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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Developments in Reproductive Endocrinology
edited by Birute Žilaitiené and Jonas Čeponis
submission deadline 25 Apr 2026 | Viewed by 350 | Submission Open
Keywords: hypogonadism; infertility; sex hormone deficiency; reproductive endocrinology; sexual health; assisted reproduction
(This special issue belongs to the Section Endocrinology & Metabolism)
Sarcoma—Clinical Updates: 2nd Edition
edited by
submission deadline 25 Apr 2026 | 1 articles | Viewed by 300 | Submission Open
Keywords: sarcoma; osteosarcoma; ewing’ s sarcoma; chondrosarcoma; soft-tissue sarcoma; undifferentiated pleo-morphic sarcoma; liposarcoma; leiomyosarcoma; rhabdomyosarcoma; metastatic sarcoma; targeted molecular therapy; immunotherapy; orthopedic oncology
(This special issue belongs to the Section Oncology)
Novel Diagnostic and Therapeutic Approaches to Urologic Oncology
edited by , Bogdan Florin Geavlete and
submission deadline 25 Apr 2026 | Viewed by 217 | Submission Open
Keywords: diagnosis; therapy; up-to-date; uro-oncologic pathology
(This special issue belongs to the Section Oncology)
New Concepts in Minimally Invasive Spine Surgery
edited by and Michael Y. Wang
submission deadline 25 Apr 2026 | Viewed by 191 | Submission Open
Keywords: minimally invasive spine surgery; image navigation; tubular retractor; endoscopic spine surgery; virtual and aug-mented reality; lateral spine surgery
(This special issue belongs to the Section Clinical Neurology)
Liver Failure: Current Status and Future Opportunities
edited by
submission deadline 25 Apr 2026 | Viewed by 107 | Submission Open
Keywords: acute liver failure; acute-on-chronic liver failure; portal hypertension; hepatic encephalopathy; pathogenesis; management
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Clinical Advances in Orthopedic Oncology
edited by
submission deadline 25 Apr 2026 | Viewed by 93 | Submission Open
Keywords: orthopedic oncology; sarcoma; soft-tissue sarcoma; osteosarcoma; chondrosarcoma; Ewings sarcoma; giant cell tumor; limb salvage; mega-prosthetic reconstruction; targeted molecular therapy; immunotherapy
(This special issue belongs to the Section Orthopedics)
Emerging Surgical Techniques in the Management of Urological Diseases
edited by
submission deadline 25 Apr 2026 | Viewed by 90 | Submission Open
Keywords: minimally invasive; robotics; partial nephrectomy; radical prostatectomy; focal therapy; benign prostatic hyperplasia; prostate cancer; bladder cancer
(This special issue belongs to the Section Nephrology & Urology)
Diagnosis, Treatment and Prognosis of Coronary Heart Disease: 2nd Edition
edited by
submission deadline 25 Apr 2026 | Viewed by 89 | Submission Open
Keywords: coronary heart disease; acute coronary syndrome; chronic coronary syndrome; ischemia with no obstructive coronary arteries (INOCA); guideline-directed optimal medical therapy; precision medicine; artificial intelligence; interventional cardiology; percutaneous coronary intervention (PCI)
(This special issue belongs to the Section Cardiology)
Advances in Reconstructive and Aesthetic Plastic Surgery
edited by
submission deadline 25 Apr 2026 | Viewed by 87 | Submission Open
Keywords: reconstructive plastic surgery; aesthetic innovation; fat grafting; microsurgery; regenerative medicine; cell-enriched lipotransfer; 3D imaging; minimally invasive techniques; hybrid injectables
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Complex Scenarios in Reverse Shoulder Arthroplasty: Bone Loss, Revisions, and Surgical Solutions
edited by Francesco Franceschi, Angelo Baldari and Antonio Caldaria
submission deadline 25 Apr 2026 | Viewed by 71 | Submission Open
Keywords: shoulder arthroplasty; revision shoulder arthroplasty; humeral fracture; failed shoulder prosthesis; bone loss management; implant failure
(This special issue belongs to the Section Orthopedics)
Personalized Therapy and Clinical Outcome for Retinal Diseases
edited by
submission deadline 25 Apr 2026 | Viewed by 64 | Submission Open
