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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Current Situation and Challenges of Endovascular Treatment Strategies for Acute Ischemic Stroke

edited by

Fusao Ikawa

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3948 | Submission Open

Keywords: acute ischemic stroke; endovascular treatment; imaging; management of ischemic stroke; system and strategy for acute ischemic stroke; multidisciplinary approach for acute ischemic stroke

(This special issue belongs to the Section Clinical Neurology)

Clinical Application of Radiotherapy in Modern Oncology

edited by

Lukas Käsmann

and

Fabian Weykamp

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3848 | Submission Open

Keywords: brain metastasis; bone metastasis; brain tumors; head and neck cancers; thoracic oncology; breast cancer; prostate cancer; sarcoma

(This special issue belongs to the Section Oncology)

Current and Emerging Therapies for Rheumatoid Arthritis

edited by

Yoshiro Horai

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3579 | Submission Open

Keywords: DMARDs (disease-modifying anti-rheumatic drugs); boDMARDs (biological DMARDs); bsDMARDs (biosimilar DMARDs); csDMARDs (conventional synthetic DMARDs); rheumatoid arthritis; tsDMARDs (targeted synthetic DMARDs)

(This special issue belongs to the Section Immunology & Rheumatology)

Advances in the Treatment of Glaucoma and Ocular Hypertension

edited by Ahnul Ha

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3522 | Submission Open

Keywords: glaucoma; ocular hypertension; intraocular pressure (IOP); minimally invasive glaucoma surgery (MIGS); artificial intelligence (AI); neuroprotection; meta-analysis

(This special issue belongs to the Section Ophthalmology)

Advanced Diagnostic and Therapeutic Strategies for Sarcoidosis

edited by

Małgorzata Sobiecka

and

Monika Szturmowicz

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3448 | Submission Open

Keywords: sarcoidosis; cardiac sarcoidosis; pulmonary fibrosis; magnetic resonance imaging; FDG-PET/CT; echocardiography; neurosarcoidosis; differential diagnosis; hypercalcaemia; IGRA; sarcoidosis-associated pulmonary hypertension; fatigue; corticosteroids; metotrexat; infliximab; antifibrotic treatment; lung transplantation; artificial intelligence; broncho-alveolar lavage; cytokines

(This special issue belongs to the Section Respiratory Medicine)

Glaucoma Surgery: Current Challenges and Future Perspectives

edited by

Tina Tzee Ling Wong

and

Esther M. Hoffmann

submission deadline 20 Jan 2026 | 4 articles | Viewed by 3003 | Submission Open

Keywords: glaucoma; filtration surgery; trabeculectomy; MIGS; scarring; anti-metabolites; wound healing; anti-fibrotics

(This special issue belongs to the Section Ophthalmology)

Advances in Tuberculosis: Comprehensive Insights and Management Strategies

edited by Aliaksandr Skrahin

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2834 | Submission Open

Keywords: pulmonary and extra-pulmonary tuberculosis (TB); TB epidemiology; TB screening; TB prevention; TB diagnostics; TB treatment; TB co-infections (e.g.; HIV; Hepatitis B and C); TB co-morbidities (e.g.; diabetes); host and Mycobacteria genetic; molecular mechanisms and genotype/phenotype correlations

(This special issue belongs to the Section Infectious Diseases)

Acute Myocardial Infarction: Diagnosis, Treatment, and Rehabilitation

edited by

Francesca Giordana

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2762 | Submission Open

Keywords: acute myocardial infarction; coronary angioplasty; acute heart failure; cardiogenic shock; rehabilitation programs

(This special issue belongs to the Section Cardiovascular Medicine)

Endometriosis: Diagnosis and Treatment

edited by

Camran R. Nezhat

and

Ceana Nezhat

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2401 | Submission Open

Keywords: endometriosis; diagnosis; video laparoscopy with and without robotic assistance; chronic pelvic pain; fertility preservation; minimally invasive surgery; biomarkers; artificial intelligence in endometriosis; adenomyosis; and adenomyoma care; multidisciplinary care; personalized medicine

(This special issue belongs to the Section Obstetrics & Gynecology)

Artificial Intelligence (AI) in Dental Clinical Practice

edited by

Eiji Tanaka

and Keiichiro Watanabe

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1727 | Submission Open

Keywords: artificial intelligence; dental diagnostics; machine learning; deep learning; digital dentistry; clinical decision support; diagnostic automation; data transparency; evidence-based dentistry

