Testicular and Penile Disorders: Reproductive, Pathophysiological, Diagnostic and Therapeutic Insights

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 465

Special Issue Editors


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Guest Editor
1. Microsurgical Potency Reconstruction and Research Center, Puli Christian Hospital, Puli 54546, Taiwan
2. Division of Cardiovascular Medicine, Microsurgery Potency Reconstruction and Research Center, Yuan Rung Hospital, Yuanlin, Changhua 51052, Taiwan
Interests: anatomy and physiology of the human penis; erection-related physiology; penile disorders; penile tunica albuginea; penile fibro-vascular assembly; varied male potency reconstruction and restoration strategies
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Interests: urology; kidney; prostate cancer; testicular disorders; penile disorders

Special Issue Information

Dear Colleagues,

In the human body, the penis and testicles are directly responsible for erectile function and male fertility; when healthy, playing an indispensable role in reproduction from generation to generation. Otherwise, infertility and impotence may ensue. Disentangling infertility and impotence is a more complex process than that of a single disease entity. As modern medicine has advanced, so have the diagnosis and treatment of male factor infertility and impotence. The microarchitecture of the testicle is straightforward; however, the de novo penile fibro-vascular assembly (DNPFA) has remained under-exploded until the past decade.

Consequently, infertility related to penile disorders might require groundbreaking exploration, which is why we sought to launch a Special Issue on “Testicular and Penile Disorders: Reproductive, Pathophysiological, Diagnostic and Therapeutic Insights”. Our aim is to establish a platform to gather together colleagues from multiple disciplinary backgrounds. This Special Issue will cover topics related to, but not limited to, the following:

  1. The anatomy and physiology of human testicles;
  2. Infertility caused by disorders of the testicle;
  3. The medical treatment of infertility caused by testicular disorders;
  4. The surgical treatment of infertility of testicular origin;
  5. Endovascular intervention for infertility;
  6. The diagnosis of penile disorders causing infertility;
  7. The medical treatment of penile disorders causing infertility;
  8. The surgical treatment of penile disorders causing infertility.

Dr. Geng-Long Hsu
Dr. Yu-Ching Wen
Guest Editors

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Keywords

  • testicular and Penile Disorders
  • testicle
  • physiology
  • infertility

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Published Papers (1 paper)

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Research

13 pages, 5262 KiB  
Article
The Relationship Between Tramadol-Induced Oxidative Testis Injury and Reproductive Function Disorder and Adenosine Triphosphate
by Fevzi Bedir, Hüseyin Kocatürk, Mehmet Sefa Altay, Renad Mammadov, Bahadır Süleyman, Taha Abdulkadir Coban, Gülce Naz Yazici, Seval Bulut and Halis Süleyman
Life 2025, 15(7), 1078; https://doi.org/10.3390/life15071078 - 6 Jul 2025
Viewed by 237
Abstract
Tramadol, a central analgesic drug, is used to treat moderate to severe pain but can cause reproductive disorders. The pathogenesis of tramadol-induced reproductive damage may involve increased oxidative stress, pro-inflammatory cytokines, ATP depletion, and reduced antioxidant levels. In this study, subjects were divided [...] Read more.
Tramadol, a central analgesic drug, is used to treat moderate to severe pain but can cause reproductive disorders. The pathogenesis of tramadol-induced reproductive damage may involve increased oxidative stress, pro-inflammatory cytokines, ATP depletion, and reduced antioxidant levels. In this study, subjects were divided into four groups: healthy control (HC), tramadol only (TM), ATP only (ATP), and ATP + tramadol (ATM). ATP was administered intraperitoneally at 4 mg/kg, and tramadol was administered orally at 50 mg/kg. Distilled water was given to the HC group. This regimen was repeated for three weeks. At the end of the treatment, testicular tissues from six rats in each group were analyzed biochemically and histopathologically after euthanasia. The remaining rats’ reproductive functions were evaluated. Long-term tramadol exposure resulted in oxidative stress, inflammation in testicular tissue, and reduced male reproductive capacity. Thinning of seminiferous tubule walls and thickening of basement membrane, irregularity in germ cells, increase in interstitial connective tissue, congestion in vessels, increase in Leyding cells and hyperplasia were found in the TM group. ATP treatment significantly reduced tramadol-induced increases in oxidants and pro-inflammatory cytokines, reversed the decline in antioxidants, and mitigated infertility in testicular tissue. Furthermore, ATP preserved the morphology of the testicular tissue. These findings suggest that ATP may offer therapeutic potential for tramadol-induced infertility. Full article
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