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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Livestock Breeding, Nutrition and Metabolism

edited by

Imran Khan

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2476 | Submission Open

Keywords: genetic selection; livestock breeding; genome editing; animal nutrition; precision feeding; nutritional additives; feed conversion; metabolism; animal health; sustainability

(This special issue belongs to the Section Animal Science)

Pathological and Clinical Updates on Eye Diseases

edited by Pier Luigi Surico and

Rohan Bir Singh

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2469 | Submission Open

Keywords: ophthalmology; eye diseases; gene therapy; ocular surface; ocular immunology; cornea

(This special issue belongs to the Section Medical Research)

Move to Thrive: Pioneering Health and Resilience Through Physical Activity

edited by

Silvana Mirella Aliberti

Franca Di Meglio

and

Daria Nurzynska

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2466 | Submission Open

Keywords: physical activity; inflammation modulation; chronic disease prevention; immune system adaptation; biomechanics; rehabilitation strategies; sports medicine; aging and physical activity; disability and movement; environmental and regional influences on exercise

(This special issue belongs to the Section Physiology and Pathology)

Helicobacter pylori: 2nd Edition

edited by

Ovidiu Pop

and

Simona Gurzu

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2299 | Submission Open

Keywords: H. pylori; cancers; antioxidative process; diagnostic methods

(This special issue belongs to the Section Microbiology)

Role of Machine and Deep Learning in Drug Screening

edited by

Shahid Ali

and

Teng Zhou

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1708 | Submission Open

Keywords: machine learning in drug screening; deep learning in drug discovery; virtual screening; molecular docking and dynamics; personalized medicine

(This special issue belongs to the Section Pharmaceutical Science)

Advances in the Glyoxalase Pathway: Implications for Oxidative Stress Management in Cancer Therapy and in Age-Related Disease

edited by

Laura Cianfruglia

and

Salvatore Vaiasicca

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1627 | Submission Open

Keywords: glyoxalase system; methylglyoxal; advanced glycation end-products; dicarbonyl stress; oxidative stress; age-related disease; cancer

(This special issue belongs to the Section Physiology and Pathology)

Research on Gastrointestinal Cancer and Nutritional Health

edited by

Irene Lidoriki

, Adam Mylonakis and Dimitrios Tsapralis

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1518 | Submission Open

Keywords: dietary patterns; gastrointestinal cancer; clinical nutrition; nutritional status; nutritional assessment; metabolism; gastric cancer; esophageal cancer; pancreatic cancer; colorectal cancer

(This special issue belongs to the Section Medical Research)

Channel Proteins and Transporters in Human Health and Disease

edited by

Giorgia Scarpellino

Giorgia Chinigò

and

Roberta De Zio

submission deadline 30 Jun 2026 | Viewed by 1085 | Submission Open

Keywords: channel proteins; transporters; ion channel

(This special issue belongs to the Section Proteins and Proteomics)

Neuroimaging and Integrative Analyses in Psychiatry and Addictive Disorders

edited by Arkadiusz Komorowski

submission deadline 30 Jun 2026 | 1 articles | Viewed by 984 | Submission Open

Keywords: psychiatry; neuroimaging; forensic psychiatry; fMRI; PET; EEG; addiction; substance use disorders (SUD); psychotherapy; treatment-resistant depression (TRD); attention deficit hyperactivity disorder (ADHD)

(This special issue belongs to the Section Physiology and Pathology)

Applications of Dermatoscopy in Skin Diseases: 2nd Edition

edited by

Paweł Pietkiewicz

Enzo Errichetti

and

Cristian Navarrete

submission deadline 30 Jun 2026 | 1 articles | Viewed by 707 | Submission Open

Keywords: melanoma; skin cancer; inflammoscopy; trichoscopy; ultraviolet reflectance dermatoscopy; skin of color; basal cell carcinoma; squamous cell carcinoma; nevus; digital dermoscopy

(This special issue belongs to the Section Medical Research)

