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Esophageal and Upper Gastrointestinal Surgery: Clinical Advances and Practical Updates

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 15 September 2026 | Viewed by 710

Editors


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Guest Editor
1. Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, Coimbra, Portugal
2. Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, Covilhã, Portugal
3. Department of General Surgery, Unidade Local de Saúde de Coimbra, Praceta Prof. Mota Pinto, Coimbra, Portugal
Interests: upper GI surgery; surgical oncology; gastric cancer; esophageal cancer; minimally invasive surgery; robotic surgery; enhanced recovery in surgery

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Guest Editor
Department of General, Visceral and Transplantation Surgery, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, Mainz, Germany
Interests: robotic surgery; upper GI surgery; surgical oncology; gastric cancer; esophageal cancer; minimally invasive surgery

Special Issue Information

Dear Colleagues,

Esophageal and upper gastrointestinal surgery has undergone significant transformation over the past few years, driven by advances in surgical techniques, perioperative care, imaging, and multidisciplinary management. Innovations in minimally invasive and robotic approaches, enhanced recovery protocols, and refined oncological strategies have contributed to improving patient outcomes and have expanded therapeutic possibilities for both benign and malignant diseases. At the same time, evolving evidence continues to reshape clinical decision-making in areas such as esophageal cancer treatment, foregut benign disorders, bariatric and metabolic surgery, and the management of complex postoperative complications.

This Special Issue aims to provide a comprehensive and up-to-date overview of current clinical advances and practical updates in esophageal and upper gastrointestinal surgery. We invite original research articles, review articles, systematic reviews, and expert perspectives that address contemporary challenges, novel surgical strategies, and future directions in this dynamic field. By bringing together contributions from surgeons, gastroenterologists, and allied specialists, this collection aims to promote knowledge exchange and support evidence-based practice, ultimately enhancing patient care and surgical outcomes worldwide.

Dr. Pedro Serralheiro
Prof. Dr. Peter Grimminger
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • esophageal cancer
  • gastric cancer
  • upper GI surgery
  • surgical oncology
  • benign upper GI surgery
  • surgical innovation
  • surgical outcomes
  • surgical guidelines
  • robotic surgery
  • minimally invasive surgery

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Published Papers (1 paper)

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Research

11 pages, 242 KB  
Article
Comparison of Endoscopic and Intraoperative Approaches in the Management of Delayed Gastric Conduit Emptying After Minimally Invasive Esophagectomy: A Single-Center Retrospective Analysis
by Ramin Raul Ossami Saidy, Philippa Seika, Max M. Maurer, Paul Viktor Ritschl, Matthias Biebl, Dino Kröll, Johann Pratschke and Christian Denecke
J. Clin. Med. 2026, 15(8), 2829; https://doi.org/10.3390/jcm15082829 - 8 Apr 2026
Viewed by 417
Abstract
Introduction: As multimodal therapy for esophageal cancer advances, addressing immediate and long-term functional outcomes following surgery has become more important. Despite surgical advancements, delayed gastric conduit emptying (DGCE) remains a primary cause of functional impairment after esophageal cancer resection. The literature addressing pylorus [...] Read more.
Introduction: As multimodal therapy for esophageal cancer advances, addressing immediate and long-term functional outcomes following surgery has become more important. Despite surgical advancements, delayed gastric conduit emptying (DGCE) remains a primary cause of functional impairment after esophageal cancer resection. The literature addressing pylorus management following minimally invasive esophagectomy (MIE) is scarce. The effects of pyloric drainage with pyloromyotomy or postoperative approaches such as intrapyloric Botox injection or dilatation on the incidence and course of DGCE were the focus of this study. Methods: A retrospective analysis of consecutive patients after minimally invasive esophagectomy with thoracic esophagogastric anastomosis and gastric tube reconstruction between 2014 and 2023 was performed. Univariate analyses were used to identify significant patient-, tumor-, and procedure-related factors affecting DGCE. Results: A total of 276 patients were included. DGCE was observed in 80 (28.9%) patients. Demographics did not differ with statistical significance. Postoperative complications were not increased in patients with DGCE. Pyloric intervention (PI) did not reduce postoperative occurrence of DGCE (PI: n = 19/23.75% compared to no PI: n = 62 (30.5%), p = 0.342). Median length of hospital stay was significantly longer, and total costs were significantly higher in patients with DGCE (p = 0.03 and p = 0.047, respectively). Analysis of endoscopic approaches was not associated with a statistically significant difference between botulinum toxin injection and pyloric dilatation with regard to reinterventions. Conclusions: While DGCE is frequent after esophagectomy, it is not associated with short-term morbidity but with prolonged total hospital stay and increased costs. Intraoperative pyloric intervention does not influence the incidence of DGCE after esophagectomy and endoscopic management was associated with therapeutic success, but choice of specific, optimal approach remains elusive. Novel concepts, including preoperative dilatation should be investigated. Full article
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