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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Neuro-Oncology: Diagnostics and Treatment

edited by

Jigisha P. Thakkar

and Derek A. Wainwright

submission deadline 20 Mar 2027 | 1 articles | Viewed by 264 | Submission Open

Keywords: glioblastoma; glioma; meningioma; brain metastases; blood–brain barrier

(This special issue belongs to the Section Clinical Neurology)

Game-Changing Advances in Minimally Invasive Spine Surgery

edited by Rouzbeh Motiei-Langroudi

submission deadline 20 Mar 2027 | Viewed by 261 | Submission Open

Keywords: minimally invasive spine surgery (MISS); technological innovation; navigation systems/robotic-assisted; endoscopic techniques; artificial intelligence/machine learning

(This special issue belongs to the Section Clinical Neurology)

Advances in Mental Health: All Ages and Multidisciplinary Clinical Perspectives

edited by Clara González-Sanguino and

Jairo Rodríguez-Medina

submission deadline 20 Mar 2027 | Viewed by 207 | Submission Open

Keywords: stigma; discrimination; mental health; clinical psychology; depression and anxiety

(This special issue belongs to the Section Mental Health)

Clinical Physical Therapy: Current Advances and Future Challenges

edited by

Andreas Brandl

and

Robert Schleip

submission deadline 20 Mar 2027 | Viewed by 175 | Submission Open

Keywords: clinical physical therapy; chronic musculoskeletal disorders; chronic pain management; manual therapy; mind–body medicine; biopsychosocial model; autoimmune diseases; fatigue syndromes; bottom-up and top-down regulation; neurophysiological mechanisms

(This special issue belongs to the Section Clinical Rehabilitation)

Advancing Precision Care in Neuropathic Pain: From Biomarkers to Neuromodulation to Artificial Intelligence

edited by Saurabh Kataria and

Jeremiah Hilkiah Wijaya

submission deadline 20 Mar 2027 | Viewed by 166 | Submission Open

Keywords: neuropathic pain; precision medicine; neuromodulation; spinal cord stimulation; peripheral nerve stimulation; ul-trasound-guided interventions; pain phenotyping; personalized therapeutics; opioid alternatives

(This special issue belongs to the Section Clinical Neurology)

Therapies for Heart Failure: Clinical Updates and Perspectives: 2nd Edition

edited by Cristina Tudoran, Stela Iurciuc and

Dragos Cozma

submission deadline 20 Mar 2027 | Viewed by 162 | Submission Open

Keywords: mechanisms of heart failure; new therapies for heart failure; chronic and acute heart failure; new approaches to managing heart failure patients; special populations; clinical outcome

(This special issue belongs to the Section Cardiology)

Psychosis Across Disciplines: Emerging Perspectives in Neuroscience, Psychiatry, and Therapy

edited by Inmaculada Peñuelas-Calvo, Roberto Rodríguez-Jiménez and

Lorena García-Fernández

submission deadline 20 Mar 2027 | Viewed by 158 | Submission Open

Keywords: psychosis; lifespan; neuroimaging; psychotherapy; prevention

(This special issue belongs to the Section Mental Health)

Clinical Updates in Type 2 Diabetes and Related Complications

edited by

Ilias Migdalis

submission deadline 20 Mar 2027 | Viewed by 154 | Submission Open

Keywords: type 2 diabetes; chronic complications; microvascular disease; macrovascular disease; treatment

(This special issue belongs to the Section Endocrinology & Metabolism)

Recent Advances in Clinical Perspectives on the Diagnosis and Treatment of Endometriosis

edited by Paweł Basta and

Krzysztof Gałczyński

submission deadline 20 Mar 2027 | Viewed by 151 | Submission Open

Keywords: endometriosis; deep endometriosis; endometrioma; infertility; laparoscopy; minimally invasive techniques; biomarkers; pain; pelvic pain; adenomyosis; adhesions; dysmenorrhea; dyspareunia

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Challenges and Advances in Hepatobiliary and Pancreatic Surgery

edited by

Marco Massani

and

Alessandro Veltri

submission deadline 20 Mar 2027 | Viewed by 146 | Submission Open

Keywords: pancreatic cancer; pancreatic cancer surgery; neoadjuvant chemotherapy; perioperative management; surgical approaches

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

The State of the Art in Robotic Thoracic Surgery: Innovation, Complexity and Outcomes

edited by Michael Zervos

submission deadline 20 Mar 2027 | Viewed by 142 | Submission Open

Keywords: thoracic surgery; robotic surgery; single-port robotic surgery; robotic-assisted thoracic surgery; minimally invasive surgery; lung cancer

