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Cross-Coupling and Related Reactions: Past and New Reactions for the Future

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 777

Special Issue Editors


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Guest Editor
Department of Chemistry, Faculty of Natural Sciences, Matej Bel University, Tajovského 40, Banska Bystrica, Slovakia
Interests: green chemistry; catalysis; supramolecular catalysis; wood-derived materials as reagents/reactants; reaction medias for organic synthesis; heterocyclic chemistry; element-organic chemistry; fluorine chemistry; phosphorus chemistry; metal-organic chemistry; transition metal chemistry; functionalization of C-H and C-F bounds; domino reactions; chromone chemistry; design of fine-tunable phosphine ligands for homogenous and organo-catalysis; molecular design; drug design; medicine chemistry; fluorine-containing bioactive molecules
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Chemistry, Faculty of Natural Sciences, Matej Bel University, Tajovského 40, Banska Bystrica, Slovakia
Interests: C-C and C-Het couplings; phosphorus chemistry; catalysis; heterocycles; fluorine; mechanochemistry; green chemistry; sustainability

Special Issue Information

Dear Colleagues,

The C-C bond is a ubiquitous structural fragment that is present in every organic molecule. Thus, the easy and straightforward construction of a C-C bond can be considered as one of the most important goals in contemporary organic chemistry. This Special Issue of Molecules is dedicated to summarizing the recent achievements in modern methodologies that enable C-C bond formation scenarios following a cross-coupling situation. The different reaction modes are considered, including transition metal-supported couplings, photoredox reactions, and unconventional reaction modes. Special attention will be paid to original contributions and feature articles describing new or improved cross-coupling protocols.

Dr. Viktor Iaroshenko
Dr. Satenik Mkrtchyan
Guest Editors

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Keywords

  • C-C- cross coupling reactions
  • C-C bond formation by transition metal catalysis
  • C-C bond formation by organocatalysis
  • C-C bond formation by photoredox catalysis
  • C-C bond formation by enzymatic catalysis
  • sustainability
  • green chemistry
  • new trends in C-C bond formation

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Published Papers (1 paper)

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Research

14 pages, 1851 KiB  
Article
Mechanochemical Sequential Deoxygenative Cross-Coupling Reactions of Phenols Under Ruthenium-Nickel Catalysis
by Satenik Mkrtchyan, Vishal B. Purohit, Michał Jakubczyk, Vaibhav D. Prajapati, Ronak V. Prajapati, Michael G. Garcia, Eugene Karpun, Vitaliy Yepishev, Manoj K. Saini, Sehrish Sarfaraz, Khurshid Ayub, Gabriela Addová, Juraj Filo and Viktor O. Iaroshenko
Molecules 2025, 30(8), 1835; https://doi.org/10.3390/molecules30081835 - 19 Apr 2025
Viewed by 651
Abstract
Herein, we report the first mechanochemical strategy for the Ru-catalyzed deoxygenative borylation of free phenols via C–O bond cleavage. This Ru-catalyzed phenolic borylation approach has been successfully extended to the Suzuki–Miyaura-type cross-coupling of phenols with aryl bromides. The protocol accepts a wide scope [...] Read more.
Herein, we report the first mechanochemical strategy for the Ru-catalyzed deoxygenative borylation of free phenols via C–O bond cleavage. This Ru-catalyzed phenolic borylation approach has been successfully extended to the Suzuki–Miyaura-type cross-coupling of phenols with aryl bromides. The protocol accepts a wide scope of phenolic substrates, allowing the synthesis of aryl pinacolboranes and biphenyl structures in excellent yields and serving as a better alternative to classical cross-coupling reactions in the context of pot, atom, and step economy synthesis. Full article
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