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Journal of Personalized Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Orthopedic Diseases: Surgical Treatments and Personalized Rehabilitation Strategies

edited by Eyal Yaacobi

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1705 | Submission Open

Keywords: orthopedic treatment; surgical technics; limb salvage; rehabilitation

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Orthopedic Diseases: Advances in Limb Reconstruction

edited by Taylor J. Reif and Jason Shih Hoellwarth

submission deadline 20 Jul 2026 | 2 articles | Viewed by 1670 | Submission Open

Keywords: limb lengthening; limb deformity; malunion; nonunion; limb salvage; amputation reconstruction; osseointegration; osteomyelitis; patient-specific surgery; patient-specific instrumentation

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Pathogenesis and Personalized Management of Asthma

edited by

Mohammed Aref Kyyaly

and S. Hasan Arshad

submission deadline 20 Jul 2026 | Viewed by 182 | Submission Open

Keywords: asthma; pathogenesis; biomarkers; personalized medicine; precision therapy; severe asthma; immunopathology; molecular diagnostics

(This special issue belongs to the Section Mechanisms of Diseases)

Recent Advances in Prenatal Diagnosis and Fetal Therapy

edited by Gabrielle Tonni

submission deadline 20 Jul 2026 | Viewed by 152 | Submission Open

Keywords: prenatal diagnosis; fetal therapy; noninvasive prenatal testing (NIPT); next-generation sequencing (NGS); 3D rendering; personalized medicine; minimally invasive surgery; patient-centered care

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Approaches in Neurosurgery

edited by Alessandro Boaro and Marco Mammi

submission deadline 25 Jul 2026 | 2 articles | Viewed by 6120 | Submission Open

Keywords: neurosurgery; neuronavigation; neuro-imaging; clinical outcomes; machine learning

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Inborn Errors of Metabolism: From Pathomechanisms to Treatment

edited by

Andrés Felipe Leal

and

Carlos J. Almeciga-Diaz

submission deadline 25 Jul 2026 | 2 articles | Viewed by 2316 | Submission Open

Keywords: inherited metabolic disorders; pathway signaling; organelle interactions; immunomodulators; antioxidants; gene therapy

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Medicine in Pathological Diagnosis

edited by

Gianpietro Volonnino

and

Aniello Maiese

submission deadline 25 Jul 2026 | 1 articles | Viewed by 1098 | Submission Open

Keywords: personalized medicine; pathology; pathological; trauma; toxicology; informed consent

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Personalized Diagnosis and Management of Stroke

edited by Rubens José Gagliardi

submission deadline 25 Jul 2026 | 1 articles | Viewed by 783 | Submission Open

Keywords: stroke; cerebrovascular disease; carotid disease; epidemiology

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Neuroimaging Biomarkers for Precision Medicine in Neuropsychiatry: A Multidisciplinary Update

edited by

Daniel Martins

submission deadline 25 Jul 2026 | Viewed by 343 | Submission Open

Keywords: neuroimaging; neuropsychiatry; psychiatry; psychology; neuroscience; biomarkers; precision medicine

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Radiomics: Unlocking Personalized Insights from Medical Images

edited by

Genti Xhepa

Baptiste Bonnet

and

Alexis Ricoeur

submission deadline 25 Jul 2026 | Viewed by 123 | Submission Open

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Molecular Pathology of Digestive Oncology

edited by

Takashi Murakami

submission deadline 25 Jul 2026 | Viewed by 64 | Submission Open

Keywords: molecular biomarkers; genetic and epigenetic alterations; tumor microenvironment; gut microbiome; carcinogenesis; early detection

(This special issue belongs to the Section Molecular Targeted Therapy)

Novel Challenges and Advances in Orthopaedic and Trauma Surgery

edited by

Dimitrios Kitridis

and

Panagiotis Givissis

submission deadline 30 Jul 2026 | 4 articles | Viewed by 13890 | Submission Open

Keywords: orthopaedic surgery; traumatology; musculoskeletal disorders; innovation in orthopaedics; individualised treatment; post-operative rehabilitation; clinical research

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Cardiothoracic Surgery: Challenges and Future Perspectives

edited by Thomas Theologou

submission deadline 30 Jul 2026 | Viewed by 90 | Submission Open

Keywords: cardiothoracic surgery; minimally invasive surgery; robotic surgery; heart transplantation; lung transplantation; thoracic oncology; perioperative care; artificial intelligence in surgery; surgical innovation; postoperative complications; personalized medicine

