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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Approaches in Obsessive–Compulsive and Related Spectrum Disorders
edited by and Andrea D. Guastello
submission deadline 20 Apr 2027 | 3 articles | Viewed by 1283 | Submission Open
Keywords: OCD; misophonia; hoarding; tic disorders; assessment; treatment
(This special issue belongs to the Section Mental Health)
Advances in Rehabilitation and Musculoskeletal Health
edited by , and Daniela Matei
submission deadline 20 Apr 2027 | 4 articles | Viewed by 1244 | Submission Open
Keywords: musculoskeletal disorders; musculoskeletal rehabilitation; physical medicine and rehabilitation; pain management; osteoarthritis; functional recovery; disability assessment; therapeutic exercise; physiotherapy; sports injuries; ultra-sound in rehabilitation; quality of life; well-being
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Advances in Hearing Loss: Diagnosis, Treatment, and Management
edited by
submission deadline 20 Apr 2027 | 2 articles | Viewed by 1227 | Submission Open
Keywords: hearing loss; deafness; bone conduction implants; middle ear implants; cochlear implants; myringoplasty; tympanoplasty; stapedotomy; ossicular chain reconstruction; imaging; audiological diagnostic
(This special issue belongs to the Section Otolaryngology)
Personalised and Precision Pharmacotherapy: Data-Driven Therapeutic Optimisation in Real-World Clinical Practice submission deadline 20 Apr 2027 | 2 articles | Viewed by 1227 | Submission Open
Keywords: precision pharmacotherapy; personalised medicine ; pharmacokinetics and pharmacodynamics ; therapeutic drug ; monitoring real-world evidence ; multimorbidity ; medication appropriateness ; model-informed precision dosing; does individualisation; clinical decision support
(This special issue belongs to the Section Pharmacology)
Advances in Diagnosis, Monitoring, and Treatment of Myocardial Infarction
edited by
submission deadline 20 Apr 2027 | 1 articles | Viewed by 1184 | Submission Open
Keywords: myocardial infarction (MI); occlusion myocardial infarction (OMI); myocardial infarction with non-obstructive coronary arteries (MINOCA); diagnosis; monitoring; treatment
(This special issue belongs to the Section Cardiovascular Medicine)
Exploring Female Infertility: Advances, Challenges, and Emerging Solutions
edited by
submission deadline 20 Apr 2027 | 2 articles | Viewed by 1076 | Submission Open
Keywords: infertility; female infertility; in vitro fertilization; PCOS; assisted reproductive technology
(This special issue belongs to the Section Obstetrics & Gynecology)
Contemporary Coronary Intervention: Innovation, Evidence, and Patient-Centred Outcomes
edited by Kevin Liou
submission deadline 20 Apr 2027 | 1 articles | Viewed by 1047 | Submission Open
Keywords: percutaneous coronary interventions; coronary imaging; coronary physiology; precision medicine; CHIP PCI; stent-less technologies; clinical outcomes; pharmacotherapy in PCI; biomarkers; artificial intelligence in PCI; sustainability in PCI
(This special issue belongs to the Section Cardiology)
Advanced Coronary Physiology and Imaging-Guided Percutaneous Cardiovascular Interventions: Treatment Approaches and Outcomes
edited by Ioannis Skalidis
submission deadline 20 Apr 2027 | 1 articles | Viewed by 1036 | Submission Open
Keywords: acute coronary syndromes; chronic coronary syndromes; coronary physiology; intravascular imaging; artificial in-telligence; percutaneous coronary intervention; complex coronary disease
(This special issue belongs to the Section Cardiology)
Current Practice and Future Directions in Hemodialysis and Peritoneal Dialysis
edited by
submission deadline 20 Apr 2027 | 1 articles | Viewed by 993 | Submission Open
Keywords: kidney replacement therapy; hemodialysis; peritoneal dialysis; dialysis nursing; continuous renal replacement therapy; incremental dialysis; decremental dialysis
(This special issue belongs to the Section Nephrology & Urology)
Physiotherapy: Multidisciplinary Interventions and Digital Health submission deadline 20 Apr 2027 | 1 articles | Viewed by 926 | Submission Open
