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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Management of Prosthetic Joint Infection (PJI)
edited by Daniel Pérez-Prieto
submission deadline 31 Dec 2025 | 7 articles | Viewed by 13623 | Submission Open
Keywords: prosthetic joint infection; debridement; biofilm; wound healing; multidisciplinary team; osteomyelitis
(This special issue belongs to the Section Orthopedics)
Challenges in the Field of Psycho-Oncology: Insights from Research
edited by , , Tânia Brandão and Ricardo Teixeira
submission deadline 31 Dec 2025 | 3 articles | Viewed by 7195 | Submission Open
Keywords: cancer; psycho-oncology; survivorship care; psychological distress; quality of life; sustainable development goals; global health; health disparities
(This special issue belongs to the Section Oncology)
New Trends and Challenges in Critical Care Management
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 5165 | Submission Open
Keywords: critical care; intensive care; extracorporeal organ support; mechanical ventilation; personalized medicine; artificial intelligence; infections; antimicrobial resistance; COVID-19
(This special issue belongs to the Section Intensive Care)
Rare Respiratory Diseases: A Personal and a Public Health Problem: 3rd Edition
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 4480 | Submission Open
Keywords: rare diseases; rare respiratory diseases; alpha-1 antitrypsin deficiency; primary ciliary dyskinesia; cystic fibrosis; idiopathic pulmonary fibrosis; lymphangioleiomyomatosis; interstitial lung diseases; pulmonary arterial hypertension
(This special issue belongs to the Section Respiratory Medicine)
Acute Kidney Injury: Latest Advances and Prospects
edited by and Kianoush Kashani
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4235 | Submission Open
Keywords: acute kidney injury (AKI); sepsis; septic shock; renal replacement therapy; intensive care; specialized interventions; biomarkers; risk factors; “ Green Practice” ; nephrology; epidemiology; multidisciplinary approach
(This special issue belongs to the Section Nephrology & Urology)
Clinical Updates on Knee and Hip Arthroplasty
edited by Amarildo Smakaj and Elena Gasbarra
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4082 | Submission Open
Keywords: knee arthroplasty; hip arthroplasty; total joint replacement; minimally invasive arthroplasty; implant durability; postoperative rehabilitation; revision arthroplasty; prosthesis-related complications; periprosthetic joint infection; implant loosening
(This special issue belongs to the Section Orthopedics)
Clinical Therapeutic Advances in Bone Fractures
edited by Simon Hackl and Eva Simone Steinhausen
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3508 | Submission Open
Keywords: stem cells; biomechanics; fracture fixation; orthobiologics; rehabilitation; personalized medicine; 3D printing; im-plant coating; nonunion; fracture-related infection
(This special issue belongs to the Section Orthopedics)
Emerging Clinical Insights into Adolescent Behavioral Development and Mental Health
edited by and Anne-Marie Iselin
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2734 | Submission Open
Keywords: adolescence; behavioral development; clinical maladjustment; adolescents’ mental health; innovative clinical approach; adolescents’ emotional problems; clinical settings; innovative developmental research; adolescents’ symptoms
(This special issue belongs to the Section Mental Health)
Pregnancy Complications and Maternal-Perinatal Outcomes
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 2246 | Submission Open
Keywords: pregnancy; high-risk; GDM; preeclampsia; fetal growth restriction; diabetes; placenta; ultrasound
(This special issue belongs to the Section Obstetrics & Gynecology)
Updates on Treatment of Chronic Kidney Disease: Novel Approaches and Future Directions
edited by Pietro C. Dattolo and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1764 | Submission Open
Keywords: chronic kidney disease; CKD treatment; SGLT2 inhibitors; GLP-1 receptor agonists; non-steroidal MRAs; precision medicine; renal replacement therapy; novel therapeutics; clinical trials; nephrology
(This special issue belongs to the Section Nephrology & Urology)
Clinical Updates on Prenatal Diagnosis
edited by Valentina D'Ambrosio
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1712 | Submission Open
Keywords: fetal anomalies; twin pregnancy; fetal therapy; prenatal genetic testing; genome sequencies
(This special issue belongs to the Section Obstetrics & Gynecology)
Novel Advanced Imaging in Cardiology: Current Status and Future Directions
edited by and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1664 | Submission Open
Keywords: cardiac imaging; cardiac magnetic resonance; echocardiography; computed tomography; trans-thoracic echocardiography global longitudinal strain (GLS) analyses; radiomics
