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Transcatheter Aortic Valve Implantation and Replacement: Prospects and Challenges
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Transcatheter Aortic Valve Implantation and Replacement: Prospects and Challenges

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 30 July 2025 | Viewed by 2052

Special Issue Editors

Prof. Dr. Konstantinos Toutouzas

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Guest Editor
First Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece
Interests: structural heart disease; mitral and aortic valvuloplasty; transcatheter aortic valve implantations; intravascular imaging; percutaneous coronary interventions
Special Issues, Collections and Topics in MDPI journals
Dr. Panayotis Vlachakis

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Guest Editor Assistant
First Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece
Interests: structural heart disease; valvulopathies; transcatheter aortic valve implantations; coronary artery disease; percutaneous coronary interventions; antiplatelet treatment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

During the last decade, scientific validation of Transcatheter Aortic Valve Implantation (TAVI) has considerably changed the management of patients with symptomatic aortic stenosis. The introduction of new technologies and the evolution of TAVI devices have already expanded current indications and refined clinical outcomes.

This Special Issue aims to address emerging challenges and knowledge gaps in the field of TAVI, focusing on expanding clinical indications, optimizing outcomes, and advancing Valve-in-Valve and TAVI-in-TAVI techniques.

We are particularly interested in studies that explore TAVI in special populations, investigate long-term durability and patient–prosthesis mismatch, and examine outcomes and decision-making for Valve-in-Valve and complex repeat-TAVI procedures.

We welcome the submission of original research, review articles, and real-world data that deepen our understanding of TAVI applications and outcomes. Topics of interest for this Special Issue include patient selection, procedural innovations, technical challenges, and long-term durability.

Prof. Dr. Konstantinos Toutouzas
Guest Editor

Dr. Panayotis Vlachakis
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • TAVI
  • aortic stenosis
  • valve-in-valve
  • structural heart disease
  • TAVI-in-TAVI

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Published Papers (2 papers)

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Research

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11 pages, 509 KiB  
Article
Impact of Right Heart Failure on Outcomes of Transcatheter Aortic Valve Implantation: Insights from the National Inpatient Sample
by Sajog Kansakar, Waqas T. Qureshi, Nava Raj Sharma, Dhan Bahadur Shrestha, Jurgen Shtembari, Vijay Shetty, Norbert Moskovits, Khagendra Dahal, Jishanth Mattumpuram and Daniel H. Katz
J. Clin. Med. 2025, 14(3), 841; https://doi.org/10.3390/jcm14030841 - 27 Jan 2025
Viewed by 880
Abstract
Background: There are limited data on the impact of right heart failure (RHF) on patients undergoing transcatheter aortic valve implantation (TAVI). We investigated the mortality, in-hospital complications, length of stay, and total hospitalization charges for TAVI admissions, with and without RHF. Methods: We [...] Read more.
Background: There are limited data on the impact of right heart failure (RHF) on patients undergoing transcatheter aortic valve implantation (TAVI). We investigated the mortality, in-hospital complications, length of stay, and total hospitalization charges for TAVI admissions, with and without RHF. Methods: We analyzed the National Inpatient Sample data from 2018 to 2022. The International Classification of Diseases–Tenth Revision (ICD-10) codes were used to define the patient cohorts. Propensity score weighting was used to balance patient demographic, hospital-level, and comorbidity data. Results: From 2018 to 2022, there were 383,860 TAVI admissions, among which 1915 (0.50%) had the presence of RHF. Compared to patients without RHF, mortality was higher in patients with RHF (7.57% vs. 1.11%, p < 0.01). Similarly, acute kidney injury (37.10% vs. 8.56%, p < 0.01), respiratory failure (12.79% vs. 1.91%, p < 0.01), and use of mechanical circulatory support (11.48% vs. 0.83%, p < 0.01) was higher in the cohort with RHF. Median length of stay (7 days vs. 2 days, p < 0.01) and hospitalization charges ($257,239 vs. $180,501, p < 0.01) were higher in patients with RHF. Conclusions: In conclusion, we report that RHF is associated with increased mortality risk, complications, and resource utilization in patients undergoing TAVI. Right ventricular function should be a part of the evaluation for TAVI, given significantly elevated risks associated with its presence. Full article
(This article belongs to the Special Issue Transcatheter Aortic Valve Implantation and Replacement: Prospects and Challenges)
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Review

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17 pages, 2755 KiB  
Review
Transcatheter Aortic Valve Implantation and Replacement: The Latest Advances and Prospects
by Milos Brankovic and Abhishek Sharma
J. Clin. Med. 2025, 14(6), 1844; https://doi.org/10.3390/jcm14061844 - 9 Mar 2025
Viewed by 846
Abstract
Transcatheter aortic valve replacement (TAVR) has revolutionized the treatment of aortic stenosis, particularly in patients at high risk of adverse events for traditional open-heart surgery. Since the early 2000s, TAVR has evolved rapidly with advancements in device technology, procedural techniques, and patient selection [...] Read more.
Transcatheter aortic valve replacement (TAVR) has revolutionized the treatment of aortic stenosis, particularly in patients at high risk of adverse events for traditional open-heart surgery. Since the early 2000s, TAVR has evolved rapidly with advancements in device technology, procedural techniques, and patient selection criteria. Over the past 20 years, this catheter-based procedure has significantly improved patient survival and quality of life, demonstrating both the safety and efficacy of TAVR, even in patients at low surgical risk. This paper reviews the latest advances in valve design and strategies for treating aortic stenosis. It explores the challenges with long-term outcomes given the younger age of patients undergoing TAVR and the prospects of emerging technologies to improve long-term outcomes. Full article
(This article belongs to the Special Issue Transcatheter Aortic Valve Implantation and Replacement: Prospects and Challenges)
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