Keywords: physiotherapy; rehabilitation; physical medicine; digital health; telemedicine; virtual reality; augmented reality; artifi-cial intelligence; robotic rehabilitation; wearable sensors; VR for educative goals; musculoskeletal, neurological, cognitive, pediatric, pulmonary, cardiac and gyneco-obstetric disorders; fibromyalgia syndrome; chronic pain; older adults
(This special issue belongs to the Section Clinical Rehabilitation)
Current Concepts and Technological Innovations in Hepato-Pancreato-Biliary Surgery and Transplantation
edited by Michele Finotti and Francesco D’Amico
submission deadline 20 Apr 2027 | 1 articles | Viewed by 900 | Submission Open
Keywords: hepato-pancreato-biliary surgery; hepato-pancreato-biliary transplantation; pancreatic cancer; hepatobiliary cancer; vascular reconstruction; minimally invasive in hepato-pancreato-biliary surgery; robotic techniques; organ-preservation strategies
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Spine Surgery: Clinical Advances and Future Directions—2nd Edition
edited by Eun-Sang Kim and
submission deadline 20 Apr 2027 | 1 articles | Viewed by 897 | Submission Open
Keywords: spine surgery; back pain; endoscopic spine surgery; cage implantation; neck pain
(This special issue belongs to the Section Clinical Neurology)
Hepatobiliary–Pancreatic Surgery in the Era of Interventional Radiology
edited by
submission deadline 20 Apr 2027 | 1 articles | Viewed by 897 | Submission Open
Keywords: hepato-biliary–pancreatic surgery; interventional radiology; percutaneous biliary drainage; percutaneous pancre-atic drainage; portal vein embolization; tumor ablation; minimally invasive surgery; cryoablation; thermoablation
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Anterior Segment Disorders
edited by Itay Lavy and
submission deadline 20 Apr 2027 | 1 articles | Viewed by 831 | Submission Open
Keywords: anterior segment disorders; corneal disease; cataract surgery; ocular surface disease; surgical outcomes; surgical techniques; artificial intelligence in diagnosis; diagnostic imaging; pharmacological and surgical interventions; refractive errors; anterior uveitis; keratitis; corneal ectasia; quality of life
(This special issue belongs to the Section Ophthalmology)
Multifactorial Causation and Therapy of Sleep Disorders
edited by
submission deadline 20 Apr 2027 | 1 articles | Viewed by 752 | Submission Open
Keywords: sleep disorders; narcolepsy; sleep-neurology; REM sleep behavior disorder; sleep apneas
(This special issue belongs to the Section Clinical Neurology)
Advances and Future Perspectives for Transcatheter Aortic Valve Replacement (TAVR)
edited by Kyriakos Spiliopoulos and Nikolaos Liaros
submission deadline 20 Apr 2027 | 1 articles | Viewed by 736 | Submission Open
Keywords: aortic stenosis; aortic valve replacement; transcatheter aortic valve replacement (TAVR); “Valve in Valve” procedure; TAVR-endocarditis; TAVR-durability; TAVR-design; cardiovascular imaging
(This special issue belongs to the Section Cardiology)
Evolution of Breast and Lymphatic Reconstruction: Current Techniques, Advances and Future Directions
edited by
submission deadline 20 Apr 2027 | 2 articles | Viewed by 639 | Submission Open
Keywords: breast reconstruction; lymphedema; physiologic lymphatic surgery; robotic-assisted surgery; surgical innovation; surgical technology; microsurgery; supermicrosurgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Managing Chronic Kidney Disease: Current Practices and Future Perspectives
edited by Maria L. Gonzalez-Suarez
submission deadline 20 Apr 2027 | 1 articles | Viewed by 617 | Submission Open
Keywords: chronic kidney disease; diabetic kidney disease; kidney failure; guideline-directed therapies; SLGT 2 inhibitors; GLP1 receptor agonists
(This special issue belongs to the Section Nephrology & Urology)
Hypertension in Adults: Current Updates on Diagnosis, Treatment and Management—Second Edition
edited by Emelina Stambolliu and Antonios A. Argyris
submission deadline 20 Apr 2027 | 1 articles | Viewed by 543 | Submission Open
Keywords: essential hypertension; nighttime blood pressure; blood pressure measurement; blood pressure management; blood pressure medical treatment; hypertension thresholds