(This special issue belongs to the Section Cardiovascular Medicine)
Children and Adolescent Mood Disorders: Risks and Treatment submission deadline 31 Dec 2025 | Viewed by 1559 | Submission Open
Keywords: emotional dysregulation; mood disorders; adolescence; anxiety; depression; addiction; psychotherapy; pharmacological treatments; prevention programs
(This special issue belongs to the Section Mental Health)
Recent Progress and Future Directions in Orthopedic Oncology
edited by and Carmine Zoccali
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1021 | Submission Open
Keywords: orthopedic oncology; bone tumors; limb-sparing surgery; reconstruction techniques; 3D-printed implants; navigation and robotics; precision medicine in musculoskeletal oncology
(This special issue belongs to the Section Orthopedics)
Clinical Challenges and Advances in Dry Eye Disease and Meibomian Gland Dysfunction submission deadline 31 Dec 2025 | 1 articles | Viewed by 782 | Submission Open
Keywords: dry eye disease; ocular surface; corneal disease; conjunctival disease; ocular biomarkers; patient-centered care; advanced diagnostics; regenerative medicine; artificial intelligence; therapeutic innovations
(This special issue belongs to the Section Ophthalmology)
Paradigms, Advances and Future Directions in Oral Medicine
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 594 | Submission Open
Keywords: oral medicine; oral potentially malignant disorders; leukoplakia; oral lichen planus; orofacial pain; biopsy and liquid biopsy; biomarkers
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advances in Gene Therapy for Retinal Diseases
edited by Tahreem Aman Mir
submission deadline 31 Dec 2025 | Viewed by 240 | Submission Open
Keywords: gene therapy; inherited retinal degenerations; age-related macular degeneration; diabetic retinopathy
(This special issue belongs to the Section Ophthalmology)
Clinical Trends in Diagnostic Radiology
edited by Wolfram Schwindt, Benjamin Noto and Anne Helfen
submission deadline 31 Dec 2025 | Viewed by 220 | Submission Open
Keywords: diagnostic imaging; radiology; nuclear medicine; hybrid imaging; artificial intelligence; radiomics; quantitative imaging; theranostics; imaging biomarkers; clinical applications
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Progress in the Multimodal Treatment of Pancreatic Disease
edited by
submission deadline 31 Dec 2025 | Viewed by 171 | Submission Open
Keywords: pancreatic diseases; pancreatic cancer; multimodal treatment; neoadjuvant therapy; imaging techniques; minimally invasive surgery; immunotherapy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Optimizing Outcomes in Deep Vein Thrombosis: A Focus on Interventional Management
edited by Adam Gwozdz
submission deadline 31 Dec 2025 | Viewed by 137 | Submission Open
Keywords: deep vein thrombosis; post-thrombotic syndrome; venous patency; emerging technology; vascular surgery
(This special issue belongs to the Section Vascular Medicine)
Broadening the Knowledge of Autism Spectrum Disorder in Adulthood: Advances in Diagnosis, Assessment and Treatment
edited by
submission deadline 5 Jan 2026 | 1 articles | Viewed by 3162 | Submission Open
Keywords: autism spectrum disorder; adulthood; autism; comorbidity; gender; age-adjusted
(This special issue belongs to the Section Mental Health)
Advances in Diagnosis and Management of Pancreatobiliary Disorders—2nd Edition
edited by
submission deadline 9 Jan 2026 | 5 articles | Viewed by 3903 | Submission Open
Keywords: pancreas diseases; pancreatic tumors; biliary tract diseases and neoplams; ERCP; EUS; cholangioscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Clinical Advances in Pancreatobiliary Diseases
edited by
submission deadline 9 Jan 2026 | 1 articles | Viewed by 1198 | Submission Open
Keywords: pancreatobiliary diseases; EUS; ERCP; interventional endoscopy; targeted therapy; pancreatobiliary cancer
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Advance in Chronic Total Occlusion Percutaneous Coronary Intervention
edited by Anbukarasi Maran and Kevin Croce
submission deadline 9 Jan 2026 | Viewed by 146 | Submission Open
Keywords: chronic total occlusion (CTO); percutaneous coronary intervention (PCI); innovative techniques; guidewire technology; retrograde PCI; interventional cardiology  
(This special issue belongs to the Section Cardiovascular Medicine)
Heart Disease and Chronic Inflammatory Conditions: New Insights
edited by Ofer Kobo and Gilad Margolis
submission deadline 10 Jan 2026 | 4 articles | Viewed by 14949 | Submission Open
Keywords: heart diseases; chronic inflammatory; rheumatoid arthritis; cardiovascular disease; inflammatory bowel disease
(This special issue belongs to the Section Cardiology)
Clinical Guidelines in Critical Care Medicine
edited by , and Daniela Bandic-Pavlovic