Keywords: retinal diseases; retinal imaging; clinical outcomes; artificial intelligence; biomarkers; optical coherence tomography (OCT); vitrectomy
(This special issue belongs to the Section Ophthalmology)
Sex- and Age-Related Differences in Exercise Response: Clinical Implications for Health and Disease
edited by
submission deadline 26 Apr 2026 | 2 articles | Viewed by 1279 | Submission Open
Keywords: exercise intervention; clinical exercise physiology; sex differences; age-related response; metabolic disorders; personalized medicine; physical activity; chronic disease management
(This special issue belongs to the Section Sports Medicine)
Recent Advances in the Diagnosis and Treatment of Gastrointestinal Diseases
edited by
submission deadline 27 Apr 2026 | 5 articles | Viewed by 5154 | Submission Open
Keywords: advanced endoscopy; innovation in GI; pathophysiology of GI disorders; artificial intelligence in GI; gastrointestinal diseases
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advancing Minimally Invasive Spine Surgery: A Special Edition on Endoscopic Spine Surgery
edited by and Gregory W. Basil
submission deadline 28 Apr 2026 | 4 articles | Viewed by 6919 | Submission Open
Keywords: minimally invasive spine surgery (MIS); endoscopic spine surgery (ESS); spine surgery; percutaneous spine surgery; full-endoscopic spine surgery; biportal endoscopic spine surgery (BESS); unilateral biportal endoscopy (UBE); percutaneous endoscopic lumbar discectomy (PELD); endoscopic decompression; transforaminal endoscopic lumbar discectomy (TELD); interlaminar endoscopic lumbar discectomy (IELD); endoscopic lumbar fusion; endoscopic transforaminal lumbar interbody fusion (Endo-TLIF)
(This special issue belongs to the Section Clinical Neurology)
Recent Advances and Clinical Outcomes of Hip and Knee Arthroplasty
edited by
submission deadline 28 Apr 2026 | 3 articles | Viewed by 2750 | Submission Open
Keywords: hip arthroplasty; knee arthroplasty; joint replacement; clinical outcomes; surgical innovation; patient recovery; prosthetics; perioperative care
(This special issue belongs to the Section Orthopedics)
Selected Papers from the 3rd International Online Conference on Clinical Medicine submission deadline 28 Apr 2026 | 1 articles | Viewed by 1608 | Submission Open
Keywords: cardiology; cardiovascular medicine; nephrology; urology; emergency medicine; nuclear medicine & radiology; general surgery; clinical rehabilitation; respiratory medicine; anesthesiology
Current Trends in Hand Surgery
edited by and Florian Frueh
submission deadline 28 Apr 2026 | 1 articles | Viewed by 1206 | Submission Open
Keywords: microsurgery; minimally invasive; arthroscopy; sonography; nerve surgery; joint replacement
(This special issue belongs to the Section Orthopedics)
Symptoms and Treatment of Cardiac Amyloidosis
edited by Syed Bukhari
submission deadline 28 Apr 2026 | Viewed by 275 | Submission Open
Keywords: cardiac amyloidosis; transthyretin amyloidosis; light chain amyloidosis; cardiac magnetic resonance; echocardiography; nuclear scintigraphy; endomyocardial biopsy; gene silencers; transthyretin stabilizers; immunotherapy
(This special issue belongs to the Section Cardiology)
Periodontal and Other Associated Oral Diseases: Diagnosis and Management in the Context of Systemic Pathology, 2nd Edition submission deadline 30 Apr 2026 | 4 articles | Viewed by 7907 | Submission Open
Keywords: periodontitis; oral diseases; periimplantitis; biomarkers; cytokines; oxidative stress markers; PCR test; point-of-care test; CBCT; periodontal treatment; immunomodulatory therapy; local drug delivery
(This special issue belongs to the Section Otolaryngology)
Sequelae of COVID-19: Clinical to Prognostic Follow-Up submission deadline 30 Apr 2026 | 6 articles | Viewed by 5356 | Submission Open
Keywords: COVID-19; post-COVID-19 syndromes; sequelae of COVID-19; pathophysiological pathways; multiorgan sequelae; long-term management of post-COVID-19 syndromes; quality of life; long-term prognosis of COVID-19