(This special issue belongs to the Section Vascular Medicine)
Emerging Technologies in Foot and Ankle Care: From Advanced Diagnosis to Innovative Treatment
edited by Jaehwang Song
submission deadline 20 Apr 2027 | 1 articles | Viewed by 543 | Submission Open
Keywords: foot; ankle; tendon; ligament; disease; MIS; deformity correction; flatfoot; cavovarus foot; WBCT
(This special issue belongs to the Section Orthopedics)
Comorbidities and Challenges Throughout the Lifespan in Down Syndrome submission deadline 20 Apr 2027 | 1 articles | Viewed by 541 | Submission Open
Keywords: Down syndrome; comorbidities; neuropathology; imaging
(This special issue belongs to the Section Clinical Neurology)
Advancements in Urolithiasis Surgery: Current Trends and Future Directions
edited by and Nir Kleinmann
submission deadline 20 Apr 2027 | 1 articles | Viewed by 455 | Submission Open
Keywords: urolithiasis; ureterocopy; laser; PCNL; ESWL; robotic surgery
(This special issue belongs to the Section Nephrology & Urology)
Advances in Clinical Oncologic Diagnostic and Interventional Radiology
edited by Alberta Cappelli
submission deadline 20 Apr 2027 | 1 articles | Viewed by 432 | Submission Open
Keywords: artificial intelligence; oncological imaging; hybrid imaging; endovascular radiology; percutaneous procedures; radiomics; MRI; CT; PET/CT; photon counting CT; cone-beam CT
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Precision Neuroimaging in Mental and Behavioral Health Research
edited by Thomas Vanicek and Arkadiusz Komorowski
submission deadline 20 Apr 2027 | Viewed by 409 | Submission Open
Keywords: psychiatry; neuroimaging; addiction; substance use disorders (SUD); attention deficit hyperactivity disorder (ADHD); imaging genomics; imaging transcriptomics
(This special issue belongs to the Section Mental Health)
The Liver–Kidney Axis in Metabolic Diseases: Biomarkers and Clinical Implications
edited by
submission deadline 20 Apr 2027 | Viewed by 397 | Submission Open
Keywords: liver; kidney; cross-organ crosstalk; mechanisms; biomarkers; metabolic diseases; clinical implications
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in AI-Powered Brain Screening and Clinical Neuroscience
edited by
submission deadline 20 Apr 2027 | 1 articles | Viewed by 379 | Submission Open
Keywords: artificial intelligence; brain screening; small vessel disease; unruptured cerebral aneurysm; stroke; dementia; prevention; clinical neuroscience
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
Clinical Advances in Adult Deformities and Spinal Disorders: Surgical Treatment and Pre- and Post-Operative Re-Habilitation
edited by
submission deadline 20 Apr 2027 | Viewed by 367 | Submission Open
Keywords: scoliosis; spine; kyphosis; degenerative spine; spine surgery
(This special issue belongs to the Section Orthopedics)
Current Trends and Innovations in Coronary Artery Disease and Myocardial Ischemia: Second Edition
edited by
submission deadline 20 Apr 2027 | Viewed by 361 | Submission Open
Keywords: coronary artery disease; fractional flow reserve; invasive coronary angiography; cardiac CT; cardiac MRI
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Approaches of Intracranial Aneurysm and Subarachnoid Hemorrhage
edited by Sylvia Bele
submission deadline 20 Apr 2027 | Viewed by 350 | Submission Open
Keywords: aSAH; clipping or coiling; extracranial complications; cerebral vasospasm; ICU treatment
(This special issue belongs to the Section Clinical Neurology)
Recent Advances in Hypercholesterolemia
edited by Ana Catarina Alves
submission deadline 20 Apr 2027 | Viewed by 327 | Submission Open
Keywords: hypercholesterolemia; cardiovascular risk; molecular diagnostics; variants of uncertain significance (VUS); functional characterisation; precision medicine; lipid-lowering therapy
(This special issue belongs to the Section Endocrinology & Metabolism)
From Imaging to Intervention: Modern Approaches in Spine Disorders Management submission deadline 20 Apr 2027 | Viewed by 320 | Submission Open
Keywords: adolescent idiopathic scoliosis (AIS); spinal fusion; Cobb angle; bracing; skeletal maturity; radiographic imaging; multidisciplinary management
