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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights into Liver Cirrhosis and Portal Hypertension
edited by Gerond V. Lake-Bakaar
submission deadline 20 Oct 2026 | 2 articles | Viewed by 922 | Submission Open
Keywords: cirrhosis; portal hypertension; liver resection; hepatocellular carcinoma; hepatic blood flow; varices; portosystemic collaterals; hepatic sinusoids
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Recent Advances and Future Trends in Shoulder Surgery
edited by Giovanni Merolla
submission deadline 20 Oct 2026 | 1 articles | Viewed by 878 | Submission Open
Keywords: rotator cuff; shoulder instability; acromion-clavicular joint; arthroplasty; shoulder rehabilitation
(This special issue belongs to the Section Orthopedics)
Rheumatoid Arthritis: New Insights and Challenges
edited by
submission deadline 20 Oct 2026 | 1 articles | Viewed by 842 | Submission Open
Keywords: DMARDs (disease-modifying anti-rheumatic drugs); boDMARDs (biological DMARDs); bsDMARDs (biosimilar DMARDs); csDMARDs (conventional synthetic DMARDs); rheumatoid arthritis; tsDMARDs (targeted synthetic DMARDs)
(This special issue belongs to the Section Immunology & Rheumatology)
Sepsis and Organ Dysfunction: New Insights into Diagnosis and Treatment—Second Edition
edited by
submission deadline 20 Oct 2026 | 1 articles | Viewed by 827 | Submission Open
Keywords: intensive care; sepsis; shock; biomarkers; rapid methods for pathogen identification; multiorgan dysfunction syndrome; extracorporeal methods; mortality
(This special issue belongs to the Section Intensive Care)
Uterine Fibroids—Quality of Life and Minimally Invasive Therapy Options
edited by and Maciej Wilczak
submission deadline 20 Oct 2026 | 1 articles | Viewed by 827 | Submission Open
Keywords: uterine fibroids; radiofrequency ablation; pain; quality of life; menstrual bleeding
(This special issue belongs to the Section Obstetrics & Gynecology)
Technological Innovations in Spine Surgery: Diagnosis and Management
edited by
submission deadline 20 Oct 2026 | 1 articles | Viewed by 788 | Submission Open
Keywords: spine surgery; neurosurgery; spinal imaging; surgical navigation; robotic spine surgery; artificial intelligence; ma-chine learning; minimally invasive spine surgery; spinal trauma; spinal tumors; surgical innovation; intraoperative technology; outcome prediction; precision surgery; digital health
(This special issue belongs to the Section Orthopedics)
Endoscopic Application of Pancreatic and Biliary Diseases: Diagnosis and Treatment submission deadline 20 Oct 2026 | 1 articles | Viewed by 768 | Submission Open
Keywords: endoscopic retrograde cholangiopancreatography (ERCP); endoscopic ultrasound (EUS); drainage; lumen-apposing metal stent (LAMS); pancreatoscopy; cholangioscopy; pancreatic cancer; pancreatitis; biliary cancer; cholangitis; gallbladder; walled-off necrosis; lithotripsy; radiofrequency ablation (RFA); photodynamic therapy (PDT); necrosectomy; EUS-guided gastroenteroanastomosis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Cutaneous Oncology: Advances in Melanoma, Basal Cell Carcinoma and Other Skin Cancers
edited by Emanuela Passoni, and
submission deadline 20 Oct 2026 | 1 articles | Viewed by 613 | Submission Open
Keywords: melanoma; basal cell carcinoma; squamous cell carcinoma; nevi; dermoscopy; skin cancers; skin tumors
(This special issue belongs to the Section Dermatology)
Current Perspectives and Emerging Insights in Urological Cancer submission deadline 20 Oct 2026 | 1 articles | Viewed by 609 | Submission Open
Keywords: prostate cancer; renal cancer; bladder cancer; urogenital cancer; urological cancer; biopsy; diagnosis; therapy
(This special issue belongs to the Section Nephrology & Urology)
Smart Anesthesia and Perioperative Care: AI, Monitoring, and Outcomes submission deadline 20 Oct 2026 | 1 articles | Viewed by 599 | Submission Open
Keywords: anesthesia; perioperative outcomes; machine learning; artificial intelligence; wearable monitoring; patient safety; critical care; postoperative surveillance
