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Latest Advances in Thoracic Surgery: 2nd Edition
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Latest Advances in Thoracic Surgery: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Respiratory Medicine".

Deadline for manuscript submissions: 15 March 2026 | Viewed by 917

Special Issue Editor

Dr. Hideki Ujiie

E-Mail Website
Guest Editor
Division of Thoracic Surgery, Department of Surgery, Faculty of Medicine, Kindai University, 1-14-1 Mihara-dai, Minami-ku, Sakai 590-0197, Osaka, Japan
Interests: cancer biology; lung cancer; surgical oncology; robotic surgery; thoracic surgery; lung diseases; minimally invasive surgery; airway obstruction; pulmonary medicine; respiration disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to contribute to this Special Issue on the “Latest Advances in Thoracic Surgery: 2nd Edition”, following the previous collection of four papers (https://www.mdpi.com/journal/jcm/special_issues/QDYMT8R149).

This Special Issue aims to discuss three primary topics:

  1. Minimally Invasive Techniques: Thoracic surgery has seen significant advancements in minimally invasive procedures. Video-assisted thoracoscopic surgery (VATS) and robotic-assisted surgery (RATS) have become more prevalent. These techniques involve smaller incisions, reduced trauma, shorter hospital stays, and faster recovery times for patients compared to traditional open surgery.
  2. Lung Cancer Treatments: Advances in lung cancer treatments have led to improved surgical outcomes. These include the application of targeted therapies and immunotherapies, which have expanded the treatment options for patients with advanced or recurrent lung cancer.
  3. Image-Guided Surgery: Advanced imaging technologies, such as 3D CT scans and intraoperative navigation systems, have allowed surgeons to gain a more precise view of thoracic structures during surgery, enabling them to perform more accurate and targeted procedures.

It is important to note that the field of medicine, including thoracic surgery, is continuously evolving. New advancements may have emerged since the previous issue, and I would like to discuss these topics.

Dr. Hideki Ujiie
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lung cancer
  • surgical oncology
  • robotic surgery
  • thoracic surgery
  • lung diseases
  • minimally invasive surgery

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Related Special Issue

Published Papers (2 papers)