Cutting-Edge Research in Rhinology and Allergy: Unraveling Disease Mechanisms and Treatment Innovations

edited by Min-Seok Rha

submission deadline 30 Jun 2026 | 1 articles | Viewed by 700 | Submission Open

Keywords: rhinology; allergy; chronic rhinosinusitis; allergic rhinitis; asthma; precision medicine; clinical immunology; immunopathology; therapeutic innovation

Perspectives on Nutrition and Livestock Health

edited by Liuting Wu, Yan Wang and

Felix Kwame Amevor

submission deadline 30 Jun 2026 | 1 articles | Viewed by 647 | Submission Open

Keywords: nutrition; animal health; animal reproductive; animal welfare; gut microbiome

(This special issue belongs to the Section Animal Science)

Vector-Borne Diseases and One Health

edited by

Jeronimo Alencar

, Shayenne Silva and

Michail Kotsyfakis

submission deadline 30 Jun 2026 | 1 articles | Viewed by 644 | Submission Open

Keywords: vector-borne diseases; One Health; malaria; dengue; Zika; chikungunya; yellow fever; West Nile virus; Lyme disease; leishmaniasis; Chagas

(This special issue belongs to the Section Animal Science)

Cranial Base Tumors: Pathogenesis, Diagnosis, and Treatments

edited by

Andrew J. Fishman

and Marcin Szymański

submission deadline 30 Jun 2026 | 1 articles | Viewed by 590 | Submission Open

Keywords: skull base tumors; neuro-oncology; endoscopic surgery; cranial nerve preservation; AI-assisted diagnostics; multidisciplinary management

(This special issue belongs to the Section Medical Research)

Impact of Environmental Factors on the Diversity and Structure of Bacterial and Eukaryotic Communities

edited by

Jun Noda

and

Daisuke Tanaka

submission deadline 30 Jun 2026 | 1 articles | Viewed by 474 | Submission Open

Keywords: environmental factors; bacterial and eukaryotic communities; climate adaptation; pollution; microbial resilience; metagenomic analysis; amplicon sequencing; bioinformatics

(This special issue belongs to the Section Microbiology)

New Advances in the Treatment and Assessment of Temporomandibular Joint Disorders

edited by

Łukasz Rafał Pałka

submission deadline 30 Jun 2026 | Viewed by 349 | Submission Open

Keywords: orofacial dysfunction; multifactorial etiology; advanced diagnostic technologies; biomechanical modeling of TMJ; novel imaging techniques; inflammatory and degenerative changes; interdisciplinary management; conservative therapy approaches; occlusal concepts; splint therapy design; physical therapy regimens; long-term implant treatment outcomes; personalized treatment strategies

(This special issue belongs to the Section Medical Research)

Autoimmune Disorders: From Pathophysiology to Therapeutics

edited by

Giulia Lanzolla

and Chiara Mura

submission deadline 30 Jun 2026 | Viewed by 311 | Submission Open

Keywords: autoimmunity; autoimmune diseases; polyglandular autoimmune syndromes; thyroid autoimmune disease; type 1 diabetes

(This special issue belongs to the Section Physiology and Pathology)

Physical Rehabilitation for Musculoskeletal Disorders: 2nd Edition

edited by

You Gyoung Yi

submission deadline 30 Jun 2026 | 1 articles | Viewed by 295 | Submission Open

Keywords: physical rehabilitation; musculoskeletal disorders; pain management; range of motion; muscle strengthening; mobility enhancement; physical therapy; manual therapy; AI in rehabilitation

(This special issue belongs to the Section Medical Research)

Update on Obstructive Sleep Apnea (OSA)

edited by

Konstantinos Chaidas

submission deadline 30 Jun 2026 | Viewed by 230 | Submission Open

Keywords: obstructive sleep apnea; snoring; sleep-disordered breathing; adult sleep apnea; pediatric sleep apnea

(This special issue belongs to the Section Physiology and Pathology)