submission deadline 10 Jan 2026 | 3 articles | Viewed by 7324 | Submission Open
Keywords: critical illness; immunocompromised host; biomarkers; thrombocytopenia; blood coagulation disorders; multiple trauma; diagnostic imaging
(This special issue belongs to the Section Intensive Care)
Heart Failure and Coronary Artery Diseases: Cardiovascular Complications and Comorbidities submission deadline 10 Jan 2026 | 3 articles | Viewed by 5200 | Submission Open
Keywords: heart failure; acute myocardial infarction; coronary artery diseases; cardiac imaging; biomarkers; artificial intelligence
(This special issue belongs to the Section Cardiovascular Medicine)
From Acute Injury to Personalized Prevention—Developing Modern Strategies submission deadline 10 Jan 2026 | 2 articles | Viewed by 2665 | Submission Open
Keywords: orthopedics; acute injury; personalized prevention; innovative methodologies; musculoskeletal disorders; musculoskeletal injury; conservative therapy; functional testing; intervention
(This special issue belongs to the Section Orthopedics)
Advancements in Spinal Oncology: The Current Landscape
edited by Aladine Elsamadicy and
submission deadline 10 Jan 2026 | 2 articles | Viewed by 2199 | Submission Open
Keywords: spinal oncology; patient outcomes; primary bone tumor; spine metastases; intradural tumors
(This special issue belongs to the Section Clinical Neurology)
Advanced Physiotherapy Practice in Patients with Musculoskeletal Disorders submission deadline 10 Jan 2026 | 1 articles | Viewed by 731 | Submission Open
Keywords: differential diagnosis; physiotherapy; rehabilitation; multidisciplinary; effectiveness; musculoskeletal disorders; screening for referral; manual therapy; exercise; cognitive behavioral therapy; pain neuroscience
(This special issue belongs to the Section Clinical Rehabilitation)
Pelvic Organ Prolapse: Clinical Advances and Challenges submission deadline 10 Jan 2026 | 1 articles | Viewed by 611 | Submission Open
Keywords: pelvic organ prolapse; pessary treatment; uterus-preserving prolapse surgery; clinical management; clinical treatment
(This special issue belongs to the Section Obstetrics & Gynecology)
Advances in Vascular and Endovascular Surgery: Second Edition
edited by and Afshin Assadian
submission deadline 11 Jan 2026 | 4 articles | Viewed by 4247 | Submission Open
Keywords: vascular surgery; endovascular surgery; aortic surgery; peripheral arterial disease; vascular imaging; EVAR; FEVAR; vascular access; vascular education; aneurysms
(This special issue belongs to the Section Vascular Medicine)
Clinical Updates in Physiotherapy for Musculoskeletal Disorders submission deadline 15 Jan 2026 | 10 articles | Viewed by 33026 | Submission Open
Keywords: musculoskeletal disorders; physiotherapy interventions; lifestyle; psychoneuroimmunology; chronic pain; inflammation; physical therapy
(This special issue belongs to the Section Clinical Rehabilitation)
Physical Therapy in Neurorehabilitation submission deadline 15 Jan 2026 | 8 articles | Viewed by 23661 | Submission Open
Keywords: physical therapy; transcutaneous electrical nerve stimulation (TENS); muscle strengthening; balance exercising; pain; quality of life; neurodegenerative disorders; neuromuscular disorders; stroke; demyelinating disorders
(This special issue belongs to the Section Clinical Neurology)
Innovative Systemic Treatments for Atopic Dermatitis
edited by
submission deadline 15 Jan 2026 | 5 articles | Viewed by 20447 | Submission Open
Keywords: atopic dermatitis; atopic eczema; JAK inhibitors; anti-IL-4; anti-IL-13; dupilumab; tralokinumab; lebrikizumab; abrocitinib; upadacitinib; baricitinib
(This special issue belongs to the Section Dermatology)
Clinical Application of Biomarkers in Cancers
edited by
submission deadline 15 Jan 2026 | 3 articles | Viewed by 17064 | Submission Open
Keywords: cancer biomarkers; early detection; personalized therapy; biomarker validation; advanced technologies; clinical implementation
(This special issue belongs to the Section Clinical Laboratory Medicine)
Current Trends and Prospects of Critical Emergency Medicine
edited by Quincy K. Tran
submission deadline 15 Jan 2026 | 8 articles | Viewed by 10665 | Submission Open
Keywords: critically ill patients; critical care; resuscitation; emergency medicine; trends; prospects; outcomes
(This special issue belongs to the Section Emergency Medicine)
Advances in Pulmonary Disease Management and Innovation in Treatment submission deadline 15 Jan 2026 | 6 articles | Viewed by 10177 | Submission Open
Keywords: severe asthma; COPD; sleep-related breathing disorders; respiratory tract infections; innovative respiratory therapies; translational pulmonary research; pulmonary vascular disease; interstitial lung disease; eHealth in respiratory care
(This special issue belongs to the Section Respiratory Medicine)
Pulmonary Embolism—Current and Novel Approaches
