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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Research and Application of Artificial Intelligence and Deep Learning in Dentistry and Oral and Maxillofacial Surgery
edited by , and Lara Katharina Franziska Schorn
submission deadline 20 Sep 2026 | 4 articles | Viewed by 2725 | Submission Open
Keywords: artificial intelligence; deep learning; machine learning; oral and maxillofacial surgery; dentistry; medical imaging; clinical decision support
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Emerging Radiotherapy Technologies and Trends
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 2669 | Submission Open
Keywords: image-guided radiotherapy (IGRT); 4D radiotherapy; SBRT; radiomics; FLASH therapy; MR-guided radiotherapy
(This special issue belongs to the Section Oncology)
Up-to-Date Research on Nerve Ultrasound
edited by and Eman A. Tawfik
submission deadline 20 Sep 2026 | 1 articles | Viewed by 2664 | Submission Open
Keywords: peripheral nerve ultrasound; polyneuropathy; nerve trauma; plexus neuritis; nerve tumors; entrapment syndromes; ultrasound techniques; guidelines
(This special issue belongs to the Section Clinical Neurology)
Alopecia, Atopic Dermatitis and Other Chronic Inflammatory Skin Diseases: Pathogenesis, Comorbidities, and Precision Management submission deadline 20 Sep 2026 | 5 articles | Viewed by 2651 | Submission Open
Keywords: alopecia; atopic dermatitis; chronic urticaria; prurigo nodularis; chronic pruritus; inflammatory skin diseases; biomarkers; biologics; JAK inhibitors; quality of life; precision medicine
(This special issue belongs to the Section Dermatology)
Management of Dyslipidemias: Enhancing Lipid Modification to Reduce Cardiovascular Risk: 2nd Edition
edited by and Etienne Khoury
submission deadline 20 Sep 2026 | 1 articles | Viewed by 2504 | Submission Open
Keywords: cardiovascular disease; dyslipidemia; lipoprotein remnant; emerging lipid-lowering therapies; rare and severe causes of atherogenic lipid disorders; cardiovascular risk-related biomarkers; drug safety and efficacy
(This special issue belongs to the Section Cardiovascular Medicine)
Neurological Injury After Cardiac Arrest: Mechanisms, Prognostication, and Emerging Therapies
edited by and Nikos Gorgoraptis
submission deadline 20 Sep 2026 | 2 articles | Viewed by 2449 | Submission Open
Keywords: cardiac arrest; hypoxic–ischaemic brain injury; neuroprognostication; neuroprotection; biomarkers; targeted tem-perature management; multimodal monitoring; neurorehabilitation
(This special issue belongs to the Section Emergency Medicine)
Current Challenges and Approaches to Post-Traumatic Stress Disorder (PTSD)
edited by
submission deadline 20 Sep 2026 | 1 articles | Viewed by 2208 | Submission Open
Keywords: PTSD treatment; implementation; prevention; prevalence; risk factors
(This special issue belongs to the Section Mental Health)
Current Clinical Research in Oral Maxillofacial Surgery
edited by , Marcin Kozakiewicz, Łukasz J. Krakowczyk and Tadeusz Morawiec
submission deadline 20 Sep 2026 | 4 articles | Viewed by 2164 | Submission Open
Keywords: oral and maxillofacial surgery; craniofacial surgery; orthognathic surgery; maxillofacial trauma; head and neck oncology; microsurgical reconstruction; temporomandibular joint (TMJ); virtual surgical planning (VSP); patient-specific implants (PSI); complications and outcomes
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Digestive Disorders: Updates on Disease Monitoring, Prediction Models and Management submission deadline 20 Sep 2026 | 3 articles | Viewed by 2163 | Submission Open
Keywords: inflammatory bowel disease; metabolic dysfunction-associated fatty liver disease; liver disease; alcohol related liver disease; infection; Clostridioides difficile infection
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Diagnosis and Treatment of Uveitis
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 1973 | Submission Open
Keywords: uveitis; intraocular tumors; medical retina; pediatric retina
(This special issue belongs to the Section Ophthalmology)
