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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pulmonary Disease and Comorbidities, Clinical and Epidemiological Studies: From Neonates to Adults
edited by
submission deadline 20 Jan 2026 | Viewed by 125 | Submission Open
Keywords: pulmonary disorders; comorbidity; neonatal lung disease; pediatric pulmonology; adult respiratory disease; chronic respiratory conditions; clinical epidemiology; pulmonary function testing; diagnostic imaging; lung biomarkers; risk factors
(This special issue belongs to the Section Respiratory Medicine)
The Association Between Cancer and Cardiovascular Diseases: Insights After a Quarter of the Century
edited by Tomer Ziv-Baran and Elena Izkhakov
submission deadline 20 Jan 2026 | Viewed by 123 | Submission Open
Keywords: cancer survivors; cardiovascular disease; cardio-oncology; chemotherapy; radiation therapy; immunotherapy; multidisciplinary approach
(This special issue belongs to the Section Epidemiology & Public Health)
Personalized Modern Oncological Strategies for Breast Cancer Treatment
edited by Vlad Alexandru Gata, Maximilian Muntean and
submission deadline 22 Jan 2026 | Viewed by 109 | Submission Open
Keywords: breast cancer; targeted and immune therapies; predictive biomarkers; surgical de-escalation; MRI of the breast; breast reconstruction
(This special issue belongs to the Section General Surgery)
Application of Artificial Intelligence in Cardiology submission deadline 23 Jan 2026 | 6 articles | Viewed by 5664 | Submission Open
Keywords: artificial intelligence; cardiology; clinical practice; valvular heart disease; arrhythmias; device therapy; machine learning
(This special issue belongs to the Section Cardiology)
Clinical Advances and New Challenges in Laparoscopic Surgery
edited by Ionut Bogdan Diaconescu and Matei Bratu
submission deadline 23 Jan 2026 | Viewed by 143 | Submission Open
Keywords: laparoscopic surgery; trauma surgery; surgical oncology; abdominal surgery; colorectal surgery; general surgery; minimally invasive surgery; gastrointestinal surgery; hernia surgery; surgery; advance laparoscopic surgery; cancer surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Advances in Glaucoma: Current Status and Prospects
edited by Rubén Sánchez-Jean, and Federico Sáenz-Francés San Baldomero
submission deadline 24 Jan 2026 | 2 articles | Viewed by 4489 | Submission Open
Keywords: glaucoma surgery; new techniques; minimally invasive glaucoma surgery; intraocular pressure; optometry; IOLs designs
(This special issue belongs to the Section Ophthalmology)
Pediatric Pulmonology: Recent Developments and Emerging Trends
edited by Athina L. Papadopoulou
submission deadline 25 Jan 2026 | 5 articles | Viewed by 20479 | Submission Open
Keywords: definition of breath sounds; lung– gut axis pathophysiology; disease endotypes and phenotypes; asthma management in children; bronchiolitis spectrum; pediatric bronchopulmonary dysplasia; pulmonary function testing in pediatric patients; pediatric sleep-disordered breathing; neonatal respiratory distress syndrome; childhood interstitial lung diseases; pulmonary hypertension in children; biomarkers in pediatric lung diseases; allergy and the lungs; diagnostic and therapeutic challenges in bronchoscopy; gene therapy in cystic fibrosis
(This special issue belongs to the Section Clinical Pediatrics)
Clinical Risks and Perinatal Outcomes in Pregnancy and Childbirth: 2nd Edition
edited by Apostolos Mamopoulos and
submission deadline 25 Jan 2026 | 6 articles | Viewed by 15974 | Submission Open
Keywords: pregnancy complications; perinatal outcomes; childbirth; hypertension; diabetes; fetal growth restriction; stillbirth; preterm delivery
(This special issue belongs to the Section Obstetrics & Gynecology)
Personalized Medicine for the Management of Non-Communicable Disease (NCDs)
edited by , Giulio Geraci and
submission deadline 25 Jan 2026 | 8 articles | Viewed by 15190 | Submission Open
Keywords: personalized medicine; precision medicine; non-communicable disease; cardiovascular disease; cancer; diabetes; chronic obstructive pulmonary disease; cognitive impairment; atherosclerosis; lipids; inflammation; immunity; therapy
(This special issue belongs to the Section Epidemiology & Public Health)
Clinical Updates on Cardiac and Vascular Toxicities from Antineoplastic Drugs and Beyond
