Towards the Sustainable Synthesis of Biologically Active Molecules in Green Solvents
Over the past decades, sustainability has become an imperative issue. In the field of organic synthesis, both academic and industrial scientists are making efforts to develop more environmentally friendly chemical processes. In the manufacturing, chemical, and pharmaceutical industries, the solvents employed in synthetic methodologies represent 75–80% of the total waste generated. Indeed, the demand for sustainable alternatives that can replace hazardous solvents has become a subject of intense research today. It could be possible to reduce the environmental impact of chemical transformation through the choice of a suitable solvent, such as through the employment of green solvents derived from renewable sources. This Special Issue plans to give an overview of the most recent advances in the field of the sustainable synthesis of biologically active molecules. The issue aims to provide selected contributions on advances in the preparation of bioactive compounds in green solvents, such as deep eutectic solvents (DES), alcohols and polyols, supercritical CO2, etc. Potential topics include, but are not limited to: Synthetic methodologies with a low environmental impact; The green synthesis of heterocycles; The more eco-friendly synthesis of compounds with possible applications in the biological pharmacological field; The synthesis of organic compounds in deep eutectic solvents; The synthesis of organic compounds in green alcohols; Synthetic strategies in supercritical CO2.
Dr. Antonio Salomone
Dr. Serena Perrone
- green synthesis
- deep eutectic solvents
- biorenewable solvents
- pharmacologically active compounds
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