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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Understanding Syncope: Multidisciplinary Approaches to Diagnosis and Management

edited by

Isabel Rocha

and Sérgio Laranjo

submission deadline 31 May 2026 | 4 articles | Viewed by 5007 | Submission Open

Keywords: syncope; diagnostic strategies; prognostication; treatment options; quality of life; wearable devices; artificial intelligence; autonomic dysfunction; orthostatic hypotension; POTS (postural orthostatic tachycardia syndrome)

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Updates on Prosthodontics

edited by

Rubén Agustín Panadero

and Carla Fons-Badal

submission deadline 31 May 2026 | 3 articles | Viewed by 2926 | Submission Open

Keywords: dental prosthesis; dental implants; gingival aesthetics; gingival treatment; dental aesthetics; dental ceramics; BOPT; surgical periodontal treatment

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advances in Male Infertility: Diagnosis, Management and ART Integration

edited by Despoina Mavrogianni and Sofoklis Stavros

submission deadline 31 May 2026 | Viewed by 1222 | Submission Open

Keywords: male infertility; assisted reproductive technologies (ART); intracytoplasmic sperm injection (ICSI); genetic testing; hormonal profiling; seminal biomarkers; sperm retrieval techniques; sperm selection; stem cell therapy; gene editing; reproductive endo-crinology; early pregnancy; implantation failure; recurrent miscarriage

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Early Prevention and Diagnosis of Atherosclerosis: From Clinical Progression to Patient Management

edited by

Anna Kabłak-Ziembicka

submission deadline 31 May 2026 | 1 articles | Viewed by 439 | Submission Open

Keywords: atherosclerosis; atherothrombotic molecular pathways; cardiovascular risk; monitoring of goals; pharmacological and non-pharmacological prevention; carotid and peripheral interventions

(This special issue belongs to the Section Cardiovascular Medicine)

Personalized Management of Abdominal Surgery and Complications

edited by Ioannis Mantzoros and

Orestis Ioannidis

submission deadline 31 May 2026 | Viewed by 109 | Submission Open

Keywords: personalized medicine; abdominal surgery; complications; emergency; innovative surgery

(This special issue belongs to the Section General Surgery)

Clinical Advances and Contemporary Applications of Echocardiography

edited by

Attila Nemes

submission deadline 31 May 2026 | Viewed by 78 | Submission Open

Keywords: echocardiography; speckle-tracking; three-dimensional; Doppler; cardiac; valve; vasculature

(This special issue belongs to the Section Cardiovascular Medicine)

Current Advances and Future Challenges in Heart Transplantation

edited by

Norihide Fukushima

submission deadline 31 May 2026 | Viewed by 72 | Submission Open

Keywords: heart transplantation; indication; surgical techniques; preoperative care; immunosuppressive regimens; mechanical circulatory support; donor assessment and management; cardiac donation after circulatory death; ex vivo machine perfusion; normothermic regional perfusion; cardiac xenotransplantation

(This special issue belongs to the Section Cardiology)

Advance in the Management of Cancer Pain

edited by Wojciech Leppert

submission deadline 31 May 2026 | Viewed by 45 | Submission Open

Keywords: analgesia; analgesics; cancer patients; chronic pain; pain in cancer patients; pain assessment; non-opioids; opioid analgesics; adjuvant analgesics; non-pharmacology methods of pain management

(This special issue belongs to the Section Epidemiology & Public Health)

Applications of Artificial Intelligence (AI) in Surgery

edited by

Syed Ali Haider

and

Antonio Jorge Forte

submission deadline 31 May 2026 | Viewed by 41 | Submission Open

Keywords: artificial intelligence; machine learning; surgical robotics; computer vision; predictive analytics; surgical decision support; perioperative care; surgical outcomes; digital surgery

(This special issue belongs to the Section General Surgery)

Diagnosis and Treatment of Pediatric Endocrine Disorders—Focus on Rare Conditions

edited by Sophia Sakka

submission deadline 1 Jun 2026 | Viewed by 1129 | Submission Open

Keywords: pediatric endocrinology; diabetes mellitus in children; bone metabolism disorders; clinical diagnosis; therapeutic strategies; skeletal dysplasias; rare endocrine conditions; pediatric type 1 diabetes; rickets management; genetic conditions; pediatric hormone therapy; achondroplasia