edited by
submission deadline 25 Jan 2026 | 5 articles | Viewed by 13514 | Submission Open
Keywords: cardiotoxicity; vascular toxicity; cardio-oncology; immune checkpoint inhibitors; anthracyclines; tyrosine kinase inhibitors; HER2; proteasome inhibitors; platinum; antimetabolites; microtubule inhibitors
(This special issue belongs to the Section Cardiovascular Medicine)
Male Fertility in the Modern Age: Challenges and Opportunities
edited by
submission deadline 25 Jan 2026 | 2 articles | Viewed by 13303 | Submission Open
Keywords: male infertility; semen parameters; sperm selection; IVF/ICSI
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Keratoconus: Current Status and Prospects
edited by and Isabel Lema
submission deadline 25 Jan 2026 | 3 articles | Viewed by 11109 | Submission Open
Keywords: keratoconus; prevention; diagnostic; biomarker discovery; genetics; exposome; treatment; personalized medicine; major challenges; technological advances
(This special issue belongs to the Section Ophthalmology)
Prevention, Diagnosis and Treatment of Oral Mucosal Diseases
edited by
submission deadline 25 Jan 2026 | 3 articles | Viewed by 10734 | Submission Open
Keywords: oral mucosal diseases; oral mucositis; oral precancerous lesions; oral cancer; oral potentially malignant disorders; OPMDs; oral leukoplakia
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Interventional Cardiology—Challenges and Solutions
edited by
submission deadline 25 Jan 2026 | 4 articles | Viewed by 5109 | Submission Open
Keywords: chronic total occlusion; highly calcified coronary or lower extremity arteries; stentless percutaneous coronary intervention; chronic limb threatening ischemia; instent restenosis in the extremity artery diseases; endovascular therapy for pulmonary thromboembolism; transcatheter aortic valve replacemment for the bicuspid aortic valve; transcatheter aortic valve replacement for the valve-in-valve procedure; endovascular therapy for tricospid valve regurgitation; transcatheter edge-to-edge repair for mitral valve regurgitation
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Advances in Treatment for Venous Thromboembolism
edited by and Georgia Kaiafa
submission deadline 25 Jan 2026 | 3 articles | Viewed by 5075 | Submission Open
Keywords: venous thromboembolism; anticoagulation; cancer-associated thrombosis; thrombosis in MPNs; thrombosis in multiple myeloma; antiphospholipidic syndrome; thrombosis in PNH; thrombosis in hemoglobinopathies; thrombophilia; pregnancy and thrombophilia; reversal of anticoagulants; thromboprophylaxis
(This special issue belongs to the Section Hematology)
Foot and Ankle Surgery: Current Advances and Prospects
edited by
submission deadline 25 Jan 2026 | 4 articles | Viewed by 4970 | Submission Open
Keywords: foot and ankle surgery; foot pathologies; ankle disease and trauma; diabetic foot; epidemiology; clinical anatomy; foot orthoses; weight-bearing CT
(This special issue belongs to the Section Orthopedics)
Autism Spectrum Disorder: Diagnosis, Treatment, and Management
edited by
submission deadline 25 Jan 2026 | 1 articles | Viewed by 4334 | Submission Open
Keywords: adult autism (including autism spectrum disorders); neurodevelopmental disorders; clinical diagnostics; digital diagnostics; artificial intelligence; multimodal treatments
(This special issue belongs to the Section Mental Health)
Clinical Diagnostic and Therapeutic Approaches in Cardiac Amyloidosis
edited by Grigorios Giamouzis
submission deadline 25 Jan 2026 | 1 articles | Viewed by 3475 | Submission Open
Keywords: cardiac amyloidosis; transthyretin amyloidosis; hypertrophic cardiomyopathy; cardiac imaging; heart failure
(This special issue belongs to the Section Cardiology)
Clinical Updates in Cardiac Electrophysiology: 2nd Edition
edited by Kenneth C. Bilchick
submission deadline 25 Jan 2026 | 1 articles | Viewed by 3394 | Submission Open
Keywords: arrhythmias; atrial fibrillation; cardiac electrophysiology; heart rhythm disorders; ablation; ventricular tachycardia; remote monitoring; digital health; artificial intelligence; cardiac magnetic resonance
(This special issue belongs to the Section Cardiology)
Inflammatory Bowel Diseases: Clinical Advances and Emerging Therapies submission deadline 25 Jan 2026 | 2 articles | Viewed by 2978 | Submission Open