(This special issue belongs to the Section General Surgery)

Developmental Transfusion Biology in Neonatal–Perinatal Medicine

edited by Thomas G. Brune

submission deadline 20 Mar 2027 | Viewed by 119 | Submission Open

Keywords: neonatal transfusion; preterm infants; fetal hemoglobin; cord blood; delayed cord clamping; oxygen transport; developmental hematology

(This special issue belongs to the Section Clinical Pediatrics)

Dentistry and Oral Surgery: Current Status and Future Prospects, 2nd Edition

edited by

Dragana Gabrić

Marko Vuletić

and

Igor Smojver

submission deadline 20 Mar 2027 | Viewed by 95 | Submission Open

Keywords: dentistry; oral surgery; dental implantology; prosthodontics; restorative dentistry; periodontology; digital dentistry; computer-guided surgery; artificial intelligence

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Diagnostic and Interventional Radiology: Advances in Treatment of Small Tumors

edited by Carolina Lanza

submission deadline 20 Mar 2027 | Viewed by 76 | Submission Open

Keywords: interventional radiology; MRI; contrast-enhanced ultrasound; CT; liver; kidney; lung; prostate; breast; multimodal imaging; diagnostic imaging; tumor

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Sarcopenia: Prevention and Treatment Options

edited by Steven Phu

submission deadline 21 Mar 2027 | 3 articles | Viewed by 1815 | Submission Open

Keywords: sarcopenia; skeletal muscle; ageing; falls; frailty; exercise; rehabilitation; nutrition

(This special issue belongs to the Section Geriatric Medicine)

Clinical Research on Robot-Assisted Thoracic Surgery and Lung Surgery

edited by Marco Scarci

submission deadline 21 Mar 2027 | 1 articles | Viewed by 963 | Submission Open

Keywords: robot-assisted thoracic surgery; robotic lung surgery; minimally invasive surgery; lobectomy; segmentectomy; thoracic oncology; surgical outcomes; learning curve; clinical research; robotic technology

(This special issue belongs to the Section General Surgery)

Macular Diseases: From Diagnosis to Treatment

edited by

Gabriella De Salvo

submission deadline 22 Mar 2027 | 3 articles | Viewed by 2936 | Submission Open

Keywords: age-related macular degeneration; retinal vascular diseases; intraocular tumours; retinal imaging; OCT; OCT angiography; anti-VEGF; laser therapy; macular surgery; gene therapy; biomarkers; progression; intravitreal injections; biomarkers

(This special issue belongs to the Section Ophthalmology)

Psychological Affliction in Pregnancy, Delivery and Postpartum Period: A Multidisciplinary Approach

edited by

Beata Pięta

and

Edyta Barnas̈

submission deadline 24 Mar 2027 | 4 articles | Viewed by 3010 | Submission Open

Keywords: maternal mental health; pregnancy; postpartum depression; perinatal anxiety; midwifery; multidisciplinary care

(This special issue belongs to the Section Mental Health)

Rewriting Metastatic Colorectal Cancer Management: Innovative Frontiers in Clinical Diagnosis and Personalized Oncology

edited by

Maria Maddalena Laterza

submission deadline 24 Mar 2027 | Viewed by 404 | Submission Open

Keywords: molecular profiling; liquid biopsy; targeted therapy; immunotherapy; biomarkers treatment; sequencing; tumor heterogeneity; personalized medicine

(This special issue belongs to the Section Oncology)

Emergency Surgery: Clinical Updates and Key Insights

edited by

Dragos Serban

submission deadline 24 Mar 2027 | Viewed by 133 | Submission Open

Keywords: minimally invasive emergency surgery; biomarkers; point-of-care imaging (POCI); frailty assessment; surgical decision-making; risk stratification; damage control surgery; enhanced recovery (ERAS); patient outcomes; multidisciplinary care

(This special issue belongs to the Section Emergency Medicine)

Obstructive Sleep Apnea: Advances in Clinical Diagnosis and Management

edited by

Gonzalo Labarca

submission deadline 25 Mar 2027 | 7 articles | Viewed by 8319 | Submission Open

Keywords: obstructive sleep apnea; sleep disorder breathing; central apnea; apnea–hypopnea index; precision medicine

(This special issue belongs to the Section Respiratory Medicine)

Thoracic Surgery: Updates and New Trends

edited by

Monica Casiraghi

submission deadline 25 Mar 2027 | 5 articles | Viewed by 7552 | Submission Open

Keywords: minimally invasive surgery; new technology; diagnosis; bronchoscopy; robotic system; artificial intelligence