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advancements in the Treatment of Myeloproliferative Neoplasms and Myelodysplastic Syndromes

edited by Ivan Krečak, Marko Skelin and Zinaida Perić

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1429 | Submission Open

Keywords: myeloproliferative neoplasms; myelodysplastic syndromes; treatment; risk stratification; prognosis

(This special issue belongs to the Section Hematology)

Neuro-Cardiology: An Obligation for Combined Care of Stress and Heart Diseases

edited by Mario J. Garcia and

Fatih Yalcin

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1297 | Submission Open

Keywords: neuro-cardiology; cardiovascular; segmental remodeling; stressors; hypertension; triple S

(This special issue belongs to the Section Cardiology)

Cardiac and Pulmonary Involvements in High-Risk Neonatal Cohorts: Short- and Long-Term Issues

edited by Arvind Sehgal

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1272 | Submission Open

Keywords: fetal growth restriction; lung disease; cardiac maladaptation; placenta; public health; neurodevelopment; long term; adulthood; Barker’ s hypothesis; newborn; vascular

(This special issue belongs to the Section Clinical Pediatrics)

Cardiac Arrest Research: Neuroprognostication and Improving Outcomes

edited by

Jae Hoon Lee

and Jin-hong Min

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1240 | Submission Open

Keywords: cardiac arrest; prognosis; hypothermia; induced; resuscitation; magnetic resonance imaging; electroencephalography; blood pressure; hypoxia-ischemia; brain; extracorporeal membrane oxygenation

(This special issue belongs to the Section Cardiovascular Medicine)

Idiopathic Pulmonary Fibrosis (IPF): Current Perspectives and Future Directions

edited by Vito D’Agnano

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1167 | Submission Open

Keywords: pulmonary fibrosis; IPF; ILD; antifibrotics; EMT; respiratory physiology; metabolism

(This special issue belongs to the Section Respiratory Medicine)

Aortic Valve Disease: Current Evolution and Future Opportunities

edited by Gianluigi Perri

submission deadline 20 Jan 2026 | 2 articles | Viewed by 991 | Submission Open

Keywords: aortic valve disease; aortic valve repair; Ross procedure; aortic valve replacement; diagnosis of aortic valve disease

(This special issue belongs to the Section Cardiology)

Current Practice and Future Perspectives on Laryngeal Surgery

edited by

Eugenia Allegra

and

Maria Rita Bianco

submission deadline 20 Jan 2026 | 1 articles | Viewed by 980 | Submission Open

Keywords: laryngeal disorders; laryngeal surgery; microsurgery; endoscopic surgery; open surgery; laser surgery

(This special issue belongs to the Section Otolaryngology)

New Perspectives in Chronic Kidney Disease, Transplantation and Immune System

edited by

Maria Daoudaki

and Dimitrios A. Tsakiris

submission deadline 20 Jan 2026 | 1 articles | Viewed by 973 | Submission Open

Keywords: kidney transplantation; HLA; matching at the epitope level; DSAs; complement; kidney disease epigenetics; diabetic nephropathy; hemostasis; graft rejection; B and T cell immunophenotyping; end stage renal disease

(This special issue belongs to the Section Nephrology & Urology)

Shaping Modern Gastroenterology: Bridging Advancements in Digestive Endoscopy and Clinical Research

edited by Manuele Furnari and Stefano Kayali

submission deadline 20 Jan 2026 | 1 articles | Viewed by 968 | Submission Open

Keywords: digestive endoscopy; gastrointestinal disorders; endoscopic ultrasound (EUS); endoscopic retrograde cholangiopancreatography (ERCP); therapeutic endoscopy; artificial intelligence; pancreatic and biliary diseases; small bowel pathology; early neoplastic lesions; inflammatory bowel diseases (IBDs); translational gastroenterology; endoscopic submucosal dissection (ESD); per-oral endoscopic myotomy (POEM); endoscopic imaging; gastrointestinal pathophysiology

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Advances in Prenatal Diagnosis and Fetal Therapy

edited by

Mar Bennasar

submission deadline 20 Jan 2026 | 1 articles | Viewed by 942 | Submission Open

Keywords: prenatal diagnosis; fetal therapy; genetic screening; non-invasive testing; fetal surgery; imaging technologies; high-risk pregnancies; in utero treatments; stem cell therapies; clinical innovations

