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Advances in the Field of Cutaneous Malignancies: Background and Clinical Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 1008

Special Issue Editors


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Guest Editor
Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, Hungary
Interests: melanoma; dermatooncology; quality of life; systemic treatment; immunotherapy
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, Hungary
Interests: dermatology; basal cell carcinoma; dermatosurgery; teledermatology; artificial intelligence
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Dermatology, Venereology and Oncodermatology, University of Pécs, H-7632 Pécs, Hungary
Interests: dermatology; melanoma; oncodermatology; circadian clocks; dermoscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to publish your manuscripts in our Special Issue entitled “Advances in the Field of Cutaneous Malignancies: Background and Clinical Management” in the Journal of Clinical Medicine, which is now open for submissions.

In the last few decades, the overall incidence and prevalence of cutaneous malignancies have shown a significant increase worldwide. While melanoma accounts for the majority of all skin-cancer-related deaths, non-melanoma skin cancers are the most common malignancies in fair-skinned populations, contributing to a significant burden for patients and healthcare systems.

Our present Special Issue will focus on the latest advances in the management of cutaneous malignancies, including the use of various biomarkers, diagnostic devices, imaging techniques (dermoscopy, optical coherence tomography, high-frequency ultrasound, reflectance confocal microscopy, etc.), and novel treatment options. New concepts on early detection, genomic and molecular testing, approaches guiding treatment decisions, and the monitoring of the therapy of cutaneous malignancies are also within the scope. Novel findings on the use of artificial intelligence to enhance the diagnostics of cutaneous malignancies are also welcome. Teledermatology, alone or in combination with artificial intelligence, is also a rapidly developing technology that has a key role in the management of cutaneous malignancies; therefore, it is also included. New data on the background and factors contributing to the development of cutaneous malignancies are of special interest.

Basic, translational, and clinical research are equally highly welcome to this Special Issue.

Prof. Dr. Péter Holló
Dr. Norbert Kiss
Dr. András Bánvölgyi
Dr. Zsuzsanna Lengyel
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dermatology
  • skin cancer
  • diagnosis
  • melanoma
  • basal cell carcinoma
  • squamous cell carcinoma
  • imaging
  • artificial intelligence
  • dermoscopy
  • treatment

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Published Papers (1 paper)

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9 pages, 3302 KB  
Case Report
Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma: A Rare and Aggressive Case Report with Clinical and Pathological Insights
by Janyna Jaramillo, Katty Méndez-Flores, Nataly Lascano, Santiago Palacios-Álvarez, Marlon Arias-Intriago and Juan S. Izquierdo-Condoy
J. Clin. Med. 2025, 14(21), 7842; https://doi.org/10.3390/jcm14217842 - 5 Nov 2025
Viewed by 446
Abstract
Introduction: Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (PCAETL) is a rare and highly aggressive subtype of cutaneous T-cell lymphoma (CTCL), accounting for less than 1% of CTCL cases. It is defined by CD8+ cytotoxic T-cell proliferation with marked epidermotropism, necrosis, and [...] Read more.
Introduction: Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (PCAETL) is a rare and highly aggressive subtype of cutaneous T-cell lymphoma (CTCL), accounting for less than 1% of CTCL cases. It is defined by CD8+ cytotoxic T-cell proliferation with marked epidermotropism, necrosis, and a high proliferative index. Clinically, it presents as ulcerated or necrotic lesions with rapid progression and poor response to conventional therapies. Aims: To describe a fatal case of PCAETL in a young adult female, emphasizing the diagnostic challenges, clinical progression, histopathological features, and treatment limitations. Case Presentation: A 41-year-old Venezuelan woman presented with a 10-month history of disseminated papules and nodules initially misdiagnosed as Hansen’s disease. After her arrival in Ecuador, she was re-evaluated and found to have generalized dermatosis with ulcerated nodules and tumors. Histopathological examination revealed atypical epidermotropic CD8+ T-cell infiltration with extensive necrosis. Immunohistochemistry demonstrated strong positivity for CD3, CD5, and CD8, and a Ki-67 index of 80%, confirming the diagnosis of PCAETL. The patient received methotrexate with partial response but experienced disease relapse during second-line etoposide therapy. She developed febrile neutropenia and died five months after diagnosis. Conclusions: This case highlights the rarity, diagnostic complexity, and aggressive nature of PCAETL. Early recognition and clinico-pathological correlation are essential for timely diagnosis. However, therapeutic options remain limited, and outcomes are poor despite systemic chemotherapy. Further research into targeted and personalized therapies is urgently needed to improve survival in this devastating disease. Full article
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