(This special issue belongs to the Section Anesthesiology)
Inflammatory Bowel Diseases: From Diagnosis to Treatment
edited by and Akira Horiuchi
submission deadline 20 Oct 2026 | 1 articles | Viewed by 594 | Submission Open
Keywords: inflammatory bowel disease; Crohn’s disease; ulcerative colitis; diagnosis and biomarker; biologics and small molecule; treat-to-target strategies; precision medicine
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Arterial Stiffness: A Key Determinant of Cardiovascular Risk in Clinical Medicine
edited by Hack-Lyoung Kim
submission deadline 20 Oct 2026 | 1 articles | Viewed by 553 | Submission Open
Keywords: cardiology; cardiovascular medicine; arterial stiffness; pulse wave velocity; central hemodynamics; vascular aging; hypertension; atherosclerosis; arteriosclerosis; cardiovascular risk stratification
(This special issue belongs to the Section Cardiology)
Insights from Cardiopulmonary Exercise Testing to Cardiac Rehabilitation
edited by
submission deadline 20 Oct 2026 | 1 articles | Viewed by 526 | Submission Open
Keywords: cardiac rehabilitation; exercise physiology; exercise performance; exercise testing; physical activity assessment; exercise; physical activity; oxygen consumption; cardiopulmonary exercise testing
(This special issue belongs to the Section Cardiology)
Clinical Insights into New Therapeutic Strategies of Atrial Fibrillation submission deadline 20 Oct 2026 | 1 articles | Viewed by 433 | Submission Open
Keywords: atrial fibrillation; rhythm control; catheter ablation; pulsed field ablation; stroke prevention; anticoagulation strategies; left atrial appendage closure; wearable technologies; artificial intelligence in cardiology; precision medicine
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Advances in Radiation Treatment of Head and Neck Cancers
edited by Daniela Dumitrescu, and Dragoș-Ovidiu Alexandru
submission deadline 20 Oct 2026 | 1 articles | Viewed by 431 | Submission Open
Keywords: head and neck cancer; radiation therapy; IMRT and VMAT; Image-guided and adaptive radiotherapy; CT, MRI, and PET imaging; post-radiotherapy response assessment; radiation-induced toxicity; skin and mucosal toxicity; dental, maxillofacial, and reconstructive complications; multimodal oncologic treatment
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Innovations in Minimally Invasive Spine Surgery (MISS): Diagnosis and Management
edited by Seong Son
submission deadline 20 Oct 2026 | Viewed by 427 | Submission Open
Keywords: spinal disease; innovative diagnosis; advanced technique; minimally invasive spine surgery; surgical technology; full-endoscopic spine surgery; uniportal endosopy; unilateral biportal endoscopy; biportal endoscopic surgery
(This special issue belongs to the Section Orthopedics)
Clinical Translational Electrophysiology and Therapeutic Innovation in Cardiovascular Disease
edited by Mena Abdelsayed
submission deadline 20 Oct 2026 | 1 articles | Viewed by 416 | Submission Open
Keywords: cardiac electrophysiology; arrhythmias; translational cardiology; hiPSC-derived cardiomyocytes; lon channels; precision medicine; drug repurposing; computational modeling; neuromodulation; mechanobiology; digital twins
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in the Management of Pediatric Neuromuscular Diseases
edited by Nicolas Deconinck
submission deadline 20 Oct 2026 | Viewed by 409 | Submission Open
Keywords: pediatric neuromuscular diseases; neuromuscular disorders (NMD); pediatric; genetic NMD; juvenile myasthenia gravis; chronic demyelinating polyneuropathy; next generation sequencing (NGS); spinal muscular atrophy; Duchenne muscular dystrophy; clinical guidelines
(This special issue belongs to the Section Clinical Neurology)
Up-to-Date Orthopedic Treatment and Care for Osteoporotic Fracture of the Elderly submission deadline 20 Oct 2026 | Viewed by 384 | Submission Open
Keywords: osteoporotic fractures; elderly patients; orthopedic surgery; minimally invasive techniques; fracture rehabilitation; kyphoplasty
(This special issue belongs to the Section Orthopedics)
The Latest Research on Male Infertility
