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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Current Advances and Future Perspectives in Cardiothoracic Surgery
edited by Tomislav Kopjar
submission deadline 20 Jul 2026 | Viewed by 28 | Submission Open
Keywords: cardiothoracic surgery; minimally invasive techniques; robotic-assisted surgery; personalized therapy; surgical innovation; prosthetic devices; perioperative management; transplantation; technological advances; postoperative care; surgical outcomes; future perspectives; healthcare disparities
(This special issue belongs to the Section General Surgery)
Optimizing Outcomes in Pancreato-Biliary Care: Integrating Technology, Technique, and Personalized Approaches
edited by
submission deadline 20 Jul 2026 | Viewed by 27 | Submission Open
Keywords: pancreato-biliary care; pancreatic diseases; biliary diseases; hepato-pancreato-biliary (HPB) surgery; interventional endoscopy; interventional radiology; minimally invasive surgery; EUS-guided procedures; ERCP; personalized care/personalized medicine; multidisciplinary care; clinical outcomes; robotics and AI in PB care
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Outcomes in Lumbar Spinal Stenosis Treatment
edited by Rafał Staszkiewicz and
submission deadline 20 Jul 2026 | Viewed by 24 | Submission Open
Keywords: lumbar spinal stenosis; clinical outcomes; decompression surgery; conservative management; molecular biomarkers; inflammation and fibrosis; neurotrophic factors; personalized medicine; siganling pathways; quality of life
(This special issue belongs to the Section Orthopedics)
State of the Art in Spinal Cord Injuries: Clinical Rehabilitation and Management
edited by
submission deadline 20 Jul 2026 | Viewed by 23 | Submission Open
Keywords: neurorehabilitation; assistive technologies; neuroplasticity; neuromodulation; spinal cord injury
(This special issue belongs to the Section Clinical Rehabilitation)
Pneumonia: From Diagnosis to Treatment submission deadline 20 Jul 2026 | Viewed by 23 | Submission Open
Keywords: pneumonia; diagnosis; treatment; multidisciplinary care; pulmonary rehabilitation
(This special issue belongs to the Section Respiratory Medicine)
Acute Coronary Syndrome(ACS): From Emergency Intervention to Long-Term Prevention
edited by Marco Ciardetti and Alessio Mattesini
submission deadline 20 Jul 2026 | Viewed by 21 | Submission Open
Keywords: acute coronary syndrome; primary percutaneous coronary intervention; antithrombotic therapy; secondary prevention; risk stratification
(This special issue belongs to the Section Cardiology)
Orthodontics: Current Management and Future Options
edited by Arūnas Vasiliauskas and Aistė Kavaliauskienė
submission deadline 20 Jul 2026 | Viewed by 20 | Submission Open
Keywords: digital orthodontics; clear aligner therapy; accelerated tooth movement; micro-implants; artificial intelligence; patient-centred outcomes; treatment efficiency
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Contactless Magnetocardiography and Related Novel Methods for Non-Invasive Experimental and Clinical Functional Imaging of Normal and Abnormal Cardiac Electrophysiology submission deadline 20 Jul 2026 | Viewed by 19 | Submission Open
Keywords: magnetocardiography; non-invasive functional imaging of cardiac electrophysiology; arrhythmogenic mechanisms; atrial fibrillation; magnetoionography; antiarrhythmic drugs; artificial intelligence
(This special issue belongs to the Section Cardiology)
Clinical Advances in Chronic Lymphocytic Leukemia: Focus on Elderly Frail Patients
edited by Driss Chaoui
submission deadline 20 Jul 2026 | Viewed by 18 | Submission Open
Keywords: CLL; elderly; frailty; guidelines; quality of life; IBTK; BCL2; antiCD20
(This special issue belongs to the Section Hematology)
Orthodontic Treatment in Clinical Practice: Strategies for Achieving Optimal Outcomes
edited by Adith Venugopal
submission deadline 20 Jul 2026 | Viewed by 15 | Submission Open
Keywords: orthodontics; biomechanics; tooth movement; bone remodeling; malocclusions; smile
