Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Natural Products in Disease Treatment submission deadline 30 May 2026 | Viewed by 138 | Submission Open
Keywords: natural products; bioactive compounds; functional foods and nutraceuticals; disease prevention and treatment
(This special issue belongs to the Section Plant Science)
Current Approaches and Future Directions in the Treatment of Gynecologic Tumors: Molecular Biology, Diagnostic Advancements and Targeted Therapeutic Strategies—2nd Edition submission deadline 30 May 2026 | Viewed by 118 | Submission Open
Keywords: gynecologic tumors; cervical cancer; ovarian cancer; endometrial cancer; vulvar cancer; vaginal cancer; gestational trophoblastic disease; molecular mechanisms; diagnostic advancements; novel therapies
(This special issue belongs to the Section Medical Research)
New Mechanisms and Insights into Insect Silk Gland Biology and Silk Production
edited by Wenliang Qian
submission deadline 30 May 2026 | Viewed by 111 | Submission Open
Keywords: silk gland morphogenesis; liquid-to-solid phase transition; biomimetic microfluidic spinning; silk gland multi-omics; silk protein evolutionary adaptations; CRISPR
(This special issue belongs to the Section Animal Science)
Advances in Skin-Related Disease: Pathogenesis and Novel Therapeutic Strategies submission deadline 31 May 2026 | 4 articles | Viewed by 14534 | Submission Open
Keywords: skin pathologies; skin cancer; eczema; acne; psoriasis; skin microbiome
(This special issue belongs to the Section Physiology and Pathology)
Prognosis and Management of Dry Eye Disease submission deadline 31 May 2026 | 3 articles | Viewed by 9011 | Submission Open
Keywords: dry eye disease; dry eye epidemiology; dry eye management; dry eye natural course; meibomian gland dysfunction; evaporative dry eye; aqueous deficiency dry eye; artificial tear substitutes; tear film lipid layer; meibomian glands
(This special issue belongs to the Section Medical Research)
New Insights into Pediatric Rheumatic and Autoimmune Diseases
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 3773 | Submission Open
Keywords: arthritis; juvenile; autoimmune diseases; biomarkers; diagnostic imaging; juvenile dermatomyositis; lupus erythematosus; systemic; pediatric rheumatology; vasculitis
(This special issue belongs to the Section Medical Research)
Current and Future Perspectives of Takotsubo Syndrome
edited by Luca Arcari
submission deadline 31 May 2026 | 2 articles | Viewed by 2884 | Submission Open
Keywords: takotsubo syndrome; heart failure; microvascular dysfunction; inflammation; myocardial edema; heart– brain axis; echocardiography; cardiac magnetic resonance; computed tomography; nuclear imaging
(This special issue belongs to the Section Physiology and Pathology)
Recent Advances in Lymphomas
edited by Magdalena Witkowska
submission deadline 31 May 2026 | 2 articles | Viewed by 2409 | Submission Open
Keywords: lymphoma; cellular therapy; epigenetics; immunotherapy; targeted therapies
(This special issue belongs to the Section Medical Research)
Innovative Cardiovascular Interventions: From Imaging to Precision Therapies submission deadline 31 May 2026 | 1 articles | Viewed by 1346 | Submission Open
Keywords: cardiovascular diseases (CVDs); diagnostic imaging; minimally invasive interventions; precision medicine; 3D/4D imaging; gene therapy; cell-based therapies
(This special issue belongs to the Section Physiology and Pathology)
Advances in Wildlife Behavior and Biodiversity submission deadline 31 May 2026 | 1 articles | Viewed by 1219 | Submission Open
Keywords: behavioral abnormalities; the ability to exhibit natural behavior; reduced genetic diversity; habitat loss; extinction of species; species rehousing; coexistence
(This special issue belongs to the Section Diversity and Ecology)
Harmful Algal Bloom Risk: Mechanisms, Prediction, Impacts and Mitigation
edited by Lixia Shang