(This special issue belongs to the Section Obstetrics & Gynecology)

Regional Anesthesia in Pain Management

edited by Jaime L. Baratta

submission deadline 20 Jan 2026 | 1 articles | Viewed by 909 | Submission Open

Keywords: acute pain; perioperative medicine; general anesthesiology; regional anesthesia; orthopedic anesthesia; multimodal analgesia

(This special issue belongs to the Section Anesthesiology)

Rehabilitation and Treatment of Post-COVID-19 Condition

edited by

Indre Bileviciute-Ljungar

submission deadline 20 Jan 2026 | 1 articles | Viewed by 877 | Submission Open

Keywords: post-COVID-19 condition; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); comorbidities; interdisciplinary; multimodal; digital medicine; rehabilitation; treatment; health-related quality of life; disability; return to work

(This special issue belongs to the Section Clinical Rehabilitation)

Multiple Myeloma: Therapeutic and Management Strategies

edited by Terri Parker

submission deadline 20 Jan 2026 | 1 articles | Viewed by 861 | Submission Open

Keywords: multiple myeloma; frontline treatment; monoclonal antibodies; sequencing of treatment; immunotherapy; CAR T; Bi-specific T cell engagers; toxicity management

(This special issue belongs to the Section Hematology)

Obesity-Related Metabolic and Cardiovascular Disorders

edited by

Lucia Frittitta

and Federica Vinciguerra

submission deadline 20 Jan 2026 | 1 articles | Viewed by 788 | Submission Open

Keywords: obesity; type 2 diabetes mellitus; insulin resistance; metabolic syndrome; cardiovascular disease; lipid disorder; adipose tissue dysfunction; visceral adiposity; cardiometabolic risk; endothelial dysfunction; health disparities; gut microbiota; bariatric surgery; precision medicine

(This special issue belongs to the Section Cardiovascular Medicine)

Recent Advances and Future Perspectives of Subarachnoid Hemorrhage

edited by Alexandros Doukas and Athanasios K. Petridis

submission deadline 20 Jan 2026 | 1 articles | Viewed by 735 | Submission Open

Keywords: subarachnoid hemorrhage; neuromonitoring; neurocritical care; neurointerventions; neurointensive care

(This special issue belongs to the Section Clinical Neurology)

Cardiopulmonary Resuscitation in the Emergency Care Unit

edited by

Martín Otero-Agra

, Felipe Fernández-Méndez,

Myriam Santos-Folgar

and

María Fernández-Méndez

submission deadline 20 Jan 2026 | 1 articles | Viewed by 691 | Submission Open

Keywords: cardiopulmonary resuscitation; advanced life support; new technologies; special circumstances; emergency care unit

(This special issue belongs to the Section Emergency Medicine)

Current Status and Future of Urological Surgery

edited by

Filippo Marino

, Davide De Marchi and

Luca Di Gianfrancesco

submission deadline 20 Jan 2026 | 1 articles | Viewed by 616 | Submission Open

Keywords: urological surgery; robotic-assisted surgery; minimally invasive surgery; artificial intelligence; augmented reality; surgical navigation; endourology; laparoscopic urology; reconstructive urology; functional urology; bph treatment; urinary incontinence; prostate cancer surgery; bladder cancer surgery; surgical innovation; digital surgery

(This special issue belongs to the Section Nephrology & Urology)

Cardiometabolic Insights into Metabolic Dysfunction: From Mechanisms to Therapeutic Strategies

edited by Alessandro Andreis,

Guglielmo Beccuti

and

Angelo Armandi

submission deadline 20 Jan 2026 | 1 articles | Viewed by 586 | Submission Open

Keywords: cardiovascular complications; pharmacological; interventional strategies; cardiology; endocrinology; hepatology

(This special issue belongs to the Section Cardiology)

Beyond the Kidney: Managing Chronic Kidney Disease in the Era of Cardio-Metabolic-Kidney Syndrome

edited by

Maria Amicone

and

Antonio Pisani

submission deadline 20 Jan 2026 | Viewed by 417 | Submission Open

Keywords: chronic kidney disease; disease-modifying therapy; physical exercise; cardio-metabolic-kidney syndrome; SGLT2 in-hibitors; MRA; renal nutrition; innovative therapies; low protein diet

(This special issue belongs to the Section Nephrology & Urology)