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advances in Lower Limb Trauma and Orthopedic Surgery: From Bench to Bedside
edited by and
submission deadline 20 Jul 2026 | Viewed by 13 | Submission Open
Keywords: lower limb trauma; fracture fixation; arthroplasty; biomechanics; orthopaedic surgery; translational research; clin-ical outcomes; minimally invasive techniques; rehabilitation
(This special issue belongs to the Section Orthopedics)
Integrating Artificial Intelligence into Plastic, Reconstructive, and Aesthetic Surgery: Innovations, Challenges, and Clinical Application submission deadline 20 Jul 2026 | Viewed by 12 | Submission Open
Keywords: plastic; reconstructive; aesthetic surgery; artificial intelligence; AI in plastic surgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
New Perspective of Oral and Maxillo-Facial Surgery:2nd Edition
edited by , and Alessandra Lucchese
submission deadline 20 Jul 2026 | Viewed by 10 | Submission Open
Keywords: maxillofacial surgery; esthetic surgery; orthognatic surgery; TMJ disorders; TMJ surgery; dental implant surgery; 3D imaging; printing applications; tissue engineering; personalized treatment planning; artificial intelligence; squamous cell carcinoma; skin tumors; plastic and reconstructive surgery; head and neck surgery; ENT surgery
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Diagnosis, Treatment and Prognosis of Head and Neck Cancer
edited by and Elena Russo
submission deadline 20 Jul 2026 | Viewed by 10 | Submission Open
Keywords: head and neck neoplasms; surgical procedures; minimally invasive surgical procedures; radiotherapy; immunotherapy; biomarkers; treatment outcome; early diagnosis; prognosis; quality of life
(This special issue belongs to the Section Oncology)
Updates on Reconstructive Urology
edited by
submission deadline 20 Jul 2026 | Viewed by 10 | Submission Open
Keywords: reconstructive urology; urethral stenosis; urethroplasty; urethral diverticulum; ureteral stenosis; male incontinence; urinary diversion; hypospadias; microsurgery; experimental microsurgery; bladder diverticulum; neobladder
(This special issue belongs to the Section Nephrology & Urology)
Spine Surgery: Clinical Advances and Practice Updates
edited by
submission deadline 20 Jul 2026 | Viewed by 8 | Submission Open
Keywords: spine surgery; minimally invasive spine surgery; endoscopic spine surgery; robotics; artificial intelligence; spinal deformity; scoliosis; spinal trauma
(This special issue belongs to the Section Orthopedics)
Outcomes in Pediatric Neurosurgery
edited by and Konstantina Svokos
submission deadline 20 Jul 2026 | Viewed by 8 | Submission Open
Keywords: functional outcomes; pediatric neurosurgery; quality of life; innovative technologies; global neurosurgery
(This special issue belongs to the Section Clinical Pediatrics)
Clinical Updates on Anesthesia and Perioperative Medicine
edited by Béla Fülesdi and
submission deadline 20 Jul 2026 | Viewed by 7 | Submission Open
Keywords: anesthesia; perioperative complications; residual neuromuscular block; postoperative pulmonary complications; intensive care unit acquired weakness; intensive care medicine; airway management; patient safety
(This special issue belongs to the Section Anesthesiology)
Applications of Artificial Intelligence and Digital Therapeutics in Clinical Medicine: 2nd Edition
edited by
submission deadline 20 Jul 2026 | Viewed by 6 | Submission Open
Keywords: artificial intelligence; biometric sensors; deep learning; digital therapies; Internet of Things; machine learning; virtual reality; augmented reality
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
Gastroparesis: Emerging Insights and Endoscopic Therapeutic Strategies
edited by Sabrina Testoni
submission deadline 20 Jul 2026 | Viewed by 6 | Submission Open
Keywords: gastroparesis; gastric dismotility; gastric emptying; gastric per-oral miotomy; pyloromyotomy; gastric electric stim-ulation; botulinum toxin
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Gynecologic Cancers: Current Clinical Management and Multidisciplinary Treatment Strategies submission deadline 20 Jul 2026 | Viewed by 5 | Submission Open