edited by Roy Beigel and Shlomi Matetzky
submission deadline 15 Jan 2026 | 3 articles | Viewed by 6279 | Submission Open
Keywords: pulmonary embolism; treatment; coagulation; venous thrombosis; thrombolysis; anticoagulation; risk stratification
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Assessment Measures and Theoretical Models of Caregivers' Sensitivity and Contingency: 2nd Edition
edited by
submission deadline 15 Jan 2026 | 3 articles | Viewed by 5440 | Submission Open
Keywords: clinical caregiving; sensitivity assessment; contingency modeling; caregiver– patient interactions; mental health outcomes; novel assessment measures; therapeutic responsiveness; caregiver interventions; clinical well-being; care recipient support
(This special issue belongs to the Section Intensive Care)
Clinical Advances in Minimally Invasive Urologic Surgery
edited by , Fabio Crocerossa and
submission deadline 15 Jan 2026 | 4 articles | Viewed by 5020 | Submission Open
Keywords: urology; uro-oncology; uro-gynecology; robotic surgery; laparoscopy; robot-assisted; artificial intelligence
(This special issue belongs to the Section Nephrology & Urology)
Clinical Management and Treatment of Psoriasis
edited by
submission deadline 15 Jan 2026 | 3 articles | Viewed by 4938 | Submission Open
Keywords: psoriasis; biological drugs; personalized medicine; comorbidities; real-world evidence
(This special issue belongs to the Section Dermatology)
Safety in Spinal Surgery
edited by Simon B. Roberts and
submission deadline 15 Jan 2026 | 1 articles | Viewed by 4877 | Submission Open
Keywords: spinal surgery; patients with spinal deformity; inherent risks; risk management; surgery safety
(This special issue belongs to the Section General Surgery)
Clinical Advances in the Diagnosis and Treatment of Cardiac Arrhythmias
edited by Fabrizio Guarracini and
submission deadline 15 Jan 2026 | 3 articles | Viewed by 4211 | Submission Open
Keywords: cardiac arrhythmias; antiarrhythmic agents; pacemakers; cardiac resynchronization; catheter ablation; electrophysiology
(This special issue belongs to the Section Cardiology)
Recent Clinical Advances in Percutaneous Coronary Intervention
edited by and Luke Pickup
submission deadline 15 Jan 2026 | 2 articles | Viewed by 3090 | Submission Open
Keywords: complex PCI; calcium modification; left main stem; stent; coronary artery disease; atherectomy; mechanical circula-tory support device; Impella; DCB; intra-coronary imaging; IVUS; OCT
(This special issue belongs to the Section Cardiology)
Up-to-Date Research in Liver Transplantation
edited by
submission deadline 15 Jan 2026 | 2 articles | Viewed by 2911 | Submission Open
Keywords: liver transplantation; acute or chronic liver diseases; hepatitis C virus infection; hepatocellular carcinoma (HCC); cirrhosis; intrahepatic (ICCA); perihilar (PCCA) cholangiocarcinoma; unresectable liver metastases; acute or chronic liver failure (ACLF); acute alcoholic hepatitis (AAH)
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Pediatric Nephrology: Advances in the Diagnosis and Management of Pediatric Kidney Disorders submission deadline 15 Jan 2026 | 3 articles | Viewed by 2863 | Submission Open
Keywords: diagnosis; management; treatment; kidney disorders; chronic kidney disease; biomarkers; genetic testing; kidney; children; newborn
(This special issue belongs to the Section Nephrology & Urology)
Diagnosis and Management of Aortic Diseases: Drafting from Theoretical Aspects to Clinical Practice—2nd Edition
edited by
submission deadline 15 Jan 2026 | 2 articles | Viewed by 2134 | Submission Open
Keywords: aortic disease; aortic aneurysm; aortic dissection; aortic surgery; diagnosis and management
(This special issue belongs to the Section Cardiovascular Medicine)
Intracranial Hemorrhage: Advances in Diagnosis, Management and Treatment
edited by Hitoshi Fukuda
submission deadline 15 Jan 2026 | 1 articles | Viewed by 1290 | Submission Open
Keywords: intracerebral hemorrhage; subarachnoid hemorrhage; traumatic hemorrhage; prehospital care; less invasive surgery; vascular malformation; antihypertensive drug; intracranial pressure elevation; decompressive craniectomy; neurocritical care; nursing care; rehabilitation
(This special issue belongs to the Section Clinical Neurology)
Advances in Oculoplastic Surgery and Ocular Surface Diseases
edited by Michael T. Yen, Francesco Quaranta Leoni and
submission deadline 15 Jan 2026 | 2 articles | Viewed by 1121 | Submission Open
Keywords: ocular surface disease; corneal neurotization; neurotrophic keratopathy; eyelid malposition; facial nerve palsy; thyroid eye disease; oculoplastic surgery; hemocomponents; dry anophthalmic socket; corneal pathology; ocular surface reconstruction; exposure keratopathy
(This special issue belongs to the Section Ophthalmology)
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