Clinical Comparisons of Nonpharmaceutical and Pharmaceutical Analgesia

edited by

Sang Hun Kim

and

Yoon Ji Choi

submission deadline 20 Jan 2026 | Viewed by 417 | Submission Open

Keywords: acute pain; chronic pain; postoperative pain; non-pharmaceutical; pharmaceutical; analgesia; clinical

(This special issue belongs to the Section Anesthesiology)

Haemophilia: Current Treatment and Clinical Outcomes, Challenges and Opportunities: 2nd Edition

edited by

Ezio Zanon

submission deadline 20 Jan 2026 | 1 articles | Viewed by 414 | Submission Open

Keywords: haemophilia A and B; FVIII EHL; FIX EHL; prophylaxis; emicizumab; health-related quality of life; population pharmacokinetics

(This special issue belongs to the Section Hematology)

Clinical Updates and Current Challenges in Obstetrical Anesthesia

edited by Michael Froelich

submission deadline 20 Jan 2026 | Viewed by 408 | Submission Open

Keywords: obstetrical anesthesia; clinical innovation; practice guidelines; neuraxial techniques; enhanced recovery; risk stratification; maternal safety; multimodal analgesia; health systems innovation; global and low-resource care

(This special issue belongs to the Section Obstetrics & Gynecology)

Innovations and Evolution of Extracorporeal Organ Support in Critical Care

edited by

Francesco Alessandri

Giovanni Giordano

and Antonella Tosi

submission deadline 20 Jan 2026 | Viewed by 295 | Submission Open

Keywords: critical care; extracorporeal organ support; critical care nephrology; cardiology; ARDS; sepsis; blood purification; liver support

(This special issue belongs to the Section Intensive Care)

Metabolic Dysregulation Across the Spectrum from Anorexia Nervosa to Obesity

edited by Andriana C. Kaliora

submission deadline 20 Jan 2026 | Viewed by 292 | Submission Open

Keywords: metabolic dysregulation; anorexia nervosa; obesity; environmental factors in metabolic health; gut microbiota and metabolism; hormonal regulation of appetite; inflammation and metabolic disorders; dietary influence on metabolism

(This special issue belongs to the Section Endocrinology & Metabolism)

Innovations in Infertility Treatment and Assisted Reproductive Technologies (ARTs)

edited by Diana Alecsandru

submission deadline 20 Jan 2026 | Viewed by 288 | Submission Open

Keywords: infertility; assisted reproductive technology (ARTs); fertility preservation; in vitro fertilization (IVF); reproductive endocrinology

(This special issue belongs to the Section Obstetrics & Gynecology)

Bronchoscopy and Interventional Pulmonology

edited by Bryan S. Benn and

Jonathan Kurman

submission deadline 20 Jan 2026 | Viewed by 276 | Submission Open

Keywords: navigation-guided bronchoscopy; Robotic-guided bronchoscopy; 3D imaging integration; lung nodule/peripheral pulmonary lesion marking; transbronchial lung cryobiopsy and interstitial lung disease; malignant and benign central airway obstruction and stenosis; airway stents; pleuroscopic procedures; bronchoscopic lung volume reduction

(This special issue belongs to the Section Respiratory Medicine)

From Dual Diagnosis to Dual Disorder(s): Bridging Comorbidity and Integrated Clinical Understanding

edited by

Angelo Giovanni Icro Maremmani

submission deadline 20 Jan 2026 | Viewed by 260 | Submission Open

Keywords: dual diagnosis; dual disorder; psychiatric comorbidity; addiction; integrated care; self-medication; substance use; mental illness; treatment models

(This special issue belongs to the Section Mental Health)

Clinical Advances in Urologic Oncology: 2nd Edition

edited by Saum Ghodoussipour

submission deadline 20 Jan 2026 | 1 articles | Viewed by 249 | Submission Open

Keywords: bladder cancer; kidney cancer; prostate cancer; testis cancer; penile cancer; minimally invasive; cancer treatment

(This special issue belongs to the Section Nephrology & Urology)

Clinical Application of Echocardiography in Heart Disease: 2nd Edition

edited by

Carlos Cotrim

submission deadline 20 Jan 2026 | Viewed by 185 | Submission Open

Keywords: transthoracic echocardiography; transesophageal echocardiography; stress echocardiography; valve disease; coronary artery disease; myocardial disease; pericardial disease; aortic disease; congenital heart disease

