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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Sepsis and Septic Shock: Diagnosis, Treatment, and Prognosis
edited by Luigi Carbone and Daniela Pugliese
submission deadline 20 Apr 2027 | 6 articles | Viewed by 4435 | Submission Open
Keywords: sepsis; septic shock; diagnosis and screening tools; risk stratification; machine learning; advanced therapies
(This special issue belongs to the Section Intensive Care)
New Clinical Advances in Chronic Asthma—2nd Edition
edited by Vitaliano Nicola Quaranta
submission deadline 20 Apr 2027 | 4 articles | Viewed by 4276 | Submission Open
Keywords: chronic asthma; breathlessness; coughing; inhaled corticosteroids (ICS); long-acting beta-agonists (LABAs); personalized treatment; chronic rhinosinusitis; nasal polyps; bronchiectasis; endotypes; oral corticosteroids
(This special issue belongs to the Section Respiratory Medicine)
Hidradenitis Suppurativa: Clinical Diagnosis, Treatment, and Management
edited by Piotr K. Krajewski
submission deadline 20 Apr 2027 | 5 articles | Viewed by 4126 | Submission Open
Keywords: hidradenitis suppurativa; acne inversa; clinical diagnosis; disease severity assessment; biologic therapy; surgical management; comorbidities; quality of life; multidisciplinary care; real world evidence
(This special issue belongs to the Section Dermatology)
Non-Pharmacological Therapies and Exercise Interventions in Clinical Populations submission deadline 20 Apr 2027 | 4 articles | Viewed by 4068 | Submission Open
Keywords: non-pharmacological interventions; physiotherapy approaches; physical activity; acute and chronic diseases; acute and chronic pain
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Outcomes of Glaucoma Surgery: Visual Acuity, Effectiveness and Quality of Life submission deadline 20 Apr 2027 | 6 articles | Viewed by 3636 | Submission Open
Keywords: glaucoma surgery; visual acuity; intraocular pressure; surgical outcomes; trabeculectomy; microinvasive glaucoma surgery; postoperative complications; functional vision
(This special issue belongs to the Section Ophthalmology)
Clinical Therapeutic Advances of Mitral Regurgitation
edited by Angelo Squeri
submission deadline 20 Apr 2027 | 4 articles | Viewed by 3386 | Submission Open
Keywords: mitral regurgitation; mitral valve prolapse; cardiovascular interventions; heart surgery; echocardiography; mag-netic resonance imaging; computed tomography
(This special issue belongs to the Section Cardiovascular Medicine)
Anesthesia and Intensive Care: Clinical Practices and Prospects
edited by
submission deadline 20 Apr 2027 | 4 articles | Viewed by 3296 | Submission Open
Keywords: artificial intelligence; clinical decision support; perioperative risk stratification; perioperative patient safety; hemodynamic optimization
(This special issue belongs to the Section Intensive Care)
Enhancing and Rehabilitation of Gait and Mobility in Chronic Stroke submission deadline 20 Apr 2027 | 1 articles | Viewed by 3113 | Submission Open
Keywords: chronic stroke; gait rehabilitation; mobility; physical therapy; technology-assisted interventions; assessment
(This special issue belongs to the Section Clinical Neurology)
Advances in the Diagnosis and Management of Age-Related Macular Degeneration: 3rd Edition
edited by Tsutomu Yasukawa
submission deadline 20 Apr 2027 | 4 articles | Viewed by 3007 | Submission Open
Keywords: age-related macular degeneration; angiography; anti-vascular endothelial growth factor therapy; geographic atrophy; macular neovascularization; multimodal imaging; ophthalmology; optical coherence tomography; photodynamic therapy; retinal pigment epithelium
(This special issue belongs to the Section Ophthalmology)
Cardiovascular Prevention and Epidemiology: Innovations and Insights Bridging Research and Practice for Effective Risk Reduction
edited by and Maria Maiello
submission deadline 20 Apr 2027 | 3 articles | Viewed by 2943 | Submission Open
Keywords: cardiovascular prevention; risk reduction; epidemiology; innovations; risk stratification; population health
(This special issue belongs to the Section Cardiovascular Medicine)
Orthopaedic Trauma and Bone Healing: Recent Advances and Future Perspectives