Keywords: gynecologic; cancer; uterus; ovarian; endometrial; cervical
(This special issue belongs to the Section Obstetrics & Gynecology)
Hypertrophic Cardiomyopathy: New Insights into Complications and Treatment
edited by Ilaria Dentamaro and Ciro Santoro
submission deadline 20 Jul 2026 | Viewed by 5 | Submission Open
Keywords: hypertrophic cardiomyopathy; complications; risk stratification; multimodality imaging; myosin inhibitors; precision medicine
(This special issue belongs to the Section Cardiology)
Current Measures for Diagnosis, Monitoring, and Outcome Assessment in Orthopedics, Traumatology, and Hand Surgery, 2nd Edition submission deadline 20 Jul 2026 | Viewed by 4 | Submission Open
Keywords: clinical evaluation; hand surgery; orthopaedics; performance-based measures; physical examination; reliability; traumatology
(This special issue belongs to the Section Orthopedics)
Clinical Updates on Application of Echocardiography
edited by Aydan Ewers
submission deadline 20 Jul 2026 | Viewed by 3 | Submission Open
Keywords: echocardiography; heart failure; cardiomyopathies; cardiac echocardiography; interventional cardiology; cardiac imaging; pulmonary hypertension
(This special issue belongs to the Section Cardiology)
The Wide World of Antinuclear Antibodies (ANA)-Associated Disorders: Patterns, Clinical Phenotypes, Comorbidities, and Impact submission deadline 20 Jul 2026 | Viewed by 3 | Submission Open
Keywords: antinuclear antibodies (ANA); ANA-associated disorders; clinical phenotypes; ANA patterns; lupus; Sjö gren’ s disease; systemic sclerosis; idiopathic inflammatory myopathies; comorbidities; connective tissue diseases; overlap syndromes; undifferentiated connective tissue disease; risk stratification; patient-centered management
(This special issue belongs to the Section Immunology & Rheumatology)
Exploring Diagnostic and Therapeutic Advances in Neurodegenerative Disorders
edited by and Effrosyni Koutsouraki
submission deadline 20 Jul 2026 | Viewed by 1 | Submission Open
Keywords: neurodegenerative disease; Parkinson’ s disease; Alzheimer’ s disease; Friedreich’ s ataxia; Huntington’ s disease; Lewy body dementia; dementia; immunosenescence; inflammaging
(This special issue belongs to the Section Clinical Neurology)
Clinical Challenges in Heart Failure Management: 2nd Edition
edited by Paolo Severino, Gaetano M. Ruocco and
submission deadline 20 Jul 2026 | Viewed by 1 | Submission Open
Keywords: acute heart failure; chronic heart failure; inotropic support; left ventricular assist device; cardiac contractility modulation; guanylate cyclase stimulators; quality of life; telemedicine; palliative care
(This special issue belongs to the Section Cardiology)
Clinical Advances in Application of Echocardiography
edited by
submission deadline 20 Jul 2026 | Submission Open
Keywords: echocardiography; Doppler; transesophageal echocardiography; stain imaging; valvular hemodynamics; non valvular hemodynamics; interventional echocardiography; 3-dimensional echocardiography; tissue Doppler imaging
(This special issue belongs to the Section Cardiology)
Targeting the Complement for the Treatment of Autoimmune and Neurodegenerative Diseases of the Central Nervous System
edited by Charalampos Skarlis, and Evangelia Liouta
submission deadline 20 Jul 2026 | Submission Open
Keywords: complement; biologics; monoclonal antibodies; neurodegenerative diseases; CNS autoimmune diseases
(This special issue belongs to the Section Clinical Neurology)
Clinical Research on Robot-Assisted Thoracic Surgery and Lung Surgery
edited by Marco Scarci
submission deadline 20 Jul 2026 | Submission Open
Keywords: robot-assisted thoracic surgery; robotic lung surgery; minimally invasive surgery; lobectomy; segmentectomy; thoracic oncology; surgical outcomes; learning curve; clinical research; robotic technology
(This special issue belongs to the Section General Surgery)
Pediatric Surgery—Current Hurdles and Future Perspectives—2nd Edition
edited by
submission deadline 20 Jul 2026 | Submission Open
Keywords: ongenital anomalies; esophageal atresia; anorectal malformations; pediatric trauma; necrotizing enterocolitis; pediatric oncology; biliary atresia
