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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Advances in Prenatal Diagnosis and Fetal Therapy
edited by
submission deadline 25 Mar 2027 | 2 articles | Viewed by 3248 | Submission Open
Keywords: prenatal diagnosis; fetal therapy; genetic screening; non-invasive testing; fetal surgery; imaging technologies; high-risk pregnancies; in utero treatments; stem cell therapies; clinical innovations
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Strategies for Preventing Healthcare-Associated Infections submission deadline 25 Mar 2027 | 2 articles | Viewed by 2500 | Submission Open
Keywords: healthcare-associated infections; multidrug resistance; prevention; screening scales; polymicrobial infections; oppor-tunistic infections; sepsis
(This special issue belongs to the Section Infectious Diseases)
New Advances in Hip and Knee Reconstructive Surgery: 2nd Edition
edited by Senthil Sambandam
submission deadline 25 Mar 2027 | 2 articles | Viewed by 1636 | Submission Open
Keywords: knee; hip; joint arthroplasty; minimally invasive surgery; revision arthroplasty; periprosthetic joint infection; muscle injury; joint alignment; surgical advances; osteotomy; fracture; robotic-assisted surgery; perioperative optimization; telerehabilitation; aseptic loosening
(This special issue belongs to the Section Orthopedics)
Obesity in the 2020s and Beyond: A Multidisciplinary Overview
edited by
submission deadline 25 Mar 2027 | 2 articles | Viewed by 720 | Submission Open
Keywords: obesity; anti-obesity pharmacotherapy; clinical pharmacology; pharmacovigilance; cardiometabolic diseases
(This special issue belongs to the Section Pharmacology)
Advances in Cardiac Electrophysiology: Mechanisms of Arrhythmias and Ablation Technologies
edited by , Valeria Rella and Emanuele Curti
submission deadline 25 Mar 2027 | Viewed by 146 | Submission Open
Keywords: cardiac arrhythmias; cardiac electrophysiology; arrhythmias pathophysiology; arrhythmia mechanisms; catheter ablation; electro-anatomical mapping; mapping techniques; pacing maneuvers; pulsed field ablation; radiofrequency; autonomic modulation; cardioneuroablation; imaging; hybrid ablation; clinical outcomes
(This special issue belongs to the Section Cardiology)
Advanced and Personalized Drug Delivery Systems: From Formulation Science to Clinical Application
edited by
submission deadline 25 Mar 2027 | Viewed by 133 | Submission Open
Keywords: drug delivery systems; nanoparticles; lipid-based carriers; transdermal delivery; controlled release; bioavailability; pharmaceutical nanotechnology; personalized medicine; polymeric carriers; targeted therapy; in vitro–in vivo cor-relation; pharmaceutical compounding; stimuli-responsive drug delivery; clinical pharmacokinetics; innovative dosage forms
(This special issue belongs to the Section Pharmacology)
Minimally Invasive Approaches in Hand Surgery: Optimizing Outcomes and Minimizing Complications
edited by
submission deadline 25 Mar 2027 | Viewed by 126 | Submission Open
Keywords: percutaneous technique; ultrasound-guided procedures; arthroscopic management; robotic surgery in the hand and upper extremity; hand surgery
(This special issue belongs to the Section Orthopedics)
Insights into Infectious Disease Epidemiology, Management and Impact on Public Health
edited by Krystyna Dobrowolska, and
submission deadline 25 Mar 2027 | Viewed by 100 | Submission Open
Keywords: infectious disease; viral infections; bacterial infections; epidemiology; public health
(This special issue belongs to the Section Epidemiology & Public Health)
Current Updates and Advances in Hemodialysis—2nd Edition
edited by Edita Žiginskienė
submission deadline 25 Mar 2027 | Viewed by 55 | Submission Open
Keywords: kidney replacement therapy; hemodialysis; hemodiafiltration; vascular access; dialysis membranes; dialysis complications; dialysis adequacy; outcomes
(This special issue belongs to the Section Nephrology & Urology)
Robotic Pancreatic Surgery: Innovation, Outcomes, and Future Directions
edited by , Dimitrios Dimitroulis and
submission deadline 25 Mar 2027 | Submission Open
Keywords: robotic surgery; pancreatic surgery; Whipple; distal pancreatectomy; spleen preserving; pylorus preserving; pan-creaticoduodenectomy; enucleation; POPF; delayed gastric emptying