Pediatric Oral Health: Developmental, Functional, and Special Care Perspectives submission deadline 20 Sep 2026 | 2 articles | Viewed by 1934 | Submission Open
Keywords: pediatric oral health; early childhood oral health; malocclusion; oral habits; craniofacial growth and development; dental development defects; dental trauma in children; orofacial functions; oral–systemic health; preventive and community dentistry; early oral intervention
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advances in Autism Management submission deadline 20 Sep 2026 | 1 articles | Viewed by 1860 | Submission Open
Keywords: autism spectrum disorder; diagnosis; child; adult; youth; early intervention; therapy; epidemiology; relatives; resources; limitations; problems; health; epidemiology; perspectives; organization
(This special issue belongs to the Section Mental Health)
Cardiometabolic Insights into Metabolic Dysfunction: From Mechanisms to Therapeutic Strategies
edited by Alessandro Andreis, and
submission deadline 20 Sep 2026 | 1 articles | Viewed by 1860 | Submission Open
Keywords: cardiovascular complications; pharmacological; interventional strategies; cardiology; endocrinology; hepatology
(This special issue belongs to the Section Cardiology)
Rehabilitation in Musculoskeletal Disease
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 1830 | Submission Open
Keywords: musculoskeletal disease; stroke rehabilitation; physical therapy; rehabilitation; chronic pain; manual therapy; exercise intervention
(This special issue belongs to the Section Clinical Rehabilitation)
Atrial Fibrillation: Screening, Management and Outcomes
edited by Ahmed AlTurki and Vidal Essebag
submission deadline 20 Sep 2026 | 2 articles | Viewed by 1811 | Submission Open
Keywords: atrial fibrillation; ablation; pulmonary vein isolation; atrial fibrillation screening; wearable devices; anti-arrhythmic drugs; cardiovascular outcomes; subclinical atrial fibrillation
(This special issue belongs to the Section Cardiology)
Advances in Physical Therapy for Healthy Aging: Innovative and Functional Rehabilitation Approaches submission deadline 20 Sep 2026 | 3 articles | Viewed by 1729 | Submission Open
Keywords: physical therapy; healthy aging; functional rehabilitation; therapeutic exercise; motor control; pelvic floor rehabilitation; preventive interventions
(This special issue belongs to the Section Clinical Rehabilitation)
Advances in Managing High-Risk Pregnancies: Innovations in Diagnosis, Prevention and Clinical Care
edited by , Vivien Dütemeyer and Jacques Jani
submission deadline 20 Sep 2026 | 3 articles | Viewed by 1704 | Submission Open
Keywords: high-risk pregnancy; maternal–fetal medicine; prenatal diagnosis; fetal growth restriction; preeclampsia; preterm birth; biomarkers; maternal comorbidities; clinical imaging; precision obstetrics
(This special issue belongs to the Section Obstetrics & Gynecology)
Current Advances in Artificial Intelligence in Oral Cancer Research, Early Diagnosis, and Personalized Therapy
edited by Aminollah Khormali
submission deadline 20 Sep 2026 | 1 articles | Viewed by 1596 | Submission Open
Keywords: artificial intelligence; precision oncology; digital pathology; deep learning; early cancer detection; predic-tive modeling; oral cancer diagnostics
(This special issue belongs to the Section Oncology)
Recent Progress and Future Perspectives in Orthodontics submission deadline 20 Sep 2026 | 2 articles | Viewed by 1567 | Submission Open
Keywords: skeletal anchorage; temporary anchorage devices; multidisciplinary orthodontic treatment; digital orthodontics; clear aligner therapy; 3D imaging and virtual treatment planning; airway-focused orthodontics
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Recent Advances in Vitreoretinal Surgery: 2nd Edition
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 1529 | Submission Open
Keywords: vitrectomy; retinal detachment; macular holes; pediatric vitreoretinal surgery; vitrectomy instrumentation; macular surgery; complex retinal detachments; vitreoretinal surgery
(This special issue belongs to the Section Ophthalmology)
The Diagnosis and Treatment of Endometriosis
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 1506 | Submission Open