(This special issue belongs to the Section Clinical Pediatrics)
Clinical Strategies for Preventing Healthcare-Associated Infections submission deadline 24 Jul 2026 | Viewed by 13 | Submission Open
Keywords: healthcare-associated infections; multidrug resistance; prevention; screening scales; polymicrobial infections; oppor-tunistic infections; sepsis
(This special issue belongs to the Section Infectious Diseases)
Recent Clinical Advances in Pelvic Organ Prolapse
edited by José Antonio García-Mejido and José Antonio Sainz-Bueno
submission deadline 24 Jul 2026 | Viewed by 6 | Submission Open
Keywords: pelvic organ prolapse; pelvic floor dysfunction; urogynecology; pelvic reconstructive surgery; pathophysiology of POP; surgical techniques; conservative management; patient-reported outcomes; biomaterials in pelvic surgery; levator ani muscle
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Advances in Spinal Neurosurgery
edited by Jang-Won Yoon
submission deadline 25 Jul 2026 | 2 articles | Viewed by 1860 | Submission Open
Keywords: minimally invasive spine surgery; lateral lumbar interbody fusion; endoscopic spine surgery; patient-reported out-comes; functional assessment; perioperative care; surgical decision-making
(This special issue belongs to the Section Clinical Neurology)
High-Risk Pregnancy Management: From Prenatal Care to Postpartum Outcomes
edited by
submission deadline 25 Jul 2026 | Viewed by 38 | Submission Open
Keywords: high-risk pregnancy; prenatal care; postpartum outcomes; postpartum mental health; birth trauma; AI in obstetrics; medico-legal liability; equity & culturally safe care; indigenous and rural/remote care; EMR-enabled decision support; quality trend monitoring; maternal morbidity and mortality; perinatal morbidity; standardized care bundles & pathways
(This special issue belongs to the Section Obstetrics & Gynecology)
Current Advances and Future Perspectives in Cardiac Arrest and Cardiogenic Shock
edited by Giulia Maj
submission deadline 25 Jul 2026 | Viewed by 22 | Submission Open
Keywords: cardiogenic shock; left ventricular unloading; biomarkers; recovery; cardiac arrest
(This special issue belongs to the Section Emergency Medicine)
Clinical Updates on Transcatheter Structural Heart Disease Interventions
edited by Nazan Puluca and Hendrik Ruge
submission deadline 25 Jul 2026 | Viewed by 18 | Submission Open
Keywords: interventional valve therapy; TAVR; TEER; TMVR; mitral valve; tricuspid valve; coronary access
(This special issue belongs to the Section Cardiology)
Recent Advance in Bariatric Surgery submission deadline 25 Jul 2026 | Viewed by 16 | Submission Open
Keywords: bariatric surgery; metabolic surgery; minimally invasive surgery; robotic surgery; endoscopic bariatric procedures; obesity management; type 2 diabetes remission; perioperative care; long-term outcomes; enhanced recovery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Sleep Disorders: Current Research and Future Directions—Second Edition
edited by Martina Vendrame
submission deadline 25 Jul 2026 | Viewed by 11 | Submission Open
Keywords: obstructive sleep apnea; parasomnia; idiopathic hypersomnia; periodic limb movement disorder; periodic limb move-ment of sleep
(This special issue belongs to the Section Clinical Neurology)
Clinical Application of Endoscopic Submucosal Dissection in Malignant Gastrointestinal Tumors and Precursors—2nd Edition submission deadline 25 Jul 2026 | Viewed by 8 | Submission Open
Keywords: endoscopy; endoscopic submucosal dissection; endoscopic surgery; laparoscopic surgery; minimally invasive surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Interaction Between Systemic Diseases and Oral Diseases: 2nd Edition
edited by
submission deadline 25 Jul 2026 | Viewed by 6 | Submission Open
Keywords: medical dental interaction; saliva; xerostomia; diagnostics; inflammatory bowel disease; cancer survivors; dental erosion; Sjö gren’ s disease; liver transplantation
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Updates in the Diagnosis, Imaging, and Treatment of Retinal and Macular Diseases