(This special issue belongs to the Section Orthopedics)
Clinical Advances in Diagnosis and Treatment of Metastatic Spinal Tumor
edited by
submission deadline 20 Apr 2027 | Viewed by 313 | Submission Open
Keywords: metastatic spinal tumors; spine surgery; bone metastasis; imaging diagnosis; minimally invasive surgery; decompression surgery; fixation surgery; emergency surgery; prognosis prediction; elderly patients; nutrition; mental health
(This special issue belongs to the Section Oncology)
Targeting Extravalvular Burden Associated with Valvular Heart Disease
edited by
submission deadline 20 Apr 2027 | Viewed by 293 | Submission Open
Keywords: valvular heart disease; systemic disorder; extravalvular burden; valve dysfunction; valve intervention; multimodality imaging
(This special issue belongs to the Section Cardiology)
Emerging Therapeutic Interventions for Eating Disorders Through Psychology
edited by Anita Federici and
submission deadline 20 Apr 2027 | Viewed by 275 | Submission Open
Keywords: eating disorders; psychological interventions; emerging psychotherapies; dialectical behavior therapy (DBT); transdiagnostic approaches; emotion regulation; severe and enduring eating disorders; treatment development and adaptation; implementation and feasibility; integrated medical–psychological care
(This special issue belongs to the Section Mental Health)
The New Frontier in Rheumatoid Arthritis: From Clinical Phenotypes to Precision Medicine
edited by Paula David and Amit Druyan
submission deadline 20 Apr 2027 | Viewed by 231 | Submission Open
Keywords: rheumatoid arthritis; precision medicine; musculoskeletal ultrasound; MRI; difficult-to-treat (D2T) RA; clinical phenotypes
(This special issue belongs to the Section Immunology & Rheumatology)
Innovations in Percutaneous Coronary Intervention
edited by Sachin Kumar and Amit Hooda
submission deadline 20 Apr 2027 | Viewed by 211 | Submission Open
Keywords: percutaneous coronary intervention; intravascular imaging; coronary physiology; complex coronary interventions; calcified coronary lesions; chronic total occlusion; atherectomy; bifurcation PCI; coronary CT angiography
(This special issue belongs to the Section Cardiology)
Clinical Strategies in Cataract and Refractive Management
edited by and Arie Marcovich
submission deadline 20 Apr 2027 | Viewed by 207 | Submission Open
Keywords: cataract management; refractive management; cataract surgery; refractive surgery; intraocular lens (IOL); IOL power calculation; surgical planning; ocular biometry; anterior segment imaging; refractive outcomes; visual quality; ocular surface optimization; dry eye disease; surgical complications; patient-reported outcomes; clinical ophthalmology
(This special issue belongs to the Section Ophthalmology)
Burning Mouth Syndrome: Advances in Diagnosis and Patient-Centred Management
edited by Daniela Adamo and
submission deadline 20 Apr 2027 | Viewed by 198 | Submission Open
Keywords: oral medicine; oral pathology; burning mouth syndrome; orofacial pain; oral mucosal diseases; psychosomatic dentistry; pharmacological treatment; pharmacotherapy; topical therapy; systemic therapy; pain management; photo-biomodulation; laser therapy; neuromodulation; psychosomatic dentistry; patient-centred care; digital health
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Bidirectional Interplay Between Hematological Malignancies and Comorbidities submission deadline 20 Apr 2027 | Viewed by 194 | Submission Open
Keywords: arrhythmias; cytokine release syndrome; heart failure; hepatitis; hypertension; leukemia; lymphoma; pulmonary fibrosis; renal dysfunction; second cancer
(This special issue belongs to the Section Hematology)
Evolving Imaging Techniques for the Tricuspid Valve and Right Ventricle: Challenges and Future Directions submission deadline 20 Apr 2027 | Viewed by 193 | Submission Open
Keywords: tricuspid valve disease; right ventricle; deformation imaging; cardiac imaging; right heart imaging
(This special issue belongs to the Section Cardiology)
New Updates on Cochlear Implantation and Hearing Rehabilitation
edited by Davide Soloperto
submission deadline 20 Apr 2027 | Viewed by 160 | Submission Open
