Topic Editors

Dipartimento di Chimica, Università degli Studi di Bari “Aldo Moro”, Consorzio C.I.N.M.P.I.S., Via E. Orabona 4, I-70125 Bari, Italy
Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Prov.le Lecce-Monteroni, I-73100 Lecce, Italy

Towards the Sustainable Synthesis of Biologically Active Molecules in Green Solvents

Abstract submission deadline
31 October 2024
Manuscript submission deadline
31 December 2024
Viewed by
2718

Topic Information

Dear Colleagues,

Over the past decades, sustainability has become an imperative issue. In the field of organic synthesis, both academic and industrial scientists are making efforts to develop more environmentally friendly chemical processes. In the manufacturing, chemical, and pharmaceutical industries, the solvents employed in synthetic methodologies represent 75–80% of the total waste generated. Indeed, the demand for sustainable alternatives that can replace hazardous solvents has become a subject of intense research today. It could be possible to reduce the environmental impact of chemical transformation through the choice of a suitable solvent, such as through the employment of green solvents derived from renewable sources. This Special Issue plans to give an overview of the most recent advances in the field of the sustainable synthesis of biologically active molecules. The issue aims to provide selected contributions on advances in the preparation of bioactive compounds in green solvents, such as deep eutectic solvents (DES), alcohols and polyols, supercritical CO2, etc. Potential topics include, but are not limited to: Synthetic methodologies with a low environmental impact; The green synthesis of heterocycles; The more eco-friendly synthesis of compounds with possible applications in the biological pharmacological field; The synthesis of organic compounds in deep eutectic solvents; The synthesis of organic compounds in green alcohols; Synthetic strategies in supercritical CO2.

Dr. Antonio Salomone
Dr. Serena Perrone
Topic Editors

Keywords

  • green synthesis
  • deep eutectic solvents
  • biorenewable solvents
  • pharmacologically active compounds

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Catalysts
catalysts
3.9 6.3 2011 14.3 Days CHF 2700 Submit
Chemistry
chemistry
2.1 2.5 2019 19.1 Days CHF 1800 Submit
Molbank
molbank
0.6 0.7 1997 15.5 Days CHF 500 Submit
Molecules
molecules
4.6 6.7 1996 14.6 Days CHF 2700 Submit
Sustainable Chemistry
suschem
- - 2020 29.1 Days CHF 1000 Submit

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Published Papers (3 papers)

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7 pages, 1222 KiB  
Short Note
(3-(4-Chlorophenyl)-4,5-dihydroisoxazol-5-yl)methyl Benzenesulfonate
Molbank 2023, 2023(4), M1732; https://doi.org/10.3390/M1732 - 22 Sep 2023
Viewed by 843
Abstract
A novel single crystal of (3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)methyl benzenesulfonate has been synthetized via a one-pot sequential strategy under sonication. The single crystal has been investigated using X-ray diffraction analysis. Hydrogen bonding between C–H···O and C–H···N produces a layer structure in the crystal. According to a [...] Read more.
A novel single crystal of (3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)methyl benzenesulfonate has been synthetized via a one-pot sequential strategy under sonication. The single crystal has been investigated using X-ray diffraction analysis. Hydrogen bonding between C–H···O and C–H···N produces a layer structure in the crystal. According to a Hirshfeld surface analysis, interactions H···H (28.9%), H···O/O···H (26.7%) and H···C/C···H (15.8%) make the largest contributions to crystal packing. The optimized structure and the solid-state structure that was obtained through experiments are compared using density functional theory at the B3LYP/6-311 G + (d,p) level. The computed energy difference between the lowest unoccupied molecular orbital (LUMO) and highest occupied molecular orbital (HOMO) is 4.6548 eV. Full article
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11 pages, 3616 KiB  
Short Note
2-(N-allylsulfamoyl)-N-propylbenzamide
Molbank 2023, 2023(3), M1678; https://doi.org/10.3390/M1678 - 30 Jun 2023
Cited by 1 | Viewed by 694
Abstract
In this work, a new compound, 2-(N-allylsulfamoyl)-N-propylbenzamide, has been synthesized via a tandem one-pot reaction under sonication. The rotational orientations of the allylsulfamoyl and the amide groups in the title molecule, C13H18N2O3 [...] Read more.
In this work, a new compound, 2-(N-allylsulfamoyl)-N-propylbenzamide, has been synthesized via a tandem one-pot reaction under sonication. The rotational orientations of the allylsulfamoyl and the amide groups in the title molecule, C13H18N2O3S, are partly determined by an intramolecular N—H···O hydrogen bond. In the crystal, a layer structure is generated by N—H···O and C—H···O hydrogen bonds plus C—H···π (ring) interactions. A Hirshfeld surface analysis indicates that the most important contributions to crystal packing are from H···H (59.2%), H···O/O···H (23.5%), and H···C/C···H (14.6%) interactions. The optimized structure calculated using density functional theory at the B3LYP/6–311 G (d,p) level is compared with the experimentally determined structure in the solid state. The calculated highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy gap is 5.3828 eV. Full article
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Figure 1

3 pages, 364 KiB  
Short Note
4,7-Dimethoxy-6-propyl-2H-1,3-benzodioxole-5-carbaldehyde
Molbank 2023, 2023(3), M1676; https://doi.org/10.3390/M1676 - 27 Jun 2023
Viewed by 774
Abstract
A simple intermediate for the synthesis of methoxy-analogues of coenzymes Q with substituents having various chain lengths based on natural polyalkoxyallylbenzene apiol has been developed. Full article
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Scheme 1

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