(This special issue belongs to the Section Vascular Medicine)
Rehabilitation Strategies for Neurological Disorders: Advances and Insights
edited by Delia Cinteză and Mihai Berteanu
submission deadline 30 Apr 2026 | 4 articles | Viewed by 3581 | Submission Open
Keywords: neurorehabilitation; physical medicine; virtual reality; AI in rehabilitation medicine; robotic rehabilitation; telerehabilitation; advanced technologies; upper neuromotor lesions; peripheral neuropathies; wearable sensor devices; assessment; goal-setting; individual rehabilitation plan
(This special issue belongs to the Section Clinical Rehabilitation)
Interstitial Lung Diseases: New Treatments and Future Directions
edited by Justyna Fijołek
submission deadline 30 Apr 2026 | 1 articles | Viewed by 3576 | Submission Open
Keywords: Interstitial Lung Disease (ILD); pulmonary fibrosis; orphan lung disease; AAV-ILD; occupational ILD; rheumatic lung disease; treatment strategies; emerging therapies; precision medicine; future directions
(This special issue belongs to the Section Respiratory Medicine)
Advances in Gastroenterological Surgery
edited by Alan Biloslavo and Antonio La Greca
submission deadline 30 Apr 2026 | 3 articles | Viewed by 3106 | Submission Open
Keywords: mini-invasive surgery; technology; artificial intelligence; negative pressure; indocyanine green; ultrasound; GE surgery; emergency surgery; precision surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Diabetic Retinopathy Screening: Current Advances and Future Options submission deadline 30 Apr 2026 | 1 articles | Viewed by 1353 | Submission Open
Keywords: diabetic retinopathy; diabetic retinopathy screening; retinal imaging; age-related macular degeneration; artificial intelli-gence; image analysis; color fundus photography; optical coherence tomography imaging; telemedicine
(This special issue belongs to the Section Ophthalmology)
New Advances in the Management of Voice Disorders: 2nd Edition submission deadline 30 Apr 2026 | 1 articles | Viewed by 1317 | Submission Open
Keywords: voice disorders; laryngology; laryngoscope; acoustic analysis; dysphonia; voice surgery; diagnosis; treatment; rehabilitation; vocal folds; voice assessment/measures
(This special issue belongs to the Section Otolaryngology)
Clinical Challenges and Innovations in Cochlear Implantation and Hearing Rehabilitation
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 359 | Submission Open
Keywords: cochlear implant outcomes; clinical efficiency; barriers to care; cochlear implant surgery; cochlear implant referral; cochlear implant evaluation; cochlear implant candidacy; rehabilitation; rehabilitation strategies; quality of life
(This special issue belongs to the Section Otolaryngology)
Skin Cancers: Update on Clinical Treatment and Management
edited by Nazzaro Gianluca
submission deadline 30 Apr 2026 | Viewed by 203 | Submission Open
Keywords: basal cell carcinoma; squamous cell carcinoma; melanoma; skin cancers; dermoscopy; ultrasonography; immunotherapy; biomarker; prevention; diagnosis; treatment; innovative treatments; prognosis
(This special issue belongs to the Section Dermatology)
New Clinical Advances in Depressive Disorders and Treatment-Resistant Depression
edited by Giacomo d'Andrea and Miriam Olivola
submission deadline 30 Apr 2026 | Viewed by 135 | Submission Open
Keywords: treatment-resistant depression; MDD; ketamine; esketamine; rTMS; psylocibin; bipolar depression; clinical pheno-typing; precision psychiatry; biomarkers
(This special issue belongs to the Section Mental Health)
New Clinical Advances in Psoriasis and Psoriatic Arthritis: 2nd Edition
edited by and Alessandra Narcisi
submission deadline 30 Apr 2026 | Viewed by 125 | Submission Open
Keywords: psoriasis; psoriatic arthritis; inflammatory skin disease; inflammatory autoimmune disease; immunotherapy; autoimmunity; comorbidities; therapeutic; diagnosis; treatment; management; biologics
(This special issue belongs to the Section Dermatology)
Advances in Clinical Craniofacial Reconstructive Surgery
edited by Rami S. Kantar