Keywords: pediatric audiology; cochlear implants; surgical strategies; robotic surgery; inner ear malformations; audiological outcomes evaluation
(This special issue belongs to the Section Otolaryngology)
Oral Hygiene: Updates and Clinical Progress—3rd Edition
edited by
submission deadline 20 Apr 2027 | Viewed by 159 | Submission Open
Keywords: oral hygiene; preventive dentistry; primary care; oral health promotion; public health; integrated care; digital health; oral–systemic health; global oral health
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advanced Therapies and Circulatory Support for Cardiogenic Shock
edited by Ingo Voigt
submission deadline 20 Apr 2027 | Viewed by 158 | Submission Open
Keywords: cardiogenic shock; mechanical circulatory support; extracorporeal membrane oxygenation; ventricular assist devices; hemodynamic monitoring; shock team; myocardial recovery
(This special issue belongs to the Section Cardiology)
Advances in Clinical Anesthesia and Analgesia: Novel Approaches for Optimal Patient Safety and Comfort—2nd Edition
edited by Giuliano Lo Bianco and
submission deadline 20 Apr 2027 | Viewed by 145 | Submission Open
Keywords: pain management; pain medicine; anesthesia; analgesia; anesthesiology; clinical anesthesia; regional anesthesia; perioperative medicine; multimodal analgesia; acute pain management; chronic pain management; enhanced recovery after surgery (ERAS); patient safety; opioid-sparing analgesia; ultrasound-guided regional anesthesia; airway management; anesthetic monitoring; hemodynamic monitoring; postoperative pain; precision anesthesia
(This special issue belongs to the Section Anesthesiology)
Ileal and Bipartition Surgeries in the Era of Incretin-Based Therapies: Defining the Future of Metabolic Surgery
edited by
submission deadline 20 Apr 2027 | Viewed by 136 | Submission Open
Keywords: metabolic surgery; ileal and bipartition surgeries; incretin-based therapies; obesity; diabetes; type 2 diabetes; pharmacological treatment
(This special issue belongs to the Section General Surgery)
Clinical Advances in Cardiac Arrhythmia Treatment
edited by Nithi Tokavanich and Narut Prasitlumkum
submission deadline 20 Apr 2027 | Viewed by 135 | Submission Open
Keywords: arrhythmia; atrial fibrillation; atrial flutter; ventricular arrhythmia; premature ventricular contraction; sudden cardiac death; ventricular fibrillation; ablation; pulse field ablation; supraventricular tachycardia
(This special issue belongs to the Section Cardiology)
The Evolving Landscape of Neuromodulation: From Technology to New Indications and Improved Outcomes
edited by Artur Vetkas and Pablo Andrade
submission deadline 20 Apr 2027 | Viewed by 132 | Submission Open
Keywords: deep brain stimulation; transcranial focused ultrasound; non-invasive neuromodulation, stereo-EEG; clinical neuroengineering; closed-loop stimulation; clinical translational neuroscience, patient outcomes
(This special issue belongs to the Section Clinical Neurology)
Transformative Advances in Crohn’s Disease: Early Disease Intervention and Pre-Clinical Intervention submission deadline 20 Apr 2027 | Viewed by 125 | Submission Open
Keywords: inflammatory bowel disease; Crohn’s disease; early treatment; effective intervention; early disease; pre-clinical disease; early medical treatment; early surgical treatment; early patient management
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Advances in Trauma and Emergency Medicine, 2nd Edition
edited by Viktoria Bogner-Flatz
submission deadline 20 Apr 2027 | Viewed by 117 | Submission Open
Keywords: resuscitation; trauma emergency management; disaster response; mild traumatic brain injury emergency management; critical emergency care
(This special issue belongs to the Section Emergency Medicine)
Clinical Progress in Hemodialysis and Peritoneal Dialysis
edited by Jyoti Baharani
submission deadline 20 Apr 2027 | Viewed by 109 | Submission Open
Keywords: hemodialysis; peritoneal dialysis; home dialysis; vascular access; chronic kidney disease; shared decision-making
(This special issue belongs to the Section Nephrology & Urology)
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