edited by Gianmaria Salvio and Nicola delli Muti
submission deadline 20 Oct 2026 | Viewed by 383 | Submission Open
Keywords: idiopathic male infertility; unexplained male infertility; semen quality; testicular dysfunction; male hypogonadism; gonadal failure
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Management of Coronary Syndrome for Better Outcome
edited by , and Antonio Luca Maria Parlati
submission deadline 20 Oct 2026 | Viewed by 350 | Submission Open
Keywords: acute coronary syndrome; chronic coronary syndrome; percutaneous coronary intervention; dual antiplatelet therapy; intravascular imaging; risk stratification; secondary prevention; cardiovascular outcomes; artificial intelligence; digital health
(This special issue belongs to the Section Cardiology)
New Insights into Breast Neoplasms: Prevention, Multidisciplinary Management and Beyond the Core Team submission deadline 20 Oct 2026 | Viewed by 340 | Submission Open
Keywords: breast cancer; tumor heterogeneity; estrogen receptor; progesterone receptor; triple-negative breast cancer; metastasis; immunotherapy; targeted therapy; early detection; prognosis; adjuvant treatment
(This special issue belongs to the Section Oncology)
Navigating Pathways for Children Who Are Deaf or Hard of Hearing: Emerging Opportunities and Challenges
edited by Valerie Sung and
submission deadline 20 Oct 2026 | Viewed by 336 | Submission Open
Keywords: childhood hearing loss; deaf; hard of hearing; children; families; lived experience; family-centered early intervention; gene therapy; screening; congenital cytomegalovirus; hearing technologies; cochlear implants
(This special issue belongs to the Section Otolaryngology)
Maternal–Fetal Medicine: Clinical Updates and Perspectives
edited by and Hadas Miremberg
submission deadline 20 Oct 2026 | Viewed by 322 | Submission Open
Keywords: preterm labor; hypertensive disorders of pregnancy; fetal growth restriction; gestational diabetes; multiple pregnancy
(This special issue belongs to the Section Obstetrics & Gynecology)
Personalized Medicine in Psychiatry: Precision Approaches to Diagnosis and Treatment
edited by Simran Maggo
submission deadline 20 Oct 2026 | Viewed by 322 | Submission Open
Keywords: pharmacogenomics; precision medicine; precision psychiatry; pharmacogenomic testing; pharmacogenomic bioinfor-matics
(This special issue belongs to the Section Mental Health)
Technological Advances and Innovations in Spine Surgery
edited by
submission deadline 20 Oct 2026 | Viewed by 313 | Submission Open
Keywords: neurosurgery; spine surgery; lumbar spine; lumbar spondylolisthesis; artificial disk/artificial facet replacement; motion preservation; patient-specific implants; enabling technologies; use of AI
(This special issue belongs to the Section Clinical Neurology)
Optimizing Post-Return of Spontaneous Circulation (Post-ROSC) Management for Out-of-Hospital Cardiac Arrest (OHCA): Strategies to Enhance Survival, Neurological Recovery, and Social Reintegration
edited by
submission deadline 20 Oct 2026 | Viewed by 309 | Submission Open
Keywords: return of spontaneous circulation (ROSC); quality of life; psychological distress; post-ROSC management; return to society
(This special issue belongs to the Section Cardiology)
Clinical Highlights and Digital Evolution in Trauma and Orthopedic Surgery submission deadline 20 Oct 2026 | Viewed by 302 | Submission Open
Keywords: trauma surgery; orthopedic surgery; musculoskeletal trauma; joint reconstruction; minimally invasive techniques; surgical innovation; implant technology; sports injuries; evidence-based orthopedics; clinical translational research; digital surgery; research reproducibility
(This special issue belongs to the Section Orthopedics)
Advances in Mapping and Catheter Ablation of Ventricular Tachycardia
edited by , , , Antonio Bisignani and Stefano Bianchi
submission deadline 20 Oct 2026 | Viewed by 278 | Submission Open
Keywords: catheter ablation; ventricular tachycardia; sudden cardiac death; structural heart disease
(This special issue belongs to the Section Cardiology)
