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Molecules
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Synthesis, Modification and Application of Heterocyclic Compounds
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Synthesis, Modification and Application of Heterocyclic Compounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 609

Special Issue Editors

Dr. Xinwei He

E-Mail Website
Guest Editor
Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials (State Key Laboratory Cultivation Base), College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, China
Interests: multicomponent reaction; transition metal-catalyzed C-H functionalizations; o-AQM chemistry in heterocyclic compound syntheses; novel methodologies development
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Yongjia Shang

E-Mail Website
Guest Editor
Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials (State Key Laboratory Cultivation Base), College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, China
Interests: organic synthesis and pharmaceutical synthesis; metal-involved organic synthesis reactions; applied organic chemistry

Special Issue Information

Dear Colleagues,

Heterocyclic structures exist in most bioactive organic compounds. The development of efficient and environmentally friendly new methods for heterocyclic compound synthesis is the basis of heterocyclic compound synthesis, and the modification of many structurally diverse heterocyclic compounds is an important source for searching for compounds with biological functions. Meanwhile, heterocyclic compounds with biological functions provide molecular tools for chemical biology research and provide guarantee for the development of new drugs. Therefore, this Special Issue aims to focus on the latest research and progress, focusing on the design, preparation and modification of heterocyclic compounds. This Special Issue will receive cutting-edge original research papers as well as the latest review articles on emerging topics in the field, with a focus on the deeper understanding of the role of organic chemistry and chemical biology in the preparation of heterocyclic compounds.

Dr. Xinwei He
Prof. Dr. Yongjia Shang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heterocyclic compounds
  • synthesis
  • modification
  • asymmetric catalysis
  • cyclization
  • natural products

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Published Papers (2 papers)

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Research

14 pages, 651 KiB  
Article
Synthesis of 1,4-Benzodiazepines via Intramolecular C–N Bond Coupling and Ring Opening of Azetidines
by Xin-Ming Xu, Sen Chen, Shao-Lei Duan, Xiang-Min Wang, Qian Liu and Kai Sun
Molecules 2025, 30(9), 2014; https://doi.org/10.3390/molecules30092014 (registering DOI) - 30 Apr 2025
Abstract
A facile and efficient synthesis of functionalized 1,4-benzodiazepine derivatives under mild conditions was developed. The CuI/N,N-dimethylglycine-catalyzed intramolecular cross-coupling reaction of 1-(2-bromobenzyl)azetidine-2-carboxamides proceeded smoothly under mild conditions to provide 1,4,9,10a-tetrahydroazeto[1,2-a]benzo[e][1,4]diazepin-10(2H)-ones. The resulting azetidine-fused 1,4-benzodiazepine compounds underwent [...] Read more.
A facile and efficient synthesis of functionalized 1,4-benzodiazepine derivatives under mild conditions was developed. The CuI/N,N-dimethylglycine-catalyzed intramolecular cross-coupling reaction of 1-(2-bromobenzyl)azetidine-2-carboxamides proceeded smoothly under mild conditions to provide 1,4,9,10a-tetrahydroazeto[1,2-a]benzo[e][1,4]diazepin-10(2H)-ones. The resulting azetidine-fused 1,4-benzodiazepine compounds underwent consecutive N-methylation with methyl triflate and the opening of the four-membered heterocyclic ring by NaN3, KCN and PhSNa to produce diverse 1,4-benzodiazepine derivatives in good to excellent yields. Upon treatment with methyl chloroformate, on the other hand, the 1,4,9,10a-tetrahydroazeto[1,2-a]benzo[e][1,4]diazepin-10(2H)-ones were straightforwardly converted into 2-chloroethyl-substituted 1,4-benzodiazepine derivatives. Full article
(This article belongs to the Special Issue Synthesis, Modification and Application of Heterocyclic Compounds)
14 pages, 3556 KiB  
Article
Microwave-Assisted Enantioselective Synthesis of (2R,5S)-Theaspirane: A Green Chemistry Approach
by Sayuri Cristina Santos Takada, Maria Carolina Blassioli-Moraes, Miguel Borges, Raul Alberto Laumann, Izabella Vitória Maravalho and Wender Alves Silva
Molecules 2025, 30(7), 1519; https://doi.org/10.3390/molecules30071519 - 29 Mar 2025
Viewed by 266
Abstract
The banana weevil (Cosmopolites sordidus) is a significant pest that reduces banana yields and can result in plant mortality. (2R,5S)-theaspirane, a kairomone from senesced banana leaves, is one of the natural banana volatiles, aiding weevil attraction. A [...] Read more.
The banana weevil (Cosmopolites sordidus) is a significant pest that reduces banana yields and can result in plant mortality. (2R,5S)-theaspirane, a kairomone from senesced banana leaves, is one of the natural banana volatiles, aiding weevil attraction. A rapid and cost-effective synthesis of (2R,5S)-theaspirane was developed utilizing microwave-assisted conditions and the principles of green chemistry. The process comprised five steps, beginning with the reduction of dihydro-β-ionone, followed by lipase-mediated kinetic resolution to attain high enantiomeric excess. Microwave-assisted heating significantly reduced reaction times. Optimized cyclization with the minimum quantities of selenium dioxide oxidation was employed. The final diastereomers were separated by chromatography, yielding compounds which exceeded 99% enantiomeric purity. Full article
(This article belongs to the Special Issue Synthesis, Modification and Application of Heterocyclic Compounds)
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