edited by Gheorghe Tomoaia and Daniel Oltean-Dan
submission deadline 20 Apr 2027 | 4 articles | Viewed by 2396 | Submission Open
Keywords: orthopaedic trauma; fractures; minimally invasive fixation; bone healing; biomaterials; periprosthetic fractures; artificial intelligence; rehabilitation; complications; orthopaedic surgery
(This special issue belongs to the Section Orthopedics)
Advances in the Management of Cervical Spine Trauma submission deadline 20 Apr 2027 | 3 articles | Viewed by 2274 | Submission Open
Keywords: cervical spine trauma; cervical fracture; high cervical injury; subaxial injury; surgical management; occipitocervical fusion; C1 fracture; C2 fracture; spinal stability; trauma imaging; spinal cord injury; neurological outcome
(This special issue belongs to the Section Orthopedics)
Clinical Advances in Geriatric Acute Care: Multimorbidity, Frailty, and Integrated Diagnostics submission deadline 20 Apr 2027 | 3 articles | Viewed by 2243 | Submission Open
Keywords: geriatric medicine; frailty; multidimensional assessment; lung ultrasound; point-of-care ultrasound; acute care of older adults; transitional care
(This special issue belongs to the Section Geriatric Medicine)
Endocrine Surgery: Current Treatment and Future Options
edited by Pietro Princi and
submission deadline 20 Apr 2027 | 1 articles | Viewed by 2227 | Submission Open
Keywords: endocrine surgery; thyroid surgery; parathyroid surgery; adrenal gland surgery; neuroendocrine neoplasms; thyroid cancer; thyroid cancer treatment; surgical endocrinology; robotic endocrine surgery; laparoscopic adrenalectomy; ret-roperitoneoscopic adrenalectomy; parathyroidectomy; benign thyroid disease; thyroid ablation
(This special issue belongs to the Section General Surgery)
From Clinical Diagnosis to Effective Treatment of Cardiomyopathy submission deadline 20 Apr 2027 | 2 articles | Viewed by 2003 | Submission Open
Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathy; non-ischemic cardiomyopathy; cardiac MRI; PET/CT; PET/MRI; cardiac imaging; sudden cardiac death
(This special issue belongs to the Section Cardiology)
Advances in Trauma and Orthopedic Surgery: 3rd Edition submission deadline 20 Apr 2027 | 2 articles | Viewed by 1868 | Submission Open
Keywords: trauma; fracture; fracture fixation; osteosynthesis; biomechanics; bone; approach; nonunion; joint replacement; outcome
(This special issue belongs to the Section Orthopedics)
Advances in Cardiac Surgery: Techniques, Outcomes, and Innovations
edited by , Horatiu Suciu and
submission deadline 20 Apr 2027 | 3 articles | Viewed by 1741 | Submission Open
Keywords: endoscopic cardiac surgery; minimally invasive cardiac surgery; MIMS; mini-AVR; MIDCAB; TCRAT; LVAD; heart transplant; congenital heart disease
(This special issue belongs to the Section Cardiology)
Spine Surgery and Postoperative Management
edited by Mitchell K. Ng
submission deadline 20 Apr 2027 | 3 articles | Viewed by 1578 | Submission Open
Keywords: spine surgery; perioperative care; enhanced recovery after surgery (ERAS); multimodal analgesia; opioid-sparing strategies; neuromonitoring; perioperative optimization
(This special issue belongs to the Section Orthopedics)
Clinical Applications and Surgical Integration of Advanced Ophthalmic Imaging
edited by Katarzyna Nowomiejska
submission deadline 20 Apr 2027 | 2 articles | Viewed by 1530 | Submission Open
Keywords: ophthalmic imaging; retina; intraoperative OCT; personalized treatment; clinical applications
(This special issue belongs to the Section Ophthalmology)
Diagnosis and Clinical Management in Hematologic Oncology
edited by Sunil Lakhwani and José María Raya-Sánchez
submission deadline 20 Apr 2027 | 3 articles | Viewed by 1519 | Submission Open
Keywords: hematologic malignancies; lymphoma; multiple myeloma; acute leukemia; myeloproliferative neoplasms; molecular diagnostics; targeted therapy; immunotherapy; prognostic biomarkers; clinical management
(This special issue belongs to the Section Hematology)
Electrotherapy and Electrodiagnostic in Modern Rehabilitation Medicine: Current Evidence, Clinical Applications, and Future Perspectives
edited by Cristina Octaviana Daia