(This special issue belongs to the Section Endocrinology & Metabolism)

Orthodontics: State of the Art and Prospects

edited by Beatriz Tarazona-Álvarez and

Natalia Zamora-Martínez

submission deadline 5 Jun 2026 | 1 articles | Viewed by 1667 | Submission Open

Keywords: digital orthodontics; clear aligners; 3D printing; accelerated orthodontics; digital treatment plan; nanotechnology

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Latest Research on Male Infertility

edited by

Manesh Kumar Panner Selvam

submission deadline 5 Jun 2026 | 1 articles | Viewed by 571 | Submission Open

Keywords: testis; sperm; seminal plasma; spermatogenesis; fertilization; omics; proteomics; oxidative stress; sperm DNA fragmentation; varicocele; male infertility; testicular cancer; infertility management; ART

(This special issue belongs to the Section Reproductive Medicine & Andrology)

New Insights on Pharmacologic and Non-Pharmacologic Therapy of Advanced Heart Failure

edited by

Michael Dandel

submission deadline 5 Jun 2026 | Viewed by 58 | Submission Open

Keywords: advanced heart failure (AHF); mechanical circulatory support systems; heart transplantation (HTx); immunosuppression; cardiac allograft rejections

(This special issue belongs to the Section Cardiology)

Sjogren’s Syndrome: Clinical Advances and Insights

edited by David A. Isenberg

submission deadline 7 Jun 2026 | Viewed by 62 | Submission Open

Keywords: xerostomia; xerophthalmia; non-Hodgkins lymphoma; autoimmune rheumatic diseases; Sjogren’ s syndrome

(This special issue belongs to the Section Immunology & Rheumatology)

Clinical Research and Personalized Medicine in Inflammatory Bowel Disease

edited by

Alfredo Papa

and Loris Riccardo Lopetuso

submission deadline 10 Jun 2026 | 4 articles | Viewed by 4888 | Submission Open

Keywords: inflammatory bowel disease (IBD); personalized medicine; precision medicine; Crohn’ s disease; ulcerative colitis; targeted therapy; artificial intelligence

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Cardiovascular Health: Advances in Prevention, Treatment and Innovative Therapies

edited by

Ibadete Bytyçi

submission deadline 10 Jun 2026 | Viewed by 1183 | Submission Open

Keywords: atherosclerosis; dyslipidemia; cardiac risk factors; premature ASCVD; left atrium function; atrial fibrillation; coronary imaging

(This special issue belongs to the Section Cardiovascular Medicine)

Surgical Management of Maxillofacial Fractures and Reconstruction of Facial Deformities

edited by

Gian Marco Prucher

Andrea Cassoni

and Francesco Arcuri

submission deadline 10 Jun 2026 | 2 articles | Viewed by 792 | Submission Open

Keywords: head and neck reconstruction; facial fractures; minimally invasive treatments; facial reconstruction; bioengineering in head and neck disorders; CAD/CAM in maxillo facial trauma and deformities

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Diabetes Mellitus and Emerging Health Challenges: A Multidisciplinary Perspective

edited by Katarzyna A. Majewska and

Agnieszka Zawada

submission deadline 10 Jun 2026 | 1 articles | Viewed by 392 | Submission Open

Keywords: diabetes mellitus; type 1 diabetes; type 2 diabetes; diabetic complications; prediabetes; diabetes treatment; autoimmune diabetes

(This special issue belongs to the Section Endocrinology & Metabolism)

Clinical Outcomes Improvement and Perioperative Management of Surgical Patients: 3rd Edition

edited by

Dimitrios E. Magouliotis

and

Dimitris Zacharoulis

submission deadline 10 Jun 2026 | Viewed by 64 | Submission Open

Keywords: clinical outcomes; surgery; quality; quality of life; quality improvement; postoperative; morbidity; postoperative care

(This special issue belongs to the Section General Surgery)

Clinical and Diagnostic Strategies for Glioma Treatment

edited by Aleksandrs Krigers and Egils Valeinis

submission deadline 10 Jun 2026 | Viewed by 62 | Submission Open

Keywords: glioma; glioblastoma; astrocytoma; oligodendroglioma; IDH; neuro-oncology; neurosurgery; radiotherapy; neuropathology; diagnostics; treatment

(This special issue belongs to the Section Clinical Neurology)