submission deadline 30 Apr 2026 | Viewed by 116 | Submission Open
Keywords: craniofacial; craniofacial conditions; craniofacial surgery; cleft; cleft lip; cleft palate; reconstructive surgery; craniofacial anomalies
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Orthopedic Approaches to Acute Trauma: Insights and Strategies in Trauma Care submission deadline 30 Apr 2026 | Viewed by 115 | Submission Open
Keywords: acute trauma; orthopedic surgery; fractures and dislocations; ligament injuries; cartilage lesions; post-traumatic degeneration; emergency trauma care; surgical and non-surgical management; rehabilitation strategies; musculo-skeletal injury outcomes
(This special issue belongs to the Section Orthopedics)
Insight into Infectious Disease Epidemiology and Public Health
edited by and Filomena Pietrantonio
submission deadline 30 Apr 2026 | Viewed by 92 | Submission Open
Keywords: gender medicine; health management; public health; infectious disease; sindemics
(This special issue belongs to the Section Infectious Diseases)
Surgical Insights into Foot and Ankle Diseases
edited by Konstantinos Tsikopoulos
submission deadline 30 Apr 2026 | Viewed by 81 | Submission Open
Keywords: lower limb surgery; infection research; foot and ankle
(This special issue belongs to the Section Orthopedics)
Clinical Updates and New Perspectives of Chronic Pain
edited by Yohannes W. Woldeamanuel
submission deadline 30 Apr 2026 | Viewed by 80 | Submission Open
Keywords: circadian rhythms; chronic pain; clock genes; neuroinflammation; chronotherapy; migraine; cancer survivors; sex differences; racial disparities; personalized medicine
(This special issue belongs to the Section Clinical Neurology)
Advances in Cardiovascular Computed Tomography (CT)
edited by
submission deadline 30 Apr 2026 | Viewed by 74 | Submission Open
Keywords: computed tomography angiography; cardiovascular imaging; contrast media; spectral computed tomography; quantitative imaging; coronary artery disease; aortic disease; pulmonary embolism; structural heart disease
(This special issue belongs to the Section Cardiovascular Medicine)
Head and Neck Cancer: Clinical Diagnostics and Treatments
edited by Matti Anniko
submission deadline 30 Apr 2026 | Viewed by 67 | Submission Open
Keywords: head and neck cancer; treatment; surgery; chemotherapy; immunotherapy; diagnostics
(This special issue belongs to the Section Otolaryngology)
Antithrombotic Therapy in Special and Overlooked Populations with Cardiovascular Diseases
edited by
submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open
Keywords: antithrombotic therapy; high-risk patients; PCI; bleeding risk; atrial fibrillation; individualized treatment; real-world evidence; complex cardiovascular disease
(This special issue belongs to the Section Cardiovascular Medicine)
Congenital Heart Disease in Adults (ACHD): Diagnosis, Therapy, and Clinical Management
edited by Mirosław Kowalski
submission deadline 30 Apr 2026 | Viewed by 23 | Submission Open
Keywords: congenital cardiac defect in adults; right ventricular failure; strain echocardiography; ventricular mechanics; cardiac resynchronizing therapy (CRT); Fontan operation; protein-losing enteropathy (PLE)
(This special issue belongs to the Section Cardiology)
Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) and Concomitant Illnesses: Diagnostic and Therapeutic Implications
edited by Kamran Qureshi and Lewis Frey
submission deadline 30 Apr 2026 | Viewed by 22 | Submission Open
Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); chronic liver diseases; metabolic syndrome; viral hepatitis; autoimmune liver diseases
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
The Role of Cardiac Rehabilitation After Myocardial Infarction, Coronary Artery Bypass Surgery, and in Other Cardiac Diseases
edited by
submission deadline 1 May 2026 | 3 articles | Viewed by 5620 | Submission Open
Keywords: cardiac rehabilitation; coronary artery disease; myocardial infarction; coronary artery bypass surgery; heart failure; ventricular assist device; heart transplantation; cardiomyopathies; cardiac remodeling; illness perception; treatment adherence; gender difference; biomarkers; endothelial function