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
The Future Direction of Medical Imaging in Hepato-Bilio-Pancreatic Oncology: Challenges and Opportunities
edited by
submission deadline 26 Mar 2027 | 1 articles | Viewed by 1853 | Submission Open
Keywords: MRI; CT; molecular imaging; radiomics; imaging; radiogenomics; precision medicine; outcome prediction; cholangiocarcinoma; pancreatic cancer; imaging biomarkers; treatment response
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Pulmonary Hypertension: Clinical Perspectives
edited by and Maria Wieteska-Miłek
submission deadline 27 Mar 2027 | Viewed by 186 | Submission Open
Keywords: pulmonary hypertension (PH); pulmonary arterial hypertension (PAH); chronic thromboembolic pulmonary hypertension (CTEPH); chronic thromboembolic pulmonary disease; pulmonary embolism; diagnosis; treatment; quality of life; physical activity; prognostic factors; nonpharmacological treatment
(This special issue belongs to the Section Respiratory Medicine)
Cardiovascular Risk in COVID-19 Survivors: From Emergency Department Management to Cardiovascular Rehabilitation
edited by and Stela Iurciuc
submission deadline 28 Mar 2027 | Viewed by 137 | Submission Open
Keywords: cardiovascular risk management; COVID-19 survivors; long COVID syndrome; post-acute sequelae of SARS-CoV-2 infection (PASC); emergency department; cardiovascular rehabilitation; risk stratification; integrated care
(This special issue belongs to the Section Cardiovascular Medicine)
Approaches to Prevention and Management of Postoperative Complications in Minimally Invasive Surgery
edited by Shingo Tsujinaka
submission deadline 30 Mar 2027 | 3 articles | Viewed by 2442 | Submission Open
Keywords: minimally invasive surgery; postoperative complications; preventive measures; risk assessment; surgical techniques; patient optimization; complication management; surgical outcomes; patient satisfaction; patient-reported outcomes
(This special issue belongs to the Section General Surgery)
The Wide World of Antinuclear Antibodies (ANA)-Associated Disorders: Patterns, Clinical Phenotypes, Comorbidities, and Impact submission deadline 31 Mar 2027 | 1 articles | Viewed by 1666 | Submission Open
Keywords: antinuclear antibodies (ANA); ANA-associated disorders; clinical phenotypes; ANA patterns; lupus, Sjögren’s disease, systemic sclerosis, idiopathic inflammatory myopathies, comorbidities; connective tissue diseases; overlap syndromes; undifferentiated connective tissue disease; risk stratification; patient-centered management
(This special issue belongs to the Section Immunology & Rheumatology)
Aortic Surgery—Back to the Roots and Looking to the Future
edited by Ezin Deniz and
submission deadline 31 Mar 2027 | 1 articles | Viewed by 1281 | Submission Open
Keywords: aortic surgery; hybrid and endovascular innovations; perioperative management; cerebral and organ protection; biomaterials; translational cardiovascular research; imaging in aortic disease; long-term outcomes; cardiovascular surgery
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in Cutaneous and Systemic Lupus Erythematosus: Diagnosis, Treatment, and Comorbidities
edited by Magdalena Spałkowska and Joanna Kosałka-Węgiel
submission deadline 31 Mar 2027 | 1 articles | Viewed by 468 | Submission Open
Keywords: systemic lupus erythematosus; cardiovascular; Raynaud’s; cutaneous lupus erythematosus; autoimmune diseases
(This special issue belongs to the Section Immunology & Rheumatology)
Interventional Cardiology: Evolving Evidence and Emerging Horizons
edited by
submission deadline 31 Mar 2027 | Viewed by 333 | Submission Open
Keywords: coronary artery disease; percutaneous coronary intervention; drug-coated balloon; intravascular imaging; fractional flow reserve; transcatheter aortic valve implantation; transcatheter mitral valve repair; clinical outcomes
(This special issue belongs to the Section Cardiology)
Clinical Advances in Coronary Artery Bypass Grafting
edited by and Mirko Doss
submission deadline 31 Mar 2027 | Viewed by 202 | Submission Open
Keywords: coronary artery bypass grafting; CABG; myocardial revascularization; multiarterial grafting; conduit selection; off-pump CABG; on-pump CABG; anaortic CABG; no-touch technique; minimally invasive coronary surgery; endo-scopic coronary surgery; robot-assisted coronary surgery; hybrid coronary revascularization; graft patency; perioper-ative outcomes; cardiac surgery; cardiovascular innovation