submission deadline 20 Apr 2027 | 1 articles | Viewed by 1397 | Submission Open
Keywords: electrotherapy; physical and rehabilitation medicine; rehabilitation technologies; neurorehabilitation; cancer rehabilitation; electromyography; nerve conduction studies; musculoskeletal ultrasound; photobiomodula-tion; neuromuscular electrical stimulation; therapeutic ultrasound; extracorporeal shockwave therapy; electromagnetic field therapy; TECAR therapy
(This special issue belongs to the Section Clinical Rehabilitation)
Heart Failure and Transplant Cardiology: Latest Advances and Prospects
edited by Monika Budnik
submission deadline 20 Apr 2027 | 1 articles | Viewed by 1307 | Submission Open
Keywords: heart failure; heart transplantation; bridge to transplant; mechanical circulatory support; cardiomyopathies
(This special issue belongs to the Section Cardiology)
Endometriosis: Advances in Diagnosis, Treatment, and Long-Term Outcomes
edited by
submission deadline 20 Apr 2027 | 2 articles | Viewed by 1257 | Submission Open
Keywords: endometriosis; diagnosis and biomarkers; medical and surgical treatment; fertility and reproductive outcomes; pain management; quality of life; long-term follow-up
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Advances in Hearing Loss: Diagnosis, Treatment, and Management
edited by
submission deadline 20 Apr 2027 | 2 articles | Viewed by 961 | Submission Open
Keywords: hearing loss; deafness; bone conduction implants; middle ear implants; cochlear implants; myringoplasty; tympanoplasty; stapedotomy; ossicular chain reconstruction; imaging; audiological diagnostic
(This special issue belongs to the Section Otolaryngology)
Contemporary Coronary Intervention: Innovation, Evidence, and Patient-Centred Outcomes
edited by Kevin Liou
submission deadline 20 Apr 2027 | 1 articles | Viewed by 948 | Submission Open
Keywords: percutaneous coronary interventions; coronary imaging; coronary physiology; precision medicine; CHIP PCI; stent-less technologies; clinical outcomes; pharmacotherapy in PCI; biomarkers; artificial intelligence in PCI; sustainability in PCI
(This special issue belongs to the Section Cardiology)
Advanced Coronary Physiology and Imaging-Guided Percutaneous Cardiovascular Interventions: Treatment Approaches and Outcomes
edited by Ioannis Skalidis
submission deadline 20 Apr 2027 | 1 articles | Viewed by 852 | Submission Open
Keywords: acute coronary syndromes; chronic coronary syndromes; coronary physiology; intravascular imaging; artificial in-telligence; percutaneous coronary intervention; complex coronary disease
(This special issue belongs to the Section Cardiology)
Current Trends and Progress in Eating Disorders and Obesity Management
edited by Davide Gravina, and
submission deadline 20 Apr 2027 | 1 articles | Viewed by 843 | Submission Open
Keywords: eating disorders; anorexia nervosa; bulimia nervosa; binge-eating disorder; ARFID; obesity; neuromodulation; biomarkers; gut microbiome; pharmacological interventions; incretin receptor agonists; GLP-1; metreleptin; psychedelics
(This special issue belongs to the Section Mental Health)
Spine Surgery: Clinical Advances and Future Directions—2nd Edition
edited by Eun-Sang Kim and
submission deadline 20 Apr 2027 | 1 articles | Viewed by 786 | Submission Open
Keywords: spine surgery; back pain; endoscopic spine surgery; cage implantation; neck pain
(This special issue belongs to the Section Clinical Neurology)
Physiotherapy: Multidisciplinary Interventions and Digital Health submission deadline 20 Apr 2027 | 1 articles | Viewed by 771 | Submission Open
Keywords: physiotherapy; rehabilitation; physical medicine; digital health; telemedicine; virtual reality; augmented reality; artifi-cial intelligence; robotic rehabilitation; wearable sensors; VR for educative goals; musculoskeletal, neurological, cognitive, pediatric, pulmonary, cardiac and gyneco-obstetric disorders; fibromyalgia syndrome; chronic pain; older adults
(This special issue belongs to the Section Clinical Rehabilitation)
Breaking the Barrier: Early Detection of Pancreatic Ductal Adenocarcinoma (PDAC) submission deadline 20 Apr 2027 | 1 articles | Viewed by 734 | Submission Open