edited by
submission deadline 26 Jul 2026 | Viewed by 26 | Submission Open
Keywords: retinal diseases; macular degeneration; diagnostic imaging; OCT/OCTA; artificial intelligence; deep learning; clinical ophthalmology; gene therapy; treatment innovations
(This special issue belongs to the Section Ophthalmology)
Improving Outcomes in Systemic Lupus Erythematosus: Latest Advances and Prospects in Relation to Comorbidity, Damage, and Quality of Life
edited by and Shaye Kivity
submission deadline 30 Jul 2026 | Viewed by 57 | Submission Open
Keywords: systemic lupus erythematosus; comorbidities; outcome measures; damage accrual; quality of life; cognitive im-pairment; infections and vaccination; treat-to-target; digital biomarkers
(This special issue belongs to the Section Immunology & Rheumatology)
Endoscopic Management of Pancreaticobiliary Diseases
edited by
submission deadline 30 Jul 2026 | Viewed by 4 | Submission Open
Keywords: pancreaticobiliary endoscopy; endoscopic ultrasound (EUS); endoscopic retrograde cholangiopancreatography (ERCP); biliary drainage; gallbladder drainage; lumen-opposing metal stents; cholangioscopy; pancreatoscopy; confocal laser endomicroscopy; pancreatic cysts; molecular diagnostics; lithotripsy (electrohydraulic and laser); radiofrequency ablation (RFA); photodynamic therapy (PDT); pancreatic and biliary tumors; interventional endoscopy; altered anatomy access; diagnostic and therapeutic endoscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Insights and Applications in Cardiac Electrophysiology
edited by and Fabrizio Guarracini
submission deadline 30 Jul 2026 | Viewed by 2 | Submission Open
Keywords: atrial fibrillation; catheter ablation; transvenous lead extraction; left atrial appendage occlusion; heart failure; subcutaneous ICD; extravascular ICD; conduction system pacing; cardiac electrophysiology; cardiac rhythm disorders; arrhythmia mapping; supraventricular arrhythmias; ventricular arrhythmias; cardiomyopathies; implantable cardiac devices; minimally invasive devices; left atrial appendage closure; personalized arrhythmia care; clinical management; innovative electrophysiological techniques
(This special issue belongs to the Section Cardiology)
Clinical Application of Physical Therapy in Neurorehabilitation: 3rd Edition submission deadline 31 Jul 2026 | Viewed by 13 | Submission Open
Keywords: physical therapy; technology-aided rehabilitation; exercise; neurorehabilitation; neuroplasticity; engagement; self-management
(This special issue belongs to the Section Clinical Rehabilitation)
The Future Direction of Medical Imaging in Hepato-Bilio-Pancreatic Oncology: Challenges and Opportunities
edited by
submission deadline 31 Jul 2026 | Viewed by 8 | Submission Open
Keywords: MRI; CT; molecular imaging; radiomics; imaging; radiogenomics; precision medicine; outcome prediction; cholangiocarcinoma; pancreatic cancer; imaging biomarkers; treatment response
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Neuro-Psychiatric Disorders: Updates on Diagnosis and Treatment—2nd Edition
edited by
submission deadline 31 Jul 2026 | Viewed by 3 | Submission Open
Keywords: neuropsychiatric disorder; diagnosis; treatment; neurobiology; organic psychiatry
(This special issue belongs to the Section Mental Health)
Sports Cardiology: Current Clinical Status and Outlook into the Future
edited by Aakash Bavishi and Matthew W Martinez
submission deadline 10 Aug 2026 | Viewed by 25 | Submission Open
Keywords: sports cardiology; athletes; cardiac imaging; hypertrophic cardiomyopathy; screening; electrocardiogram; electrophysiology; echocardiography; sudden cardiac death
(This special issue belongs to the Section Cardiology)
Neurovascular Canvas: From Basic Science to Clinical Breakthroughs
edited by , Nicola Giannini and
submission deadline 15 Aug 2026 | Viewed by 38 | Submission Open
Keywords: neurovascular unit (NVU); neurodegeneration; vascular biology; stroke; disease modeling
(This special issue belongs to the Section Clinical Neurology)
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