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Applications and Advances in Arthroscopic, Endoscopic, and Minimally Invasive Techniques in Orthopaedics
edited by Stylianos Kapetanakis
submission deadline 31 Mar 2027 | 1 articles | Viewed by 188 | Submission Open
Keywords: arthroscopy; endoscopic surgery; minimally invasive surgery; orthopaedic surgery; sports medicine; spine surgery; surgery; robotics
(This special issue belongs to the Section Orthopedics)
JSOPB 2025–2026 Congress Special Issue—Update on Organ Preservation and Transplantation submission deadline 31 Mar 2027 | Viewed by 169 | Submission Open
Keywords: organ preservation; transplantation; pharmacology; clinical engineering; stem cell therapy
(This special issue belongs to the Section General Surgery)
Clinical Updates on Pediatric Gastrointestinal and Nutritional Disorders submission deadline 3 Apr 2027 | Viewed by 98 | Submission Open
Keywords: gastrointestinal; malnutrition; obesity; nutrition; pancreas; cystic fibrosis; epidemiology; eosinophilic esophagitis; liver disorders; endoscopy
(This special issue belongs to the Section Clinical Pediatrics)
Emerging Therapeutic Strategies for Coronary and Structural Heart Disease
edited by
submission deadline 5 Apr 2027 | Viewed by 87 | Submission Open
Keywords: coronary artery disease; structural heart disease; transcatheter interventions; percutaneous coronary intervention; valvular heart disease; cardiovascular therapeutics; interventional cardiology
(This special issue belongs to the Section Cardiovascular Medicine)
New Insights into Glaucoma: 2nd Edition
edited by and
submission deadline 10 Apr 2027 | 2 articles | Viewed by 1643 | Submission Open
Keywords: glaucoma; intraocular pressure (IOP); risk calculators; glaucoma screening glaucoma surgery; cataract surgery; trabeculectomy; glaucoma drainage devices; minimally invasive glaucoma surgery (MIGS); artificial intelligence (AI)
(This special issue belongs to the Section Ophthalmology)
Crohn’s Disease: Ongoing Challenges, and Future Directions in Diagnosis and Monitoring
edited by Laura Maria Minordi and
submission deadline 10 Apr 2027 | Viewed by 49 | Submission Open
Keywords: Crohn’s disease; imaging; endoscopy; complications; advanced therapies; radiomic; surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Functional Diagnostics and Physiotherapy of Musculoskeletal Disorders submission deadline 10 Apr 2027 | Viewed by 48 | Submission Open
Keywords: functional diagnostics; physiotherapy; rehabilitation; musculoskeletal system; functional assessment; gait analysis; movement biomechanics; postural control; postural stability; muscle strength; muscle tone; digital technologies in rehabilitation; objective measurement methods
(This special issue belongs to the Section Clinical Rehabilitation)
Contemporary Advances in Cardiomyopathies: Diagnosis, Risk Assessment and Therapeutic Innovation
edited by Maria Cristina Carella and
submission deadline 15 Apr 2027 | Viewed by 64 | Submission Open
Keywords: cardiomyopathies; cardiovascular genetics; cardiac magnetic resonance; advanced cardiovascular imaging; heart failure; sports cardiology; precision medicine
(This special issue belongs to the Section Cardiology)
Advances in Retinal Diseases—Mechanisms, Diagnostics, and Emerging Therapies, 2nd Edition
edited by
submission deadline 15 Apr 2027 | Viewed by 62 | Submission Open
Keywords: inherited retinal diseases; age-related macular degeneration; diabetic retinopathy; multimodal retinal imaging; treatment
(This special issue belongs to the Section Ophthalmology)
The Role of Non-Radiological Imaging in Interventional Arrhythmology Procedures: Challenges and New Perspectives
edited by and Stefano Bandino
submission deadline 15 Apr 2027 | Viewed by 53 | Submission Open
Keywords: cardiac interventional arrhythmology; cardiac ultrasound; echocardiography; near-zero x-ray; electroanatomical mapping; intracardiac echocardiography; thoracic ultrasound
(This special issue belongs to the Section Cardiology)
Sports Injury Rehabilitation and Clinical Recovery Strategies submission deadline 15 Apr 2027 | Viewed by 48 | Submission Open