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Medicine in Orthopaedics, 2nd Edition

edited by

Arne Kienzle

and

Henrik Bäcker

submission deadline 31 Jul 2026 | 7 articles | Viewed by 16600 | Submission Open

Keywords: outcomes; orthopedic surgery; traumatology; radiography; complication

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Personalized Treatment for Heart Failure

edited by Shunsuke Kiuchi

submission deadline 31 Jul 2026 | 4 articles | Viewed by 6907 | Submission Open

Keywords: hypertension; heart failure; prevention; left ventricular contractility; cardiovascular outcomes; cardiology

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

New Advances in Techniques and Personalized Medicine in Cardiology

edited by

Camilla Calvieri

submission deadline 31 Jul 2026 | 1 articles | Viewed by 5988 | Submission Open

Keywords: cardiovascular precision therapy; cardiovascular pharmacological therapy; pharmacogenetics; cardio-imaging; epigenetics; personalized medicine

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Medicine in Metabolism Disorders

edited by Mehrnaz Abbasi

submission deadline 31 Jul 2026 | Viewed by 241 | Submission Open

Keywords: metabolic syndrome; obesity; insulin resistance; hypertension; type 2 diabetes; energy metabolism; fatty acid oxida-tion; gut microbiota; brown adipose tissue (BAT); white adipose tissue (WAT); nutritional interventions; lifestyle modifications; pharmacological treatments; phytochemicals; vitamins and supplements; public health; epidemiology of obesity; preventive strategies; genetic factors; metabolic health research; adipose tissue function

(This special issue belongs to the Section Mechanisms of Diseases)

Clinical Progress of Diabetic Foot

edited by

Piergiorgio Francia

Roberto Anichini

Leonardo Bocchi

and Alessandra De Bellis

submission deadline 31 Jul 2026 | Viewed by 133 | Submission Open

Keywords: diabetic foot; personalized medicine; advanced therapies; clinical management; biomarkers; diabetes complications; risk assessment; preventive care; artificial intelligence; data science

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Medicine in Kidney Transplantation

edited by Jon Von Visger

submission deadline 31 Jul 2026 | Viewed by 120 | Submission Open

Keywords: kidney transplantation personalized medicine renal disease nephrology graft survival immunosuppressive therapy recurrent disease patient survival access to transplant

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Advances in Ischemic Stroke Management: Toward Precision Medicine

edited by Bruno Kusznir Vitturi

submission deadline 31 Jul 2026 | Viewed by 44 | Submission Open

Keywords: cerebrovascular diseases; ischemic stroke; brain hemorrhage; secondary prevention; thrombolysis; endovascular treatment

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Gastric Cancer Treatment: Recent Progress and Future Perspectives

edited by Gagandeep Brar

submission deadline 10 Aug 2026 | Viewed by 77 | Submission Open

Keywords: gastric cancer; biomarkers; targeted therapy; personalized medicine

(This special issue belongs to the Section Precision Oncology)

Recent Innovations and Artificial Intelligence in Interventional Radiology: A Step Towards Personalized Medicine

edited by

Maurizio Cè

, Giuseppe Pellegrino and Salvatore Alessio Angileri

submission deadline 15 Aug 2026 | 3 articles | Viewed by 2826 | Submission Open

Keywords: interventional radiology; artificial intelligence; augmented reality

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Ehealth, Telemedicine, and AI in the Precision Medicine Era

edited by

Mirella Veras

submission deadline 20 Aug 2026 | 4 articles | Viewed by 23419 | Submission Open

Keywords: digital health; artificial intelligence; telemedicine; telerehabilitation; E-health; precision medicine; remote monitoring; wearable devices; mobile health (mHealth); virtual health; health informatics; machine learning; predictive analytics; personalized medicine; health technology

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Clinical Research of Minimally Invasive Spine Surgery

edited by

Paulo Pereira

and Bertrand Debono

submission deadline 20 Aug 2026 | 2 articles | Viewed by 4118 | Submission Open

Keywords: minimally invasive spine surgery; MISS; surgical techniques; patient outcomes; clinical research; technological advancements; robotics; navigation systems; patient safety; quality of life

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Therapeutic Strategies in Gastrointestinal Surgery

edited by Francesco Santullo

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1649 | Submission Open

Keywords: surgical oncology; cytoreductive surgery; laparoscopic surgery; colorectal surgery; gastric cancer; hipec; pipac; peritoneal metastases

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

Mechanisms of Airway Inflammation in Asthma

edited by Kathleen Haley

submission deadline 20 Aug 2026 | Viewed by 552 | Submission Open

Keywords: asthma; inflammation in asthma; targeted therapies; acute respiratory distress syndrome; chronic lung diseases; critical care

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

State of the Art in Cardiac Imaging

edited by

Katarzyna Holcman

submission deadline 25 Aug 2026 | 2 articles | Viewed by 4324 | Submission Open

Keywords: cardiology; imaging; scintigraphy; SPECT; PET; computed tomography; magnetic resonance; echocardiography; heart failure; coronary artery disease