submission deadline 31 May 2026 | 1 articles | Viewed by 872 | Submission Open
Keywords: harmful algal blooms; marine risk; bloom mechanisms; prediction models; mitigation strategies; ecosystem impact
(This special issue belongs to the Section Diversity and Ecology)
Physiological, Pathological, and Clinical Effects of Exercise Training and Physical Activity
edited by Chia-Huei Lin
submission deadline 31 May 2026 | 1 articles | Viewed by 505 | Submission Open
Keywords: exercise training; physical activity; individualized exercise prescription; physiological adaptation; chronic disease prevention; cardiovascular fitness; musculoskeletal health; neuroplasticity; metabolic syndrome; inflammation and immunity; stroke recovery; physical activity monitoring; mental health and exercise; cognitive function; aging and physical activity; sedentary behavior; physical function outcomes; patient-reported outcomes; clinical trial
(This special issue belongs to the Section Physiology and Pathology)
Hybrid Molecules in Drug Discovery: From Antidiabetic Agents to Anticancer Therapeutics
edited by Jatinder Singh and Shreyosree Chatterjee
submission deadline 31 May 2026 | Viewed by 256 | Submission Open
Keywords: hybrid molecules; drug discovery; antidiabetic; oncology; structure— activity relationships
(This special issue belongs to the Section Pharmaceutical Science)
Biofluid Mechanics and Medical Diagnostic Simulations submission deadline 31 May 2026 | Viewed by 200 | Submission Open
Keywords: biofluid mechanics; computational modeling; medical diagnostics; fluid-structure interaction; patient-specific modeling
(This special issue belongs to the Section Medical Research)
New Screening Methods for Diagnosis of Cardiovascular Diseases
edited by , Ruxandra Maria Ilie-Mihai and Damaris Cristina Gheorghe
submission deadline 31 May 2026 | Viewed by 183 | Submission Open
Keywords: cardiovascular diseases; biomarkers; screening methods; sensor; spectroscopic methods; chromatographic methods
(This special issue belongs to the Section Medical Research)
Artificial Intelligence and Machine Learning for Biomedical Diagnostics and Prognostics submission deadline 31 May 2026 | Viewed by 169 | Submission Open
Keywords: artificial intelligence; machine learning; diagnostic and prognostic modeling; multimodal data integration; explainable AI
(This special issue belongs to the Section Medical Research)
Understanding Early Dysmetabolism in Adolescents: Bridging Research, Mechanisms and Clinical Management
edited by Anna Di Sessa
submission deadline 31 May 2026 | Viewed by 133 | Submission Open
Keywords: dysmetabolism; biomarkers; intervention; prevention; early diagnosis; strategies; children; adolescents
(This special issue belongs to the Section Physiology and Pathology)
Comorbidities of Migraine: Clinical and Research Perspectives
edited by
submission deadline 31 May 2026 | Viewed by 129 | Submission Open
Keywords: migraine; pain; headache; comorbidities; internal medicine; complex disorders
(This special issue belongs to the Section Medical Research)
Objective Tools to Aid the Diagnosis and Treatment of Neurodevelopmental Disorders
edited by
submission deadline 31 May 2026 | Viewed by 128 | Submission Open
Keywords: intervertion training  ; eye tracker  ; dyslexia  ; postural sways  ; reading  ; ASD  ; ADHD  ; attention  ; emotion
(This special issue belongs to the Section Medical Research)
Gut Microbial Dysbiosis in the Pathogenesis of Gastrointestinal Disorders
edited by Giovanni Tomasello
submission deadline 31 May 2026 | Viewed by 82 | Submission Open
Keywords: gut dysbiosis; gastrointestinal; probiotics; inflammatory bowel diseases
(This special issue belongs to the Section Microbiology)
Epidemiological Insights into Cardiovascular Risk and Outcomes
edited by Rui Providência
submission deadline 8 Jun 2026 | Viewed by 99 | Submission Open