Keywords: sports injury; rehabilitation; recovery; return to sport; return to performance; mechanobiology; load management; neuromuscular control; digital health; injury prevention
(This special issue belongs to the Section Sports Medicine)
Biomarkers in Cancer Diagnosis and Prognosis
edited by Gina Gheorghe
submission deadline 15 Apr 2027 | Submission Open
Keywords: cancer biomarkers; cancer diagnosis; cancer prognosis; liquid biopsy; precision oncology; tumor microenvironment; treatment response; personalized medicine
(This special issue belongs to the Section Oncology)
Cardiac Arrest: From Prevention to Survivorship—Advancing the Chainmail of Survival submission deadline 16 Apr 2027 | Viewed by 135 | Submission Open
Keywords: cardiac arrest; cardiopulmonary resuscitation (CPR); emergency medicine; emergency department; critical care; basic life support (BLS); advanced life support (ALS); chain of survival; chainmail of survival
(This special issue belongs to the Section Emergency Medicine)
Challenges in Diagnosis and Treatment of Infertility—2nd Edition
edited by Konstantinos A. Zikopoulos
submission deadline 20 Apr 2027 | 5 articles | Viewed by 24822 | Submission Open
Keywords: fertility; regeneration; age-related infertility; preimplantation diagnosis; precision assessment; individualized fertility needs; clinical diagnosis; in vitro fertilization
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Advances in Cardiac Surgery: Techniques, Outcomes, and Innovations
edited by , Horatiu Suciu and
submission deadline 20 Apr 2027 | 1 articles | Viewed by 955 | Submission Open
Keywords: endoscopic cardiac surgery; minimally invasive cardiac surgery; MIMS; mini-AVR; MIDCAB; TCRAT; LVAD; heart transplant; congenital heart disease
(This special issue belongs to the Section Cardiology)
Electrotherapy and Electrodiagnostic in Modern Rehabilitation Medicine: Current Evidence, Clinical Applications, and Future Perspectives
edited by Cristina Octaviana Daia
submission deadline 20 Apr 2027 | 1 articles | Viewed by 435 | Submission Open
Keywords: electrotherapy; physical and rehabilitation medicine; rehabilitation technologies; neurorehabilitation; cancer rehabilitation; electromyography; nerve conduction studies; musculoskeletal ultrasound; photobiomodula-tion; neuromuscular electrical stimulation; therapeutic ultrasound; extracorporeal shockwave therapy; electromagnetic field therapy; TECAR therapy
(This special issue belongs to the Section Clinical Rehabilitation)
Advances and Future Perspectives for Transcatheter Aortic Valve Replacement (TAVR)
edited by Kyriakos Spiliopoulos and Nikolaos Liaros
submission deadline 20 Apr 2027 | Viewed by 147 | Submission Open
Keywords: aortic stenosis; aortic valve replacement; transcatheter aortic valve replacement (TAVR); “Valve in Valve” procedure; TAVR-endocarditis; TAVR-durability; TAVR-design; cardiovascular imaging
(This special issue belongs to the Section Cardiology)
Innovations in Percutaneous Coronary Intervention
edited by Sachin Kumar and Amit Hooda
submission deadline 20 Apr 2027 | Viewed by 120 | Submission Open
Keywords: percutaneous coronary intervention; intravascular imaging; coronary physiology; complex coronary interventions; calcified coronary lesions; chronic total occlusion; atherectomy; bifurcation PCI; coronary CT angiography
(This special issue belongs to the Section Cardiology)
Advances in Rehabilitation and Musculoskeletal Health
edited by , and Daniela Matei
submission deadline 20 Apr 2027 | Viewed by 115 | Submission Open
Keywords: musculoskeletal disorders; musculoskeletal rehabilitation; physical medicine and rehabilitation; pain management; osteoarthritis; functional recovery; disability assessment; therapeutic exercise; physiotherapy; sports injuries; ultra-sound in rehabilitation; quality of life; well-being
(This special issue belongs to the Section Clinical Rehabilitation)
The New Frontier in Rheumatoid Arthritis: From Clinical Phenotypes to Precision Medicine
edited by Paula David and Amit Druyan
submission deadline 20 Apr 2027 | Viewed by 112 | Submission Open
Keywords: rheumatoid arthritis; precision medicine; musculoskeletal ultrasound; MRI; difficult-to-treat (D2T) RA; clinical phenotypes
(This special issue belongs to the Section Immunology & Rheumatology)
Burning Mouth Syndrome: Advances in Diagnosis and Patient-Centred Management
edited by Daniela Adamo and
