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Uterine Fibroids—Quality of Life and Minimally Invasive Therapy Options
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Uterine Fibroids—Quality of Life and Minimally Invasive Therapy Options

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 20 October 2026 | Viewed by 613

Editors

Dr. Karolina Chmaj-Wierzchowska

E-Mail Website
Guest Editor
Department of Maternal and Child Health and Minimally Invasive Surgery, Poznan University of Medical Sciences, 33 Polna Street, 60-535 Poznań, Poland
Interests: gynecology; uro-gynecology; laparoscopy; hysteroscopy
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Maciej Wilczak

E-Mail Website
Guest Editor
Department of Mother and Child Health, Faculty of Health Sciences, Poznan University of Medical Sciences, 33 Polna St., 60-535 Poznań, Poland
Interests: gynecology; uro-gynecology; laparoscopy; hysteroscopy

Special Issue Information

Dear Colleagues,

Uterine fibroids are the predominant pelvic benign neoplasms occurring in reproductive-aged women and the leading benign indication for undergoing hysterectomy. The incidence rate of fibroids is 2.0–9.2 per 1000 woman-years, and the incidence increases with age until menopause.

Traditional treatments for symptomatic fibroids include major surgeries such as hysterectomy and myomectomy, which are associated with significant complications and high morbidity. In the last few years, researchers have proposed some alternative minimally invasive approaches to treat symptomatic uterine fibroids: uterine artery embolization (UAE) or radiofrequency ablation (RFA). Minimally invasive treatment for fibroids is an option for women who choose to preserve their uterus.

Dr. Karolina Chmaj-Wierzchowska
Prof. Dr. Maciej Wilczak
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • uterine fibroids
  • radiofrequency ablation
  • pain
  • quality of life
  • menstrual bleeding

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Published Papers (1 paper)

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Research

17 pages, 2000 KB  
Article
Early Vascular and Morphological Response After Transvaginal Radiofrequency Ablation of Uterine Fibroids: A Doppler-Based Retrospective Study
by Karolina Chmaj-Wierzchowska, Agnieszka Lach, Maja Bera, Klaudia Cieślicka, Filip Domagalski, Weronika Glaser, Zofia Kasprzak, Michalina Kowalczyk, Alan Bruszewski, Adam Malinger and Maciej Wilczak
J. Clin. Med. 2026, 15(13), 5223; https://doi.org/10.3390/jcm15135223 - 3 Jul 2026
Viewed by 290
Abstract
Background/Objectives: Uterine fibroids are one of the most prevalent forms of benign tumors in women and may substantially impair quality of life due to heavy menstrual bleeding, pelvic pain, and pressure-related symptoms. Transvaginal radiofrequency ablation (TV-RFA) has emerged as a promising minimally invasive, [...] Read more.
Background/Objectives: Uterine fibroids are one of the most prevalent forms of benign tumors in women and may substantially impair quality of life due to heavy menstrual bleeding, pelvic pain, and pressure-related symptoms. Transvaginal radiofrequency ablation (TV-RFA) has emerged as a promising minimally invasive, uterus-sparing treatment approach. However, there exists a paucity of data regarding the early vascular response evaluated through quantitative Doppler parameters. This study aimed to assess the short-term clinical outcomes and ultrasound effectiveness of TV-RFA in treating symptomatic uterine fibroids, with particular emphasis on early vascular and morphological response. Methods: This retrospective study included 38 women who presented with symptomatic uterine fibroids and underwent TV-RFA between July 2024 and December 2025. Inclusion criteria were as follows: (1) presence of up to three intramural fibroids (FIGO types 3–6) and (2) maximum diameter of fibroids: ≤6 cm. Patients were assessed at baseline and at 1- and 3-month follow-up visits. Ultrasound evaluation included the measurement of fibroid dimensions and volume as well as quantitative Doppler parameters (Pixels Power, Ratio, and CM2 Power Index). Clinical outcomes were assessed based on the intensity and duration of menstrual bleeding. Statistical analysis was performed using nonparametric tests with significance set at p < 0.05. Results: Significant reductions in fibroid dimensions and volume were observed at both follow-up time points, with the greatest effect at 3 months (p < 0.001). Doppler analysis demonstrated a marked decrease in vascularization parameters, particularly CM2 Power Index and Pixels Power (p < 0.001), suggesting an early vascular response to treatment. Clinically, the proportion of patients experiencing heavy menstrual bleeding considerably reduced, accompanied by a significant shortening of bleeding duration (p < 0.001). No major complications requiring surgical intervention were reported. Conclusions: TV-RFA was associated with significant short-term reductions in fibroid vascularization, fibroid volume, and bleeding-related symptoms in this cohort of women with symptomatic uterine fibroids. Quantitative Doppler parameters may serve as valuable early markers of treatment response; however, further studies with larger cohorts and a longer follow-up duration are warranted. Full article
(This article belongs to the Special Issue Uterine Fibroids—Quality of Life and Minimally Invasive Therapy Options)
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