(This special issue belongs to the Section Respiratory Medicine)

Update on Acute Severe Respiratory Infections: 2nd Edition

edited by

Jean-Francois Timsit

submission deadline 25 Mar 2027 | 6 articles | Viewed by 6321 | Submission Open

Keywords: acute severe respiratory infection (ASRI); acute respiratory distress syndrome (ARDS); severe pneumonia; sepsis; ICU; viral respiratory infection; COVID-19; bacterial co-infection; diagnostic technology; treatment strategy; mechanical ventilation; extracorporeal membrane oxygenation (ECMO); antibiotics; non-antibiotics; pulmonary rehabilitation

(This special issue belongs to the Section Respiratory Medicine)

Sleep Disorders: Current Research and Future Directions—Second Edition

edited by Martina Vendrame

submission deadline 25 Mar 2027 | 6 articles | Viewed by 6071 | Submission Open

Keywords: obstructive sleep apnea; parasomnia; idiopathic hypersomnia; periodic limb movement disorder; periodic limb move-ment of sleep

(This special issue belongs to the Section Clinical Neurology)

Clinical Diagnosis and Management of Corneal Diseases

edited by

Eirini-Kanella Panagiotopoulou

Georgios Labiris

and Panagiota Ntonti

submission deadline 25 Mar 2027 | 4 articles | Viewed by 5921 | Submission Open

Keywords: corneal imaging; corneal disease diagnosis; corneal therapeutics; regenerative corneal treatments; artificial intelligence in corneal diagnostics; corneal cross-linking; lamellar keratoplasty

(This special issue belongs to the Section Ophthalmology)

Aortic Diseases: Modern Strategies in Diagnosis, Management, and Prevention of Complications

edited by

Petroula N. Nana

, Tilo Kölbel and José Ignacio F. Torrealba

submission deadline 25 Mar 2027 | 7 articles | Viewed by 5079 | Submission Open

Keywords: aortic aneurysm; aortic dissection; genetic aortic disease; acute aortic syndromes; endovascular repair; complica-tions; outcomes

(This special issue belongs to the Section Vascular Medicine)

Applications of Artificial Intelligence and Digital Therapeutics in Clinical Medicine: 2nd Edition

edited by

Carlos Escobar

submission deadline 25 Mar 2027 | 4 articles | Viewed by 4319 | Submission Open

Keywords: artificial intelligence; biometric sensors; deep learning; digital therapies; Internet of Things; machine learning; virtual reality; augmented reality

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)

Clinical Advances in Prenatal Diagnosis and Fetal Therapy

edited by

Mar Bennasar

submission deadline 25 Mar 2027 | 3 articles | Viewed by 4292 | Submission Open

Keywords: prenatal diagnosis; fetal therapy; genetic screening; non-invasive testing; fetal surgery; imaging technologies; high-risk pregnancies; in utero treatments; stem cell therapies; clinical innovations

(This special issue belongs to the Section Obstetrics & Gynecology)

Obesity in the 2020s and Beyond: A Multidisciplinary Overview

edited by

Andrej Belančić

submission deadline 25 Mar 2027 | 2 articles | Viewed by 3861 | Submission Open

Keywords: obesity; anti-obesity pharmacotherapy; clinical pharmacology; pharmacovigilance; cardiometabolic diseases

(This special issue belongs to the Section Pharmacology)

Clinical Strategies for Preventing Healthcare-Associated Infections

edited by

Monica Marilena Țânțu

Rogozea Liliana Marcela

and

Corneliu Ovidiu Vrancianu

submission deadline 25 Mar 2027 | 3 articles | Viewed by 3406 | Submission Open

Keywords: healthcare-associated infections; multidrug resistance; prevention; screening scales; polymicrobial infections; oppor-tunistic infections; sepsis

(This special issue belongs to the Section Infectious Diseases)

Endoscopic Management of Pancreaticobiliary Diseases

edited by

Kamran Ayub

submission deadline 25 Mar 2027 | 4 articles | Viewed by 3130 | Submission Open

Keywords: pancreaticobiliary endoscopy; endoscopic ultrasound (EUS); endoscopic retrograde cholangiopancreatography (ERCP); biliary drainage; gallbladder drainage; lumen-opposing metal stents; cholangioscopy; pancreatoscopy; confocal laser endomicroscopy; pancreatic cysts; molecular diagnostics; lithotripsy (electrohydraulic and laser); radiofrequency ablation (RFA); photodynamic therapy (PDT); pancreatic and biliary tumors; interventional endoscopy; altered anatomy access; diagnostic and therapeutic endoscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Advances in Hip and Knee Reconstructive Surgery: 2nd Edition

edited by Senthil Sambandam

submission deadline 25 Mar 2027 | 2 articles | Viewed by 1880 | Submission Open

Keywords: knee; hip; joint arthroplasty; minimally invasive surgery; revision arthroplasty; periprosthetic joint infection; muscle injury; joint alignment; surgical advances; osteotomy; fracture; robotic-assisted surgery; perioperative optimization; telerehabilitation; aseptic loosening