submission deadline 20 Apr 2027 | Viewed by 100 | Submission Open
Keywords: oral medicine; oral pathology; burning mouth syndrome; orofacial pain; oral mucosal diseases; psychosomatic dentistry; pharmacological treatment; pharmacotherapy; topical therapy; systemic therapy; pain management; photo-biomodulation; laser therapy; neuromodulation; psychosomatic dentistry; patient-centred care; digital health
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Ileal and Bipartition Surgeries in the Era of Incretin-Based Therapies: Defining the Future of Metabolic Surgery
edited by
submission deadline 20 Apr 2027 | Viewed by 87 | Submission Open
Keywords: metabolic surgery; ileal and bipartition surgeries; incretin-based therapies; obesity; diabetes; type 2 diabetes; pharmacological treatment
(This special issue belongs to the Section General Surgery)
Advances in AI-Powered Brain Screening and Clinical Neuroscience
edited by
submission deadline 20 Apr 2027 | Viewed by 86 | Submission Open
Keywords: artificial intelligence; brain screening; small vessel disease; unruptured cerebral aneurysm; stroke; dementia; prevention; clinical neuroscience
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
Comorbidities and Challenges Throughout the Lifespan in Down Syndrome submission deadline 20 Apr 2027 | Viewed by 78 | Submission Open
Keywords: Down syndrome; comorbidities; neuropathology; imaging
(This special issue belongs to the Section Clinical Neurology)
Clinical Strategies in Cataract and Refractive Management
edited by and Arie Marcovich
submission deadline 20 Apr 2027 | Viewed by 78 | Submission Open
Keywords: cataract management; refractive management; cataract surgery; refractive surgery; intraocular lens (IOL); IOL power calculation; surgical planning; ocular biometry; anterior segment imaging; refractive outcomes; visual quality; ocular surface optimization; dry eye disease; surgical complications; patient-reported outcomes; clinical ophthalmology
(This special issue belongs to the Section Ophthalmology)
Clinical Advances in Cardiac Arrhythmia Treatment
edited by Nithi Tokavanich and Narut Prasitlumkum
submission deadline 20 Apr 2027 | Viewed by 73 | Submission Open
Keywords: arrhythmia; atrial fibrillation; atrial flutter; ventricular arrhythmia; premature ventricular contraction; sudden cardiac death; ventricular fibrillation; ablation; pulse field ablation; supraventricular tachycardia
(This special issue belongs to the Section Cardiology)
New Updates on Cochlear Implantation and Hearing Rehabilitation
edited by Davide Soloperto
submission deadline 20 Apr 2027 | Viewed by 72 | Submission Open
Keywords: pediatric audiology; cochlear implants; surgical strategies; robotic surgery; inner ear malformations; audiological outcomes evaluation
(This special issue belongs to the Section Otolaryngology)
Advanced Therapies and Circulatory Support for Cardiogenic Shock
edited by Ingo Voigt
submission deadline 20 Apr 2027 | Viewed by 71 | Submission Open
Keywords: cardiogenic shock; mechanical circulatory support; extracorporeal membrane oxygenation; ventricular assist devices; hemodynamic monitoring; shock team; myocardial recovery
(This special issue belongs to the Section Cardiology)
Bidirectional Interplay Between Hematological Malignancies and Comorbidities submission deadline 20 Apr 2027 | Viewed by 64 | Submission Open
Keywords: arrhythmias; cytokine release syndrome; heart failure; hepatitis; hypertension; leukemia; lymphoma; pulmonary fibrosis; renal dysfunction; second cancer
(This special issue belongs to the Section Hematology)
Evolving Imaging Techniques for the Tricuspid Valve and Right Ventricle: Challenges and Future Directions submission deadline 20 Apr 2027 | Viewed by 64 | Submission Open
Keywords: tricuspid valve disease; right ventricle; deformation imaging; cardiac imaging; right heart imaging
(This special issue belongs to the Section Cardiology)
Evolution of Breast and Lymphatic Reconstruction: Current Techniques, Advances and Future Directions
edited by
submission deadline 20 Apr 2027 | Viewed by 61 | Submission Open
Keywords: breast reconstruction; lymphedema; physiologic lymphatic surgery; robotic-assisted surgery; surgical innovation; surgical technology; microsurgery; supermicrosurgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
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