Post-Concussion Syndrome and Functional Neurological Disorder

edited by

Ioannis Asterios Mavroudis

submission deadline 30 Jun 2026 | Viewed by 218 | Submission Open

Keywords: post-concussion syndrome; functional neurological disorder; mild traumatic brain injury; cognitive dysfunction ; neuroimaging; biomarkers; neurorehabilitation

(This special issue belongs to the Section Medical Research)

Placental Spectrum Disorders and Gynecological Oncology

edited by Gianluca Raffaello Damiani

submission deadline 30 Jun 2026 | Viewed by 171 | Submission Open

Keywords: placenta; trophoblastic tumor; mola; tumors; bleeding

(This special issue belongs to the Section Medical Research)

Advances in Bioorganic and Medicinal Chemistry

edited by Sahar Kandil

submission deadline 30 Jun 2026 | Viewed by 157 | Submission Open

Keywords: medicinal chemistry; drug discovery; biological chemistry; therapeutic targets; therapeutic agents; treatment of diseases; new therapeutic strategies

Transplant Medicine: Updates and Current Challenges

edited by Phillipe Abreu

submission deadline 30 Jun 2026 | Viewed by 139 | Submission Open

Keywords: robotic transplantation; organ transplants; transplant oncology

(This special issue belongs to the Section Medical Research)

“Out-of-the-Organics-Box” Reflections On and Scenarios for Life’s Emergence

edited by

Wolfgang Nitschke

submission deadline 30 Jun 2026 | Viewed by 130 | Submission Open

Keywords: emergence of life; thermodynamics; bioenergetics; information theory; early metabolism; metal ions in biochemistry

(This special issue belongs to the Section Origin of Life)

Sleep-Disordered Breathing: Key Pathophysiological Mechanisms and Their Clinical Implications

edited by

Jinkwan Kim

submission deadline 30 Jun 2026 | Viewed by 124 | Submission Open

Keywords: sleep-disordered breathing; sleep fragmentation; inflammation; cardiovascular disease; insulin resistance

(This special issue belongs to the Section Physiology and Pathology)

Advances and Challenges in Urothelial and Prostate Cancer: Toward Precision Urologic Oncology

edited by Sashi S. Kommu

submission deadline 30 Jun 2026 | Viewed by 110 | Submission Open

Keywords: urothelial carcinoma; prostate cancer; immunotherapy; genomics and biomarkers; precision imaging (PSMA PET; mpMRI); targeted therapies (PARP; FGFR; DDR); focal therapy and theranostics; tumour microenvironment; quality of life and survivorship; health disparities in cancer care; artificial intelligence

(This special issue belongs to the Section Medical Research)

Neural Mechanisms of Brain–Computer Interfaces

edited by

Miguel Pais-Vieira

submission deadline 30 Jun 2026 | Viewed by 89 | Submission Open

Keywords: brain– machine interfaces; neurophysiology; somatosensory cortex; motor cortex

(This special issue belongs to the Section Physiology and Pathology)

Mechanisms and Modulation of Pain: From Ion Channels to Translational Therapeutics

edited by Álvaro Yogi

submission deadline 30 Jun 2026 | Viewed by 82 | Submission Open

Keywords: pain; mechanisms; signaling pathways; ion channels; therapeutic targets; neuropathic pain; inflammatory pain; pre-clinical models

(This special issue belongs to the Section Pharmaceutical Science)

Drug Safety and Outcomes in Respiratory and Critical Care Medicine

edited by

Josef Yayan

submission deadline 30 Jun 2026 | Viewed by 82 | Submission Open

Keywords: drug safety; adverse drug reactions; pharmacovigilance; critical care medicine; respiratory diseases; clinical outcomes; intensive care pharmacotherapy; drug– drug interactions

(This special issue belongs to the Section Pharmaceutical Science)

Neurodegeneration Across Mechanisms, Epidemiology, and Emerging Therapies: Inflammation, Metabolism, Aging, and Neuromodulation

edited by Julian Benito Leon

submission deadline 30 Jun 2026 | Viewed by 80 | Submission Open

Keywords: neurodegeneration; neuroinflammation; metabolic dysfunction; aging and inflammaging; epidemiology; biomarkers; neuromodulation; transcranial magnetic stimulation (TMS)