Cardiac Arrest and Postcardiac Arrest Care: State of the Art and Future Directions

edited by

Jae-Hyug Woo

and Soheil Saadat

submission deadline 10 Jun 2026 | Viewed by 54 | Submission Open

Keywords: out-of-hospital cardiac arrest; cardiopulmonary resuscitation; postcardiac arrest syndrome; postcardiac arrest care; survival; neurologic outcomes

(This special issue belongs to the Section Emergency Medicine)

Cardiomyopathy: Diagnosis and Therapeutic Advances

edited by Ilaria Dentamaro and Annagrazia Cecere

submission deadline 10 Jun 2026 | Viewed by 50 | Submission Open

Keywords: cardiomiopathy; cardiac magnetic resonance (CMR); advanced echocardiography; heart failure; hypertrophic cardiomyopathy

(This special issue belongs to the Section Cardiology)

New Technologies for Personalized Medicine in Head and Neck Surgery

edited by

Carlos Navarro-Cuéllar

and

José Luis Cebríán-Carretero

submission deadline 10 Jun 2026 | Viewed by 50 | Submission Open

Keywords: personalized medicine; head and neck surgery; 3D printing; surgical navigation; artificial intelligence; computer-assisted surgery; regenerative medicine; precision oncology; craniofacial reconstruction; biomaterials; virtual surgical planning; genomics and proteomics; tissue engineering; functional rehabilitation

(This special issue belongs to the Section Otolaryngology)

Clinical Advancements in Intraocular Lens Power Calculation Methods

edited by

Christoph Martin Lwowski

and Thomas Kohnen

submission deadline 12 Jun 2026 | 2 articles | Viewed by 2111 | Submission Open

Keywords: emmetropia; IOL power calculation; effective lens position; refractive lens exchange; IOL; refractive surgery; biometry

(This special issue belongs to the Section Ophthalmology)

Systemic Sclerosis: State of the Art and Future Directions

edited by Antonino Mazzone and

Paola Maria Luigia Faggioli

submission deadline 12 Jun 2026 | Viewed by 45 | Submission Open

Keywords: systemic sclerosis; current knowledge; advanced knowledge; vasculopathy; interstitial lung disease; pulmonary arterial hypertension; perspectives; novelties

(This special issue belongs to the Section Dermatology)

Evidence-Based Clinical Management of Orthopaedic Trauma: 25 Years in Retrospect, and a Forecast of 25 Years to Come

edited by Dirk Stengel and

Paul Alfred Grützner

submission deadline 15 Jun 2026 | 5 articles | Viewed by 9612 | Submission Open

Keywords: evidence-based medicine; orthopaedic surgery; clinical trials; systematic reviews; patient outcomes; multiple trauma; artificial intelligence; injuries

(This special issue belongs to the Section Orthopedics)

Coronary Heart Disease: Causes, Diagnosis and Management

edited by

Andrea Denegri

submission deadline 15 Jun 2026 | 3 articles | Viewed by 9275 | Submission Open

Keywords: coronary heart disease; coronary revascularization; coronary artery disease; ischemic heart disease; atherosclerosis

(This special issue belongs to the Section Cardiology)

Advances in the Diagnosis and Treatment of Glaucoma

edited by

Alessio Martucci

submission deadline 15 Jun 2026 | 4 articles | Viewed by 4753 | Submission Open

Keywords: OCT; glaucoma; MIGS; neuroprotection; drug delivery systems; artificial intelligence; pharmacologic agents; per-sonalized medicine

(This special issue belongs to the Section Ophthalmology)

Arthroplasty: Advances in Surgical Techniques and Patient Outcomes—2nd Edition

edited by Senthil Sambandam

submission deadline 15 Jun 2026 | 2 articles | Viewed by 2941 | Submission Open

Keywords: hip arthroplasty; knee arthroplasty; hip fractures; arthroplasty; osteoarthritis; knee arthroscopy; joint replacement

(This special issue belongs to the Section Orthopedics)

Emergency Surgery: Clinical Updates and New Perspectives

edited by

Bruno Cirillo

submission deadline 15 Jun 2026 | 1 articles | Viewed by 1849 | Submission Open

Keywords: emergency surgery; trauma surgery; acute abdomen; hernia emergencies; surgical decision making; perioperative care; damage control surgery; emergency management; critical care surgery; multidisciplinary approach