(This special issue belongs to the Section Orthopedics)

Segmentectomy and Lobectomy in Early-Stage Lung Cancer Management

edited by Yujin Kudo

submission deadline 25 Mar 2027 | 1 articles | Viewed by 1235 | Submission Open

Keywords: lung cancer; segmentectomy; lobectomy; thoracic surgery; early-stage NSCLC; oncologic outcomes; pulmonary function; surgical planning

(This special issue belongs to the Section Respiratory Medicine)

Exercise for Healthy Aging: Clinical Physiology, Functional Outcomes, and Implications for Clinical Practice

edited by

Jerónimo Aragón-Vela

and

Rafael A. Casuso

submission deadline 25 Mar 2027 | 1 articles | Viewed by 1036 | Submission Open

Keywords: exercise; healthy aging; functional independence; mitochondrial adaptations; physical activity interventions; neuromuscular function; cardiorespiratory fitness; metabolic health; biomarkers of aging

(This special issue belongs to the Section Sports Medicine)

Innovations in Elbow and Shoulder Surgery: Techniques, Outcomes, and Rehabilitation

edited by Andrea Celli

submission deadline 25 Mar 2027 | 1 articles | Viewed by 593 | Submission Open

Keywords: orthopedic; elbow surgery; shoulder surgery; infection; nonunion; malunion; ligaments injuries; tendon injuries; el-bow and shoulder replacement; arthroscopy

(This special issue belongs to the Section Orthopedics)

Integrated Assessment and Management of Heart Failure Syndromes

edited by Damiano Magrì and Emiliano Fiori

submission deadline 25 Mar 2027 | Viewed by 333 | Submission Open

Keywords: heart failure; functional capacity; multimodality assessment; advanced imaging; coronary and structural interventions; device therapies

(This special issue belongs to the Section Cardiology)

Advances in Cardiac Electrophysiology: Mechanisms of Arrhythmias and Ablation Technologies

edited by

Federico Landra

, Valeria Rella and Emanuele Curti

submission deadline 25 Mar 2027 | Viewed by 231 | Submission Open

Keywords: cardiac arrhythmias; cardiac electrophysiology; arrhythmias pathophysiology; arrhythmia mechanisms; catheter ablation; electro-anatomical mapping; mapping techniques; pacing maneuvers; pulsed field ablation; radiofrequency; autonomic modulation; cardioneuroablation; imaging; hybrid ablation; clinical outcomes

(This special issue belongs to the Section Cardiology)

Minimally Invasive Approaches in Hand Surgery: Optimizing Outcomes and Minimizing Complications

edited by

Hyunil Lee

submission deadline 25 Mar 2027 | Viewed by 184 | Submission Open

Keywords: percutaneous technique; ultrasound-guided procedures; arthroscopic management; robotic surgery in the hand and upper extremity; hand surgery

(This special issue belongs to the Section Orthopedics)

Advanced and Personalized Drug Delivery Systems: From Formulation Science to Clinical Application

edited by

Hudson C. Polonini

submission deadline 25 Mar 2027 | Viewed by 168 | Submission Open

Keywords: drug delivery systems; nanoparticles; lipid-based carriers; transdermal delivery; controlled release; bioavailability; pharmaceutical nanotechnology; personalized medicine; polymeric carriers; targeted therapy; in vitro–in vivo cor-relation; pharmaceutical compounding; stimuli-responsive drug delivery; clinical pharmacokinetics; innovative dosage forms

(This special issue belongs to the Section Pharmacology)

Insights into Infectious Disease Epidemiology, Management and Impact on Public Health

edited by Krystyna Dobrowolska,

Agnieszka Walczyk

and

Piotr Lewitowicz

submission deadline 25 Mar 2027 | Viewed by 150 | Submission Open

Keywords: infectious disease; viral infections; bacterial infections; epidemiology; public health

(This special issue belongs to the Section Epidemiology & Public Health)