Keywords: inflammatory bowel disease (IBD); ulcerative colitis; Crohn’ s disease; gut inflammation; bowel perforation
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advancements in Individualized Plastic and Reconstructive Surgery: Second Edition
edited by , Peter Niclas Broer and Denis C. Ehrl
submission deadline 25 Jan 2026 | 2 articles | Viewed by 2022 | Submission Open
Keywords: patient-specific reconstructive procedures; microsurgical precision techniques; autologous tissue transplantation; digital imaging and customization; biomaterials in reconstructive surgery; tissue engineering for plastic reconstruction; flap surgery innovations; personalized cleft surgery; personalized aesthetic surgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Shoulder and Elbow Surgery: Clinical Updates and Perspectives
edited by Taku Hatta, Akihiko Hasegawa and Takuma Yuri
submission deadline 25 Jan 2026 | 2 articles | Viewed by 1038 | Submission Open
Keywords: rotator cuff injuries; shoulder arthroplasty; elbow surgery; shoulder surgery; shoulder and elbow disease; arthroscopic surgery; orthopedic surgery
(This special issue belongs to the Section Orthopedics)
Ocular Surface Disease: Epidemiology, Diagnosis and Management submission deadline 25 Jan 2026 | Viewed by 950 | Submission Open
Keywords: dry eye disease; risk factors; ocular surface disease; inflammatory biomarkers; anterior segment imaging; emerging therapies
(This special issue belongs to the Section Ophthalmology)
Kidney Transplantation: Challenges, Advances and Lessons Learnt submission deadline 25 Jan 2026 | 2 articles | Viewed by 863 | Submission Open
Keywords: kidney transplantation; nephrology; transplant medicine; patient selection criteria; immunosuppressive treatment; long-term outcomes; graft survival; complication; multi-organ transplant consideration; innovation
(This special issue belongs to the Section Nephrology & Urology)
Machine Learning and Artificial Intelligence in Neurosurgery
edited by Jan Oliver Neumann and
submission deadline 25 Jan 2026 | Viewed by 548 | Submission Open
Keywords: artificial intelligence; neurosurgery; neuro-oncology; spinal neurosurgery; neuro-ICU; stereotactic neurosurgery; pre-operative planning
(This special issue belongs to the Section Clinical Neurology)
Recent Clinical Advances in Reconstructive Urology and Prosthetic Surgery
edited by Elisa Berdondini and
submission deadline 25 Jan 2026 | Viewed by 188 | Submission Open
Keywords: reconstructive urology; penile prosthesis; artificial urinary sphincter; urethral stricture; reconstructive surgery; minimally invasive procedures
(This special issue belongs to the Section Nephrology & Urology)
Clinical Updates in the Use of Artificial Intelligence for Radiology
edited by
submission deadline 25 Jan 2026 | Viewed by 167 | Submission Open
Keywords: deep learning; denoising; calculator; nn-UNet; automation; outcomes; quality control; DICE; Halsdorrf; Jaccard
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Further Advances in Electrocardiography, Cardiac Arrhythmias, and Arrhythmogenic Disorders: 2nd Edition
edited by
submission deadline 25 Jan 2026 | Viewed by 152 | Submission Open
Keywords: electrocardiography; cardiac arrhythmias; genetics; cardiac pacing; implantable cardioverter defibrillators; cardiac resynchronization therapy; magnetic resonance imaging; catheter ablation; arrhythmogenic disorders; channelopathy; cardiomyopathy
(This special issue belongs to the Section Cardiology)
Otologic Disorders and Hearing Impairment: From Diagnosis to Rehabilitation
edited by Andrea Albera and Andrea Canale
submission deadline 25 Jan 2026 | Viewed by 124 | Submission Open
Keywords: otology; hearing loss; cochlear implants; middle ear surgery; otitis media; otosclerosis; auditory rehabilitation; ves-tibular disorders; hearing aid; bone-conduction implants
(This special issue belongs to the Section Otolaryngology)
Novel Developments on Diagnosis and Treatment of Atrial Fibrillation
edited by and Mihaela-Viviana Ivan
submission deadline 26 Jan 2026 | 5 articles | Viewed by 6387 | Submission Open
Keywords: atrial fibrillation; supraventricular arrhythmia; cardiovascular risk; oxidative stress; inflammation
(This special issue belongs to the Section Cardiovascular Medicine)
New Insights into Peritoneal Dialysis and Hemodialysis: 2nd Edition submission deadline 26 Jan 2026 | 2 articles | Viewed by 3035 | Submission Open