(This special issue belongs to the Section Cardiology)

Recent Management of Hip Fractures

edited by

Toshiyuki Kawai

submission deadline 20 Jan 2026 | Viewed by 185 | Submission Open

Keywords: hip fracture; internal fixation; hemiarthroplasty; arthroplasty and fixation; osteoporosis management; fracture prevention; multidisciplinary care; surgical treatment; rehabilitation strategies

(This special issue belongs to the Section Orthopedics)

Advances in Chronic Pain Research and Therapy

edited by Elena Makovac

submission deadline 20 Jan 2026 | Viewed by 183 | Submission Open

Keywords: chronic pain; pain perception; brain-body interactions; therapeutic effectiveness; integrated approach

(This special issue belongs to the Section Clinical Rehabilitation)

Therapeutic Strategies for Obesity and Diabetes in Cardiovascular Disease Patients

edited by Davide D'Andrea

submission deadline 20 Jan 2026 | Viewed by 179 | Submission Open

Keywords: obesity; diabetes; cardiovascular complications; diabetes management; pharmacological treatment; bariatric surgery; regular monitoring

(This special issue belongs to the Section Cardiovascular Medicine)

Preventive Strategies and Novel Treatments for Rheumatoid Arthritis

edited by

Vincent Goeb

submission deadline 20 Jan 2026 | Viewed by 176 | Submission Open

Keywords: rheumatoid arthritis; antibodies; biologics; JAK; environment; susceptibility; therapeutic strategies

(This special issue belongs to the Section Immunology & Rheumatology)

Emerging Trends in Multiple Myeloma

edited by

Despina Fotiou

submission deadline 20 Jan 2026 | Viewed by 175 | Submission Open

Keywords: multiple myeloma; personalized medicine; high-risk disease; cellular therapies; refractory disease

(This special issue belongs to the Section Hematology)

Current Trends and Future Challenges in Heart Failure

edited by Oren Caspi and

Robert Zukermann

submission deadline 20 Jan 2026 | Viewed by 175 | Submission Open

Keywords: heart failure; guideline-directed therapy; digital health; biomarkers; multidisciplinary care; artificial intelligence; cardiorenal syndrome; remote hemodynamic monitoring; cardiac amyloidosis; exercise rehabilitation

(This special issue belongs to the Section Cardiology)

Clinical Update on Aortic Valve Disease Treatments

edited by

Giovanni Concistre

submission deadline 20 Jan 2026 | Viewed by 156 | Submission Open

Keywords: aortic valve disease; minimally invasive surgery; transcatheter procedures; echocardiography; diagnosis; therapy; innovation

(This special issue belongs to the Section Cardiology)

Clinical Advances, Opportunities, and Challenges in Digestive Diseases of the Foregut

edited by Valentin Mocanu and

Salvador Navarrete

submission deadline 20 Jan 2026 | Viewed by 148 | Submission Open

Keywords: obesity; achalasia; reflux; malrotation; therapeutic endoscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Lung Transplantation: Current Challenges and New Perspectives

edited by Reinaldo E. Rampolla and Pedro A. Catarino

submission deadline 20 Jan 2026 | Viewed by 148 | Submission Open

Keywords: lung transplantation; interstitial lung diseases; pulmonary hypertension; chronic obstructive pulmonary disease; bronchiectasis; extra corporeal membrane oxygenation; robotic lung transplantation

(This special issue belongs to the Section Respiratory Medicine)

New Clinical Perception of Cardiac Rehabilitation

edited by

Antonello D’Andrea

and Mario Pacileo

submission deadline 20 Jan 2026 | Viewed by 133 | Submission Open

Keywords: cardiac rehabilitation; digital health; exercise therapy; cardiovascular prevention; chronic disease management; psychosocial support; personalized medicine

(This special issue belongs to the Section Clinical Rehabilitation)

Pulmonary Disease and Comorbidities, Clinical and Epidemiological Studies: From Neonates to Adults

edited by

Roxana Maria Nemes

submission deadline 20 Jan 2026 | Viewed by 125 | Submission Open

Keywords: pulmonary disorders; comorbidity; neonatal lung disease; pediatric pulmonology; adult respiratory disease; chronic respiratory conditions; clinical epidemiology; pulmonary function testing; diagnostic imaging; lung biomarkers; risk factors

(This special issue belongs to the Section Respiratory Medicine)

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