Recent Updates in Minimally Invasive Surgery
edited by Simona Parisi and
submission deadline 20 Oct 2026 | Viewed by 274 | Submission Open
Keywords: mini-invasive surgery; robotic surgery; patient compliance; mini-invasive diagnostic procedures; patient comfort
(This special issue belongs to the Section General Surgery)
A New Era of Myalgic Encephalomyelitis (ME) Evolving from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
edited by
submission deadline 20 Oct 2026 | Viewed by 271 | Submission Open
Keywords: myalgic encephalomyelitis; chronic fatigue syndrome; post-exertional malaise; central nervous system; neuroinflammation; orthostatic intolerance; disequilibrium; neuroimmune disorder
(This special issue belongs to the Section Clinical Neurology)
Best Practices in Kidney Transplantation Across the Continuum: Evaluation to Graft Failure
edited by Sami Alasfar
submission deadline 20 Oct 2026 | Viewed by 261 | Submission Open
Keywords: kidney transplantation; allograft rejection; biomarkers; immunosuppression; failing allograft; retransplantation; transplant outcomes
(This special issue belongs to the Section Nephrology & Urology)
State of the Art: Updates in Preterm Labor and Preterm Birth—2nd Edition
edited by and Moti Gulersen
submission deadline 20 Oct 2026 | Viewed by 258 | Submission Open
Keywords: prenatal diagnosis; fetal neurosonography; detection of fetal anomalies in the first trimester; preterm birth; antenatal corticosteroids; cerclage; mutiple gestations
(This special issue belongs to the Section Obstetrics & Gynecology)
Cardiogenic Shock: New Insights into Diagnosis, Management and Prognosis
edited by Faisal Rahman
submission deadline 20 Oct 2026 | Viewed by 254 | Submission Open
Keywords: cardiogenic shock; patient outcomes; mechanical circulatory support; hemodynamics; care disparities; healthcare
(This special issue belongs to the Section Cardiology)
Spinal Cord Injury in Elderly People: Prevention of Complications
edited by Vaidyanathan Subramanian
submission deadline 20 Oct 2026 | Viewed by 252 | Submission Open
Keywords: spinal cord injury; demography; morbidities; complications; spinal injuries; patients; family members; caregivers; general practitioners; discharge; elderly
(This special issue belongs to the Section Geriatric Medicine)
Clinical Blood Transfusion: History, Development, Need, Demand and Use submission deadline 20 Oct 2026 | Viewed by 251 | Submission Open
Keywords: clinical blood transfusion; quality management; demands; needs; uses
(This special issue belongs to the Section Hematology)
Procedural Planning in Congenital Heart Disease
edited by Reza Ashrafi and Sarah Moharem-Elgamal
submission deadline 20 Oct 2026 | Viewed by 242 | Submission Open
Keywords: congenital heart disease; CPEX; echocardiography; CT; MRI; procedural planning
(This special issue belongs to the Section Cardiology)
Musculoskeletal Radiology: Advances and Innovations in Sports Medicine
edited by , and Evangelia E. Vassalou
submission deadline 20 Oct 2026 | Viewed by 234 | Submission Open
Keywords: musculoskeletal radiology; sports injury diagnosis and management; quantitative magnetic resonance imaging (MRI); imaging biomarkers in orthopedic medicine; artificial intelligence in sports imaging; image-guided musculoskeletal interventions; post-traumatic osteoarthritis assessment
(This special issue belongs to the Section Sports Medicine)
Oral and Maxillofacial Surgery: Current Trends, Innovations and Techniques
edited by Gabriel Armencea and
submission deadline 21 Oct 2026 | 2 articles | Viewed by 4055 | Submission Open
Keywords: maxillofacial; trauma; deformities; cleft lip and palate; OMF surgery; head and neck; head and neck oncology; orthognathic surgery
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
State-of-the-Art Innovations in Oral and Maxillofacial Surgery: 2nd Edition
edited by Marcin Kozakiewicz and
submission deadline 22 Oct 2026 | 4 articles | Viewed by 2714 | Submission Open
Keywords: oral surgery; maxillofacial surgery; traumatology; orthognatic surgery; infections; oncology; diagnostics; treatment; implantology; augmentation; imaging; computer-assisted techniques
