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Cardiac Arrest: Appropriate Prognostication and Therapeutic Options

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 15 September 2026 | Viewed by 314

Special Issue Editors


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Guest Editor
Department of Emergency Medicine, Dong-A University College of Medicine, Busan 49201, Republic of Korea
Interests: post-cardiac arrest care; emergency imaging; frontal EEG; echocardiography; volume responsiveness
Special Issues, Collections and Topics in MDPI journals

E-Mail
Guest Editor
Department of Emergency Medicine, College of Medicine, Chungnam National University, 266, Munhwa-ro, Jung-gu, Daejeon, Republic of Korea
Interests: cardiac arrest; post-cardiac arrest care; emergency imaging; frontal EEG; echocardiography; volume responsiveness
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Many efforts have been made to improve the survival rates of cardiac arrest patients. Despite ongoing debates, there remains a pressing need for better treatment methods and guidelines. Prognostic tools for identifying groups at risk of moderate-to-severe anoxic ischemia and management strategies for improving their outcomes are critical issues of our time. While concerns about early prognostication persist, it is essential to use modalities such as brain MRI, EEG, and others for early prognosis prediction and to consider therapeutic interventions for eligible patients. Rapid CPR, early defibrillation, cause-specific treatments for cardiac arrest, and various supportive care options can enhance the neurological outcomes of these patients. In this Special Issue, we invite authors to submit papers on novel approaches and improved therapeutic options based on prognosis in cardiac arrest patients.

Dr. Jae Hoon Lee
Dr. Jin-hong Min
Guest Editors

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Keywords

  • cardiac arrest
  • prognosis
  • hypothermia, induced
  • resuscitation
  • magnetic resonance imaging
  • electroencephalog-raphy
  • blood pressure
  • hypoxia-ischemia, brain
  • extracorporeal membrane oxygenation

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Published Papers (1 paper)

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Research

12 pages, 373 KB  
Article
Association Between Illness Severity Scores and Quantitatively Measured Brain Injury in Cardiac Arrest Survivors
by Junho Lee, Jung Soo Park, Yeonho You, Jin Hong Min, So Young Jeon, Wonjoon Jeong and Changshin Kang
J. Clin. Med. 2026, 15(9), 3427; https://doi.org/10.3390/jcm15093427 - 30 Apr 2026
Viewed by 154
Abstract
Introduction: This study explored how illness severity scores correspond to hypoxic-ischemic brain injury (HIBI) after cardiac arrest. Methods: This study included cardiac arrest survivors with sufficient data to calculate the Pittsburgh Cardiac Arrest Category (PCAC) and revised post-cardiac arrest syndrome for [...] Read more.
Introduction: This study explored how illness severity scores correspond to hypoxic-ischemic brain injury (HIBI) after cardiac arrest. Methods: This study included cardiac arrest survivors with sufficient data to calculate the Pittsburgh Cardiac Arrest Category (PCAC) and revised post-cardiac arrest syndrome for therapeutic hypothermia (rCAST) scores who underwent brain magnetic resonance imaging and cerebrospinal fluid neuron–specific enolase (CSF-NSE) measurement within 6 h after return of spontaneous circulation. The primary outcome was the association of PCAC and rCAST with quantitative brain injury markers assessed using whole brain mean apparent diffusion coefficient (mean ADC), low ADC volume fractions (PV600, 650, and 700), and CSF-NSE. Results: In total, 81 patients were included. PCAC was not significantly associated with CSF-NSE, mean ADC, or PVs. The rCAST score was significantly associated with higher CSF-NSE, lower mean ADC, and higher PV700. The neurologic sub-score of PCAC was independently associated with all evaluated brain injury markers, whereas the systemic sub-score was not. Of the individual rCAST components, anoxic time was independently associated with CSF-NSE, whereas no other single component was associated with these markers. Conclusions: rCAST was significantly associated with degree of HIBI, whereas PCAC was not. The neurologic sub-score of PCAC showed independent associations with HIBI. Full article
(This article belongs to the Special Issue Cardiac Arrest: Appropriate Prognostication and Therapeutic Options)
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