(This special issue belongs to the Section Medical Research)

Extracellular Vesicles: Biology, Mechanisms, and Therapies for Cerebrovascular Disorders

edited by Jinju Wang

submission deadline 30 Jun 2026 | Viewed by 64 | Submission Open

Keywords: extracellular vesicles; cerebrovascular disorders; dementia; extracellular vesicle-based therapy

(This special issue belongs to the Section Physiology and Pathology)

Comprehensive Treatment and Precision Medicine Strategies for Heart Disease

edited by Serge Sicouri

submission deadline 30 Jun 2026 | Viewed by 61 | Submission Open

Keywords: precision medicine; artificial intelligence; risk stratification; machine learning; translational research; cardiovascular outcomes

(This special issue belongs to the Section Medical Research)

Rewiring Bacterial Communication: Extracellular Vesicles and Microbial Signals Across Host Interfaces

edited by Sara Carloni

submission deadline 30 Jun 2026 | Viewed by 47 | Submission Open

Keywords: bacterial extracellular vesicles (bEVs); host– microbe communication; microbiota dynamics; immune modulation; translational applications

(This special issue belongs to the Section Microbiology)

Cancer Genomics and Transcriptomics: Uncovering New Frontiers in Tumor Biology

edited by

Panagiotis Adamopoulos

and Panagiotis Tsiakanikas

submission deadline 14 Jul 2026 | Viewed by 375 | Submission Open

Keywords: transcriptomic profiling; tumor heterogeneity; integrative omics; non-coding RNAs; oncogenes

(This special issue belongs to the Section Genetics and Genomics)

Antimicrobial Innovations

edited by

Pere Puigbò

and Miho Nakamura

submission deadline 15 Jul 2026 | 1 articles | Viewed by 4271 | Submission Open

Keywords: antimicrobial resistance; biopreservation; lactic acid bacteria; bacteriocins; bacteriophages; natural antimicrobials; antimicrobial peptides; foodborne pathogens; antimicrobial biomaterials; race for the surface; microbial growth models; food safety

(This special issue belongs to the Section Microbiology)

New Insights into Diagnosis and Therapeutic Strategies for Chronic Liver Diseases

edited by

Cristina Marginean

submission deadline 20 Jul 2026 | 5 articles | Viewed by 10241 | Submission Open

Keywords: chronic liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); drug-induced liver injury (DILI); hepatocellular carcinoma; biomarkers of liver fibrosis; imaging of liver fibrosis; CEUS; novel therapeutic strategies for CLDs

(This special issue belongs to the Section Medical Research)

Herbal Extracts in Skin Health and Disease

edited by

Josipa Bukić

submission deadline 20 Jul 2026 | Viewed by 134 | Submission Open

Keywords: herbal extracts; natural products; skin disorders; skin care

(This special issue belongs to the Section Pharmaceutical Science)

Emerging Knowledge on Human Immunodeficiency Virus

edited by

Giota Lourida

and

Dimitrios Paraskevis

submission deadline 22 Jul 2026 | 3 articles | Viewed by 24812 | Submission Open

Keywords: HIV; antiretroviral treatment; long-acting ART; pre-exposure prophylaxis; HIV surveillance; antiretroviral resistance; primary resistance; HIV epidemiology; special populations; cascade of care; HIV diagnosis

(This special issue belongs to the Section Medical Research)

Genetics, Breeding, and Reproduction of Cattle

edited by

Hailiang Zhang

and

Shanjiang Zhao

submission deadline 24 Jul 2026 | Viewed by 255 | Submission Open

Keywords: cattle; genetic selection; reproductive physiology and technology

(This special issue belongs to the Section Animal Science)