Keywords: endometriosis; infertility; pregnancy; hysterosalpingography; deep lesions; medical imaging; diagnostic techniques; ultrasonography; magnetic resonance imaging (MRI); laparoscopy; pelvic imaging; fertility assessment; imaging modalities; gynecological imaging; radiological approaches; reproductive medicine; immunotherapy; inflammation; antioxidants
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Challenges and Future Directions of Interstitial Lung Disease
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 1428 | Submission Open
Keywords: interstitial lung disease; progressive pulmonary fibrosis; early detection; clinical diagnosis; multidisciplinary discussion; treatment; non-pharmacological therapy; end-of-life care; patient-centered management
(This special issue belongs to the Section Respiratory Medicine)
Vertigo and Dizziness in Children: Clinical Updates submission deadline 20 Sep 2026 | 1 articles | Viewed by 1371 | Submission Open
Keywords: vertigo; dizziness; children; vestibular disorders; otorhinolaryngology
(This special issue belongs to the Section Clinical Pediatrics)
Perinatal and Postnatal Mental Health: State of the Art
edited by Adriana Mihai
submission deadline 20 Sep 2026 | 1 articles | Viewed by 1336 | Submission Open
Keywords: peripartum depression; post-partum depression; parental–infant well-being; early detection; perinatal mental health; postnatal mental health; psychotherapy interventions
(This special issue belongs to the Section Mental Health)
Treatment and Clinical Management of Necrotizing Pancreatitis submission deadline 20 Sep 2026 | 2 articles | Viewed by 1316 | Submission Open
Keywords: necrotizing pancreatitis; infected necrosis; step-up approach; necrosectomy; minimally invasive surgery; artificial intelligence; lumen-apposing metal stent; pancreatic necrosis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Updates in the Use of Pharmacogenetics in Clinical Practice
edited by Rocío Morón Romero and Xando Díaz-Villamarín
submission deadline 20 Sep 2026 | 1 articles | Viewed by 1306 | Submission Open
Keywords: pharmacogenetics; personalized medicine; clinical implementation; drug response; pharmacogenomics; precision medicine; healthcare integration; decision support; clinical implications of genetic testing
(This special issue belongs to the Section Pharmacology)
Emerging Trends in Atrial Fibrillation Management
edited by Guy Rozen
submission deadline 20 Sep 2026 | 1 articles | Viewed by 1271 | Submission Open
Keywords: cardiology; atrial fibrillation; left atrial appendage occlusion; echocardiography; pulse field ablation
(This special issue belongs to the Section Cardiology)
Beyond Efficacy and Trials: Real-World Value and Effectiveness in Autoimmune Rheumatic Joint Diseases
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 1267 | Submission Open
Keywords: effectiveness; efficacy; autoimmune rheumatic joint diseases; patient-reported outcomes; quality of life
(This special issue belongs to the Section Immunology & Rheumatology)
Innovations and Clinical Advances in CMR and Echocardiography
edited by Raluca Tomoaia and
submission deadline 20 Sep 2026 | 1 articles | Viewed by 1156 | Submission Open
Keywords: cardiac magnetic resonance; echocardiography; cardiomyopathy; ischaemic heart disease; valvular heart disease; risk stratification; clinical outcomes
(This special issue belongs to the Section Cardiology)
Diagnosis, Treatment and Comorbidities in Chronic Obstructive Pulmonary Disease (COPD): 3rd Edition
edited by Juan Luis Rodriguez Hermosa, José Luis Álvarez-Sala Walther and Myriam Calle Rubio
submission deadline 20 Sep 2026 | 2 articles | Viewed by 1098 | Submission Open
Keywords: COPD; diagnosis; comorbidities; respiratory rehabilitation; inhaled therapy; biological therapies
(This special issue belongs to the Section Respiratory Medicine)
Diabetic Foot: From Prevention to Diagnosis and Treatment
edited by , and Michael Edmonds
submission deadline 20 Sep 2026 | 1 articles | Viewed by 994 | Submission Open
Keywords: diabetic foot ulcer; peripheral arterial disease; diabetic foot infection; Charcot foot; diabetic foot mortality
(This special issue belongs to the Section Endocrinology & Metabolism)
