Molecular Insights in Cardiovascular Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 89
Special Issue Editor
Interests: heart failure; gut microbiome dysbiosis-cardiotoxicity; diabetic cardiomyopathy; cardiovascular aging; cancer biology; chemotherapy associated cardiotoxicity; autophagy; mitochondrial dysfunction
Special Issue Information
Dear Colleagues,
Heart failure remains a critical and expanding health concern worldwide, characterized by widespread incidence, high mortality, and considerable strain on healthcare resources. Although progress has been made in early detection, prevention, and treatment, the condition continues to challenge clinical management due to its complex and multifactorial nature. Current research emphasizes a deeper exploration of underlying mechanisms, highlighting the roles of immune responses, cytokine signalling, and growth factor activity in disease progression. Emerging evidence also connects heart failure with conditions such as diabetic cardiomyopathy, cardiovascular aging, and chemotherapy-induced cardiotoxicity.
At the molecular level, disruptions in autophagy, mitochondrial function, and energy metabolism contribute significantly to cardiac dysfunction, while alterations in ion channel activity and rhythmic stability further complicate disease outcomes. Additionally, gut microbiome dysbiosis is increasingly recognized as a contributor to cardiotoxic effects. Structural and functional cardiac remodelling, often driven by hypertension and other risk factors, plays a central role in disease advancement.
Advances in diagnostic approaches, particularly echocardiography, support earlier and more accurate assessment, while therapeutic strategies continue to evolve from conventional pharmacological treatments to innovative device-based interventions. Overall, a comprehensive and integrative understanding of these interconnected pathways is essential for improving prevention, diagnosis, and treatment of heart failure.
The Special Issue titled “Molecular Insights in Cardiovascular Disease” seeks to encourage in-depth and integrative research approaches. It welcomes contributions addressing the mechanisms underlying heart failure and its causes, including molecular pathways, as well as diagnostic techniques. Additionally, it covers therapeutic strategies ranging from pharmacological treatments to device-based interventions.
This Special Issue emphasizes the integration of fundamental research, translational studies, and clinical evidence to advance a comprehensive understanding of heart failure pathophysiology, taking into account the multifaceted nature of this complex condition.
Dr. Sudhir Pandey
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
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Keywords
- heart failure
- gut microbiome dysbiosis-cardiotoxicity
- diabetic cardiomyopathy
- cardiovascular aging
- chemotherapy associated cardiotoxicity
- autophagy
- mitochondrial dysfunction
- rhythmic disorders
- risk factors
- ion channels
- energy metabolism
- cardiac hypertension
- echocardiography
- remodelling
- transplantation
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