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Life
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Lipid Metabolism Pathways: From Life to Disease
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Lipid Metabolism Pathways: From Life to Disease

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Cell Biology and Tissue Engineering".

Deadline for manuscript submissions: 21 November 2025 | Viewed by 1364

Special Issue Editor

Dr. Anna Eiring

E-Mail Website
Guest Editor
Department of Biological Sciences, College of Science, The University of Texas at El Paso, El Paso, TX 79902, USA
Interests: myeloid malignancies; hematopoiesis; lipid metabolism; 26S proteasome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Lipid metabolism is a highly regulated process that is essential in both life and disease. Lipids contribute to the regulation of normal cellular processes like membrane dynamics, energy homeostasis, and cell survival and play a critical role in signal transduction pathways. For these reasons, the dysregulation of lipid metabolism can have a large impact on normal cell function, including the regulation of energy metabolism and the structural integrity of cellular membranes, and can also impact therapeutic responses in several different diseases. Indeed, altered lipid metabolism is associated with various disease states, such as neurodegenerative diseases, metabolic syndrome, cardiovascular disease, and cancer. Current methods for targeting lipid metabolism pathways include disrupting lipid synthesis and uptake or oxidation pathways. In this Special Issue, we aim to present advances in our understanding of lipid metabolism in life and disease, emphasizing the importance of key lipid species like phospholipids, sphingolipids, sterols, and triglycerides and how they regulate critical cell processes such as apoptosis, ferroptosis, autophagy, and oxidative phosphorylation, among others. Prospective authors should first send a short abstract or tentative title to the Editorial Office. If the Editors deem the topic to be appropriate for inclusion in this Special Issue, the author will be invited to submit a full version of their manuscript.

Dr. Anna Eiring
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lipid metabolism
  • lipid signaling
  • apoptosis
  • ferroptosis
  • autophagy
  • membrane dynamics
  • fatty acid oxidation
  • obesity

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Published Papers (1 paper)

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Review

13 pages, 419 KiB  
Review
Lipid Metabolism and Breast Cancer: A Narrative Review of the Prognostic Implications and Chemotherapy-Induced Dyslipidemia
by Ionut Flaviu Faur, Amadeus Dobrescu, Ioana Adelina Clim, Paul Pasca, Cosmin Burta, Marco Marian, Dan Brebu, Andreea-Adriana Neamtu, Vlad Braicu, Talpai Tamas, Ciprian Duta and Bogdan Totolici
Life 2025, 15(5), 689; https://doi.org/10.3390/life15050689 - 23 Apr 2025
Viewed by 1298
Abstract
Introduction: Lipid metabolism plays a crucial role in breast cancer’s progression, treatment response, and prognosis. Alterations in triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) have been implicated in tumor aggressiveness and chemotherapy outcomes. This review examines the relationship between [...] Read more.
Introduction: Lipid metabolism plays a crucial role in breast cancer’s progression, treatment response, and prognosis. Alterations in triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) have been implicated in tumor aggressiveness and chemotherapy outcomes. This review examines the relationship between dyslipidemia and breast cancer, with a focus on chemotherapy-induced lipid alterations and their prognostic significance. Methods: A comprehensive literature search was conducted in PUBMED, Web of Science, and Google Scholar, identifying 108 unique studies. After applying the inclusion criteria, 21 studies were selected for analysis, covering lipid profile changes before, during, and after chemotherapy, as well as their impact on treatment response and clinical outcomes. Results: Breast cancer patients exhibited lower baseline TC, TG, and LDL-C levels compared to healthy controls; however, chemotherapy significantly increased these markers while decreasing HDL-C from 1.1 to 0.9 mmol/L. The incidence of dyslipidemia rose from 42.98% pre-treatment to 58.28% post-treatment. Chemotherapy-induced lipid alterations were most pronounced in anthracycline- and taxane-based regimens, leading to a 38% increase in TGs and a 23% reduction in HDL-C. While some studies reported that lipid levels normalized post-treatment, others indicated persistent dyslipidemia up to 12 months later. High baseline HDL-C was associated with a better chemotherapy response, whereas elevated TGs and LDL-C correlated with increased tumor aggressiveness, lower pathological complete response rates, and a higher relapse risk. Patients with persistently high post-treatment TGs had significantly worse disease-free survival, with a 30% relapse rate compared to 18% in those with normal TG. Preliminary evidence suggests that lipid-lowering therapies, such as statins, may offer therapeutic benefits in breast cancer by targeting the cholesterol synthesis pathways involved in tumor growth, though further clinical trials are required. Conclusions: Dyslipidemia is a key metabolic factor influencing breast cancer’s progression, treatment response, and long-term prognosis. Chemotherapy-induced lipid alterations may persist, increasing cardiovascular risk and potentially affecting therapeutic efficacy. Routine lipid monitoring and metabolic interventions could enhance treatment outcomes and survivorship. Future research should focus on developing lipid-targeted strategies to optimize breast cancer management. Full article
(This article belongs to the Special Issue Lipid Metabolism Pathways: From Life to Disease)
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