Obsessive–Compulsive Disorder (OCD): Understanding, Treatment, and New Directions in Psychotherapy
edited by Franziska Sophia Miegel
submission deadline 20 Sep 2026 | 1 articles | Viewed by 820 | Submission Open
Keywords: obsessive–compulsive disorder; clinical psychopathology; mechanisms of change; psychotherapeutic interventions; treatment delivery; accessibility of care; innovative treatment approaches; technology-supported interventions
(This special issue belongs to the Section Mental Health)
Enhanced Recovery After Surgery: Guidelines and Implementation Methods
edited by Ilda Hoxhaj and
submission deadline 20 Sep 2026 | 1 articles | Viewed by 802 | Submission Open
Keywords: enhanced recovery after surgery (ERAS); surgical outcomes; perioperative care; clinical guidelines; patient-centered care
(This special issue belongs to the Section General Surgery)
Challenges and Innovations in Thrombosis and Haemostasis
edited by Vasiliki Danilatou and Fotios I. Girtovitis
submission deadline 20 Sep 2026 | Viewed by 784 | Submission Open
Keywords: air pollution and thrombosis; antiphospholipid syndrome; antithrombotic therapy; arterial thrombosis; artificial intelligence in thrombosis and haemostasis; biology of arterial thrombosis; biomarkers in thrombosis and haemostasis; cancer-associated thrombosis; clinical decision support; current concepts and novel targets for antiplatelet treatments; digital health in heamostasis and thrombosis; endotheliopathy and thrombosis; ethical challenges in thrombosis care; hemophilia and von willebrand disease; innovative therapies in thrombosis and haemostasis; pediatric thrombosis; platelet biology and function: new concepts and clinical perspectives; rare blood disorders; thrombophilia; thrombosis and hemostasis guidelines; thrombosis in pregnancy; thrombo-inflammation; trauma-induced coagulopathy; venous thromboembolism
(This special issue belongs to the Section Vascular Medicine)
Multifactorial Causation and Therapy of Sleep Disorders
edited by
submission deadline 20 Sep 2026 | 1 articles | Viewed by 720 | Submission Open
Keywords: sleep disorders; narcolepsy; sleep-neurology; REM sleep behavior disorder; sleep apneas
(This special issue belongs to the Section Clinical Neurology)
New Perspectives in the Diagnosis and Management of Skin Cancer
edited by Emily Avitan-Hersh
submission deadline 20 Sep 2026 | 1 articles | Viewed by 661 | Submission Open
Keywords: skin cancer; melanoma; cutaneous lymphoma; Kaposi; Merkel cell carcinoma; basal cell carcinoma; immunotherapy
(This special issue belongs to the Section Dermatology)
Clinical Challenges and Prognosis of Hemodialysis
edited by Guido Gembillo
submission deadline 20 Sep 2026 | 1 articles | Viewed by 444 | Submission Open
Keywords: hemodialysis; uremic toxins; inflammation; fluid management; vascular access; chronic kidney disease
(This special issue belongs to the Section Nephrology & Urology)
Oral and Maxillofacial Surgery: From Disease Diagnosis and Treatment to Functional and Esthetic Reconstruction
edited by Sho Mitsugi, Manabu Habu and Masahiro Watanabe
submission deadline 20 Sep 2026 | Viewed by 406 | Submission Open
Keywords: jaw deformity; orthognathic surgery; oral cancer; reconstructive surgery; temporomandibular joint; jaw fracture; AI; simulation
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Current Concepts in Prostate Cancer: From Early Detection to Therapeutic Innovations
edited by , and Igor Duquesne
submission deadline 20 Sep 2026 | 1 articles | Viewed by 393 | Submission Open
Keywords: prostate cancer; miRNA; PSMA PET/CT; radiomics; multiparametric MRI (mpMRI); active surveillance; robot-assisted radical prostatectomy (RARP); focal therapy; functional outcomes; Quality of Life (QoL)
(This special issue belongs to the Section Oncology)
Extracorporeal Membrane Oxygenation (ECMO): Clinical Application and Advances
edited by
submission deadline 20 Sep 2026 | Viewed by 392 | Submission Open
Keywords: extracorporeal membrane oxygenation (ECMO); venoarterial ECMO; venovenous ECMO; extracorporeal cardiopulmonary resuscitation (ECPR); cardiogenic shock; acute respiratory distress syndrome (ARDS); mechanical circulatory support; ECMELLA; ECCO2R; cannulation techniques; anticoagulation; mobile ECMO; donation after circulatory death (DCD); normothermic regional perfusion (NRP); organ donation; organ preservation; transplantation
