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Chemical Profiling of Plant Extracts with Antioxidant Activity: Identification of Bioactive Compounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 3386

Special Issue Editor

Dr. Marcos Soto-Hernández

E-Mail Website
Guest Editor
Colegio de Postgraduados, Campus Montecillo, Km. 36.5, Carretera México-Texcoco, Montecillo, Texcoco 56230, Mexico
Interests: phytochemistry; natural product chemistry; biological activity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Plant extracts are a rich source of many bioactive compounds, and their antioxidant activity is related to different health benefits. In many cases, this activity is related to a set of compounds that together enhance antioxidant activity, for example, flavonoids, phenolic acids, terpenoids, and so on. In this Special Issue, we expect to receive contributions that can broaden the knowledge of this important biological activity of plant extracts.

Dr. Marcos Soto-Hernández
Guest Editor

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Keywords

  • flavonoids
  • phenolic acids
  • terpenoids
  • anthocyanins
  • antioxidant activity
  • chemical profiling

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Published Papers (2 papers)

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Research

17 pages, 6901 KiB  
Article
Phytochemical Analysis, Antioxidant and Antibacterial Activities, Minerals Element Profiling, and Identification of Bioactive Compounds by UPLC-HRMS Orbitrap in Four Aromatic and Medicinal Plants
by Aicha Boubker, Abdelmoula El Ouardi, Taha El Kamli, Adnane El Hamidi, Mohammed Kaicer, Faouzi Kichou, Najia Ameur, Khaoula Errafii, Rachid Ben Aakame and Aicha Sifou
Molecules 2025, 30(6), 1279; https://doi.org/10.3390/molecules30061279 - 12 Mar 2025
Viewed by 902
Abstract
Four aromatic and therapeutic plants, Thymus vulgaris, Rosmarinus officinalis, Pimpinella anisum, and Foeniculum vulgare, were examined in this comparative study. The objectives were to assess its phytochemical composition; polyphenol, flavonoid, and tannin content; antioxidant and antibacterial activity; bioactive molecule [...] Read more.
Four aromatic and therapeutic plants, Thymus vulgaris, Rosmarinus officinalis, Pimpinella anisum, and Foeniculum vulgare, were examined in this comparative study. The objectives were to assess its phytochemical composition; polyphenol, flavonoid, and tannin content; antioxidant and antibacterial activity; bioactive molecule identification; and critical trace element quantification. Its aqueous and organic extracts were examined, focusing on ethanolic extracts. The ethanolic extract’s ability to neutralize free radicals was validated by phytochemical studies and antioxidant tests, underscoring their role in preventing oxidative stress. An Ultra-Performance Liquid Chromatography—High-Resolution Mass Spectrometry Orbitrap Exploris 120 (UPLC–HRMS Orbitrap) was used to identify the bioactive chemicals, and the results showed a variety of compounds having antibacterial and antioxidant properties. The important trace elements found in these plants were also measured using a Graphite Furnace-Atomic Absorption Spectrometer (GF-AAS). These components are essential to the biological characteristics of the plants, especially their antioxidant and antibacterial capacities. Among the aqueous extracts, it was observed that Rosmarinus officinalis and Foeniculum vulgare exhibited a MIC of 3.91 µg/mL against Staphylococcus. Additionally, R. officinalis also demonstrated a MIC of 3.91 µg/mL against Escherichia coli. All of the data were interpreted and shown using principal component analysis. The results were grouped and explained using this statistical method, which revealed a strong association between the abundance of antibacterial and antioxidant chemicals in the four plants under investigation. Full article
(This article belongs to the Special Issue Chemical Profiling of Plant Extracts with Antioxidant Activity: Identification of Bioactive Compounds)
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18 pages, 3259 KiB  
Article
Comparative Metabolomic Analysis and Antinociceptive Effect of Methanolic Extracts from Salvia cinnabarina, Salvia lavanduloides and Salvia longispicata
by Nancy Ortiz-Mendoza, Juan L. Monribot-Villanueva, José A. Guerrero-Analco, Martha J. Martínez-Gordillo, Francisco A. Basurto-Peña, Eva Aguirre-Hernandez and Marcos Soto-Hernández
Molecules 2024, 29(22), 5465; https://doi.org/10.3390/molecules29225465 - 20 Nov 2024
Viewed by 1167
Abstract
Mexico is considered one of the countries with the greatest diversity of the Salvia genus. A significant percentage of its species are known for their use in traditional medicine, highlighting their use as an analgesic. The objective of this work was to determine [...] Read more.
Mexico is considered one of the countries with the greatest diversity of the Salvia genus. A significant percentage of its species are known for their use in traditional medicine, highlighting their use as an analgesic. The objective of this work was to determine the chemical composition of the methanolic extracts of S. cinnabarina, S. lavanduloides and S. longispicata through untargeted metabolomics, as well as the in vivo evaluation of the antinociceptive effect and acute oral toxicity. The chemical profiling was performed using ultra-high performance liquid chromatography coupled with a high-resolution mass spectrometry (UPLC-ESI+/−-MS-QTOF) system and tentative identifications were performed using a compendium of information on compounds previously isolated from Mexican species of the genus. Pharmacological evaluation was carried out using the formalin test and OECD guidelines. The analysis of the spectrometric features of the mass/charge ratios of the three salvias shows that a low percentage of similarity is shared between them. Likewise, the putative identification allowed the annotation of 46 compounds, mainly of diterpene and phenolic nature, with only four compounds shared between the three species. Additionally, the extracts of the three salvias produced a significant antinociceptive effect at a dose of 300 mg/kg administered orally and did not present an acute oral toxicity effect at the maximum dose tested, indicating a parameter of LD50 > 2000 mg/kg. The exploration of the chemical profile of the three salvias by untargeted metabolomics shows that, despite being species with antinociceptive potential, they have different chemical profiles and therefore different active metabolites. Full article
(This article belongs to the Special Issue Chemical Profiling of Plant Extracts with Antioxidant Activity: Identification of Bioactive Compounds)
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