Molecular Mechanisms of Addiction and Substance Abuse Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 108
Special Issue Editor
Special Issue Information
Dear Colleagues,
There is an epidemic of drug addiction/substance use disorders that continues to exert a huge socioeconomic impact on society. There are not many FDA-approved pharmacotherapies for this condition, complicating our ability to effectively address it. What is clear is that these substances exert pharmacological and behavioral effects on the user to initiate and maintain their use/abuse, which eventually leads to use disorders. These pharmacological and behavioral effects are governed by molecular mechanisms. To understand substance use disorders, it is essential to apprehend the molecular mechanisms underlying these conditions.
This Special Issue aims to decode the molecular mechanisms underlying addiction. Topics of interest include but are not limited to molecular pharmacology, genomics, transcriptomics, epigenetics, proteomics and metabolomics. Topics of interest include but are not limited to gene functional assays–loss-of-function assays and gain-of-function assays.
Translational studies linking molecular findings to clinical outcomes, treatment selection, and novel therapeutic strategies are particularly encouraged. By bridging molecular discoveries with clinical implications, this Special Issue seeks to provide a comprehensive platform for understanding the molecular mechanisms of addiction and substance abuse disorders.
Dr. Martin O. Job
Guest Editor
Manuscript Submission Information
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Keywords
- psychostimulant use disorders
- opioid use disorders
- addiction
- biomarkers
- phenotypes
- heterogeneity
- genomics
- epigenetics
- metabolomics
- translational research
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