The Design, Synthesis, and Biological Activity of New Drug Candidates, 2nd Edition
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 423
Special Issue Editors
Interests: organic synthesis; ionic liquids; green chemistry; pharmaceutics and pharmaceutical technology; ligand; catalysis; toxicology
Special Issues, Collections and Topics in MDPI journals
2. iBB—Institute for Bioengineering and Biosciences and Associate Laboratory i4HB—Institute for Health and Bioeconomy, Instituto Superior Técnico, University of Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal
3. CQC-IMS, Department of Chemistry, University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal
Interests: drug delivery; drug discovery; medicinal chemistry; biomaterials; sustainability; multicomponent reactions
Special Issues, Collections and Topics in MDPI journals
Interests: organic synthesis; synthesis; polymers; synthetic organic chemistry; synthetic chemistry; medicinal and pharmaceutical chemistry; heterocyclic chemistry; antimicrobials; organic chemistry synthesis; biomaterials
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Over the last decades, tremendous efforts have been made by the scientific community to transform the world to a better place. Ending poverty and hunger, protecting the planet from degradation and ensuring healthier lives are the main long-term goals. In particular, through drug discovery and development, researchers are committed to fight against complex and mortal diseases, study their physiopathology and intervene in the discovery of new therapeutic options, or the best practices to provide patients longer (and better) lives, while focusing on the sustainability of these approaches, decreasing the impact on resources, and simultaneously decreasing the socioeconomic burden of diseases.
The design and synthesis of new bioactive molecules, as well as new approaches to attain well-known active pharmaceutical ingredients (APIs) and natural products, while promoting sustainability, continue to be contemporary challenges, growing with the emergence to cure or ameliorate complex diseases and downplay drug resistance.
This Special Issue intends to emphasize updated contributions in the design, synthesis and application of bioactive compounds as drug candidates, revealing the discovery of promising hit scaffolds, hit-to-lead generation strategies and privilege units as pharmacophores. New and sustainable approaches to synthesise well-established APIs and natural products that can contribute to improving medicine accessibility will also be considered. Works that analyse sustainable, innovative and economically favoured strategies in the design of the focused libraries will enrich the Special Issue. Review articles by experts in the field are also welcome.
Dr. Carolina S. Marques
Dr. Pedro Brandão
Dr. Anthony J. Burke
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- bioactive
- in silico
- in vitro
- in vivo
- ADMET
- synthesis
- privilege scaffold
- active pharmaceutical ingredients
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