Keywords: pancreatic ductal adenocarcinoma (PDAC); pancreatic cancer; IPMN; PDAC screening; early PDAC detection; PDAC biomarkers; CT; NMR
(This special issue belongs to the Section Oncology)
Hepatobiliary–Pancreatic Surgery in the Era of Interventional Radiology
edited by
submission deadline 20 Apr 2027 | 1 articles | Viewed by 729 | Submission Open
Keywords: hepato-biliary–pancreatic surgery; interventional radiology; percutaneous biliary drainage; percutaneous pancre-atic drainage; portal vein embolization; tumor ablation; minimally invasive surgery; cryoablation; thermoablation
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Anterior Segment Disorders
edited by Itay Lavy and
submission deadline 20 Apr 2027 | 1 articles | Viewed by 713 | Submission Open
Keywords: anterior segment disorders; corneal disease; cataract surgery; ocular surface disease; surgical outcomes; surgical techniques; artificial intelligence in diagnosis; diagnostic imaging; pharmacological and surgical interventions; refractive errors; anterior uveitis; keratitis; corneal ectasia; quality of life
(This special issue belongs to the Section Ophthalmology)
Advances in Diagnosis, Monitoring, and Treatment of Myocardial Infarction
edited by
submission deadline 20 Apr 2027 | 1 articles | Viewed by 682 | Submission Open
Keywords: myocardial infarction (MI); occlusion myocardial infarction (OMI); myocardial infarction with non-obstructive coronary arteries (MINOCA); diagnosis; monitoring; treatment
(This special issue belongs to the Section Cardiovascular Medicine)
Current Practice and Future Directions in Hemodialysis and Peritoneal Dialysis
edited by
submission deadline 20 Apr 2027 | 1 articles | Viewed by 595 | Submission Open
Keywords: kidney replacement therapy; hemodialysis; peritoneal dialysis; dialysis nursing; continuous renal replacement therapy; incremental dialysis; decremental dialysis
(This special issue belongs to the Section Nephrology & Urology)
Advances in Rehabilitation and Musculoskeletal Health
edited by , and Daniela Matei
submission deadline 20 Apr 2027 | 1 articles | Viewed by 517 | Submission Open
Keywords: musculoskeletal disorders; musculoskeletal rehabilitation; physical medicine and rehabilitation; pain management; osteoarthritis; functional recovery; disability assessment; therapeutic exercise; physiotherapy; sports injuries; ultra-sound in rehabilitation; quality of life; well-being
(This special issue belongs to the Section Clinical Rehabilitation)
Advances and Future Perspectives for Transcatheter Aortic Valve Replacement (TAVR)
edited by Kyriakos Spiliopoulos and Nikolaos Liaros
submission deadline 20 Apr 2027 | 1 articles | Viewed by 490 | Submission Open
Keywords: aortic stenosis; aortic valve replacement; transcatheter aortic valve replacement (TAVR); “Valve in Valve” procedure; TAVR-endocarditis; TAVR-durability; TAVR-design; cardiovascular imaging
(This special issue belongs to the Section Cardiology)
Current Concepts and Technological Innovations in Hepato-Pancreato-Biliary Surgery and Transplantation
edited by Michele Finotti and Francesco D’Amico
submission deadline 20 Apr 2027 | Viewed by 388 | Submission Open
Keywords: hepato-pancreato-biliary surgery; hepato-pancreato-biliary transplantation; pancreatic cancer; hepatobiliary cancer; vascular reconstruction; minimally invasive in hepato-pancreato-biliary surgery; robotic techniques; organ-preservation strategies
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Precision Neuroimaging in Mental and Behavioral Health Research
edited by Thomas Vanicek and Arkadiusz Komorowski
submission deadline 20 Apr 2027 | Viewed by 373 | Submission Open
Keywords: psychiatry; neuroimaging; addiction; substance use disorders (SUD); attention deficit hyperactivity disorder (ADHD); imaging genomics; imaging transcriptomics
(This special issue belongs to the Section Mental Health)
The Liver–Kidney Axis in Metabolic Diseases: Biomarkers and Clinical Implications
edited by
submission deadline 20 Apr 2027 | Viewed by 356 | Submission Open
Keywords: liver; kidney; cross-organ crosstalk; mechanisms; biomarkers; metabolic diseases; clinical implications