Keywords: hemodialysis; peritoneal dialysis; end-stage renal disease; kidney replacement therapy (KRT); pathophysiology; di-alysis membranes; dialysis preparation; dialysis modality; cardiovascular events; vascular access; PD-related perito-nitis; unfavorable adverse effects; complications; challenges; inflammation
(This special issue belongs to the Section Nephrology & Urology)
Osteoporotic Fractures of the Pelvis, Hip and Femur: Current Challenges and New Perspectives (2nd Edition)
edited by Andreas Hoch
submission deadline 26 Jan 2026 | Viewed by 125 | Submission Open
Keywords: osteoporosis; fracture management; pelvic fractures; periprosthetic fractures; proximal femoral fractures; non-operative therapies
(This special issue belongs to the Section Orthopedics)
Challenges in Diagnosis and Treatment of Infertility—2nd Edition
edited by Konstantinos A. Zikopoulos
submission deadline 27 Jan 2026 | 1 articles | Viewed by 6143 | Submission Open
Keywords: fertility; regeneration; age-related infertility; preimplantation diagnosis; precision assessment; individualized fertility needs; clinical diagnosis; in vitro fertilization
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Diagnosis and Treatment for Bone Tumor
edited by Antonio Ziranu and Luigi Cianni
submission deadline 27 Jan 2026 | 4 articles | Viewed by 4926 | Submission Open
Keywords: bone tumor; oncology; osteosarcoma; chondrosarcoma; megaprosthesis; bone resection; chemotherapy; radiotherapy; sarcoma; custom-made
(This special issue belongs to the Section Orthopedics)
Clinical Advances in Scleral Lenses: New Insights in Lens Fitting and Customization
edited by and
submission deadline 27 Jan 2026 | Viewed by 547 | Submission Open
Keywords: scleral lenses; scleral lens customization; higher-order aberrations; scleral lens optics; corneoscleral profilometry; keratoconus; ocular surface diseases; dry eye; wavefront-guided correction
(This special issue belongs to the Section Ophthalmology)
Heart Valve Surgery: Recent Trends and Future Perspective
edited by Per Nils J.F. Wierup, Johan Sjögren and Nina Hakacova
submission deadline 27 Jan 2026 | Viewed by 143 | Submission Open
Keywords: heart valve; diagnostics; surgery; echocardiography; computer simulation; prediction models
(This special issue belongs to the Section Cardiology)
Inflammatory Bowel Disease: Pathogenesis and Management Strategies
edited by
submission deadline 28 Jan 2026 | 2 articles | Viewed by 1894 | Submission Open
Keywords: inflammatory bowel diseases; ulcerative colitis; Crohn’ s disease; biomarkers; risk factors; pharmacology; advanced therapy; endoscopic evaluation and procedures; extraintestinal manifestations; IBD-associated neoplasm
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Hepatitis: Prevention, Treatment, and Global Health Impact submission deadline 28 Jan 2026 | 2 articles | Viewed by 1143 | Submission Open
Keywords: hepatitis B; hepatitis C; liver disease; direct-acting antivirals (DAAs); global health; public health policy; viral hepa-titis elimination; health disparities; cirrhosis; vaccination programs
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current Evidence and Future Directions in Clostridioides difficile Infection Epidemiology, Diagnosis and Treatment submission deadline 28 Jan 2026 | Viewed by 158 | Submission Open
Keywords: Clostridioides difficile infection; infection control; contact isolation; community-acquired CDI; CDI recurrence; recurrence prevention; rCDI; host and microbiota interaction; antimicrobial treat-ment; microbiota transplant; underdiagnosis
(This special issue belongs to the Section Infectious Diseases)
Acute Myocardial Infarction: Clinical Advances in Prognostic Stratification, Diagnosis, and Treatment submission deadline 29 Jan 2026 | 5 articles | Viewed by 9066 | Submission Open
Keywords: acute myocardial infarction (AMI); atherosclerosis; ST segment elevation myocardial infarction (STEMI); non-ST elevation myocardial infarction (NSTEMI); acute coronary syndrome (ACS); prognosis; coronary CT angiography (CCTA); cardiac magnetic resonance (CMR); reperfusion therapy; antiplatelet therapy
(This special issue belongs to the Section Cardiology)
Cerebral Palsy: Clinical Rehabilitation and Treatment
edited by Joav Merrick and