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Interventional Cardiology: Latest Technology, Progress and Challenge

edited by Grzegorz Sobieszek and Maksymilian P. Opolski

submission deadline 25 Aug 2026 | 2 articles | Viewed by 3848 | Submission Open

Keywords: interventional cardiology; chronic total occlusions (CTO); complex and high-risk coronary interventions (CHIP); intravascular lithotripsy (IVL); structural heart interventions; heart failure interventional treatment; electrotherapy; right- and left-ventricle hemodynamic support; left-ventricle assist device (LVAD)

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Precision Pathology: Bridging Digital Innovation and Molecular Diagnostics

edited by

Albino Eccher

and Stefano Marletta

submission deadline 25 Aug 2026 | 1 articles | Viewed by 706 | Submission Open

Keywords: precision pathology; digital pathology; molecular diagnostics; artificial intelligence in pathology; computational pathology; multi-omics integration; biomarker discovery; translational medicine

(This special issue belongs to the Section Omics/Informatics)

Personalized Management of Heart Failure: From Biomarkers to Clinical Practice

edited by

Andre Rodrigues Durães

submission deadline 25 Aug 2026 | 1 articles | Viewed by 641 | Submission Open

Keywords: heart failure (HF); cardiac biomarkers; guideline-directed medical therapy (GDMT); risk stratification; HF phenotypes; HF management; digital health

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Gestational Diabetes: Challenges and Cutting-Edge Research

edited by

Athanasios N. Tsartsalis

and

George I. Lambrou

submission deadline 25 Aug 2026 | 1 articles | Viewed by 437 | Submission Open

Keywords: gestational diabetes; continuous glucose monitor; fetal health; pregnancy; macrosomia; personalized management

(This special issue belongs to the Section Mechanisms of Diseases)

Personalized Medicine in Pediatric Surgery: Updates and Perspectives

edited by

George Vaos

and

Nikolaos Zavras

submission deadline 25 Aug 2026 | Viewed by 70 | Submission Open

Keywords: personalized medicine; pediatric surgery; genomics; surgical oncology; inflammatory bowel disease; obesity; metabolic surgery; Hirschsprung's disease; artificial intelligence; machine learning

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Advancing Tailored Diagnostics and Therapeutics in Autoimmune and Rheumatic Diseases via Integration of Traditional Approaches and AI Technologies

edited by Edda Russo and Francesca Romano

submission deadline 25 Aug 2026 | Viewed by 70 | Submission Open

Keywords: autoimmune diseases; personalized therapeutics; biomarker profiling; artificial intelligence (AI); targeted immunotherapy

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Medicine in Anesthesia and Intensive Care

edited by Marc Olivier Fischer

submission deadline 27 Aug 2026 | 1 articles | Viewed by 399 | Submission Open

Keywords: anaesthesia; critical care; personalized medicine; preoperative risk stratification; close loop anaesthesia; mechanical ventilation; individualized sedation; postoperative outcome; postoperative trajectories

(This special issue belongs to the Section Personalized Medical Care)

Urological Diseases: Updates and Challenges on Personalized Diagnosis, Treatment, and Management

edited by Michael Chrisofos

submission deadline 27 Aug 2026 | Viewed by 79 | Submission Open

Keywords: minimally invasive surgeries; robotic surgery; laparoscopic surgery; personalized medicine; diagnostic modalities; precision diagnosis; incontinence; endourology; andrology; urologic surgery; urological diseases; prostate cancer

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Biomedical Tools in Diagnosis and Personalized Therapy of Cardiovascular Disease

edited by Nikolaos Koumallos and Konstantinos A. Aznaouridis

submission deadline 30 Aug 2026 | 2 articles | Viewed by 5149 | Submission Open

Keywords: cardiovascular disease; diagnosis; personalized therapy; biomedical tools; cardiovascular imaging

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

State of the Art in Pathogenesis and Targeted Therapy in Chronic Obstructive Pulmonary Disease

edited by Emanuela Tudorache

submission deadline 30 Aug 2026 | 1 articles | Viewed by 426 | Submission Open

Keywords: COPD; effective treatments; molecular; genetic; inflammation; biomarkers for diagnosis and prognosis; personalized medicine; novel drug delivery systems; patient outcomes; clinical practice

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Management of Inflammatory Bowel Diseases

edited by

Tommaso Innocenti

submission deadline 30 Aug 2026 | Viewed by 91 | Submission Open

Keywords: inflammatory bowel disease; precision medicine; personalized management; biomarkers; intestinal ultrasound; advanced imaging; disease monitoring