Current Updates and Advances in Hemodialysis—2nd Edition

edited by Edita Žiginskienė

submission deadline 25 Mar 2027 | Viewed by 117 | Submission Open

Keywords: kidney replacement therapy; hemodialysis; hemodiafiltration; vascular access; dialysis membranes; dialysis complications; dialysis adequacy; outcomes

(This special issue belongs to the Section Nephrology & Urology)

Robotic Pancreatic Surgery: Innovation, Outcomes, and Future Directions

edited by

Konstantinos Kossenas

, Dimitrios Dimitroulis and

Nikolaos Machairas

submission deadline 25 Mar 2027 | Viewed by 96 | Submission Open

Keywords: robotic surgery; pancreatic surgery; Whipple; distal pancreatectomy; spleen preserving; pylorus preserving; pan-creaticoduodenectomy; enucleation; POPF; delayed gastric emptying

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Hypertrophic Cardiomyopathy: Diagnosis and Management

edited by Muhammad Fuad Jan and Abdul Jamil Tajik

submission deadline 25 Mar 2027 | Viewed by 48 | Submission Open

Keywords: hypertrophic cardiomyopathy; genetics; heart failure; sudden death; echocardiography

(This special issue belongs to the Section Cardiology)

Retinal Diseases: Innovations in Diagnosis, Imaging, and Treatment

edited by

Alaa Din Abdin

and Hakan Kaymak

submission deadline 25 Mar 2027 | Viewed by 28 | Submission Open

Keywords: retinal diseases; biomarkers; spectral-domain optical coherence tomography; vitreoretinal surgery; retinal laser therapy

(This special issue belongs to the Section Ophthalmology)

The Future Direction of Medical Imaging in Hepato-Bilio-Pancreatic Oncology: Challenges and Opportunities

edited by

Nicolò Brandi

submission deadline 26 Mar 2027 | 2 articles | Viewed by 2439 | Submission Open

Keywords: MRI; CT; molecular imaging; radiomics; imaging; radiogenomics; precision medicine; outcome prediction; cholangiocarcinoma; pancreatic cancer; imaging biomarkers; treatment response

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Pulmonary Hypertension: Clinical Perspectives

edited by

Marta Banaszkiewicz

and Maria Wieteska-Miłek

submission deadline 27 Mar 2027 | Viewed by 232 | Submission Open

Keywords: pulmonary hypertension (PH); pulmonary arterial hypertension (PAH); chronic thromboembolic pulmonary hypertension (CTEPH); chronic thromboembolic pulmonary disease; pulmonary embolism; diagnosis; treatment; quality of life; physical activity; prognostic factors; nonpharmacological treatment

(This special issue belongs to the Section Respiratory Medicine)

Neuromuscular Diseases and Musculoskeletal Disorders

edited by

Anna Christakou

submission deadline 28 Mar 2027 | 5 articles | Viewed by 8332 | Submission Open

Keywords: neuromuscular diseases; osteoporosis; fractures; muscle weakness; muscle intolerance; shoulder dysfunction; myopathy; physiotherapy; rehabilitation

(This special issue belongs to the Section Clinical Neurology)

Cardiovascular Risk in COVID-19 Survivors: From Emergency Department Management to Cardiovascular Rehabilitation

edited by

Florina Nicoleta Buleu

and Stela Iurciuc

submission deadline 28 Mar 2027 | 1 articles | Viewed by 224 | Submission Open

Keywords: cardiovascular risk management; COVID-19 survivors; long COVID syndrome; post-acute sequelae of SARS-CoV-2 infection (PASC); emergency department; cardiovascular rehabilitation; risk stratification; integrated care

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Diagnosis and Treatment Strategies in Sjogren's Disease (SjD)

edited by

Nancy L. Carteron

Ava Wu

and Nancy McNamara

submission deadline 29 Mar 2027 | Viewed by 545 | Submission Open

Keywords: Sjogren; Sjogren’s disease; lymphocytic tissue infiltration; interdisciplinary care; pathogenesis; caries; corneal erosions; autoimmunity; lymphoproliferative (or lymphoma)

(This special issue belongs to the Section Immunology & Rheumatology)

Approaches to Prevention and Management of Postoperative Complications in Minimally Invasive Surgery

edited by Shingo Tsujinaka

submission deadline 30 Mar 2027 | 4 articles | Viewed by 3119 | Submission Open

Keywords: minimally invasive surgery; postoperative complications; preventive measures; risk assessment; surgical techniques; patient optimization; complication management; surgical outcomes; patient satisfaction; patient-reported outcomes

(This special issue belongs to the Section General Surgery)

Displaying special issue 1151-1200 on page 24 of 30.

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