Bioinformatics and Phylogenetics of Molecular Pathways and Human Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Informatics".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 134
Editor
Interests: bioinformatics; machine learning; deep learning; text mining
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue focuses on the intersection of bioinformatics, phylogenetic analysis, and molecular pathway dynamics, and their implications for human disease. With the rapid development of high-throughput sequencing technologies, large-scale multi-omics data have enabled more comprehensive exploration of the evolutionary patterns and functional regulation of molecular pathways. However, the complexity and dynamic nature of these pathways still present significant challenges for understanding disease mechanisms.
This Special Issue aims to highlight advanced computational and integrative approaches that can decode the evolutionary and functional complexity of molecular pathways involved in disease pathogenesis, progression, and therapeutic resistance. In particular, studies integrating multi-omics data and phylogenetic frameworks to reveal pathway evolution, network remodeling, and regulatory interactions are highly encouraged. By improving our understanding of how molecular pathways change across different biological conditions, this collection seeks to provide new insights into disease mechanisms and identify potential biomarkers and therapeutic targets.
We welcome original research, reviews, and methodological papers covering:
- Phylogenetic and comparative genomic analyses of disease-related pathways;
- Bioinformatics tools for multi-omics integration and pathway enrichment;
- AI-driven models and disease knowledge graph methods for predicting pathway-disease associations;
- Translational applications in precision medicine and biomarker discovery.
By bringing together researchers from computational biology, genomics, bioinformatics, translational medicine and clinical sciences, this Special Issue seeks to advance our understanding of molecular pathway dysregulation and foster the development of novel therapeutic strategies for human diseases.
Dr. Yang Yang
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- bioinformatics
- phylogenetics
- molecular pathways
- human disease
- multi-omics integration
- biomarker discovery
- disease knowledge graph
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