Contemporary Therapeutic Strategies for Solid Tumors

edited by Chohao Lee

submission deadline 26 Jul 2026 | 1 articles | Viewed by 429 | Submission Open

Keywords: therapeutic strategies; survival analysis; solid tumors; cancer treatment; targeted therapy; immunotherapy; precision medicine; clinical outcomes; prognostic factors

(This special issue belongs to the Section Medical Research)

Promising Therapeutic Horizons for Regenerative Medicine in Animals

edited by

Hussein M. El-Husseiny

and

Sharun Khan

submission deadline 28 Jul 2026 | Viewed by 287 | Submission Open

Keywords: stem cells; induced pluripotent stem cells (iPSCs); soft tissue engineering; in vivo and in vitro investigations; extracellular vesicles; preclinical studies; clinical studies; platelet-rich plasma; platelet-rich fibrin; cell-based therapy; cell-free therapy; orthopedics; cardiology

(This special issue belongs to the Section Animal Science)

New Insights into Parkinson’s Disease: From Molecular Basis to Therapy—2nd Edition

edited by

Kallirhoe Kalinderi

submission deadline 28 Jul 2026 | Viewed by 53 | Submission Open

(This special issue belongs to the Section Medical Research)

Migraine and Headache: From Pathophysiological Aspects

edited by

Jacob Genizi

submission deadline 30 Jul 2026 | 3 articles | Viewed by 4338 | Submission Open

Keywords: migraine; headache; pathophysiology; treatment; medication

(This special issue belongs to the Section Physiology and Pathology)

Prostate Cancer: 4th Edition

edited by

Paula Oliveira

and

Ana Faustino

submission deadline 30 Jul 2026 | 2 articles | Viewed by 4197 | Submission Open

Keywords: incidence; mortality; diagnosis; histopathology; imaging; treatment; prognosis; case report; animals; humans; modeling

(This special issue belongs to the Section Medical Research)

Advances in Fetal Medicine: From Prenatal Diagnosis to Fetal and Neonatal Therapy

edited by Przemysław Kosinski

submission deadline 30 Jul 2026 | 2 articles | Viewed by 2050 | Submission Open

Keywords: fetal medicine; prenatal diagnosis; non-invasive prenatal testing (NIPT); fetal imaging; fetal therapy; fetal surgery; neonatal intensive care; genetic and genomic advances; perinatal outcomes; maternal-fetal health

(This special issue belongs to the Section Reproductive and Developmental Biology)

Therapeutic Effects of Natural Products on Human Diseases—3rd Edition

edited by

Seung Ho Lee

submission deadline 30 Jul 2026 | 1 articles | Viewed by 837 | Submission Open

Keywords: natural products; natural extracts; cancer; neurodegenerative diseases; immunological disorders; metabolic diseases; oriental medicine; microorganisms; algae; functional foods

(This special issue belongs to the Section Pharmaceutical Science)

Treatment and Prognosis of Thoracic Diseases

edited by

Alessandro Gonfiotti

and

Alice Ravasin

submission deadline 30 Jul 2026 | 1 articles | Viewed by 725 | Submission Open

Keywords: thoracic malignancies; lung cancer management ; targeted therapy ; immunotherapy ; molecular diagnostics ; multidisciplinary care ; personalized treatment

(This special issue belongs to the Section Medical Research)

Recent Advances in Bone Biology

edited by Barbara Peruzzi,

Martina Leopizzi

and Giulia Battafarano

submission deadline 30 Jul 2026 | 1 articles | Viewed by 667 | Submission Open

Keywords: bone tissue engineering; bone-targeted therapies; genetic bone diseases; bone mechanotransduction; bone cell pathophysiology; bone metabolism

(This special issue belongs to the Section Physiology and Pathology)

Migraine and Headache: From Clinical and Therapeutic Aspects

edited by

Jacob Genizi

submission deadline 30 Jul 2026 | Viewed by 258 | Submission Open

Keywords: migraine; headache; treatment; medication

(This special issue belongs to the Section Medical Research)

Advances and Applications of Sport Physiology: 2nd Edition

edited by