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Novel Approaches in Obsessive–Compulsive and Related Spectrum Disorders
edited by and Andrea D. Guastello
submission deadline 20 Apr 2027 | Viewed by 353 | Submission Open
Keywords: OCD; misophonia; hoarding; tic disorders; assessment; treatment
(This special issue belongs to the Section Mental Health)
Clinical Advances in Adult Deformities and Spinal Disorders: Surgical Treatment and Pre- and Post-Operative Re-Habilitation
edited by
submission deadline 20 Apr 2027 | Viewed by 346 | Submission Open
Keywords: scoliosis; spine; kyphosis; degenerative spine; spine surgery
(This special issue belongs to the Section Orthopedics)
Emerging Technologies in Foot and Ankle Care: From Advanced Diagnosis to Innovative Treatment
edited by Jaehwang Song
submission deadline 20 Apr 2027 | 1 articles | Viewed by 338 | Submission Open
Keywords: foot; ankle; tendon; ligament; disease; MIS; deformity correction; flatfoot; cavovarus foot; WBCT
(This special issue belongs to the Section Orthopedics)
Current Trends and Innovations in Coronary Artery Disease and Myocardial Ischemia: Second Edition
edited by
submission deadline 20 Apr 2027 | Viewed by 325 | Submission Open
Keywords: coronary artery disease; fractional flow reserve; invasive coronary angiography; cardiac CT; cardiac MRI
(This special issue belongs to the Section Cardiovascular Medicine)
Personalised and Precision Pharmacotherapy: Data-Driven Therapeutic Optimisation in Real-World Clinical Practice submission deadline 20 Apr 2027 | Viewed by 309 | Submission Open
Keywords: precision pharmacotherapy; personalised medicine ; pharmacokinetics and pharmacodynamics ; therapeutic drug ; monitoring real-world evidence ; multimorbidity ; medication appropriateness ; model-informed precision dosing; does individualisation; clinical decision support
(This special issue belongs to the Section Pharmacology)
Clinical Approaches of Intracranial Aneurysm and Subarachnoid Hemorrhage
edited by Sylvia Bele
submission deadline 20 Apr 2027 | Viewed by 295 | Submission Open
Keywords: aSAH; clipping or coiling; extracranial complications; cerebral vasospasm; ICU treatment
(This special issue belongs to the Section Clinical Neurology)
From Imaging to Intervention: Modern Approaches in Spine Disorders Management submission deadline 20 Apr 2027 | Viewed by 289 | Submission Open
Keywords: adolescent idiopathic scoliosis (AIS); spinal fusion; Cobb angle; bracing; skeletal maturity; radiographic imaging; multidisciplinary management
(This special issue belongs to the Section Orthopedics)
Recent Advances in Hypercholesterolemia
edited by Ana Catarina Alves
submission deadline 20 Apr 2027 | Viewed by 286 | Submission Open
Keywords: hypercholesterolemia; cardiovascular risk; molecular diagnostics; variants of uncertain significance (VUS); functional characterisation; precision medicine; lipid-lowering therapy
(This special issue belongs to the Section Endocrinology & Metabolism)
Targeting Extravalvular Burden Associated with Valvular Heart Disease
edited by
submission deadline 20 Apr 2027 | Viewed by 273 | Submission Open
Keywords: valvular heart disease; systemic disorder; extravalvular burden; valve dysfunction; valve intervention; multimodality imaging
(This special issue belongs to the Section Cardiology)
Hypertension in Adults: Current Updates on Diagnosis, Treatment and Management—Second Edition
edited by Emelina Stambolliu and Antonios A. Argyris
submission deadline 20 Apr 2027 | Viewed by 265 | Submission Open
Keywords: essential hypertension; nighttime blood pressure; blood pressure measurement; blood pressure management; blood pressure medical treatment; hypertension thresholds
(This special issue belongs to the Section Vascular Medicine)
Advances in Clinical Oncologic Diagnostic and Interventional Radiology
edited by Alberta Cappelli
submission deadline 20 Apr 2027 | 1 articles | Viewed by 262 | Submission Open
Keywords: artificial intelligence; oncological imaging; hybrid imaging; endovascular radiology; percutaneous procedures; radiomics; MRI; CT; PET/CT; photon counting CT; cone-beam CT
(This special issue belongs to the Section Nuclear Medicine & Radiology)
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