Keywords: cohort study; Mendelian randomization; myocardial infarction; heart failure; stroke; atrial fibrillation; risk prediction
(This special issue belongs to the Section Epidemiology)
Agri-Food Waste Extracts: Structural and Functional Characterization
edited by
submission deadline 12 Jun 2026 | 1 articles | Viewed by 831 | Submission Open
Keywords: agri-food waste; extracts; extraction techniques; chemical characterization; bioactivity; cytotoxicity and cytocompatibility; isolation of bioactive molecules
(This special issue belongs to the Section Plant Science)
Ultrasound and Anatomical Studies
edited by , Ingrid Moller and
submission deadline 15 Jun 2026 | Viewed by 155 | Submission Open
Keywords: ultrasound techniques; musculoskeletal system; human anatomy; medicine specialties; clinical students; ultrasound teaching
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Epigenetics, Microbiota, and Food—Shaping Immune Health and Longevity
edited by
submission deadline 18 Jun 2026 | 3 articles | Viewed by 8287 | Submission Open
Keywords: epigenetics; nutrigenomics; aging; microRNA; DNA methylation; diet; nutrients; microbiota; longevity; natural components
(This special issue belongs to the Section Physiology and Pathology)
Advances in Research on Motor Deficits Caused by Neurological Disorders: From Mechanism to Treatment
edited by and Hans Hultborn
submission deadline 18 Jun 2026 | 2 articles | Viewed by 5776 | Submission Open
Keywords: neurological disorders; neurodegenerative diseases; brain injury; spinal cord injury; stroke; cerebral palsy; peripheral nerve injury; paralysis; spasticity; contracture; muscle weakness; postural asymmetry; gate pattern changes; uncontrolled movements
(This special issue belongs to the Section Medical Research)
Lipid Metabolism Pathways: From Life to Disease
edited by
submission deadline 19 Jun 2026 | 1 articles | Viewed by 5913 | Submission Open
Keywords: lipid metabolism; lipid signaling; apoptosis; ferroptosis; autophagy; membrane dynamics; fatty acid oxidation; obesity
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Dive into Myopia
edited by
submission deadline 19 Jun 2026 | 3 articles | Viewed by 5739 | Submission Open
Keywords: myopia; hyperopia; myopia control; axial length; axial length retardation; axial length elongation; myopia complications; refraction measurement; atropine; rebound effect; orthokeratology; missight; defocus incorporated multiple segments (DIMSs); highly aspherical lenslets (HALs); red light; repeated low-level red light (RLRL) therapy; enhance myopia control; customized myopia control; peripheral refraction; peripheral myopia; refractive surgery; PRK; LASIK; smile; contact lens; spectacles
(This special issue belongs to the Section Medical Research)
An Integrated Approach on Diagnosis and Treatment of Cerebral Veins and Intracranial Dural Sinuses Thrombosis (CVT)
edited by and
submission deadline 20 Jun 2026 | Viewed by 189 | Submission Open
Keywords: cerebral veins and intracranial dural sinuses thrombosis (CVT); thrombophilia; intracranial hypertension; non-enhanced computer tomography (NECT) of the head; computer tomography venography (CTV); magnetic resonance imaging (MRI) of the head; magnetic resonance venography (MRV); anticoagulation
(This special issue belongs to the Section Medical Research)
Advances in Knee Biomechanics—2nd Edition
edited by Jason Shearn
submission deadline 22 Jun 2026 | Viewed by 83 | Submission Open
Keywords: knee; tendon; ligament; injury; repair; healing; biomechanics; advanced techniques
(This special issue belongs to the Section Physiology and Pathology)
Reconstruction of Bone Defects submission deadline 23 Jun 2026 | 7 articles | Viewed by 9686 | Submission Open
Keywords: bone and fracture biomechanics; bone healing; critical size bone defects; fracture non-union; inflammation; joint arthroplasty and fracture osteosynthesis; implant designs; materials proprieties; patient selection; primary and revision settings