submission deadline 30 Jan 2026 | 7 articles | Viewed by 18890 | Submission Open
Keywords: cerebral palsy; physiotherapy; occupational therapy; orthopedic management; medical management; rehabilitation approaches
(This special issue belongs to the Section Clinical Neurology)
New Advances in Cardiorenal Syndrome: 2nd Edition submission deadline 30 Jan 2026 | 5 articles | Viewed by 18772 | Submission Open
Keywords: cardiorenal syndrome; outcome; hyperkalemia; acute kidney injury; chronic kidney disease; chronic heart failure
(This special issue belongs to the Section Cardiology)
Advances and Perspectives in Cancer Diagnostics and Treatment
edited by Alexandru E. Eniu, and
submission deadline 30 Jan 2026 | 8 articles | Viewed by 7521 | Submission Open
Keywords: solid tumors; new advances; diagnostics and treatment; clinical– pathological; genetic factors; AI; RWD; radiotherapy; biomarkers; prevention in cancer care; target therapy; immunotherapy
(This special issue belongs to the Section Oncology)
Clinical Updates in Bleeding and Thrombotic Disorders
edited by
submission deadline 30 Jan 2026 | 2 articles | Viewed by 4161 | Submission Open
Keywords: autoimmune-acquired coagulation deficiency; acquired hemophilia A; disseminated intravascular coagulation; thrombotic microangiopathy; venous thromboembolism; acute coronary syndrome; clot waveform analysis; thrombin generation test; thromboelastogram
(This special issue belongs to the Section Hematology)
The Current Status and Future Directions of Pancreatoduodenectomy and Pancreatectomy
edited by , and Somaiah Aroori
submission deadline 30 Jan 2026 | 2 articles | Viewed by 3568 | Submission Open
Keywords: pancreatic resection types; techniques and modifications; anastomotic techniques; open resection; minimally invasive surgery; laparoscopic resection; robotic resection; hybrid resection techniques; pancreatic resection post neoadjuvant treatment; lymphadenectomy; vascular resections; organ-sparing procedures; radicality; indications; complications
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current Advances in General and Regional Anesthesia
edited by Eleni Laou, Eleana Garini and Giolanda Varvarousi
submission deadline 30 Jan 2026 | 2 articles | Viewed by 3212 | Submission Open
Keywords: anesthesiology; general anesthesia; regional anesthesia; pediatric anesthesia; perioperative medicine; surgery; postoperative outcome; monitoring; analgesia; safety
(This special issue belongs to the Section Anesthesiology)
Advances in Minimally Invasive Surgery: Transformative Technologies, Techniques and Trends
edited by Michail Pitiakoudis
submission deadline 30 Jan 2026 | 2 articles | Viewed by 2159 | Submission Open
Keywords: minimally invasive surgery; laparoscopic surgery; robotic surgery; surgical innovation; hernia repair; colorectal surgery; gastrointestinal surgery; hepatopancreatobiliary surgery; surgical simulation; virtual reality; augmented reality; artificial intelligence; surgical training; patient outcomes; surgical oncology
(This special issue belongs to the Section General Surgery)
Mind–Body Connection: The Impact of Mental Health on Physical Well-Being
edited by
submission deadline 30 Jan 2026 | 2 articles | Viewed by 1705 | Submission Open
Keywords: mind– body connection; mental health; well-being; metabolic balance; immune system; chronic medical conditions; body perception; self-image; eating disorders; psychosomatic disorders; psychosomatic medicine; innovative thera-peutic approaches; mindfulness; mind-wandering; integrated healthcare
(This special issue belongs to the Section Mental Health)
The Optimal Hybrid Revascularization Approach for Multilevel Peripheral Arterial Disease
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 1627 | Submission Open
Keywords: peripheral arterial disease; revascularization; endovascular procedure; endarterectomy; limb salvage; patency; hybrid procedures; lower extremity; stents; angioplasty
(This special issue belongs to the Section Vascular Medicine)
Insights on Cancer Diagnosis, Treatment and Side Effects Management submission deadline 30 Jan 2026 | 1 articles | Viewed by 1493 | Submission Open
Keywords: cancer diagnosis; cancer treatment; side effects management; oncology; personalized medicine; supportive care
(This special issue belongs to the Section Oncology)
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