(This special issue belongs to the Section Intensive Care)
Acute Cardiovascular Care in Cardio-Oncology: Present Challenges and Future Pathways
edited by and Maria Bergami
submission deadline 20 Sep 2026 | Viewed by 378 | Submission Open
Keywords: cardiotoxicity; cardio-oncology; acute cardiovascular care; acute cardiovascular complications; disparities in care
(This special issue belongs to the Section Cardiovascular Medicine)
Novel Clinical Applications of Cardiac Magnetic Resonance Imaging
edited by Bobby Heydari
submission deadline 20 Sep 2026 | 1 articles | Viewed by 346 | Submission Open
Keywords: cardiac magnetic resonance; CMR; cardiovascular imaging; tissue characterization; cardiomyopathy; myocardial ischemia; advanced imaging techniques; artificial intelligence; tissue mapping; quantitative stress perfusion; 4D flow; spectroscopy
(This special issue belongs to the Section Cardiology)
Clinical Strategies in Structural Heart and Cardiothoracic Interventions
edited by
submission deadline 20 Sep 2026 | Viewed by 329 | Submission Open
Keywords: structural heart disease; heart team; valvular heart disease; cardiac surgery; transcatheter interventions; patient selection; real-world outcomes
(This special issue belongs to the Section Cardiology)
Clinical Challenges in Obstetrics and Gynecology: Interactions Between Gynecological and Obstetric Disorders, Quality of Life, and Mental Health in Women—2nd Edition
edited by and Daniel María Lubián López
submission deadline 20 Sep 2026 | Viewed by 324 | Submission Open
Keywords: perinatal mental health; gynecological disorders; sexual disorders; women’s quality of life; obstetric complications; women’s health; women’s psychological well-being
(This special issue belongs to the Section Obstetrics & Gynecology)
Mitral Valve Surgery: Current Status and Future Challenges—2nd Edition
edited by Antonio Lio and Marco Russo
submission deadline 20 Sep 2026 | Viewed by 315 | Submission Open
Keywords: mitral valve; mitral valve repair; mitral valve replacement; minimally invasive surgery; robotic surgery
(This special issue belongs to the Section Cardiology)
Human Microbiota Analysis: Focus on Pediatric Clinical Applications submission deadline 20 Sep 2026 | Viewed by 314 | Submission Open
Keywords: microbiota; diet; lifestyle; eubiosis; dysbiosis; omics approach; pediatric
(This special issue belongs to the Section Clinical Pediatrics)
Exercise and Chronic Pain
edited by Nuria Marín-Jiménez and Milkana Borges-Cosic
submission deadline 20 Sep 2026 | Viewed by 307 | Submission Open
Keywords: chronic pain; exercise therapy; physical activity; fitness; pain management; quality of life; non-pharmacological interventions
(This special issue belongs to the Section Sports Medicine)
Advanced Technologies in Orthopedic Surgery: Progress, Challenges and Opportunities
edited by and Daniel Pérez-Prieto
submission deadline 20 Sep 2026 | Viewed by 300 | Submission Open
Keywords: orthopedic surgery; traumatology; orthopedic infections; osteomyelitis; prosthetic joint infections; robotic-assisted surgery; biomaterials; 3D printing surgical planning; AI in orthopedics
(This special issue belongs to the Section Orthopedics)
PET/CT Imaging in Oncology: Clinical Applications and Updates submission deadline 20 Sep 2026 | Viewed by 298 | Submission Open
Keywords: Positron Emission Tomography/Computed Tomography (PET/CT); molecular imaging; oncology; Fluoro-Deoxy-Glucose (FDG); novel tracers (PSMA, FAPI, radiolabeled peptides); quantitative PET
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Advances in Imaging and Therapeutic Strategies for Cardiomyopathy Care
edited by Fabio Vagnarelli and
submission deadline 20 Sep 2026 | Viewed by 291 | Submission Open
Keywords: cardiomyopathy; amyloidosis; cardiovascular magnetic resonance; cardiogenetics; multimodality imaging; therapeutic strategies
(This special issue belongs to the Section Cardiology)
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