(This special issue belongs to the Section Medical Research)
Recent Advances in Vascular Biology and Chronic Kidney Disease (CKD)
edited by
submission deadline 26 Jun 2026 | 1 articles | Viewed by 7416 | Submission Open
Keywords: chronic kidney disease; vascular dysfunction; endothelial cells
(This special issue belongs to the Section Medical Research)
Advances in Anesthesia and Critical Care
edited by
submission deadline 26 Jun 2026 | 5 articles | Viewed by 6804 | Submission Open
Keywords: anesthesia; intensive care training; updates in anesthesia; machine learning
(This special issue belongs to the Section Medical Research)
Advances in Dryland Agriculture Science
edited by and Hangyu Dong
submission deadline 26 Jun 2026 | 3 articles | Viewed by 4140 | Submission Open
Keywords: dry farming; climate smart agriculture; soil and water protection; conservation tillage; intercropping; crop rotation; saving irrigation
(This special issue belongs to the Section Plant Science)
Innovations in Thoracic Medicine: Advancements and Challenges—2nd Edition
edited by Paolo Scanagatta
submission deadline 26 Jun 2026 | 1 articles | Viewed by 352 | Submission Open
Keywords: thoracic medicine; lung cancer; artificial intelligence (AI); minimally invasive intervention; thoracic anesthesia; clinical innovation; technological advances
(This special issue belongs to the Section Medical Research)
Feature Papers in Medical Research: 4th Edition
edited by
submission deadline 26 Jun 2026 | Viewed by 334 | Submission Open
Keywords: dermatological research; cancer research; cardiovascular research; general medicine; gastroenterological research; hematological research; immunological research; infectious diseases research; metabolism and endocrinology; nervous system research; nursing; pediatrics; pulmonary research; psychiatric research; rehabilitation; renal and urinary research; reproductive research and women's health; rheumatological research; skeletal and muscular research; vision research
(This special issue belongs to the Section Medical Research)
Application of Mass Spectrometry-Based Multi-Omics in Biomedical Research submission deadline 26 Jun 2026 | Viewed by 89 | Submission Open
Keywords: mass spectrometry; multi-omics; proteomics; metabolomics; lipidomics; mass spectrometry imaging (MSI); biomarker discovery; translational research
(This special issue belongs to the Section Medical Research)
Harnessing Mitochondrial Rewiring for Cancer Therapy: Novel Strategies in the Era of Precision Medicine
edited by and Maria Sideridou
submission deadline 26 Jun 2026 | Viewed by 59 | Submission Open
Keywords: Oxidative stress; Metabolic rewiring; Carcinogenesis; DNA repair; Cancer therapy; Heteroplasmy
(This special issue belongs to the Section Physiology and Pathology)
Advanced Technologies and Clinical Practice of Cancer Radiotherapy
edited by
submission deadline 26 Jun 2026 | Viewed by 50 | Submission Open
Keywords: proton therapy; BNCT; in vivo dose verification in radiotherapy; accelerators for radiation therapy; simulation of radiotherapies
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Leveraging the Power of Enzymes in Biotechnological Applications
edited by
submission deadline 28 Jun 2026 | Viewed by 426 | Submission Open
Keywords: enzyme; 3D structure; function/activity; enzyme engineering; beneficial variants; industrial application
Recent Advances in Physiotherapy for Musculoskeletal submission deadline 30 Jun 2026 | 6 articles | Viewed by 16265 | Submission Open
Keywords: musculoskeletal rehabilitation; emerging technologies; virtual reality; artificial intelligence; inflammatory genetics; physiotherapy; sports medicine; functional recovery
(This special issue belongs to the Section Physiology and Pathology)
Effects of Exercise and Functional Interventions on Musculoskeletal Health
edited by