(This special issue belongs to the Section Otolaryngology)
Advancing Minimally Invasive Spine Surgery: A Special Edition on Endoscopic Spine Surgery
edited by and Gregory W. Basil
submission deadline 23 Oct 2026 | 9 articles | Viewed by 21844 | Submission Open
Keywords: minimally invasive spine surgery (MIS); endoscopic spine surgery (ESS); spine surgery; percutaneous spine surgery; full-endoscopic spine surgery; biportal endoscopic spine surgery (BESS); unilateral biportal endoscopy (UBE); percutaneous endoscopic lumbar discectomy (PELD); endoscopic decompression; transforaminal endoscopic lumbar discectomy (TELD); interlaminar endoscopic lumbar discectomy (IELD); endoscopic lumbar fusion; endoscopic transforaminal lumbar interbody fusion (Endo-TLIF)
(This special issue belongs to the Section Clinical Neurology)
Clinical Updates in Physiotherapy for Musculoskeletal Disorders: 2nd Edition submission deadline 23 Oct 2026 | 2 articles | Viewed by 1626 | Submission Open
Keywords: musculoskeletal disorders; physiotherapy interventions; lifestyle; psychoneuroimmunology; chronic pain, inflammation; physical therapy
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Research in Macular Degeneration and Other Retinal Diseases
edited by
submission deadline 23 Oct 2026 | 2 articles | Viewed by 1399 | Submission Open
Keywords: macular degeneration; retinal diseases; clinical research; retinal imaging; real-world data; drug-induced retinal toxicity; epidemiology; screening strategies
(This special issue belongs to the Section Ophthalmology)
Clinical Advances in Anesthesia and Critical Care
edited by Vincenzo Russotto and
submission deadline 23 Oct 2026 | 1 articles | Viewed by 811 | Submission Open
Keywords: anesthesia; critical care; perioperative critical care; emergency medicine; prehospital emergency care; infectious diseases in critical care; antimicrobial stewardship; sepsis
(This special issue belongs to the Section Intensive Care)
Advances in Spine Surgery: Current Innovations and Future Directions
edited by and Jesús Burgos
submission deadline 24 Oct 2026 | 5 articles | Viewed by 4799 | Submission Open
Keywords: spine; clinical studies; robotics; minimally invasive; complications; patient-reported outcomes; reviews
(This special issue belongs to the Section Orthopedics)
Clinical Management of Oral Healthcare in Diverse Patient Populations: Second Edition submission deadline 25 Oct 2026 | 14 articles | Viewed by 39048 | Submission Open
Keywords: special needs patients; oral healthcare; pediatric dentistry; dental hygiene; oral pathology; orthodontics; periodontics
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advances in Diabetes, Obesity, and Hypertension submission deadline 25 Oct 2026 | 11 articles | Viewed by 22003 | Submission Open
Keywords: obesity; hypertension; diabetes; lifestyle; physical activity; risk factors
(This special issue belongs to the Section Endocrinology & Metabolism)
Hand Surgery: Latest Advances and Prospects
edited by and Lorenzo Rocchi
submission deadline 25 Oct 2026 | 9 articles | Viewed by 17190 | Submission Open
Keywords: hand surgery; musculoskeletal and nerve disorders; innovative surgical procedures; minimally invasive techniques; rehabilitation strategies; robotic surgery
(This special issue belongs to the Section Orthopedics)
Knee Arthroplasty Surgery: Management and Future Opportunities: 2nd Edition submission deadline 25 Oct 2026 | 8 articles | Viewed by 16000 | Submission Open
Keywords: knee; knee replacement; knee arthroplasty; knee alignment technique; robotic knee arthroplasty
(This special issue belongs to the Section Orthopedics)
Autoimmune Skin Diseases: Innovations, Challenges, and Opportunities
edited by Shany Sherman
submission deadline 25 Oct 2026 | 6 articles | Viewed by 13654 | Submission Open
Keywords: healthcare utilization; inflammatory skin diseases; photodermatoses; collagen vascular disease; immunobullous disorders; graft-versus-host disease
(This special issue belongs to the Section Dermatology)
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