Recent Advances in Lymphedema

Dear Colleagues,

Lymphedema is a chronic, progressive condition that significantly impairs physical function, quality of life, and long-term health outcomes in patients worldwide. Over the past decade, substantial advances have been achieved in the understanding of lymphatic biology, pathophysiology, diagnostic imaging, and multidisciplinary treatment strategies. In particular, progress in microsurgical techniques such as lymphaticovenular anastomosis (LVA), vascularized lymph node transfer (VLNT), and immediate lymphatic reconstruction has transformed the surgical management of lymphedema.

At the same time, innovations in imaging and quantitative assessment modalities—including indocyanine green lymphography, ultrasonography, bioimpedance analysis, MRI lymphangiography, and other objective evaluation tools—have improved disease staging, early diagnosis, and treatment planning. Furthermore, emerging insights from molecular biology, inflammation, fibrosis research, and patient-reported outcome measures are reshaping how lymphedema is evaluated and treated.

This Special Issue aims to provide a comprehensive overview of recent advances in lymphedema through clinical innovations and outcome evaluation. We welcome original research articles, reviews, and clinical studies that contribute to improving prevention, diagnosis, and treatment strategies for lymphedema across disciplines.

Dr. Shinsuke Akita
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the Special Issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.