submission deadline 30 Jun 2026 | 7 articles | Viewed by 14726 | Submission Open
Keywords: musculoskeletal health; exercise; physical function; joint stability; fall prevention; rehabilitation science
(This special issue belongs to the Section Medical Research)
The Emerging Role of Microbiota in Health and Diseases
edited by Edyta Juszczuk-Kubiak and Katarzyna Góralska
submission deadline 30 Jun 2026 | 6 articles | Viewed by 13628 | Submission Open
Keywords: microbiota; eubiosis; dysbiosis; microbiota– host interaction; microbiota– gut– brain axis; microbiome; bacteria– fungi interactions; microbiota modification; holobiont; cross-feeding; microbiota related diseases; microbiota functions
(This special issue belongs to the Section Microbiology)
2nd Edition—Featured Papers on the Origins of Life
edited by James R. Lyons
submission deadline 30 Jun 2026 | 5 articles | Viewed by 11413 | Submission Open
Keywords: astrobiology; astrochemistry; planetary science; prebiotic chemistry; chirality; chemical evolution; protocells; synthetic biology; complex systems
(This special issue belongs to the Section Origin of Life)
Current Advances in Lung Cancer Diagnosis and Treatment
edited by , Daesik Yang and
submission deadline 30 Jun 2026 | 4 articles | Viewed by 9579 | Submission Open
Keywords: lung cancer; underlying lung disease; radiotherapy; systemic therapy; survival outcomes; complication; biomarkers
(This special issue belongs to the Section Medical Research)
Common and Novel Markers of Inflammation and Tissue Damage in Various Pathological Conditions—2nd Edition submission deadline 30 Jun 2026 | 5 articles | Viewed by 7752 | Submission Open
Keywords: body fluids; cytokines; damage-associated molecular patterns (DAMPs); inflammatory response; injury; markers of inflammation and tissue damage; metalloproteinases; novel markers; pathological conditions; proteasome; tissue damage; tissue repair processes; various diseases
(This special issue belongs to the Section Physiology and Pathology)
Update on Microalgae Metabolites submission deadline 30 Jun 2026 | 2 articles | Viewed by 3811 | Submission Open
Keywords: biosynthesis; culture conditions; bioactive compounds; biological activity; biorefinery; proteins; peptides; antifreeze proteins; enzymes; carbohydrates; exocellular polysaccharides; carbohydrate-binding proteins; lipids; fatty acids; chlorophylls; carotenoids; phycobiliproteins; vitamins; minerals; trace elements; sterols; secondary metabolites; downstream processing; purification; safety; regulatory issues; clinical tests
(This special issue belongs to the Section Microbiology)
Musculoskeletal Imaging: Innovations in Diagnostics and Interventional Therapies
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 3562 | Submission Open
Keywords: magnetic resonance imaging; bone and bones; computed tomography; sarcoma; interventional radiology
(This special issue belongs to the Section Medical Research)
Sialic Acid and Sialic Acid Derivatives in Biomedicine
edited by and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 3507 | Submission Open
Keywords: sialic acid; drug development; sialidase inhibitors; sialylation; sialidase; biomarker
(This special issue belongs to the Section Physiology and Pathology)
Microalgae and Their Biotechnological Potential
edited by , Yi Xin and Yuanxue Liang
submission deadline 30 Jun 2026 | 2 articles | Viewed by 3214 | Submission Open
Keywords: microalgae; biofuels; bioproducts; lipid metabolism; synthetic biology; system engineering
(This special issue belongs to the Section Microbiology)
Latest Updates on Clinical Microbiology and Antimicrobial Resistant Infection
edited by Jun Sung Hong
submission deadline 30 Jun 2026 | 2 articles | Viewed by 3109 | Submission Open
Keywords: enterobacteriaceae; antimicrobial resistance; infection; health
(This special issue belongs to the Section Microbiology)
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