(This special issue belongs to the Section Emergency Medicine)

Gender Differences and Diversity in the Treatment of Gastric Cancer and Other Malignancies

edited by Claus Schildberg and Frank Meyer

submission deadline 15 Jun 2026 | 2 articles | Viewed by 1393 | Submission Open

Keywords: gastric cancer; other cancers; other treatment; gender differences; diversity; new challances

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Updates on Valvular Heart Diseases: A New Era in Personalized Treatment

edited by Massimiliano Mariani

submission deadline 15 Jun 2026 | 2 articles | Viewed by 1242 | Submission Open

Keywords: valvular heart disease; structural heart intervention; imaging in valve disease; interventional echocardiography; minimally invasive cardiac surgery; aortic valve intervention; tricuspid valve intervention; valve intervention in GUCH; patient-specific therapy; advanced diagnostic techniques; gutting-edge cardiac imaging; catheter-based interventions; innovative cardiac therapies

(This special issue belongs to the Section Cardiology)

Thoracic Surgery: Current Practice and Future Directions: 2nd Edition

edited by

Dania Nachira

submission deadline 15 Jun 2026 | 3 articles | Viewed by 1231 | Submission Open

Keywords: NSCLC; mediastinum; thymoma; esophageal disease; immunotherapy; new technologies; minimally invasive surgery; VATS; RATS

(This special issue belongs to the Section Respiratory Medicine)

Blood Cancers: Current Status and Future Challenges

edited by

Salvatore Perrone

and Massimo Breccia

submission deadline 15 Jun 2026 | 1 articles | Viewed by 1064 | Submission Open

Keywords: acute myeloid leukemia; hematology; leukemia; venetoclax; blood disorders

(This special issue belongs to the Section Hematology)

Cardiac Arrest: Strategies, Innovations, and Improvements in Outcomes

edited by

Kei Hayashida

submission deadline 15 Jun 2026 | Viewed by 964 | Submission Open

Keywords: cardiac arrest; cardiopulmonary resuscitation; post-cardiac arrest syndrome; neurological outcomes

(This special issue belongs to the Section Cardiology)

New Clinical Advances in Pediatric Asthma

edited by

Davor Plavec

submission deadline 15 Jun 2026 | 1 articles | Viewed by 862 | Submission Open

Keywords: pediatric asthma; clinical management; treatment advances; diagnostic advances; biologic therapy; inhaled steroids; control of asthma; exacerbation prevention; quality of life

(This special issue belongs to the Section Clinical Pediatrics)

Transjugular Intrahepatic Portosystemic Shunt: Challenges and Perspectives—2nd Edition

edited by

Lorenzo Ridola

, Stefania Gioia and

Silvia Nardelli

submission deadline 15 Jun 2026 | 1 articles | Viewed by 589 | Submission Open

Keywords: hepatic encephalopathy; spontaneous portal-systemic shunts; transjugular intrahepatic portosystemic shunt; cirrhosis; portal hypertension; sarcopenia; myosteatosis; gastrointestinal bleeding; ascites; non cirrhotic portal hypertension

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Congenital Heart Diseases: Epidemiology, Treatment and Lifelong Support

edited by Sebastian Freilinger,

Renate Oberhoffer-Fritz

Harald Kaemmerer

and Oliver Dewald

submission deadline 15 Jun 2026 | 1 articles | Viewed by 459 | Submission Open

Keywords: congenital heart disease (CHD); adults with CHD; epidemiology; comorbidities; intervention; surgical treatment; psychological aspects; quality of life (QoL); risk factors; rehabilitation; health promotion; prevention; health literacy; physical activity; lifelong support

(This special issue belongs to the Section Cardiology)

Clinical Advances in Cancer Imaging

edited by

Paul-Andrei Ștefan

submission deadline 15 Jun 2026 | Viewed by 204 | Submission Open

Keywords: pelvic oncology; cancer imaging; CT; MRI; tumor staging; treatment response; morphological criteria; gynecologic cancer; bladder cancer; rectal cancer; artificial intelligence; radiomics; texture analysis; image biomarkers; clinical imaging

(This special issue belongs to the Section Oncology)

Dental Implantology: Clinical Updates and Perspectives—2nd Edition

edited by

Roberta Gasparro

submission deadline 15 Jun 2026 | Viewed by 102 | Submission Open

Keywords: dental implantology; reconstructive surgery; biomaterials; tissue engineering; regenerative medicine; digital dentis-try; periimplantitis; peri-implant soft tissues