(This special issue belongs to the Section Cardiology)
Recent Advancements in Periodontal and Peri-Implant Disease Management
edited by and Leticia Helena Theodoro
submission deadline 5 May 2026 | Viewed by 241 | Submission Open
Keywords: periodontal disease; peri-implantitis; periodontal medicine; complications and management
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advancements and Challenges in Reconstructive Urology and Urethral Surgery
edited by
submission deadline 10 May 2026 | 3 articles | Viewed by 3302 | Submission Open
Keywords: reconstructive urology; urethral surgery; urethroplasty; minimally invasive surgery; robotic-assisted surgery; urinary tract reconstruction; surgical innovation; patient-reported outcomes
(This special issue belongs to the Section Nephrology & Urology)
Advances in Chronic Pain and Related Management
edited by
submission deadline 10 May 2026 | Viewed by 131 | Submission Open
Keywords: chronic pain; musculoskeletal pain; neuropathic pain; fibromyalgia syndrome; somatoform disorder; post-COVID syndrome; small fiber disease; invasive pain therapy; vagus stimulation
(This special issue belongs to the Section Anesthesiology)
Quality of Life in Patients with Gynecological Cancers
edited by , and Monika Englert-Golon
submission deadline 10 May 2026 | Viewed by 81 | Submission Open
Keywords: quality of life; gynecology oncology; ovarian cancer; breast cancer; cervical cancer; endometrial cancer; women; gynecological diseases; oncological diseases
(This special issue belongs to the Section Obstetrics & Gynecology)
Prevention and Management of Sexual Dysfunction
edited by Grażyna Jarząbek-Bielecka and Katarzyna Plagens-Rotman
submission deadline 10 May 2026 | Viewed by 68 | Submission Open
Keywords: sexual health; sexual dysfunction; reproductive health; general sexuology; sexological care
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Innovations, Biomarkers, and Challenges in Cancer Immunotherapy
edited by and Mahzad Akbarpour
submission deadline 10 May 2026 | Viewed by 64 | Submission Open
Keywords: next-generation cellular therapies; CAR-NK cell therapy; CAR-T cell therapy; combination strategies; exosomes; T-cell engagers; oncolytic viruses; cancer immunotherapy; biomarkers for therapy response; translational immunotherapy; tumor microenvironment modulation; immune evasion mechanisms
(This special issue belongs to the Section Oncology)
Challenging ICU Dogma: Where Routine Practice and Evidence Collide
edited by and Nobutake Shimojo
submission deadline 10 May 2026 | Viewed by 38 | Submission Open
Keywords: critical care; intensive care unit (ICU); clinical dogma; de-implementation; medical reversal; routine practices; clinical decision-making
(This special issue belongs to the Section Intensive Care)
Revolutionizing Arrhythmia Therapy: Novel Approaches in Pacing and Defibrillation submission deadline 10 May 2026 | Viewed by 34 | Submission Open
Keywords: cardiac resynchronization therapy; conduction system pacing; left bundle branch area pacing; S-ICD; EV-ICD
(This special issue belongs to the Section Cardiology)
Advances in the Management of Chronic Lymphocytic Leukemia submission deadline 12 May 2026 | 1 articles | Viewed by 377 | Submission Open
Keywords: chronic lymphocytic leukemia; lymphoproliferative disorders; prognostic factors; targeted therapy; CAR T cell; elderly patients; comorbidities
(This special issue belongs to the Section Hematology)
Chronic Kidney Disease Management: Integrating Pharmacotherapy, Biomarkers, and Lifestyle Interventions for Improved Outcomes
edited by
submission deadline 15 May 2026 | 2 articles | Viewed by 1884 | Submission Open
Keywords: nephrology; chronic kidney disease; cardiovascular risk; risk stratification; biomarkers; evidence-based treatment
(This special issue belongs to the Section Nephrology & Urology)
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