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Research

11 pages, 1084 KB  
Article
Recurrent Malignant Pericardial Effusion Management: The Pericardio-Peritoneal Window
by Antonio Mazzella, Giovanni Caffarena, Claudia Bardoni, Giuseppe Nicolosi, Patrick Maisonneuve, Giorgia Cerretani, Giulia Sedda, Luca Bertolaccini, Giorgio Lo Iacono, Monica Casiraghi and Lorenzo Spaggiari
J. Clin. Med. 2026, 15(1), 83; https://doi.org/10.3390/jcm15010083 (registering DOI) - 22 Dec 2025
Abstract
Introduction: Malignant pericardial effusion (MPE) represents a relatively rare complication in various types of solid tumors. Its management is often challenging. One solution can be represented by surgical approaches, including a pericardio-peritoneal window (PPW), which allows draining the fluid into the abdominal [...] Read more.
Introduction: Malignant pericardial effusion (MPE) represents a relatively rare complication in various types of solid tumors. Its management is often challenging. One solution can be represented by surgical approaches, including a pericardio-peritoneal window (PPW), which allows draining the fluid into the abdominal cavity. The aim of this study is to investigate the efficacy and long-term outcomes of the PPW procedure as a definitive therapeutic strategy for MPE. Materials and methods: We retrospectively and prospectively observed pre-, peri-, and postoperative data of patients undergoing pericardio-peritoneal window creation from 2010 to December 2023 at the European Institute of Oncology (IEO), including the surgical procedures needed, total and specific postoperative complications, 30-day mortality rate, relapse rate, and the treatment of possible relapses. Results: A total of 44 consecutive patients underwent a pericardio-peritoneal window. In 28 patients (63.8%) PPW was associated with mono or bilateral videothoracoscopy for pleural biopsies/talc poudrage. In 23 cases, pre-operative percutaneous pericardial drainage (usually 1–2 days before surgery) was performed. No intraoperative deaths were observed. The 30-day mortality was 9% (four patients). We observed pericardial effusion recurrence in three patients at two months and in five patients at six months. In only two cases we treated this condition because of a pre-tamponade condition, treated by percutaneous pericardial drainage. The success rate of the PPW regarding pericardial relapse requiring further procedures was 95.5%. Conclusions: Patients presenting with a favorable short-term prognosis benefit from the pericardio-peritoneal window as a safe and effective method for resolving malignant pericardial effusion. Conversely, pericardial drainage is recommended as the most appropriate therapy for those with a less favorable prognosis. Full article
(This article belongs to the Special Issue Latest Advances in Thoracic Surgery: 2nd Edition)
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15 pages, 728 KB  
Article
Outcomes of Lobar and Sublobar Resection for Clinical Stage I Lung Neuroendocrine Tumors: An ENETS Center of Excellence Experience
by Ranin Hojerat, Islam Idais, Gal Aviel, Anat Bel-Ange, Simona Grozinsky-Glasberg, Simona Ben-Haim, Benjamin Nisman, Ofra Maimon, Karine Atlan, Oz M. Shapira, Amit Korach, Uzi Izhar, Guy Pines and Ori Wald
J. Clin. Med. 2025, 14(22), 7927; https://doi.org/10.3390/jcm14227927 - 8 Nov 2025
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Abstract
Objectives: Lung neuroendocrine tumors (LNETs) are rare, comprising 1–2% of lung cancers. This study aimed to compare overall survival (OS) and recurrence-free survival (RFS) after lobar resection versus sublobar resection for LNETs and to identify factors associated with prognosis and resection extent. Methods: [...] Read more.
Objectives: Lung neuroendocrine tumors (LNETs) are rare, comprising 1–2% of lung cancers. This study aimed to compare overall survival (OS) and recurrence-free survival (RFS) after lobar resection versus sublobar resection for LNETs and to identify factors associated with prognosis and resection extent. Methods: We retrospectively analyzed patients with clinical stage I (T ≤ 4 cm, N0M0) typical or atypical carcinoid who underwent curative resection at Hadassah Medical Center and Kaplan medical Center between 2010 and 2024. Results: Seventy patients (mean age 56.8 ± 16 years; 63% female) were included. Lobar resection was performed in 40 (57%) and sublobar resection in 30 (43%; 15 segmentectomies, 15 wedge resections). Pathology revealed 50 typical carcinoid (71.43%) and 20 atypical carcinoid (28.57%). Final pathological stage was I in 57 patients (81.42%), II in 9 (12.86%), and III in 4 (5.71%), reflecting surgical upstaging in 13 patients (18.57%), all due to nodal involvement. Atypical carcinoid was associated with worse RFS, nodal upstaging, and adjuvant therapy (all p < 0.01). Patients undergoing sublobar resection were older, had higher comorbidity scores, more frequently presented with peripheral tumors, and underwent less frequent lymph node assessment (all p < 0.01). At a median follow-up of 3.8 years for OS and 2.0 years for RFS, survival rates were 95.7% for both. Neither OS, RFS, nor postoperative normalization of plasma pro-gastrin-releasing peptide (ProGRPp) levels differed significantly between lobar resection and sublobar resection (p = 0.94, p = 0.42, and p = 0.205, respectively). Conclusions: Sublobar resection may represent an acceptable surgical option for selected patients with clinical stage I LNETs, particularly for peripheral tumors ≤ 2 cm in older or comorbid patients. The high rate of nodal upstaging underscores the need for lymph node assessment, irrespective of resection extent. Full article
(This article belongs to the Special Issue Latest Advances in Thoracic Surgery: 2nd Edition)
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