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

New Advances of Infectious Disease Epidemiology

edited by

Francisco Guillen-Grima

submission deadline 15 Jun 2026 | Viewed by 90 | Submission Open

Keywords: infectious disease epidemiology; genomic sequencing; computational modeling; collaborative surveillance; digital epidemiology; one health; pandemic intelligence; public health data integration; emerging pathogens; epidemiologic insights

(This special issue belongs to the Section Epidemiology & Public Health)

Traumatic Brain Injury: Clinical Diagnosis and Management

edited by Alessio Caccioppola

submission deadline 15 Jun 2026 | Viewed by 83 | Submission Open

Keywords: glasgow coma scale; intracranial pressure monitoring; traumatic brain injury; diffuse axonal injury; post-traumatic epilepsy; decompressive craniectomy; neuromonitoring

(This special issue belongs to the Section Brain Injury)

Current Challenges and Opportunities in Assisted Reproductive Technologies

edited by Andrea Milostić-Srb and

Davor Jezek

submission deadline 15 Jun 2026 | Viewed by 67 | Submission Open

Keywords: artificial reproductive technologies; ART; mental health effect on ART; IVF; AI in reproductive medicine

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Advancements in Foot and Ankle Surgery: 2nd Edition

edited by

Ho-seong Lee

submission deadline 15 Jun 2026 | Viewed by 64 | Submission Open

Keywords: flat foot; hindfoot motion; diabetic foot; hallux valgus; foot infection; foot trauma

(This special issue belongs to the Section Orthopedics)

Clinical Diagnosis and Management of Erectile Dysfunction

edited by Maurizio De Rocco Ponce and

Giuseppe Grande

submission deadline 15 Jun 2026 | Viewed by 31 | Submission Open

Keywords: erectile dysfunction; clinical management; cardiovascular disease; penile prosthesis; personalized medicine; hipogonadism

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Aortic Surgery: State of the Art and Future Directions

edited by

Dimos E. Karangelis

submission deadline 15 Jun 2026 | Viewed by 30 | Submission Open

Keywords: aortic surgery; aortic aneurysm; aortic dissection; aortic arch; biomaterials; endovascular approach; FET; TEVAR

(This special issue belongs to the Section Cardiovascular Medicine)

Novel Diagnostic and Therapeutic Perspectives in Systemic Sclerosis

edited by Mislav Radić

submission deadline 15 Jun 2026 | Viewed by 25 | Submission Open

Keywords: systemic sclerosis; biomarkers; diagnosis; treatment; diagnostic imaging technique; early detection

(This special issue belongs to the Section Immunology & Rheumatology)

Gynecologic Oncology: Current Therapies and New Frontiers

edited by Laura Paleari and Mariangela Rutigliani

submission deadline 19 Jun 2026 | Viewed by 58 | Submission Open

Keywords: ovarian cancers; gynecological cancer; drug delivery; AI; screening; new therapies

(This special issue belongs to the Section Obstetrics & Gynecology)

Gynecologic and Obstetric Pathologies: From Birth to Menopause (Third Edition)

edited by

Panagiotis Christopoulos

submission deadline 20 Jun 2026 | 6 articles | Viewed by 18244 | Submission Open

Keywords: obstetrics; gynecology; pathology; pediatric and adolescent gynecology; menopause; urinary disorders; infertility; gynecologic oncology; maternal– fetal medicine; incontinence; menstruation; reproduction; polycystic ovarian syndrome; endometriosis; dysmenorrhea; assisted reproduction; IVF; laparoscopy; hysteroscopy; gynecologic robotic surgery; high-risk pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Advancements in Gait Rehabilitation: Innovative Approaches and Clinical Insights

edited by

Shinichi Watanabe

Nobuto Nakanishi

and

Yuki Iida

submission deadline 20 Jun 2026 | 4 articles | Viewed by 5399 | Submission Open

Keywords: sarcopenia; swallowing therapy; physical therapy; early mobilization; early rehabilitation; robot-assisted gait training; neurorehabilitation; wearable sensors

(This special issue belongs to the Section Clinical Rehabilitation)

Displaying special issue 1251-1300 on page 26 of 32.

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