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Towards Precision Anesthesia and Pain Management

edited by

Giustino Varrassi

, Joseph V. Pergolizzi and Filomena Puntillo

submission deadline 31 Aug 2026 | 4 articles | Viewed by 17510 | Submission Open

Keywords: precision medicine; anesthesia; pain medicine

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

United Airway Disease: Current Perspectives

edited by

Luca Malvezzi

and

Manuele Casale

submission deadline 31 Aug 2026 | 2 articles | Viewed by 10024 | Submission Open

Keywords: chronic rhinosinusitis; asthma; personalized medicine; type-2 inflammation; united airway; obstructive sleep apnoea; monoclonal antibodies; endotype; rhinology

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Clinical Advances in Traumatic Brain Injury and Concussion

edited by Spencer W. Liebel

submission deadline 31 Aug 2026 | 1 articles | Viewed by 8913 | Submission Open

Keywords: traumatic brain injury; concussion; personalized medicine; neuroimaging; cognitive functioning; depression; connectomics; brain injury treatment

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Clinical Advances in Diagnosis and Personalized Treatments of Chronic Kidney Diseases

edited by

Claudia Torino

and

Vincenzo Antonio Panuccio

submission deadline 31 Aug 2026 | 4 articles | Viewed by 6261 | Submission Open

Keywords: biomarkers for early diagnosis; genetic testing; precision medicine approaches; novel therapies; telemedicine and remote monitoring; nutritional interventions; regenerative medicine

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Advances in Prenatal Diagnosis and Maternal Fetal Medicine

edited by

Themistoklis I. Dagklis

submission deadline 31 Aug 2026 | 3 articles | Viewed by 5336 | Submission Open

Keywords: prenatal diagnosis; maternal– fetal medicine; fetal anomalies; genetic screening; fetal imaging; non-invasive prenatal testing (NIPT); obstetric care; perinatal outcomes; diagnostic technologies; artificial intelligence

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Updates on Heart Valve Diseases: Personalized Treatment and Management

edited by Chiara Tessari

submission deadline 31 Aug 2026 | 4 articles | Viewed by 5047 | Submission Open

Keywords: heart valve disease; congenital heart valve disease; transcatheter valve implantation/replacement; surgical technique; device technology; tissue engineering; structural valve deterioration; device failure/success

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Personalized Medicine in Infectious Diseases

edited by

Cleo Anastassopoulou

and

George P. Patrinos

submission deadline 31 Aug 2026 | 1 articles | Viewed by 4547 | Submission Open

Keywords: infectious diseases; genetic predisposition; post-acute infection syndromes; long-COVID; response; potential adverse events; and duration of protection of vaccines; response to therapy and development of resistance; personalized medicine; precision diagnostics; treatment strategies

(This special issue belongs to the Section Personalized Therapy and Drug Delivery)

Personalized Medicine in the ICU—2nd Edition

edited by

Epaminondas Zakynthinos

and

Vasiliki Tsolaki

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2748 | Submission Open

Keywords: ARDS; mechanical ventilation; respiratory mechanics; monitoring; ultrasonography; respiratory muscles; diaphragm; cardiomyopathy; arrhythmias; sepsis; blood stream infections; antimicrobial resistance; ventilator-associated pneumonia; neuromonitoring; MODS; COVID-19

(This special issue belongs to the Section Personalized Medical Care)

Integrating Mathematical Modeling and Data Analysis in Personalized Medical Research

edited by

Dorota Bielińska-Wąż

and

Piotr Wąż

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2393 | Submission Open

Keywords: personalized medicine; health informatics; mathematical modeling; data analysis; bioinformatics; artificial intelligence; machine learning

(This special issue belongs to the Section Omics/Informatics)

Novel Applications of Artificial Intelligence in Personalized Medicine

edited by Aikaterini Sakagianni

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1964 | Submission Open

Keywords: artificial intelligence ; personalized medicine ; predictive modeling ; genomics ; proteomics ; AI-driven diagnostics ; patient-specific treatment ; drug discovery ; healthcare innovation ; clinical applications of AI

(This special issue belongs to the Section Methodology, Drug and Device Discovery)

New Insights into the Diagnosis and Treatment of Gastroenterological Diseases

edited by Ebubekir Dağlılar and Harleen Chela

submission deadline 31 Aug 2026 | Viewed by 120 | Submission Open

Keywords: gastroenterology; precision medicine; multi-omics integration; pharmacogenomics; liquid biopsy; gastrointestinal biomarkers; inflammatory bowel disease (IBD); individualized treatment strategies

(This special issue belongs to the Section Personalized Therapy in Clinical Medicine)

Cell-Free Nucleic Acids as Precision Biomarkers for Therapeutic Decision-Making Across Diseases

edited by