram-positive bacteria and Gram-negative bacteria, with compound 1 showing MIC values of 32–64 μg/mL. In antifouling assays, compounds 1 and 2 displayed moderate activity against Micrococcus luteus KCTC 3063, while compound 3 exhibited weak activity against all tested bacteria. Full article
(This article belongs to the Special Issue Discovery of Microbial Natural Products)
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